PDB: 47065 件ウェブページステータス検索Chemie searchBIRD

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9B5Z	GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of LBD-TMD-TARPgamma2 分子名称: Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit 著者 Nakagawa, T, Greger, I.H. 登録日 2024-03-23 公開日 2024-07-31 実験手法 ELECTRON MICROSCOPY (2.71 Å) 主引用文献 Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization To Be Published
9BBM	PHF filament generated from 4E-Tau(297-407) under neutral Mg2+ condition 分子名称: Isoform Tau-F of Microtubule-associated protein tau 著者 Duan, P, El Mammeri, N. 登録日 2024-04-06 公開日 2024-05-08 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Milligram-scale assembly and NMR fingerprint of tau fibrils adopting the Alzheimer's disease fold. J.Biol.Chem., 300, 2024
9EP4	Structure of Integrator subcomplex INTS5/8/15 分子名称: Integrator complex subunit 15, Integrator complex subunit 5, Integrator complex subunit 8 著者 Razew, M, Galej, W.P. 登録日 2024-03-17 公開日 2024-06-12 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis of the Integrator complex assembly and association with transcription factors. Mol.Cell, 84, 2024
9EUA	The FK1 domain of FKBP51 in complex with SAFit-analog 23d 分子名称: (1-propylpyrazol-4-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 著者 Meyners, C, Buffa, V, Hausch, F. 登録日 2024-03-27 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. Chemmedchem, 2024
9B12	Structure of Optineurin bound to HOIP NZF1 domain and M1-linked diubiquitin, crystal form 1 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, E3 ubiquitin-protein ligase RNF31, ... 著者 Michel, M.A, Scutts, S, Komander, D. 登録日 2024-03-12 公開日 2024-07-31 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Linkage and substrate specificity conferred by NZF ubiquitin binding domains To Be Published
9EU9	The FK1 domain of FKBP51 in complex with SAFit-analog 15i 分子名称: (4-chloranyl-1,3-thiazol-5-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 著者 Meyners, C, Buffa, V, Hausch, F. 登録日 2024-03-27 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. Chemmedchem, 2024
8Z5J	Beta-catenin Crystal Structure 分子名称: Catenin beta-1 著者 Tim, F. 登録日 2024-04-18 公開日 2024-05-22 最終更新日 2024-07-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting beta-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of Antigen Presentation of cDC1 Cells. J.Med.Chem., 2024
9B63	GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of TMD-TARPgamma2 分子名称: Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit 著者 Nakagawa, T, Greger, I.H. 登録日 2024-03-23 公開日 2024-07-31 実験手法 ELECTRON MICROSCOPY (2.76 Å) 主引用文献 Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization To Be Published
8ZJK	Structure of DOCK5/ELMO1/Rac1 core (RhoG/DOCK5/ELMO1/Rac1 dataset, class 3) 分子名称: Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 著者 Kukimoto-Niino, M, Katsura, K, Ishizuka-Katsura, Y, Mishima-Tsumagari, C, Yonemochi, M, Inoue, M, Nakagawa, R, Kaushik, R, Zhang, K.Y.J, Shirouzu, M. 登録日 2024-05-15 公開日 2024-06-26 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.23 Å) 主引用文献 RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state. J.Biol.Chem., 300, 2024
9EY4	The FK1 domain of FKBP51 in complex with (3S,11S)-12-((3,5-dichlorophenyl)sulfonyl)-5-oxo-11-vinyldecahydro-1H-6,10-epiminopyrrolo[1,2-a]azonine-3-carboxamide 分子名称: (1~{S},4~{S},7~{S},8~{S},9~{R})-13-[3,5-bis(chloranyl)phenyl]sulfonyl-8-ethenyl-2-oxidanylidene-3,13-diazatricyclo[7.3.1.0^{3,7}]tridecane-4-carboxamide, Peptidyl-prolyl cis-trans isomerase FKBP5 著者 Meyners, C, Krajczy, P, Hausch, F. 登録日 2024-04-09 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.16 Å) 主引用文献 Structure-Based Design of Ultrapotent Tricyclic Ligands for FK506-Binding proteins. Chemistry, 2024
9BH6	Human DNA polymerase theta helicase domain tetramer in the apo form 分子名称: DNA polymerase theta 著者 Zerio, C.J, Lander, G.C. 登録日 2024-04-19 公開日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Human polymerase theta helicase positions DNA microhomologies for double-strand break repair To Be Published
