PDB: 72236 件ウェブページステータス検索Chemie searchBIRD

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1DHF	CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE 分子名称: DIHYDROFOLATE REDUCTASE, FOLIC ACID 著者 Davies /II, J.F, Kraut, J. 登録日 1989-10-25 公開日 1990-07-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate. Biochemistry, 29, 1990
6I5L	Crystal structure of CLK1 in complexed with furo[3,2-b]pyridine compound VN316 (derivative of compound 12h) 分子名称: 3-(3-cyclobutylphenyl)-5-(1-methylpyrazol-4-yl)furo[3,2-b]pyridine, Dual specificity protein kinase CLK1, GLYCEROL, ... 著者 Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Paruch, K, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2018-11-13 公開日 2019-01-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway. Angew. Chem. Int. Ed. Engl., 58, 2019
8E7E	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient 分子名称: Transthyretin 著者 Nguyen, B.A, Singh, V, Afrin, S, Saelices, L. 登録日 2022-08-23 公開日 2023-08-30 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.61 Å) 主引用文献 Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024
8E7J	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient 分子名称: Transthyretin 著者 Nguyen, B.A, Saelices, L. 登録日 2022-08-24 公開日 2023-08-30 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024
6I6C	SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 2 分子名称: (1~{R},2~{S},4~{S})-~{N}-(3-chloranyl-4-cyano-phenyl)sulfonylbicyclo[2.2.1]heptane-2-carboxamide, 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Alen, J, Schade, M, Wagener, M, Blaesse, M. 登録日 2018-11-15 公開日 2019-07-10 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J.Med.Chem., 62, 2019
6I5H	Crystal structure of CLK1 in complex with furanopyrimidin VN412 分子名称: 1,2-ETHANEDIOL, 5-(1-methylpyrazol-4-yl)-3-(3-phenoxyphenyl)furo[3,2-b]pyridine, Dual specificity protein kinase CLK1, ... 著者 Schroeder, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Paruch, K, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2018-11-13 公開日 2019-01-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway. Angew. Chem. Int. Ed. Engl., 58, 2019
3OIB	Crystal structure of a putative ACYL-COA Dehydrogenase from mycobacterium smegmatis, Iodide soak 分子名称: 1,2-ETHANEDIOL, Acyl-CoA dehydrogenase, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2010-08-18 公開日 2010-09-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 SAD phasing using iodide ions in a high-throughput structural genomics environment. J Struct Funct Genomics, 12, 2011
3ODZ	Crystal structure of P38alpha Y323R active mutant 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Livnah, O, Tzarum, N. 登録日 2010-08-12 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Active mutants of the TCR-mediated p38alpha alternative activation site show changes in the phosphorylation lip and DEF site formation. J.Mol.Biol., 405, 2011
1Y6X	The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis 分子名称: Phosphoribosyl-ATP pyrophosphatase 著者 Javid-Majd, F, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2004-12-07 公開日 2005-03-01 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.D, 64, 2008
6H3D	Staphylopine dehydrogenase in complex with xNA 分子名称: D-HISTIDINE, DUF2338 domain-containing protein, GLYCEROL, ... 著者 Hajjar, C, Arnoux, P. 登録日 2018-07-18 公開日 2019-04-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Control by Metals of Staphylopine Dehydrogenase Activity during Metallophore Biosynthesis. J.Am.Chem.Soc., 141, 2019
6H4A	Human MALT1(329-728) in complex with MLT-748 分子名称: 1-[2-chloranyl-7-[(1~{R},2~{R})-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-[5-chloranyl-6-(1,2,3-triazol-2-yl)pyridin-3-yl]urea, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 著者 Renatus, M, Renatus, M. 登録日 2018-07-20 公開日 2019-02-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat. Chem. Biol., 15, 2019
6H4M	TarP-UDP-GlcNAc-3RboP 分子名称: CHLORIDE ION, MAGNESIUM ION, Probable ss-1,3-N-acetylglucosaminyltransferase, ... 著者 Guo, Y, Stehle, T. 登録日 2018-07-22 公開日 2018-09-26 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity. Nature, 563, 2018
