PDB: 367 件ウェブページステータス検索Chemie searchBIRD

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5O98	Binary complex of Catharanthus roseus Vitrosamine Synthase with NADP+ 分子名称: Alcohol dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Stavrinides, A.K, Tatsis, E.C, Dang, T.T, Caputi, L, Stevenson, C.E.M, Lawson, D.M, Schneider, B, O'Connor, S.E. 登録日 2017-06-16 公開日 2018-02-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Discovery of a Short-Chain Dehydrogenase from Catharanthus roseus that Produces a New Monoterpene Indole Alkaloid. Chembiochem, 19, 2018
5PGX	CRYSTAL STRUCTURE OF 11BETA-HSD1 DOUBLE MUTANT (L262R, F278E) COMPLEXED WITH 2-(2-BENZYL-6-HYDROXYADAMANTAN-2-YL)-1-(3-HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE 分子名称: 2-(2-BENZYL-6-HYDROXYADAMANTAN-2-YL)-1-(3-HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Sheriff, S. 登録日 2017-02-06 公開日 2017-11-01 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J. Med. Chem., 60, 2017
4YAC	Crystal structure of LigO in complex with NADH from Sphingobium sp. strain SYK-6 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, C alpha-dehydrogenase 著者 Pereira, J.H, McAndrew, R.P, Heins, R.A, Sale, K.L, Simmons, B.A, Adams, P.D. 登録日 2015-02-17 公開日 2016-03-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Structural and Biochemical Characterization of the Early and Late Enzymes in the Lignin beta-Aryl Ether Cleavage Pathway from Sphingobium sp. SYK-6. J.Biol.Chem., 291, 2016
4YAG	Crystal structure of LigL in complex with NADH from Sphingobium sp. strain SYK-6 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, C alpha-dehydrogenase 著者 Pereira, J.H, McAndrew, R.P, Heins, R.A, Sale, K.L, Simmons, B.A, Adams, P.D. 登録日 2015-02-17 公開日 2016-03-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural and Biochemical Characterization of the Early and Late Enzymes in the Lignin beta-Aryl Ether Cleavage Pathway from Sphingobium sp. SYK-6. J.Biol.Chem., 291, 2016
5PGY	CRYSTAL STRUCTURE OF 11BETA-HSD1 DOUBLE MUTANT (L262R, F278E) COMPLEXED WITH 2-[(5R,7S)-6-HYDROXY-2-PHENYLADAMANTAN-2-YL]-1-(3-HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE (BMS-816336) 分子名称: 2-[(5R,7S)-6-HYDROXY-2-PHENYLADAMANTAN-2-YL]-1-(3-HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Sheriff, S. 登録日 2017-02-06 公開日 2017-11-01 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J. Med. Chem., 60, 2017
2Y99	Crystal Structure of cis-Biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)from Pandoraea pnomenusa strain B-356 complex with co-enzyme NAD 分子名称: CIS-2,3-DIHYDROBIPHENYL-2,3-DIOL DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Dhindwal, S, Patil, D.N, Kumar, P. 登録日 2011-02-12 公開日 2011-08-31 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Biochemical Studies and Ligand-Bound Structures of Biphenyl Dehydrogenase from Pandoraea Pnomenusa Strain B-356 Reveal a Basis for Broad Specificity of the Enzyme. J.Biol.Chem., 286, 2011
4KZP	Crystal Structure of a Putative Short Chain Dehydrogenase from Mycobacterium smegmatis 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Oxidoreductase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2013-05-30 公開日 2013-07-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Crystal Structure of a Putative Short Chain Dehydrogenase from Mycobacterium smegmatis To be Published
