9MG2
 
 | | Structure of Kluyveromyces lactis mRNA cap (guanine-N7) methyltransferase, Abd1, in complex with sinefungin | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Nilson, D.J, Fedorov, E, Ghosh, A. | | 登録日 | 2024-12-10 | | 公開日 | 2025-07-09 | | 最終更新日 | 2025-08-06 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Structural basis for sensitivity and acquired resistance of fungal cap guanine-N7 methyltransferases to the antifungal antibiotic sinefungin.
Nucleic Acids Res., 53, 2025
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9CXW
 | | Crystal structure of Human FN3K bound with ADP and DMF (II) | | 分子名称: | 1-deoxy-1-(morpholin-4-yl)-D-fructose, ADENOSINE-5'-DIPHOSPHATE, Fructosamine-3-kinase, ... | | 著者 | Garg, A, On, K.F, Joshua-Tor, L. | | 登録日 | 2024-07-31 | | 公開日 | 2024-12-18 | | 最終更新日 | 2025-02-05 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The molecular basis of Human FN3K mediated phosphorylation of glycated substrates.
Nat Commun, 16, 2025
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9CX8
 | | Crystal structure of Human FN3K in apo-state | | 分子名称: | 1,2-ETHANEDIOL, Fructosamine-3-kinase, SULFATE ION | | 著者 | Garg, A, On, K.F, Joshua-Tor, L. | | 登録日 | 2024-07-30 | | 公開日 | 2024-12-18 | | 最終更新日 | 2025-02-05 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | The molecular basis of Human FN3K mediated phosphorylation of glycated substrates.
Nat Commun, 16, 2025
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6H0A
 | | Serum paraoxonase-1 by directed evolution with the L69G/H115W/H134R/F222S/T332S mutations | | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, CALCIUM ION, ... | | 著者 | Ben-David, M, Sussman, J.L, Tawfik, D.S. | | 登録日 | 2018-07-07 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.
Mol.Biol.Evol., 37, 2020
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9MG1
 | | Structure of Kluyveromyces lactis mRNA cap (guanine-N7) methyltransferase, Abd1, in complex with adenine and m7GTP | | 分子名称: | 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Nilson, D.J, Fedorov, E, Ghosh, A. | | 登録日 | 2024-12-10 | | 公開日 | 2025-07-09 | | 最終更新日 | 2025-08-06 | | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | | 主引用文献 | Structural basis for sensitivity and acquired resistance of fungal cap guanine-N7 methyltransferases to the antifungal antibiotic sinefungin.
Nucleic Acids Res., 53, 2025
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9D8Z
 | | Crystal structure of the ACVR1 (ALK2) Kinase Domain in complex with inhibitor CDD-2282 | | 分子名称: | 1-[(1r,3r)-3-(methylcarbamoyl)cyclobutyl]-N-[(1-methylpiperidin-4-yl)methyl]-2-(3,4,5-trimethoxyphenyl)-1H-1,3-benzimidazole-6-carboxamide, Activin receptor type-1, PHOSPHATE ION | | 著者 | Ta, H.M, Kim, C, Jimmidi, R, Matzuk, M.M. | | 登録日 | 2024-08-20 | | 公開日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9E0D
 | | Structure of proline utilization A complexed with piperonyl alcohol | | 分子名称: | (2H-1,3-benzodioxol-5-yl)methanol, Bifunctional protein PutA, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Tanner, J.J, Meeks, K.R. | | 登録日 | 2024-10-17 | | 公開日 | 2024-11-27 | | 最終更新日 | 2024-12-11 | | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | | 主引用文献 | Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-gamma-semialdehyde Dehydrogenase.
Molecules, 29, 2024
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3MCB
 | | Crystal structure of NAC domains of human nascent polypeptide-associated complex (NAC) | | 分子名称: | IODIDE ION, Nascent polypeptide-associated complex subunit alpha, Transcription factor BTF3 | | 著者 | Wang, L.F, Zhang, W.C, Wang, L, Zhang, X.J.C, Li, X.M, Rao, Z. | | 登録日 | 2010-03-29 | | 公開日 | 2010-07-14 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit
Protein Cell, 1, 2010
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5YRV
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4Y8Q
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6H5D
 | | Crystal structure of DHQ1 from Salmonella typhi covalently modified by ligand 2 | | 分子名称: | (1~{S},3~{S},4~{R},5~{R})-3-methyl-1,4,5-tris(hydroxyl)cyclohexane-1-carboxylic acid, 3-dehydroquinate dehydratase | | 著者 | Sanz-Gaitero, M, Maneiro, M, Lence, E, Otero, J.M, Thompson, P, Hawkins, A.R, Gonzalez-Bello, C, van Raaij, M.J. | | 登録日 | 2018-07-24 | | 公開日 | 2019-07-24 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Hydroxylammonium Derivatives for Selective Active-site Lysine Modification in the Anti-virulence Bacterial Target DHQ1 Enzyme.
