PDB: 31311 件ウェブページステータス検索Chemie searchBIRD

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7PSJ	Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with covalent inhibitor VL166 分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, Beta-glucuronidase 著者 Armstrong, Z, Wu, L, Davies, G.J. 登録日 2021-09-23 公開日 2022-08-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
8PBS	Mutant K1482M of the dihydroorotase domain of human CAD protein in apo form 分子名称: CAD protein, FORMIC ACID, GLYCEROL, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8SIP	Structure of a mouse IgG antibody fragment that binds Inosine, an RNA modification 分子名称: INOSINE, Inosine binding IgG Fab, heavy chain, ... 著者 Aoki, S.T. 登録日 2023-04-16 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Structure of a mouse IgG antibody fragment that binds Inosine, an RNA modification To Be Published
5E2L	3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with D-phenylalanine 分子名称: 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase, CHLORIDE ION, D-PHENYLALANINE, ... 著者 Reichau, S, Jiao, W, Parker, E.J. 登録日 2015-10-01 公開日 2016-06-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using -Amino Acids. Plos One, 11, 2016
7PTH	C54S mutant of choline-sulfatase from E. meliloti CECT4857 bound to choline 分子名称: 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... 著者 Gavira, J.A, Martinez-Rodriguez, S. 登録日 2021-09-27 公開日 2022-08-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding. Acta Crystallogr D Struct Biol, 78, 2022
7TGK	Crystal structure of ATP bound DesD, the desferrioxamine synthetase from the Streptomyces griseoflavus ferrimycin biosynthetic pathway 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Patel, K.D, Gulick, A.M. 登録日 2022-01-07 公開日 2022-07-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD. J.Biol.Chem., 298, 2022
8SUD	JC Polyomavirus LTA NLS bound to importin alpha 2 分子名称: Importin subunit alpha-1, Large T antigen 著者 Cross, E.M, Forwood, J.K, Alvisi, G. 登録日 2023-05-12 公開日 2024-02-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
7PR6	Crystal structure of E. coli beta-glucuronidase in complex with covalent inhibitor ME727 分子名称: (2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, Beta-glucuronidase 著者 Wu, L, Armstrong, Z, Davies, G.J. 登録日 2021-09-20 公開日 2022-08-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
7YPR	Structural basis of a superoxide dismutase from a tardigrade, Ramazzottius varieornatus strain YOKOZUNA-1. 分子名称: COPPER (II) ION, POTASSIUM ION, Superoxide dismutase [Cu-Zn], ... 著者 Sim, K.-S, Fukuda, Y, Inoue, T. 登録日 2022-08-04 公開日 2023-12-06 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1. Acta Crystallogr.,Sect.F, 79, 2023
5UV4	Crystal Structure of Maize SIRK1 (sucrose-induced receptor kinase 1) kinase domain bound to AMP-PNP 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Putative leucine-rich repeat protein kinase family protein 著者 Counago, R.M, Aquino, B, Massirer, K.B, Gileadi, O, Arruda, P, Structural Genomics Consortium (SGC) 登録日 2017-02-17 公開日 2017-04-26 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of Maize SIRK1 (sucrose-induced receptor kinase 1) kinase domain bound to AMP-PNP To Be Published
8PND	The ES3 intermediate of hydroxymethylbilane synthase R167Q variant 分子名称: 1,2-ETHANEDIOL, 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid, GLYCEROL, ... 著者 Saeter, M.C, Bustad, H.J, Laitaoja, M, Janis, J, Martinez, A, Aarsand, A.K, Kallio, J.P. 登録日 2023-06-30 公開日 2023-11-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 One ring closer to a closure: the crystal structure of the ES 3 hydroxymethylbilane synthase intermediate. Febs J., 291, 2024
7PZV	LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria 分子名称: (2S,4S)-N-[(3R,5R)-1-cyclopropylcarbonyl-5-[[[4-[2-[4-[(1S)-2-methoxy-1-oxidanyl-ethyl]phenyl]ethynyl]phenyl]carbonylamino]methyl]pyrrolidin-3-yl]-4-fluoranyl-pyrrolidine-2-carboxamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION 著者 Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. 登録日 2021-10-13 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria To Be Published
