PDB: 37044 件ウェブページステータス検索Chemie searchBIRD

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4K45	Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, short peptide 著者 Sondek, J, Hajicek, N. 登録日 2013-04-11 公開日 2013-06-26 最終更新日 2014-01-22 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52, 2013
3ZD1	STRUCTURE OF THE TWO C-TERMINAL DOMAINS OF COMPLEMENT FACTOR H RELATED PROTEIN 2 分子名称: 1,2-ETHANEDIOL, COMPLEMENT FACTOR H-RELATED PROTEIN 2 著者 Caesar, J.J.E, Goicoechea de Jorge, E, Pickering, M.C, Lea, S.M. 登録日 2012-11-23 公開日 2013-03-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Dimerization of Complement Factor H-Related Proteins Modulates Complement Activation in Vivo. Proc.Natl.Acad.Sci.USA, 110, 2013
4FH7	Structure of DHP A in complex with 2,4,6-tribromophenol in 20% methanol 分子名称: 2,4,6-TRIBROMOPHENOL, Dehaloperoxidase A, METHANOL, ... 著者 de Serrano, V.S, Franzen, S. 登録日 2012-06-05 公開日 2013-03-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structural and Kinetic Study of an Internal Substrate Binding Site in Dehaloperoxidase-Hemoglobin A from Amphitrite ornata. Biochemistry, 52, 2013
1GBB	Alpha-lytic protease with met 190 replaced by ALA AND GLY 216 replaced by ALA complex with METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID 分子名称: ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-ALANINE BORONIC ACID INHIBITOR, SULFATE ION 著者 Mace, J.E, Agard, D.A. 登録日 1995-09-06 公開日 1996-01-29 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity. J.Mol.Biol., 254, 1995
4K69	Crystal Structure of Human Chymase in Complex with Fragment Linked Benzimidazolone Inhibitor: (3S)-3-{3-[(6-bromo-2-oxo-2,3-dihydro-1H-indol-4-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid 分子名称: (3S)-3-{3-[(6-bromo-2-oxo-2,3-dihydro-1H-indol-4-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Chymase, ... 著者 Collins, B.K, Padyana, A.K. 登録日 2013-04-15 公開日 2013-05-29 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies. J.Med.Chem., 56, 2013
3ZHG	Crystallographic structure of the native mouse SIGN-R1 CRD domain 分子名称: CALCIUM ION, CD209 ANTIGEN-LIKE PROTEIN B, SULFATE ION 著者 Silva-Martin, N, Bartual, S.G, Hermoso, J.A. 登録日 2012-12-21 公開日 2014-01-15 最終更新日 2020-03-11 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structural Basis for Selective Recognition of Endogenous and Microbial Polysaccharides by Macrophage Receptor Sign-R1. Structure, 22, 2014
4FL8	HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate 分子名称: CHLORIDE ION, GLYCEROL, HIV-1 protease, ... 著者 Tie, Y.F, Shen, C.H, Weber, I.T. 登録日 2012-06-14 公開日 2012-10-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Capturing the Reaction Pathway in Near-Atomic-Resolution Crystal Structures of HIV-1 Protease. Biochemistry, 51, 2012
7Y9M	Crystal structure of P450 BM3-2F from Bacillus megaterium 分子名称: Bifunctional cytochrome P450/NADPH--P450 reductase, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE 著者 Wang, Q, Zhang, L.L, Liu, W.D, Huang, J.-W, Yang, Y, Chen, C.-C, Guo, R.-T. 登録日 2022-06-25 公開日 2023-07-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Crystal structure of P450 BM3-2F from Bacillus megaterium to be published
1GE2	CRYSTAL STRUCTURE OF MUTANT HUMAN LYSOZYME SUBSTITUTED AT LEFT-HANDED HELICAL POSITIONS 分子名称: LYSOZYME C, SODIUM ION 著者 Takano, K, Yamagata, Y, Yutani, K. 登録日 2000-10-06 公開日 2000-11-08 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Role of non-glycine residues in left-handed helical conformation for the conformational stability of human lysozyme Proteins, 44, 2001
1FXY	COAGULATION FACTOR XA-TRYPSIN CHIMERA INHIBITED WITH D-PHE-PRO-ARG-CHLOROMETHYLKETONE 分子名称: COAGULATION FACTOR XA-TRYPSIN CHIMERA, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide 著者 Hopfner, K.P, Kopetzki, E, Kresse, G.-B, Huber, R, Bode, W, Engh, R.A. 登録日 1998-04-22 公開日 1998-06-17 最終更新日 2013-02-27 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 New enzyme lineages by subdomain shuffling. Proc.Natl.Acad.Sci.USA, 95, 1998
7YEX	Structure of MmIGF2BP3 in complex with 8-mer RNA 分子名称: Insulin-like growth factor 2 mRNA-binding protein 3, RNA (5'-R(P*CP*AP*CP*AP*CP*AP*CP*A)-3') 著者 Li, X.J, Wu, B.X. 登録日 2022-07-06 公開日 2023-07-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of MmIGF2BP3 in complex with 8-mer RNA To Be Published
2XN3	Crystal structure of thyroxine-binding globulin complexed with mefenamic acid 分子名称: 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID, THYROXINE-BINDING GLOBULIN 著者 Qi, X, Yan, Y, Wei, Z, Zhou, A. 登録日 2010-07-30 公開日 2011-02-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins. J.Biol.Chem., 286, 2011
