PDB: 55698 件ウェブページステータス検索Chemie searchBIRD

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9BK2	Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (S-enantiomer, monoclinic P form) 分子名称: (2S)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid, DIMETHYL SULFOXIDE, L-lactate dehydrogenase A chain, ... 著者 Lovell, S, Cooper, A, Battaile, K.P, Sharma, H, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2024-04-26 公開日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer. Eur.J.Med.Chem., 275, 2024
9B35	Ligand-binding and transmembrane domains of kainate receptor GluK2 in the open state, a complex with agonist glutamate and positive allosteric modulator BPAM344 分子名称: GLUTAMIC ACID, Glutamate receptor ionotropic, kainate 2 著者 Nadezhdin, K.D, Gangwar, S.P, Sobolevsky, A.I. 登録日 2024-03-18 公開日 2024-05-22 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Kainate receptor channel opening and gating mechanism. Nature, 630, 2024
8UP3	Structure of atypical asparaginase from Rhodospirillum rubrum (mutant Y21F) 分子名称: 1,2-ETHANEDIOL, ASPARTIC ACID, Asparaginase, ... 著者 Lubkowski, J, Wlodawer, A, Zhang, D. 登録日 2023-10-20 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases. Protein Sci., 33, 2024
9AXH	Crystal structure of KSR1/MEK1 complex heterotetramer with NST-628 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Quade, B, Huang, X. 登録日 2024-03-06 公開日 2024-04-17 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
9BK3	Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (R-enantiomer, orthorhombic P form) 分子名称: (2R)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid, CHLORIDE ION, L-lactate dehydrogenase A chain, ... 著者 Lovell, S, Cooper, A, Battaile, K.P, Sharma, H. 登録日 2024-04-26 公開日 2024-07-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer. Eur.J.Med.Chem., 275, 2024
8UPC	Structure of atypical asparaginase from Rhodospirillum rubrum (mutant K158M) 分子名称: Asparaginase, CHLORIDE ION, GLYCEROL 著者 Lubkowski, J, Wlodawer, A, Zhang, D. 登録日 2023-10-22 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases. Protein Sci., 33, 2024
9B5V	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class 10 map and model from cluster 1 (ATP/Mg) 分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.94 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
8WT1	Crystal structure of S9 carboxypeptidase from Geobacillus sterothermophilus 分子名称: ALANINE, CITRATE ANION, GLYCEROL, ... 著者 Chandravanshi, K, Kumar, A, Sen, C, Singh, R, Bhange, G.B, Makde, R.D. 登録日 2023-10-17 公開日 2024-03-13 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure and solution scattering of Geobacillus stearothermophilus S9 peptidase reveal structural adaptations for carboxypeptidase activity. Febs Lett., 598, 2024
9B5T	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - cluster 5 map and model (ATP/Mg) 分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
9ASL	Human DNA polymerase theta helicase domain tetramer, apo-form 分子名称: DNA polymerase theta 著者 Ito, F, Li, Z, Chen, X.S. 登録日 2024-02-26 公開日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining. Biorxiv, 2024
9B56	Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 2 分子名称: 4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
8UOO	Structure of atypical asparaginase from Rhodospirillum rubrum 分子名称: Asparaginase, CHLORIDE ION, GLYCEROL 著者 Lubkowski, J, Wlodawer, A, Zhang, D. 登録日 2023-10-20 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases. Protein Sci., 33, 2024
8UP7	Structure of atypical asparaginase from Rhodospirillum rubrum (mutant K19A) 分子名称: Asparaginase, CHLORIDE ION 著者 Lubkowski, J, Wlodawer, A, Zhang, D. 登録日 2023-10-21 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases. Protein Sci., 33, 2024
8UP9	Structure of atypical asparaginase from Rhodospirillum rubrum (mutant K19Q) 分子名称: 1,2-ETHANEDIOL, Asparaginase, CHLORIDE ION, ... 著者 Lubkowski, J, Wlodawer, A, Zhang, D. 登録日 2023-10-21 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases. Protein Sci., 33, 2024
3VET	Crystal structure of the O-carbamoyltransferase TobZ in complex with Tobramycin, carbamoyl phosphate and ADP 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, FE (II) ION, ... 著者 Parthier, C, Stubbs, M.T, Goerlich, S, Jaenecke, F. 登録日 2012-01-09 公開日 2012-01-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The O-Carbamoyltransferase TobZ Catalyzes an Ancient Enzymatic Reaction. Angew.Chem.Int.Ed.Engl., 51, 2012
8UOR	Structure of atypical asparaginase from Rhodospirillum rubrum (mutant K19E) 分子名称: 1,2-ETHANEDIOL, Asparaginase, CHLORIDE ION 著者 Lubkowski, J, Wlodawer, A, Zhang, D. 登録日 2023-10-20 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases. Protein Sci., 33, 2024
9B58	Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 4 分子名称: 4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
8ZKV	Engineering Threonine Deaminase Catalytic Domain into a Tetrameric Configuration, Independent of Allosteric Regulation 分子名称: L-threonine dehydratase biosynthetic IlvA, SULFATE ION 著者 Khodi, S. 登録日 2024-05-17 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 Investigating the Dynamics of Catalytic Domains in Threonine Deaminase to Elucidating Allosteric Regulation To Be Published
9B5N	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class 1 map and model from consensus 分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
1A1A	C-SRC (SH2 DOMAIN WITH C188A MUTATION) COMPLEXED WITH ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE) 分子名称: ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE 著者 Shewchuk, L, Jordan, S. 登録日 1997-12-10 公開日 1998-04-08 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997
9B5R	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - cluster 3 map and model (ATP/Mg) 分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
9B5P	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - cluster 1 map and model (ATP/Mg) 分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.08 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
9B5S	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - cluster 4 map and model (ATP/Mg) 分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.96 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published
8UOU	Structure of atypical asparaginase from Rhodospirillum rubrum in complex with L-Asp 分子名称: ASPARTIC ACID, Asparaginase, CHLORIDE ION 著者 Lubkowski, J, Wlodawer, A, Zhang, D. 登録日 2023-10-20 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases. Protein Sci., 33, 2024
9B5X	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class 10 map and model from cluster 5 (ATP/Mg) 分子名称: 4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (4.16 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway To be published

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