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7MR9
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Crystal structure of the first bromodomain (BD1) of human BRD4 bound to NC-II-153
分子名称: 1,2-ETHANEDIOL, 2-methyl-4-[3-(2-oxopyrrolidin-1-yl)phenyl]isoquinolin-1(2H)-one, Bromodomain-containing protein 4
著者Chan, A, Schonbrunn, E.
登録日2021-05-07
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.19 Å)
主引用文献Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity.
J.Med.Chem., 65, 2022
7MRA
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Crystal structure of the first bromodomain (BD1) of human BRD4 bound to NC-II-259
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-[3-(2-methyl-1-oxo-1,2-dihydroisoquinolin-4-yl)phenyl]ethanesulfonamide
著者Chan, A, Schonbrunn, E.
登録日2021-05-07
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.16 Å)
主引用文献Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity.
J.Med.Chem., 65, 2022
7MRB
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Crystal structure of the first bromodomain (BD1) of human BRD4 bound to NC-III-53
分子名称: Bromodomain-containing protein 4, N-[4-(4-chlorophenoxy)-3-(2-methyl-1-oxo-1,2-dihydroisoquinolin-4-yl)phenyl]ethanesulfonamide
著者Chan, A, Schonbrunn, E.
登録日2021-05-07
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity.
J.Med.Chem., 65, 2022
7MRH
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BU of 7mrh by Molmil
Crystal structure of the first bromodomain (BD1) of human BRDT bound to NC-II-259
分子名称: Bromodomain testis-specific protein, N-[3-(2-methyl-1-oxo-1,2-dihydroisoquinolin-4-yl)phenyl]ethanesulfonamide
著者Chan, A, Schonbrunn, E.
登録日2021-05-07
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity.
J.Med.Chem., 65, 2022
7MRG
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BU of 7mrg by Molmil
Crystal structure of the first bromodomain (BD1) of human BRDT bound to NC-II-153
分子名称: 1,2-ETHANEDIOL, 2-methyl-4-[3-(2-oxopyrrolidin-1-yl)phenyl]isoquinolin-1(2H)-one, Bromodomain testis-specific protein, ...
著者Chan, A, Schonbrunn, E.
登録日2021-05-07
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity.
J.Med.Chem., 65, 2022
7MSS
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BU of 7mss by Molmil
Human E105Qa GTP-specific succinyl-CoA synthetase complexed with succinate, magnesium ion and CoA
分子名称: COENZYME A, GLYCEROL, MAGNESIUM ION, ...
著者Huang, J, Fraser, M.E.
登録日2021-05-12
公開日2022-10-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The structure of succinyl-CoA synthetase bound to the succinyl-phosphate intermediate clarifies the catalytic mechanism of ATP-citrate lyase
Acta Crystallogr.,Sect.F, 78, 2022
7MSR
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BU of 7msr by Molmil
Human E105Qa GTP-specific succinyl-CoA synthetase complexed with succinyl-phosphate, magnesium ion and desulfo-coenzyme A
分子名称: 1,2-ETHANEDIOL, 4-oxo-4-(phosphonooxy)butanoic acid, DESULFO-COENZYME A, ...
著者Huang, J, Fraser, M.E.
登録日2021-05-12
公開日2022-10-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献The structure of succinyl-CoA synthetase bound to the succinyl-phosphate intermediate clarifies the catalytic mechanism of ATP-citrate lyase
Acta Crystallogr.,Sect.F, 78, 2022
3JAE
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BU of 3jae by Molmil
Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine-bound state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1
著者Du, J, Lu, W, Wu, S.P, Cheng, Y.F, Gouaux, E.
登録日2015-06-08
公開日2015-09-09
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Glycine receptor mechanism elucidated by electron cryo-microscopy.
Nature, 526, 2015
7N2O
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BU of 7n2o by Molmil
AS4.2-YEIH-HLA*B27
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, GLYCEROL, ...
著者Yang, X, Jude, K.M, Garcia, K.C.
登録日2021-05-29
公開日2022-12-07
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
7N2Q
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AS4.3-YEIH-HLA*B27
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, AS4.3 T cell receptor alpha chain, AS4.3 T cell receptor beta chain, ...
著者Yang, X, Jude, K.M, Garcia, K.C.
登録日2021-05-29
公開日2022-12-07
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
7N2S
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AS3.1-PRPF3-HLA*B27
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, GLYCEROL, ...
著者Yang, X, Jude, K.M, Garcia, K.C.
登録日2021-05-29
公開日2022-12-07
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
7N2R
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BU of 7n2r by Molmil
AS4.3-PRPF3-HLA*B27
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, AS4.3 T cell receptor alpha chain, ...
著者Yang, X, Jude, K.M, Garcia, K.C.
