3S8P
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![BU of 3s8p by Molmil](/molmil-images/mine/3s8p) | Crystal Structure of the SET Domain of Human Histone-Lysine N-Methyltransferase SUV420H1 In Complex With S-Adenosyl-L-Methionine | 分子名称: | Histone-lysine N-methyltransferase SUV420H1, S-ADENOSYLMETHIONINE, ZINC ION | 著者 | Lam, R, Zeng, H, Loppnau, P, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2011-05-30 | 公開日 | 2011-07-06 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2. Febs Lett., 587, 2013
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3S97
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![BU of 3s97 by Molmil](/molmil-images/mine/3s97) | PTPRZ CNTN1 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Contactin-1, Receptor-type tyrosine-protein phosphatase zeta | 著者 | Bouyain, S. | 登録日 | 2011-05-31 | 公開日 | 2011-09-28 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2971 Å) | 主引用文献 | A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. Proc.Natl.Acad.Sci.USA, 108, 2011
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3SK6
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![BU of 3sk6 by Molmil](/molmil-images/mine/3sk6) | |
3SA4
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![BU of 3sa4 by Molmil](/molmil-images/mine/3sa4) | |
3SAC
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![BU of 3sac by Molmil](/molmil-images/mine/3sac) | |
3SBI
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![BU of 3sbi by Molmil](/molmil-images/mine/3sbi) | Crystal structure of human carbonic anhydrase isozyme II with 4-[(2-pyrimidinylsulfanyl)acetyl]benzenesulfonamide | 分子名称: | 4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide, BICINE, Carbonic anhydrase 2, ... | 著者 | Grazulis, S, Manakova, E, Tamulaitiene, G. | 登録日 | 2011-06-05 | 公開日 | 2012-04-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases. Eur.J.Med.Chem., 51, 2012
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3SL3
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![BU of 3sl3 by Molmil](/molmil-images/mine/3sl3) | Crystal structure of the apo form of the catalytic domain of PDE4D2 | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Feil, S.F. | 登録日 | 2011-06-24 | 公開日 | 2011-10-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2. Bioorg.Med.Chem.Lett., 21, 2011
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3SBU
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![BU of 3sbu by Molmil](/molmil-images/mine/3sbu) | |
3SNV
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![BU of 3snv by Molmil](/molmil-images/mine/3snv) | |
3SO5
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![BU of 3so5 by Molmil](/molmil-images/mine/3so5) | |
3S29
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![BU of 3s29 by Molmil](/molmil-images/mine/3s29) | |
3SH5
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![BU of 3sh5 by Molmil](/molmil-images/mine/3sh5) | |
3S4C
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![BU of 3s4c by Molmil](/molmil-images/mine/3s4c) | Lactose phosphorylase in complex with sulfate | 分子名称: | 1,4-DIETHYLENE DIOXIDE, Lactose Phosphorylase, SULFATE ION | 著者 | Van Hoorebeke, A, Stout, J, Soetaert, W, Van Beeumen, J, Desmet, T, Savvides, S. | 登録日 | 2011-05-19 | 公開日 | 2012-06-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Cellobiose phosphorylase: reconstructing the structural itinerary along the catalytic pathway To be Published
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3S5T
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3SHZ
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![BU of 3shz by Molmil](/molmil-images/mine/3shz) | Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors | 分子名称: | 5-chloro-6-ethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Chen, T.T, Chen, T, Xu, Y.C. | 登録日 | 2011-06-17 | 公開日 | 2011-08-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.449 Å) | 主引用文献 | Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors. J.Med.Chem., 54, 2011
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3TKQ
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![BU of 3tkq by Molmil](/molmil-images/mine/3tkq) | Crystal structure of full-length human peroxiredoxin 4 with mixed conformation | 分子名称: | Peroxiredoxin-4 | 著者 | Wang, X, Wang, L, Wang, X, Sun, F, Wang, C.-C. | 登録日 | 2011-08-28 | 公開日 | 2011-10-05 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4 Biochem.J., 2011
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3TJP
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![BU of 3tjp by Molmil](/molmil-images/mine/3tjp) | Crystal Structure of PI3K gamma with N6-(3,4-dimethoxyphenyl)-2-morpholino-[4,5'-bipyrimidine]-2',6-diamine | 分子名称: | N~6~-(3,4-dimethoxyphenyl)-2-(morpholin-4-yl)-4,5'-bipyrimidine-2',6-diamine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | 著者 | Knapp, M.S, Elling, R.A, Ornelas, E. | 登録日 | 2011-08-24 | 公開日 | 2012-08-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The Identification of 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine (NVP-BKM120) as a Potent, Selective and Orally Bioavailable Class I PI3 Kinase Inhibitor for the Treatment of Cancer To be Published
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3TP7
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![BU of 3tp7 by Molmil](/molmil-images/mine/3tp7) | |
3TP2
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![BU of 3tp2 by Molmil](/molmil-images/mine/3tp2) | |
3TPP
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![BU of 3tpp by Molmil](/molmil-images/mine/3tpp) | Crystal structure of BACE1 complexed with an inhibitor | 分子名称: | Beta-secretase 1, CHLORIDE ION, N-[(1S,2R)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2-HYDROXYPROPYL]-5-[METHYL(METHYLSULFONYL)AMINO]-N'-[(1R)-1-PHENYLETHYL]ISOPHTHALAMIDE, ... | 著者 | Xu, Y.C, Li, M.J, Greenblatt, H, Chen, T.T, Silman, I, Sussman, J.L. | 登録日 | 2011-09-08 | 公開日 | 2011-11-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations Acta Crystallogr.,Sect.D, 68, 2012
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3TQN
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![BU of 3tqn by Molmil](/molmil-images/mine/3tqn) | Structure of the transcriptional regulator of the GntR family, from Coxiella burnetii. | 分子名称: | Transcriptional regulator, GntR family | 著者 | Rudolph, M, Cheung, J, Franklin, M.C, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-28 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TQZ
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![BU of 3tqz by Molmil](/molmil-images/mine/3tqz) | Structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) from Coxiella burnetii | 分子名称: | Deoxyuridine 5'-triphosphate nucleotidohydrolase, SULFATE ION | 著者 | Cheung, J, Franklin, M, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-21 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TQT
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![BU of 3tqt by Molmil](/molmil-images/mine/3tqt) | Structure of the D-alanine-D-alanine ligase from Coxiella burnetii | 分子名称: | D-alanine--D-alanine ligase | 著者 | Rudolph, M, Cheung, J, Franklin, M.C, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TR6
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![BU of 3tr6 by Molmil](/molmil-images/mine/3tr6) | Structure of a O-methyltransferase from Coxiella burnetii | 分子名称: | NICKEL (II) ION, O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Cheung, J, Franklin, M.C, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-28 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3TRB
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![BU of 3trb by Molmil](/molmil-images/mine/3trb) | Structure of an addiction module antidote protein of a HigA (higA) family from Coxiella burnetii | 分子名称: | Virulence-associated protein I | 著者 | Cheung, J, Franklin, M.C, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | 登録日 | 2011-09-09 | 公開日 | 2011-09-28 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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