4YAE	Crystal structure of LigL-apo form from Sphingobium sp. strain SYK-6 分子名称: C alpha-dehydrogenase 著者 Pereira, J.H, McAndrew, R.P, Heins, R.A, Sale, K.L, Simmons, B.A, Adams, P.D. 登録日 2015-02-17 公開日 2016-03-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.602 Å) 主引用文献 Structural and Biochemical Characterization of the Early and Late Enzymes in the Lignin beta-Aryl Ether Cleavage Pathway from Sphingobium sp. SYK-6. J.Biol.Chem., 291, 2016
4YAI	Crystal structure of LigL in complex with NADH and GGE from Sphingobium sp. strain SYK-6 分子名称: (1S,2R)-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, C alpha-dehydrogenase, ... 著者 Pereira, J.H, McAndrew, R.P, Heins, R.A, Sale, K.L, Simmons, B.A, Adams, P.D. 登録日 2015-02-17 公開日 2016-03-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural and Biochemical Characterization of the Early and Late Enzymes in the Lignin beta-Aryl Ether Cleavage Pathway from Sphingobium sp. SYK-6. J.Biol.Chem., 291, 2016
4Y98	Crystal structure of LigD-apo form from Sphingobium sp. strain SYK-6 分子名称: C alpha-dehydrogenase 著者 Pereira, J.H, McAndrew, R.P, Heins, R.A, Sale, K.L, Simmons, B.A, Adams, P.D. 登録日 2015-02-17 公開日 2016-03-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.648 Å) 主引用文献 Structural and Biochemical Characterization of the Early and Late Enzymes in the Lignin beta-Aryl Ether Cleavage Pathway from Sphingobium sp. SYK-6. J.Biol.Chem., 291, 2016
4YA6	Crystal structure of LigO-apo form from Sphingobium sp. strain SYK-6 分子名称: C alpha-dehydrogenase 著者 Pereira, J.H, McAndrew, R.P, Heins, R.A, Sale, K.L, Simmons, B.A, Adams, P.D. 登録日 2015-02-17 公開日 2016-03-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Structural and Biochemical Characterization of the Early and Late Enzymes in the Lignin beta-Aryl Ether Cleavage Pathway from Sphingobium sp. SYK-6. J.Biol.Chem., 291, 2016
3BHI	Crystal structure of human Carbonyl Reductase 1 in complex with NADP 分子名称: CHLORIDE ION, Carbonyl reductase [NADPH] 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Rauh, D, Bateman, R.L, Shokat, K.M. 登録日 2007-11-28 公開日 2008-10-21 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Human carbonyl reductase 1 is an s-nitrosoglutathione reductase J.Biol.Chem., 283, 2008
4Y9D	Crystal structure of LigD in complex with NADH from Sphingobium sp. strain SYK-6 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, C alpha-dehydrogenase 著者 Pereira, J.H, McAndrew, R.P, Heins, R.A, Sale, K.L, Simmons, B.A, Adams, P.D. 登録日 2015-02-17 公開日 2016-03-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.012 Å) 主引用文献 Structural and Biochemical Characterization of the Early and Late Enzymes in the Lignin beta-Aryl Ether Cleavage Pathway from Sphingobium sp. SYK-6. J.Biol.Chem., 291, 2016
4N5M	Crystal structure of (R)-3-hydroxybutyryl-CoA dehydrogenase from Ralstonia eutropha in complexed with acetoacetyl-CoA 分子名称: ACETOACETYL-COENZYME A, Acetoacetyl-CoA reductase, GLYCEROL 著者 Kim, J.-E, Kim, S, Kim, K.-J. 登録日 2013-10-10 公開日 2013-12-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Crystal structure of (R)-3-hydroxybutyryl-CoA dehydrogenase PhaB from Ralstonia eutropha Biochem.Biophys.Res.Commun., 443, 2014
5O3Z	Crystal structure of Sorbitol-6-Phosphate 2-dehydrogenase SrlD from Erwinia amylovora 分子名称: CHLORIDE ION, Sorbitol-6-phosphate dehydrogenase 著者 Salomone-Stagni, M, Bartho, J.D, Bellini, D, Walsh, M.A, Benini, S. 登録日 2017-05-25 公開日 2018-06-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Structural and functional analysis of Erwinia amylovora SrlD. The first crystal structure of a sorbitol-6-phosphate 2-dehydrogenase. J.Struct.Biol., 203, 2018