7YEW	Structure of MmIGF2BP3 in complex with 7-mer RNA 分子名称: Insulin-like growth factor 2 mRNA-binding protein 3, RNA (5'-R(P*CP*AP*CP*AP*CP*AP*C)-3') 著者 Li, X.J, Wu, B.X. 登録日 2022-07-06 公開日 2023-07-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of MmIGF2BP3 in complex with 7-mer RNA To Be Published
4K9X	Complex of human CYP3A4 with a desoxyritonavir analog 分子名称: 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-methylbutanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE 著者 Sevrioukova, I.F, Poulos, T.L. 登録日 2013-04-21 公開日 2013-06-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Dissecting Cytochrome P450 3A4-Ligand Interactions Using Ritonavir Analogues. Biochemistry, 52, 2013
1GBA	ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA AND GLY 216 REPLACED BY ALA 分子名称: ALPHA-LYTIC PROTEASE, SULFATE ION 著者 Mace, J.E, Agard, D.A. 登録日 1995-09-06 公開日 1996-01-29 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity. J.Mol.Biol., 254, 1995
3ZQK	Von Willebrand Factor A2 domain with calcium 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... 著者 Jakobi, A.J, Huizinga, E.G. 登録日 2011-06-09 公開日 2011-07-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Calcium Modulates Force Sensing by the Von Willebrand Factor A2 Domain. Nat.Commun., 2, 2011
3RSV	Structure of Bace-1 (Beta-Secretase) in complex with (R)-3-(2-amino-6-o-tolylquinolin-3-yl)-N-((R)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-2-methylpropanamide 分子名称: (2R)-3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-N-[(4R)-2,2-dimethyltetrahydro-2H-pyran-4-yl]-2-methylpropanamide, Beta-secretase 1, GLYCEROL, ... 著者 Sickmier, E.A. 登録日 2011-05-02 公開日 2011-08-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011
7Y9L	Crystal structure of P450 BM3-2F from Bacillus megaterium in complex with 2-Hydroxy-5-Nitrobenzonitrile 分子名称: 5-nitro-2-oxidanyl-benzenecarbonitrile, Bifunctional cytochrome P450/NADPH--P450 reductase, NICKEL (II) ION, ... 著者 Wang, Q, Zhang, L.L, Liu, W.D, Huang, J.-W, Yang, Y, Chen, C.-C, Guo, R.-T. 登録日 2022-06-25 公開日 2023-07-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Crystal structure of P450 BM3-2F from Bacillus megaterium in complex with 2-Hydroxy-5-Nitrobenzonitrile to be published
3ZKI	BACE2 MUTANT STRUCTURE WITH LIGAND 分子名称: 5-(2,2,2-Trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((S)-2-amino-1,4-dimethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-4-yl)-phenyl]-amide, BETA-SECRETASE 2 著者 Banner, D.W, Kuglstatter, A, Benz, J, Stihle, M, Ruf, A. 登録日 2013-01-23 公開日 2013-05-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Mapping the Conformational Space Accessible to Bace2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones Acta Crystallogr.,Sect.D, 69, 2013
3RTH	Structure of Bace-1 (Beta-Secretase) in Complex with 6-(2-(3,3-Dimethylbut-1-ynyl)phenyl)quinolin-2-amine 分子名称: 6-[2-(3,3-dimethylbut-1-yn-1-yl)phenyl]quinolin-2-amine, Beta-secretase 1, IODIDE ION 著者 Sickmier, E.A. 登録日 2011-05-03 公開日 2011-08-31 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011
2Y22	Human AlphaB-crystallin Domain (residues 67-157) 分子名称: ALPHA-CRYSTALLIN B 著者 Naylor, C.E, Bagneris, C, Clark, A.R, Keep, N.H, Slingsby, C. 登録日 2010-12-13 公開日 2011-03-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Crystal Structure of R120G Disease Mutant of Human Alphab-Crystallin Domain Dimer Shows Closure of a Groove J.Mol.Biol., 408, 2011
2Y46	Structure of the mixed-function P450 MycG in complex with mycinamicin IV in C 2 2 21 space group 分子名称: BENZAMIDINE, GLYCEROL, MYCINAMICIN IV, ... 著者 Li, S, Kells, P.M, Sherman, D.H, Podust, L.M. 登録日 2011-01-05 公開日 2012-01-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
1GI7	A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE 分子名称: 2-(2-OXO-1,2-DIHYDRO-PYRIDIN-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE, CITRIC ACID, UROKINASE-TYPE PLASMINOGEN ACTIVATOR 著者 Katz, B.A, Elrod, K, Luong, C, Rice, M, Mackman, R.L, Sprengeler, P.A, Spencer, J, Hatayte, J, Janc, J, Link, J, Litvak, J, Rai, R, Rice, K, Sideris, S, Verner, E, Young, W. 登録日 2001-01-22 公開日 2002-01-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. J.Mol.Biol., 307, 2001
4F4V	Human Insulin 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. 登録日 2012-05-11 公開日 2013-05-15 最終更新日 2013-12-18 実験手法 X-RAY DIFFRACTION (1.637 Å) 主引用文献 Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4F51	Human Insulin 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. 登録日 2012-05-11 公開日 2013-05-15 最終更新日 2013-12-18 実験手法 X-RAY DIFFRACTION (1.637 Å) 主引用文献 Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013

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