PDB: 46200 件ウェブページステータス検索Chemie searchBIRD

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4L5J	Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition 分子名称: 5-O-phosphono-alpha-D-ribofuranose, Transcriptional regulator LsrR 著者 Ryu, K.S, Ha, J.H, Eo, Y. 登録日 2013-06-11 公開日 2013-11-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structures of the LsrR Proteins Complexed with Phospho-AI-2 and Two Signal-Interrupting Analogues Reveal Distinct Mechanisms for Ligand Recognition. J.Am.Chem.Soc., 135, 2013
6KD6	Shuguo PWWP domain 分子名称: LD23804p 著者 Liu, Y.C, Huang, Y. 登録日 2019-07-01 公開日 2020-07-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Shuguo PWWP domain To Be Published
6ZU8	Crystal structure of human Brachyury G177D variant in complex with Afatinib 分子名称: Brachyury protein, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide, ZINC ION 著者 Newman, J.A, Gavard, A.E, Shrestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. 登録日 2020-07-21 公開日 2020-08-05 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of human Brachyury G177D variant in complex with Afatinib To Be Published
7QQ3	Cryo-EM structure of the E.coli 50S ribosomal subunit in complex with the antibiotic Myxovalargin A. 分子名称: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... 著者 Koller, T.O, Beckert, B, Wilson, D.N. 登録日 2022-01-06 公開日 2023-01-18 最終更新日 2023-02-01 実験手法 ELECTRON MICROSCOPY (2.1 Å) 主引用文献 The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition. J.Am.Chem.Soc., 145, 2023
6L54	Structure of SMG189 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein SMG8, ... 著者 Xu, Y, Qi, Y. 登録日 2019-10-22 公開日 2020-04-15 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.43 Å) 主引用文献 Cryo-EM structure of SMG1-SMG8-SMG9 complex. Cell Res., 29, 2019
8J1Z	The global structure of pre50S related to DbpA in state3 分子名称: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... 著者 Yu, T, Zeng, F. 登録日 2023-04-13 公開日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 PTC Remodeling in Pre50S Intermediates: Insights into the Role of DEAD-box RNA Helicase DbpA To Be Published
4AGP	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5176 分子名称: 2-{[4-(diethylamino)piperidin-1-yl]methyl}-6-iodo-4-(3-phenoxyprop-1-yn-1-yl)phenol, CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C, Wilcken, R, Fersht, A.R, Boeckler, F.M. 登録日 2012-01-30 公開日 2012-03-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012
6L53	Structure of SMG1 分子名称: Serine/threonine-protein kinase SMG1 著者 Xu, Y, Qi, Y. 登録日 2019-10-22 公開日 2020-04-15 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.63 Å) 主引用文献 Cryo-EM structure of SMG1-SMG8-SMG9 complex. Cell Res., 29, 2019
5GAE	RNC in complex with a translocating SecYEG 分子名称: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... 著者 Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. 登録日 2015-11-25 公開日 2016-01-27 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.33 Å) 主引用文献 Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon. Nat Commun, 7, 2016
4AGN	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5116 分子名称: 2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4-(3-HYDROXYPROP-1-YN-1-YL)-6-IODOPHENOL, CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R. 登録日 2012-01-30 公開日 2012-03-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012
4AGO	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5174 分子名称: CELLULAR TUMOR ANTIGEN P53, TERT-BUTYL [3-(3-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4-HYDROXY-5-IODOPHENYL)PROP-2-YN-1-YL]CARBAMATE, ZINC ION 著者 Joerger, A.C, Wilcken, R, Fersht, A.R, Boeckler, F.M. 登録日 2012-01-30 公開日 2012-03-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012
4AGQ	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5196 分子名称: 2-{[4-(diethylamino)piperidin-1-yl]methyl}-6-iodo-4-[3-(phenylamino)prop-1-yn-1-yl]phenol, CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R. 登録日 2012-01-30 公開日 2012-03-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012
4AGL	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan784 分子名称: 2,4-BIS(IODANYL)-6-[[METHYL-(1-METHYLPIPERIDIN-4-YL)AMINO]METHYL]PHENOL, CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R. 登録日 2012-01-30 公開日 2012-03-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012