8Q2E	The 1.68-A X-ray crystal structure of Sporosarcina pasteurii urease inhibited by thiram and bound to dimethylditiocarbamate 分子名称: 1,2-ETHANEDIOL, HYDROXIDE ION, NICKEL (II) ION, ... 著者 Mazzei, L, Cianci, M, Ciurli, S. 登録日 2023-08-02 公開日 2023-11-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Kinetic and structural details of urease inactivation by thiuram disulphides. J.Inorg.Biochem., 250, 2023
7TTJ	Stable-5-LOX elongated Ha2 分子名称: Arachidonate 5-lipoxygenase, FE (II) ION 著者 Gilbert, N.C, Newcomer, M.E. 登録日 2022-02-01 公開日 2022-08-31 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators. J.Biol.Chem., 298, 2022
7MWH	Crystal structure of BAZ2A with DNA 分子名称: Bromodomain adjacent to zinc finger domain protein 2A, DNA (5'-D(*CP*GP*GP*AP*AP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*TP*TP*CP*CP*G)-3'), ... 著者 Liu, K, Dong, A, Li, Y, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Min, J, Structural Genomics Consortium (SGC) 登録日 2021-05-17 公開日 2022-08-31 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Crystal structure of the BAZ2B TAM domain. Heliyon, 8, 2022
5HWE	high resolution structure of barbiturase 分子名称: (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, Barbiturase, MAGNESIUM ION, ... 著者 Peat, T.S, Scott, C. 登録日 2016-01-29 公開日 2017-02-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 High-Resolution X-Ray Structures of Two Functionally Distinct Members of the Cyclic Amide Hydrolase Family of Toblerone Fold Enzymes. Appl. Environ. Microbiol., 83, 2017
5DW3	Tryptophan Synthase beta-subunit from Pyrococcus furiosus with product L-tryptophan non-covalently bound in the active site 分子名称: PHOSPHATE ION, SODIUM ION, TRYPTOPHAN, ... 著者 Buller, A.R, Arnold, F.H. 登録日 2015-09-22 公開日 2015-11-11 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation. Proc.Natl.Acad.Sci.USA, 112, 2015
7TZ9	Structure of PQS Response Protein PqsE(E182W) Variant 分子名称: FE (III) ION, Quinolone signal response protein 著者 Jeffrey, P.D, Taylor, I.R, Bassler, B.L. 登録日 2022-02-15 公開日 2022-08-31 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa. Biochemistry, 61, 2022
7Q0Q	Acetyltrasferase(3) type IIIa in complex with 3-N-methyl-nemycin B 分子名称: 3N methyl nemycin B, ACETATE ION, Aminoglycoside N(3)-acetyltransferase III, ... 著者 Pontillo, N, Guskov, A. 登録日 2021-10-16 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 The 3-N-alkylation of the neomycin B outmaneuvers the aminoglycoside resistant enzyme acetyltransferase(3)IIIa via an unexpected mechanism To Be Published
7PSH	Crystal structure of beta-glucuronidase from Acidobacterium capsulatum at 1.24 Angstrom resolution 分子名称: Beta-glucuronidase 著者 Armstrong, Z, Wu, L, Davies, G.J. 登録日 2021-09-23 公開日 2022-08-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
6NJZ	EphA2 LBD in complex with YSA-GSGSK-bio peptide 分子名称: BIOTIN, Ephrin type-A receptor 2, GLYCEROL, ... 著者 Lechtenberg, B.C, Pasquale, E.B. 登録日 2019-01-04 公開日 2019-05-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling. J.Biol.Chem., 294, 2019
7MZQ	Crystal structure of the UcaD lectin-binding domain in complex with fucose 分子名称: CHLORIDE ION, Fimbrial adhesin UcaD, beta-L-fucopyranose 著者 Ve, T, Lo, A.W, Schembri, M.A, Kobe, B. 登録日 2021-05-24 公開日 2022-07-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli. Plos Pathog., 18, 2022
7TGN	Crystal structure of DesD, the desferrioxamine synthetase from the Streptomyces violaceus salmycin biosynthetic pathway 分子名称: 1,2-ETHANEDIOL, CITRATE ANION, Desferrioxamine synthetase DesD, ... 著者 Patel, K.D, Gulick, A.M. 登録日 2022-01-07 公開日 2022-07-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD. J.Biol.Chem., 298, 2022
7MZO	Crystal structure of the UcaD lectin-binding domain 分子名称: CHLORIDE ION, Fimbrial adhesin UcaD 著者 Ve, T, Lo, A.W, Schembri, M.A, Kobe, B. 登録日 2021-05-24 公開日 2022-07-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli. Plos Pathog., 18, 2022
7PZS	LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria 分子名称: (2S,4S)-N-((3R,5R)-5-((2-chloro-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamido)methyl)-1-(cyclopropanecarbonyl)pyrrolidin-3-yl)-4-fluoropyrrolidine-2-carboxamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION 著者 Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. 登録日 2021-10-13 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria To Be Published

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