登録日2021-05-29
公開日2022-12-07
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
7N2N
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BU of 7n2n by Molmil
TCR-antigen complex AS4.2-PRPF3-HLA*B27
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, GLYCEROL, ...
著者Yang, X, Jude, K.M, Garcia, K.C.
登録日2021-05-29
公開日2022-12-07
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
3JVN
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BU of 3jvn by Molmil
Crystal Structure of the acetyltransferase VF_1542 from Vibrio fischeri, Northeast Structural Genomics Consortium Target VfR136
分子名称: Acetyltransferase, SULFATE ION
著者Forouhar, F, Neely, H, Seetharaman, J, Mao, M, Xiao, R, Ciccosanti, C, Zhao, L, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
登録日2009-09-17
公開日2009-09-29
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Northeast Structural Genomics Consortium Target VfR136
To be Published
7N2P
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BU of 7n2p by Molmil
AS4.3-RNASEH2b-HLA*B27
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, AS4.3 T cell receptor alpha chain, AS4.3 T cell receptor beta chain, ...
著者Yang, X, Jude, K.M, Garcia, K.C.
登録日2021-05-29
公開日2022-12-07
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
7N4O
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BU of 7n4o by Molmil
Crystal structure of R20A human Galectin-7 mutant
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Galectin-7
著者Pham, N.T.H, Calmettes, C, Doucet, N.
登録日2021-06-04
公開日2023-01-25
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structure of R20A human Galectin-7 mutant
To Be Published
7N8G
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BU of 7n8g by Molmil
Crystal structure of R20A-R22A human Galectin-7 mutant
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ...
著者Pham, N.T.H, Calmettes, C, Doucet, N.
登録日2021-06-14
公開日2023-01-25
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of R20A human Galectin-7 mutant
To Be Published
7MXR
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BU of 7mxr by Molmil
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (r-2)
分子名称: DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), Exonuclease 1, ...
著者Shi, Y, Beese, L.S.
登録日2021-05-19
公開日2023-05-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.101 Å)
主引用文献Structures of reaction intermediates reveal transient Mg2+-binding events that dynamically coordinate Human Exonuclease I activities
To Be Published
7MXS
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BU of 7mxs by Molmil
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (cr)
分子名称: DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), Exonuclease 1, ...
著者Shi, Y, Beese, L.S.
登録日2021-05-19
公開日2023-05-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.798 Å)
主引用文献Structures of reaction intermediates reveal transient Mg2+-binding events that dynamically coordinate Human Exonuclease I activities
To Be Published
7MXU
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Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' flap DNA (cf2)
分子名称: DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*A)-3'), DNA (5'-D(P*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), Exonuclease 1, ...
著者Shi, Y, Beese, L.S.
登録日2021-05-19
公開日2023-05-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.042 Å)
主引用文献Structures of reaction intermediates reveal transient Mg2+-binding events that dynamically coordinate Human Exonuclease I activities
To Be Published
7MXV
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BU of 7mxv by Molmil
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (ur)
分子名称: DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), Exonuclease 1, ...
著者Shi, Y, Beese, L.S.
登録日2021-05-19
公開日2023-05-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.211 Å)
主引用文献Structures of reaction intermediates reveal transient Mg2+-binding events that dynamically coordinate Human Exonuclease I activities
To Be Published
7MXT
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BU of 7mxt by Molmil
Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (cmr)
分子名称: DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), Exonuclease 1, ...
著者Shi, Y, Beese, L.S.
登録日2021-05-19
公開日2023-05-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.048 Å)
主引用文献Structures of reaction intermediates reveal transient Mg2+-binding events that dynamically coordinate Human Exonuclease I activities
To Be Published
7N6C
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BU of 7n6c by Molmil
Crystal structure of R22A human Galectin-7 mutant
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ...
著者Pham, N.T.H, Calmettes, C, Doucet, N.
登録日2021-06-08
公開日2023-01-25
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of R20A human Galectin-7 mutant
To Be Published
3JZY
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BU of 3jzy by Molmil
Crystal structure of human Intersectin 2 C2 domain
分子名称: Intersectin 2, UNKNOWN ATOM OR ION
著者Shen, Y, Tempel, W, Tong, Y, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2009-09-24
公開日2009-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Crystal structure of human Intersectin 2 C2 domain
To be Published
7N96
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BU of 7n96 by Molmil
Crystal structure of D103A human Galectin-7 mutant
分子名称: GLYCEROL, Galectin-7
著者Pham, N.T.H, Calmettes, C, Doucet, N.
登録日2021-06-16
公開日2023-01-25
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Crystal structure of D103A human Galectin-7 mutant
To Be Published

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件を2025-07-09に公開中

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