PDB: 22634 件ウェブページステータス検索Chemie searchBIRD

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7O1L	Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme alpha-H462A mutant 分子名称: 3-hydroxyacyl-CoA dehydrogenase, COENZYME A, GLYCEROL, ... 著者 Dalwani, S, Wierenga, R.K, Venkatesan, R. 登録日 2021-03-29 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosis beta-oxidation trifunctional enzyme. J.Struct.Biol., 213, 2021
7O1J	Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme beta-C92A mutant 分子名称: 3-hydroxyacyl-CoA dehydrogenase, GLYCEROL, Putative acyltransferase Rv0859, ... 著者 Dalwani, S, Wierenga, R.K, Venkatesan, R. 登録日 2021-03-29 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosis beta-oxidation trifunctional enzyme. J.Struct.Biol., 213, 2021
7O1M	Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme alpha-H462A, beta-C92A mutant 分子名称: 3-hydroxyacyl-CoA dehydrogenase, GLYCEROL, Putative acyltransferase Rv0859, ... 著者 Dalwani, S, Wierenga, R.K, Venkatesan, R. 登録日 2021-03-29 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosis beta-oxidation trifunctional enzyme. J.Struct.Biol., 213, 2021
8CUY	ACP1-KS-AT domains of mycobacterial Pks13 分子名称: 4'-PHOSPHOPANTETHEINE, Polyketide synthase PKS13, UNKNOWN LIGAND 著者 Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. 登録日 2022-05-17 公開日 2023-02-15 最終更新日 2023-03-29 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
8CV0	KS-AT domains of mycobacterial Pks13 with outward AT conformation 分子名称: Polyketide synthase PKS13, UNKNOWN LIGAND 著者 Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. 登録日 2022-05-17 公開日 2023-02-15 最終更新日 2023-03-29 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
8CUZ	KS-AT domains of mycobacterial Pks13 with inward AT conformation 分子名称: Polyketide synthase PKS13, UNKNOWN LIGAND 著者 Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. 登録日 2022-05-17 公開日 2023-02-15 最終更新日 2023-03-29 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
8CV1	ACP1-KS-AT domains of mycobacterial Pks13 分子名称: Polyketide synthase PKS13, UNKNOWN LIGAND 著者 Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. 登録日 2022-05-17 公開日 2023-02-15 最終更新日 2023-03-29 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
6ZT4	Pentapeptide repeat protein MfpA from Mycobacterium smegmatis 分子名称: 1,2-ETHANEDIOL, Pentapeptide repeat protein MfpA 著者 Feng, L, Mundy, J.E.A, Stevenson, C.E.M, Mitchenall, L.A, Lawson, D.M, Mi, K, Maxwell, A. 登録日 2020-07-17 公開日 2021-03-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic. Proc.Natl.Acad.Sci.USA, 118, 2021
7JGA	Cryo-EM structure of bedaquiline-saturated Mycobacterium smegmatis ATP synthase rotational state 3 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... 著者 Guo, H, Courbon, G.M, Rubinstein, J.L. 登録日 2020-07-18 公開日 2020-08-19 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline. Nature, 589, 2021
7JG6	Cryo-EM structure of bedaquiline-free Mycobacterium smegmatis ATP synthase rotational state 2 (backbone model) 分子名称: ATP synthase epsilon chain, ATP synthase gamma chain, ATP synthase subunit a, ... 著者 Guo, H, Courbon, G.M, Rubinstein, J.L. 登録日 2020-07-18 公開日 2020-08-19 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline. Nature, 589, 2021
7JG5	Cryo-EM structure of bedaquiline-free Mycobacterium smegmatis ATP synthase rotational state 1 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... 著者 Guo, H, Courbon, G.M, Rubinstein, J.L. 登録日 2020-07-18 公開日 2020-08-19 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline. Nature, 589, 2021
7JG9	Cryo-EM structure of bedaquiline-saturated mycobacterium smegmatis ATP synthase rotational state 2 (backbone model) 分子名称: ATP synthase epsilon chain, ATP synthase gamma chain, ATP synthase subunit a, ... 著者 Guo, H, Courbon, G.M, Rubinstein, J.L. 登録日 2020-07-18 公開日 2020-08-19 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline. Nature, 589, 2021
7JG7	Cryo-EM structure of bedaquiline-free Mycobacterium smegmatis ATP synthase rotational state 3 (backbone model) 分子名称: ATP synthase epsilon chain, ATP synthase gamma chain, ATP synthase subunit a, ... 著者 Guo, H, Courbon, G.M, Rubinstein, J.L. 登録日 2020-07-18 公開日 2020-08-19 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline. Nature, 589, 2021
7JG8	Cryo-EM structure of bedaquiline-saturated Mycobacterium smegmatis ATP synthase rotational state 1 (backbone model) 分子名称: ATP synthase epsilon chain, ATP synthase gamma chain, ATP synthase subunit a, ... 著者 Guo, H, Courbon, G.M, Rubinstein, J.L. 登録日 2020-07-18 公開日 2020-08-19 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline. Nature, 589, 2021