Org Chem Front, 9, 2019
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4Y77
 | | Yeast 20S proteasome in complex with Ac-LAF-ep | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ac-LAF-ep, CHLORIDE ION, ... | | 著者 | Huber, E.M, Groll, M. | | 登録日 | 2015-02-13 | | 公開日 | 2015-06-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors.
J.Am.Chem.Soc., 137, 2015
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4Y8O
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6X89
 | | Vigna radiata mitochondrial complex I* | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | | 著者 | Letts, J.A, Maldonado, M, Padavannil, A, Zhou, L, Guo, F. | | 登録日 | 2020-06-01 | | 公開日 | 2020-09-02 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Atomic structure of a mitochondrial complex I intermediate from vascular plants.
Elife, 9, 2020
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4YA2
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4Y6Z
 | | Yeast 20S proteasome in complex with Ac-PAL-ep | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ac-PAL-ep, CHLORIDE ION, ... | | 著者 | Groll, M, Huber, E.M. | | 登録日 | 2015-02-13 | | 公開日 | 2015-06-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors.
J.Am.Chem.Soc., 137, 2015
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8KBL
 | | Structure of AcrIIA7 complexed with 1',3'-cADPR and cGG | | 分子名称: | (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Inhibitor of Type II CRISPR-Cas system | | 著者 | Xiao, Y, Feng, Y. | | 登録日 | 2023-08-04 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-12-04 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBJ
 | | Structure of HgmTad2 complexed with 1',2'-cADPR | | 分子名称: | (1S,3R,4R,6R,9S,11R,14R,15S,16R,18R)-4-(6-amino-9H-purin-9-yl)-9,11,15,16,18-pentahydroxy-2,5,8,10,12,17-hexaoxa-9lambda~5~,11lambda~5~-diphosphatricyclo[12.2.1.1~3,6~]octadecane-9,11-dione, Inhibitor of Type II CRISPR-Cas system | | 著者 | Xiao, Y, Feng, Y. | | 登録日 | 2023-08-04 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-12-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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6STV
 | | Adenovirus 29 Fiber Knob protein | | 分子名称: | Fiber, GLYCEROL, PHOSPHATE ION | | 著者 | Mundy, R.M, Baker, A.T, Rizkallah, P.J, Parker, A.L. | | 登録日 | 2019-09-11 | | 公開日 | 2021-03-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Broad sialic acid usage amongst species D human adenovirus
npj Viruses, 1, 2023
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4Y7W
 | | Yeast 20S proteasome in complex with Ac-LAE-ep | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ac-LAE-ep, CHLORIDE ION, ... | | 著者 | Huber, E.M, Groll, M. | | 登録日 | 2015-02-16 | | 公開日 | 2015-06-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors.
J.Am.Chem.Soc., 137, 2015
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4Y8J
 | | Yeast 20S proteasome in complex with Ac-LLL-ep | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ac-PLL-ep, CHLORIDE ION, ... | | 著者 | Huber, E.M, Groll, M. | | 登録日 | 2015-02-16 | | 公開日 | 2015-06-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors.
J.Am.Chem.Soc., 137, 2015
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4Y9Z
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6GW4
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6FK1
 | | Cyclophilin A | | 分子名称: | 1,2-ETHANEDIOL, Peptidyl-prolyl cis-trans isomerase A | | 著者 | Lisboa, J, dos Santos, N.M.S. | | 登録日 | 2018-01-23 | | 公開日 | 2019-02-06 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.299 Å) | | 主引用文献 | Production, crystallization and structure determination of cyclophilin A from Mus musculus
To Be Published
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7C7F
 | | Crystal structures of AKR1C3 binary complex with NADP+ | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Aldo-keto reductase family 1 member C3, ... | | 著者 | Irie, K, Toyooka, N, Endo, S. | | 登録日 | 2020-05-25 | | 公開日 | 2020-09-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer.
J.Med.Chem., 63, 2020
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