9F4R	UP1 in complex with Z802821712 分子名称: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, N-ethyl-6-methylpyridazin-3-amine 著者 Dunnett, L, Prischi, F. 登録日 2024-04-28 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9FW2	SARS CoV-2 nsp10 in complex with the ExoN domain from nsp14 分子名称: GLYCEROL, Guanine-N7 methyltransferase nsp14, Non-structural protein 11, ... 著者 Fisher, S.Z. 登録日 2024-06-28 公開日 2024-07-10 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 SARS CoV-2 nsp10 in complex with the ExoN domain from nsp14 To Be Published
9F4M	UP1 in complex with Z1401276297 分子名称: (5~{R})-7-pyrazin-2-yl-2-oxa-7-azaspiro[4.4]nonane, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 著者 Dunnett, L, Prischi, F. 登録日 2024-04-28 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
8Y1D	2up-TM conformation of HKU1-B S protein after incubation of the receptor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... 著者 Xia, L.Y, Zhang, Y.Y, Zhou, Q. 登録日 2024-01-24 公開日 2024-05-01 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2. Cell Res., 34, 2024
9F7F	UP1 in complex with Z1491353358 分子名称: (3S)-1-(phenylsulfonyl)pyrrolidin-3-amine, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 著者 Dunnett, L, Prischi, F. 登録日 2024-05-03 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
8ZM2	Structure of human pyruvate dehydrogenase kinase 2 complexed with compound 16 分子名称: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, methyl (9~{R})-9-oxidanyl-9-(trifluoromethyl)fluorene-4-carboxylate 著者 Akai, S, Orita, T, Nomura, A, Adachi, T. 登録日 2024-05-22 公開日 2024-06-19 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase. Bioorg.Med.Chem.Lett., 109, 2024
9G2R	Endophilin B1 dimers bound to nanodiscs 分子名称: Endophilin-B1 著者 Thorlacius, A, Sundborger-Lunna, A. 登録日 2024-07-11 公開日 2024-08-07 実験手法 ELECTRON MICROSCOPY (3.88 Å) 主引用文献 Endophilin B1 dimers bound to nanodiscs To Be Published
8YD8	Structure of FADD/Caspase-8/cFLIP death effector domain assembly 分子名称: CASP8 and FADD-like apoptosis regulator subunit p43, Caspase-8, FAS-associated death domain protein 著者 Lin, S.-C, Yang, C.-Y. 登録日 2024-02-19 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis. Nat Commun, 15, 2024
8YBX	Structure of the FADD/Caspase-8/cFLIP death effector domain assembly 分子名称: CASP8 and FADD-like apoptosis regulator subunit p43, Caspase-8 subunit p10, FAS-associated death domain protein 著者 Lin, S.-C, Yang, C.-Y. 登録日 2024-02-16 公開日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.68 Å) 主引用文献 Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis. Nat Commun, 15, 2024
9ICC	DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYADENOSINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DATP AND CRCL3 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CHROMIUM ION, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), ... 著者 Pelletier, H, Sawaya, M.R. 登録日 1995-12-15 公開日 1995-12-15 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis. Biochemistry, 35, 1996
9B60	GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of TMD-TARPgamma2 分子名称: Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit 著者 Nakagawa, T, Greger, I.H. 登録日 2024-03-23 公開日 2024-07-31 実験手法 ELECTRON MICROSCOPY (2.57 Å) 主引用文献 Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization To Be Published
9EMC	RUVBL1/2 in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RuvB-like 1, ... 著者 Lopez-Perrote, A, Llorca, O, Garcia-Martin, C. 登録日 2024-03-11 公開日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Mechanism of allosteric inhibition of RUVBL1-RUVBL2 by the small-molecule CB-6644 Cell Rep Phys Sci, 2024
9EUB	The FK1 domain of FKBP51 in complex with SAFit-analog 24e 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, [1-(2-hydroxyethyl)pyrazol-4-yl]methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate 著者 Meyners, C, Buffa, V, Hausch, F. 登録日 2024-03-27 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. Chemmedchem, 2024
8Z3S	Activation mechanism and novel binding site of the BKCa channel activator CTIBD 分子名称: 4-[4-(4-chlorophenyl)-3-(trifluoromethyl)-1,2-oxazol-5-yl]benzene-1,3-diol, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... 著者 Lee, N, Kim, S, Jo, H, Lee, N.Y, Jin, M.S, Park, C.S. 登録日 2024-04-16 公開日 2024-07-31 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Activation mechanism and novel binding site of the BKCa channel activator CTIBD To Be Published

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