5QII	CRYSTAL STRUCTURE OF 11BETA-HSD1 DOUBLE MUTANT (L262R, F278E) COMPLEXED WITH 2-(3-(1-(4-CHLOROPHENYL)CYCLOPROPYL) -[1,2,4]TRIAZOLO[4,3-A]PYRIDIN-8-YL)PROPAN-2-OL 分子名称: 2-{3-[1-(4-chlorophenyl)cyclopropyl][1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Sheriff, S. 登録日 2018-07-03 公開日 2018-12-19 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1). ACS Med Chem Lett, 9, 2018
4N5L	Crystal structure of (R)-3-hydroxybutyryl-CoA dehydrogenase from Ralstonia eutropha 分子名称: Acetoacetyl-CoA reductase 著者 Kim, J.-E, Kim, S, Kim, K.-J. 登録日 2013-10-10 公開日 2013-12-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of (R)-3-hydroxybutyryl-CoA dehydrogenase PhaB from Ralstonia eutropha Biochem.Biophys.Res.Commun., 443, 2014
3BYZ	2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors 分子名称: (5S)-2-(cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-one, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Zhang, J, Jordan, S.R, Li, V. 登録日 2008-01-16 公開日 2008-02-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice. J.Med.Chem., 51, 2008
8AEQ	Malonyl-CoA reductase from Chloroflexus aurantiacus - C-terminal R773Q variant 分子名称: Short-chain dehydrogenase/reductase SDR 著者 Kabasakal, B.V, Murray, J.W. 登録日 2022-07-13 公開日 2023-04-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction. Biochimie, 219, 2023
4K6C	X-ray crystal structure of a putative Acetoacyl-CoA reductase from Burkholderia cenocepacia 分子名称: 1,2-ETHANEDIOL, Acetoacetyl-CoA reductase, CHLORIDE ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2013-04-15 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 X-ray crystal structure of a putative Acetoacyl-CoA reductase from Burkholderia cenocepacia TO BE PUBLISHED
8AET	Malonyl-CoA reductase from Chloroflexus aurantiacus - C-terminal E779W variant 分子名称: SULFATE ION, Short-chain dehydrogenase/reductase SDR 著者 Kabasakal, B.V, Murray, J.W. 登録日 2022-07-13 公開日 2023-04-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction. Biochimie, 219, 2023
4K26	4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes 分子名称: (4aS,8aR)-N-cyclohexyl-4a,5,6,7,8,8a-hexahydro-4,1,2-benzoxathiazin-3-amine 1,1-dioxide, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Loenze, P, Schimanski-Breves, S, Vonderheyden, C, Engel, C.K. 登録日 2013-04-08 公開日 2014-04-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11-HSD1 inhibitors for the treatment of diabetes. Bioorg.Med.Chem.Lett., 23, 2013
8AEO	Malonyl-CoA reductase from Chloroflexus aurantiacus - C-terminal R773A variant 分子名称: SULFATE ION, Short-chain dehydrogenase/reductase SDR 著者 Kabasakal, B.V, Murray, J.W. 登録日 2022-07-13 公開日 2023-04-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction. Biochimie, 219, 2023
8AER	Malonyl-CoA reductase from Chloroflexus aurantiacus - C-terminal Y731A variant 分子名称: MAGNESIUM ION, Short-chain dehydrogenase/reductase SDR 著者 Kabasakal, B.V, Murray, J.W. 登録日 2022-07-13 公開日 2023-04-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction. Biochimie, 219, 2023
4K1L	4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 beta-HSD1 inhibitors for the treatment of diabetes 分子名称: (4aS,8aR)-N-cyclohexyl-4a,5,6,7,8,8a-hexahydro-4,1,2-benzoxathiazin-3-amine 1,1-dioxide, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Loenze, P, Schimanski-Breves, S, Von der Heyden, C, Engel, C.K. 登録日 2013-04-05 公開日 2014-04-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11-HSD1 inhibitors for the treatment of diabetes. Bioorg.Med.Chem.Lett., 23, 2013

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