4AGM	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5086 分子名称: 2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4,6-DIIODOPHENOL, CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R. 登録日 2012-01-30 公開日 2012-03-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012
4BHP	A structural model of CAP mutant (T127L and S128I) in cGMP-bound state 分子名称: CAMP RECEPTOR PROTEIN 著者 Tzeng, S.R, Kalodimos, C.G. 登録日 2013-04-04 公開日 2013-05-08 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Allosteric Inhibition Through Suppression of Transient Conformational States. Nat.Chem.Biol., 9, 2013
4BH9	A structural model of CAP mutant (T127L and S128I) in the apo state 分子名称: cAMP-activated global transcriptional regulator CRP 著者 Tzeng, S.R, Kalodimos, C.G. 登録日 2013-03-30 公開日 2013-05-08 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Allosteric inhibition through suppression of transient conformational states. Nat. Chem. Biol., 9, 2013
4U50	Crystal structure of Verrucarin bound to the yeast 80S ribosome 分子名称: (4S,5R,10E,12Z,16R,16aS,17S,18R,19aR,23aR)-4-hydroxy-5,16a,21-trimethyl-4,5,6,7,16,16a,22,23-octahydro-3H,18H,19aH-spiro[16,18-methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene-17,2'-oxirane]-3,9,14-trione, 18S ribosomal RNA, 25S ribosomal RNA, ... 著者 Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. 登録日 2014-07-24 公開日 2014-10-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
8FKP	Human nucleolar pre-60S ribosomal subunit (State A1) 分子名称: 28S rRNA, 5.8S rRNA, 60S ribosomal protein L13, ... 著者 Vanden Broeck, A, Klinge, S. 登録日 2022-12-21 公開日 2023-07-12 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.85 Å) 主引用文献 Principles of human pre-60 S biogenesis. Science, 381, 2023
8FKR	Human nucleolar pre-60S ribosomal subunit (State B1) 分子名称: 28S rRNA, 5.8S rRNA, 60S ribosomal protein L12, ... 著者 Vanden Broeck, A, Klinge, S. 登録日 2022-12-21 公開日 2023-07-12 最終更新日 2023-07-19 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Principles of human pre-60 S biogenesis. Science, 381, 2023
8FKS	Human nucleolar pre-60S ribosomal subunit (State B2) 分子名称: 28S rRNA, 5.8S rRNA, 60S ribosomal protein L12, ... 著者 Vanden Broeck, A, Klinge, S. 登録日 2022-12-21 公開日 2023-07-12 最終更新日 2023-07-19 実験手法 ELECTRON MICROSCOPY (2.88 Å) 主引用文献 Principles of human pre-60 S biogenesis. Science, 381, 2023
4U4R	Crystal structure of Lactimidomycin bound to the yeast 80S ribosome 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 4-{(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4E,6Z,10E)-3-methyl-12-oxooxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-en-1-yl}piperidine-2,6-dione, ... 著者 Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. 登録日 2014-07-24 公開日 2014-10-22 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.801 Å) 主引用文献 Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
8FKQ	Human nucleolar pre-60S ribosomal subunit (State A2) 分子名称: 28S rRNA, 5.8S rRNA, 60S ribosomal protein L13, ... 著者 Vanden Broeck, A, Klinge, S. 登録日 2022-12-21 公開日 2023-07-12 最終更新日 2023-07-19 実験手法 ELECTRON MICROSCOPY (2.76 Å) 主引用文献 Principles of human pre-60 S biogenesis. Science, 381, 2023
4U3M	Crystal structure of Anisomycin bound to the yeast 80S ribosome 分子名称: 18S rRNA, 25s rRNA, 40S ribosomal protein S0-A, ... 著者 Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. 登録日 2014-07-22 公開日 2014-10-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
4U4N	Crystal structure of Edeine bound to the yeast 80S ribosome 分子名称: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... 著者 Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. 登録日 2014-07-24 公開日 2014-10-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
4U55	Crystal structure of Cryptopleurine bound to the yeast 80S ribosome 分子名称: (14aR)-2,3,6-trimethoxy-11,12,13,14,14a,15-hexahydro-9H-dibenzo[f,h]pyrido[1,2-b]isoquinoline, 18S ribosomal RNA, 25S ribosomal RNA, ... 著者 Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. 登録日 2014-07-24 公開日 2014-10-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014

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