8VYC
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8VY9
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![BU of 8vy9 by Molmil](/molmil-images/mine/8vy9) | CryoEM structure of Ggust-coupled TAS2R14 with cholesterol and an intracellular tastant | 分子名称: | 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Kim, Y, Gumpper, R.H, Roth, B.L. | 登録日 | 2024-02-07 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature, 628, 2024
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8VY8
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8VY7
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![BU of 8vy7 by Molmil](/molmil-images/mine/8vy7) | CryoEM structure of Gi-coupled TAS2R14 with cholesterol and an intracellular tastant | 分子名称: | 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Kim, Y, Gumpper, R.H, Roth, B.L. | 登録日 | 2024-02-07 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature, 628, 2024
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8VY6
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![BU of 8vy6 by Molmil](/molmil-images/mine/8vy6) | Murine light chain dimer | 分子名称: | 6A8 light chain, SULFATE ION | 著者 | Kapingidza, A.B, Dolamore, C, Hyduke, N.P, Easly, W, Chivv, C, Pomes, A, Chruszcz, M. | 登録日 | 2024-02-07 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural, Biophysical, and Computational Studies of a Murine Light Chain Dimer. Molecules, 29, 2024
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8VXY
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![BU of 8vxy by Molmil](/molmil-images/mine/8vxy) | Structure of HamA(E138A,K140A)B-plasmid DNA complex from the Escherichia coli Hachiman defense system | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, HamA, HamB, ... | 著者 | Tuck, O.T, Hu, J.J, Doudna, J.A. | 登録日 | 2024-02-06 | 公開日 | 2024-03-13 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Hachiman is a genome integrity sensor. Biorxiv, 2024
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8VXU
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8VXQ
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8VXF
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![BU of 8vxf by Molmil](/molmil-images/mine/8vxf) | Structure of Casein kinase I isoform delta (CK1d) complexed with inhibitor 15 | 分子名称: | (2P,3P,8S)-2-(5-fluoropyridin-2-yl)-6,6-dimethyl-3-(1H-pyrazolo[3,4-b]pyridin-4-yl)-6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazine, Casein kinase I isoform delta | 著者 | Thompson, A.A, Milligan, C.M, Sharma, S. | 登録日 | 2024-02-04 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structure-Based Optimization of Selective and Brain Penetrant CK1 delta Inhibitors for the Treatment of Circadian Disruptions. Acs Med.Chem.Lett., 15, 2024
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8VXE
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![BU of 8vxe by Molmil](/molmil-images/mine/8vxe) | Structure of p38 alpha (Mitogen-activated protein kinase 14) complexed with inhibitor 6 | 分子名称: | (4M)-4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine, Mitogen-activated protein kinase 14 | 著者 | Blaesse, M, Steinbacher, S, Shaffer, P.L, Sharma, S, Thompson, A.A. | 登録日 | 2024-02-04 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure-Based Optimization of Selective and Brain Penetrant CK1 delta Inhibitors for the Treatment of Circadian Disruptions. Acs Med.Chem.Lett., 15, 2024
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8VXD
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8VXC
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8VXA
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8VX9
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8VX0
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![BU of 8vx0 by Molmil](/molmil-images/mine/8vx0) | CRYSTAL STRUCTURE OF CYP2C9*14 IN COMPLEX WITH LOSARTAN | 分子名称: | Cytochrome P450 2C9, PHOSPHATE ION, POTASSIUM ION, ... | 著者 | Shah, M.B. | 登録日 | 2024-02-02 | 公開日 | 2024-06-12 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Structural and biophysical analysis of cytochrome P450 2C9*14 and *27 variants in complex with losartan. J.Inorg.Biochem., 258, 2024
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8VWR
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![BU of 8vwr by Molmil](/molmil-images/mine/8vwr) | Structure of steroid hydratase from Comamonas testosteroni | 分子名称: | Acyl dehydratase, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Schroeter, K.L, Forrester, T.J.B, Kimber, M.S, Seah, S.Y.K. | 登録日 | 2024-02-02 | 公開日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Shy is a Proteobacterial steroid hydratase which catalyzes steroid side chain degradation without requiring a catalytically inert partner domain. J.Biol.Chem., 2024
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8VWP
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8VW5
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![BU of 8vw5 by Molmil](/molmil-images/mine/8vw5) | Crystal structure of Cbl-b TKB bound to compound 2 | 分子名称: | CALCIUM ION, E3 ubiquitin-protein ligase CBL-B, MAGNESIUM ION, ... | 著者 | Yu, C, Murray, J, Hsu, P.L. | 登録日 | 2024-01-31 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding. Acs Med.Chem.Lett., 15, 2024
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8VW4
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![BU of 8vw4 by Molmil](/molmil-images/mine/8vw4) | Crystal structure of Cbl-b TKB bound to compound 26 | 分子名称: | (7-methoxy-2-{2-[(1S,3S,4S)-3-(3-methoxy-2-methyl-5-nitrophenyl)-1-methyl-5-oxo-1,5-dihydroimidazo[1,5-a]pyridin-2(3H)-yl]-2-oxoethoxy}quinolin-8-yl)acetic acid, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase CBL-B, ... | 著者 | Yu, C, Murray, J, Hsu, P.L. | 登録日 | 2024-01-31 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding. Acs Med.Chem.Lett., 15, 2024
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8VW2
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8VW1
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8VW0
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8VVO
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![BU of 8vvo by Molmil](/molmil-images/mine/8vvo) | Structure of FabS1CE2-EPR1-1 in complex with the erythropoietin receptor | 分子名称: | CHLORIDE ION, Erythropoietin receptor, S1CE2 VARIANT OF FAB-EPR-1 heavy chain, ... | 著者 | Singer, A.U, Bruce, H.A, Pavlenco, A, Ploder, L, Luu, G, Blazer, L, Adams, J.J, Sidhu, S.S. | 登録日 | 2024-01-31 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33, 2024
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8VVM
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![BU of 8vvm by Molmil](/molmil-images/mine/8vvm) | Structure of FabS1CE1-EPR1-1 in complex with the erythropoietin receptor | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Singer, A.U, Bruce, H.A, Pavlenco, A, Ploder, L, Luu, G, Blazer, L, Adams, J.J, Sidhu, S.S. | 登録日 | 2024-01-31 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33, 2024
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8VVL
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![BU of 8vvl by Molmil](/molmil-images/mine/8vvl) | CCHFV GP38 bound to c13G8 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Hjorth, C.K, Mishra, A.K, McLellan, J.S. | 登録日 | 2024-01-31 | 公開日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crimean-Congo Hemorrhagic Fever Survivors Elicit Protective Non-Neutralizing Antibodies that Target 11 Overlapping Regions on Viral Glycoprotein GP38 To Be Published
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