6DZK	Cryo-EM Structure of Mycobacterium smegmatis C(minus) 30S ribosomal subunit with MPY 分子名称: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... 著者 Sharma, M.R, Li, Y, Korripella, R, Yang, Y, Kaushal, P.S, Lin, Q, Wade, J.T, Gray, A.G, Derbyshire, K.M, Agrawal, R.K, Ojha, A. 登録日 2018-07-05 公開日 2018-09-19 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Zinc depletion induces ribosome hibernation in mycobacteria. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4U5Q	High resolution crystal structure of reductase (R) domain of nonribosomal peptide synthetase from Mycobacterium tuberculosis 分子名称: 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, Peptide synthetase 著者 Patel, K.D, Haque, A.S, Priyadarshan, K, Sankaranarayanan, R. 登録日 2014-07-25 公開日 2016-01-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.811 Å) 主引用文献 High resolution structure of R-domain of nonribosomal peptide synthetase from Mycobacterium tuberculosis To Be Published
8OQM	Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-10 分子名称: 3-hydroxyacyl-CoA dehydrogenase, 6-[(6-azanyl-4-oxidanyl-naphthalen-2-yl)sulfonylamino]-4-oxidanyl-naphthalene-2-sulfonic acid, 6-azanyl-4-oxidanyl-naphthalene-2-sulfonic acid, ... 著者 Dalwani, S, Wierenga, R.K, Venkatesan, R. 登録日 2023-04-12 公開日 2024-01-24 最終更新日 2024-08-14 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them. Acta Crystallogr D Struct Biol, 80, 2024
6ZT3	N-terminal 47 kDa fragment of the Mycobacterium smegmatis DNA Gyrase B subunit complexed with ADPNP 分子名称: 1,2-ETHANEDIOL, DNA gyrase subunit B, MAGNESIUM ION, ... 著者 Feng, L, Mundy, J.E.A, Stevenson, C.E.M, Mitchenall, L.A, Lawson, D.M, Mi, K, Maxwell, A. 登録日 2020-07-17 公開日 2021-03-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic. Proc.Natl.Acad.Sci.USA, 118, 2021
7PXA	Open-gate mycobacterium 20S CP proteasome in complex MPA - global 3D refinement 分子名称: AAA ATPase forming ring-shaped complexes, Proteasome subunit alpha, Proteasome subunit beta 著者 Jomaa, A, Kavalchuk, M, Weber-Ban, E. 登録日 2021-10-08 公開日 2022-01-19 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex. Nat Commun, 13, 2022
7JGC	Cryo-EM structure of bedaquiline-saturated Mycobacterium smegmatis ATP synthase FO region 分子名称: ATP synthase subunit a, ATP synthase subunit b, ATP synthase subunit b-delta, ... 著者 Guo, H, Courbon, G.M, Rubinstein, J.L. 登録日 2020-07-18 公開日 2020-08-19 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline. Nature, 589, 2021
5V7Q	Cryo-EM structure of the large ribosomal subunit from Mycobacterium tuberculosis bound with a potent linezolid analog 分子名称: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... 著者 Yang, K, Chang, J.-Y, Cui, Z, Zhang, J. 登録日 2017-03-20 公開日 2017-09-20 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res., 45, 2017
8OPX	Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Trehalose (Fragment-B-TRE) 分子名称: 3-hydroxyacyl-CoA dehydrogenase, Putative acyltransferase Rv0859, SULFATE ION, ... 著者 Dalwani, S, Wierenga, R.K, Venkatesan, R. 登録日 2023-04-10 公開日 2024-01-24 最終更新日 2024-08-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them. Acta Crystallogr D Struct Biol, 80, 2024
8OQO	Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-49 分子名称: GLYCEROL, Probable fatty oxidation protein FadB, Putative acyltransferase Rv0859, ... 著者 Dalwani, S, Wierenga, R.K, Venkatesan, R. 登録日 2023-04-12 公開日 2024-01-24 最終更新日 2024-08-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them. Acta Crystallogr D Struct Biol, 80, 2024
8OQT	Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-91 分子名称: 3-hydroxyacyl-CoA dehydrogenase, 4-bromanylbenzenesulfonic acid, GLYCEROL, ... 著者 Dalwani, S, Wierenga, R.K, Venkatesan, R. 登録日 2023-04-12 公開日 2024-01-24 最終更新日 2024-08-28 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them. Acta Crystallogr D Struct Biol, 80, 2024
8OPU	Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Sulfamethoxazole (Fragment-B-E1) 分子名称: 3-hydroxyacyl-CoA dehydrogenase, GLYCEROL, Putative acyltransferase Rv0859, ... 著者 Dalwani, S, Wierenga, R.K, Venkatesan, R. 登録日 2023-04-10 公開日 2024-01-24 最終更新日 2024-08-14 実験手法 X-RAY DIFFRACTION (3.04 Å) 主引用文献 Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them. Acta Crystallogr D Struct Biol, 80, 2024

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