3OEF	Crystal structure of Y323F inactive mutant of p38alpha MAP kinase 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Livnah, O, Tzarum, N. 登録日 2010-08-12 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Active mutants of the TCR-mediated p38alpha alternative activation site show changes in the phosphorylation lip and DEF site formation. J.Mol.Biol., 405, 2011
6GIL	NMR structure of temporin B in SDS micelles 分子名称: Temporin-B 著者 Manzo, G, Mason, J.A. 登録日 2018-05-12 公開日 2018-06-13 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity. Sci Rep, 9, 2019
1ZYK	Anthranilate Phosphoribosyltransferase in complex with PRPP, anthranilate and magnesium 分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, ... 著者 Marino, M, Deuss, M, Sterner, R, Mayans, O. 登録日 2005-06-10 公開日 2006-05-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus. J.Biol.Chem., 281, 2006
6HZD	X-ray structure of furin in complex with the cyclic inhibitor c[glutaryl-Arg-Arg-Arg-Lys]-Arg-4-Amba 分子名称: ARG-ARG-ARG-LYS-ARG-00S, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O. 登録日 2018-10-23 公開日 2019-02-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
6HQ5	Structure of EAL Enzyme Bd1971 - cAMP and cyclic-di-GMP bound form 分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, ... 著者 Lovering, A.L, Cadby, I.T. 登録日 2018-09-24 公開日 2019-07-31 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase. Embo J., 38, 2019
6HVF	Kinase domain of cSrc in complex with compound 29B 分子名称: 1,2-ETHANEDIOL, Proto-oncogene tyrosine-protein kinase Src, ~{N}-[3-[3-ethyl-6-[4-(4-methylpiperazin-1-yl)phenyl]-4-oxidanylidene-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]prop-2-enamide 著者 Keul, M, Mueller, M.P, Rauh, D. 登録日 2018-10-10 公開日 2019-10-23 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S. Chem Sci, 10, 2019
1ESL	INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS 分子名称: CALCIUM ION, CHLORIDE ION, HUMAN E-SELECTIN 著者 Graves, B.J, Crowther, R.L. 登録日 1994-06-03 公開日 1994-08-31 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains. Nature, 367, 1994
6HZC	X-ray structure of furin in complex with the cyclic inhibitor c[glutaryl-BVK-Lys-Arg-Arg-Tle-Lys]-4-Amba 分子名称: 2-[4-(aminomethyl)phenyl]ethanoic acid, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O. 登録日 2018-10-23 公開日 2019-02-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
6HZB	X-ray structure of furin in complex with the cyclic inhibitor c[glutaryl-Arg-Arg-Lys]-Lys-4-Amba 分子名称: ARG-ARG-LYS-LYS-00S, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O. 登録日 2018-10-23 公開日 2019-02-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
6I6F	SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 1 分子名称: 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Sepiapterin reductase, ... 著者 Alen, J, Schade, M, Wagener, M, Blaesse, M. 登録日 2018-11-15 公開日 2019-07-10 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J.Med.Chem., 62, 2019
6I6V	SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 6 分子名称: 1,2-ETHANEDIOL, 2-[[(3~{R})-oxan-3-yl]methylsulfonyl]-2-azaspiro[4.5]decane, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Alen, J, Schade, M, Wagener, M, Blaesse, M. 登録日 2018-11-15 公開日 2019-07-10 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. J.Med.Chem., 62, 2019
1YS7	Crystal structure of the response regulator protein prrA complexed with Mg2+ 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, GLYCEROL, ... 著者 Nowak, E, Panjikar, S, Tucker, P, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) 登録日 2005-02-07 公開日 2006-02-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 The structural basis of signal transduction for the response regulator PrrA from Mycobacterium tuberculosis. J.Biol.Chem., 281, 2006
1YME	STRUCTURE OF CARBOXYPEPTIDASE 分子名称: CARBOXYPEPTIDASE A ALPHA, ZINC ION 著者 Greenblatt, H.M, Tucker, P.A, Shoham, G. 登録日 1996-07-15 公開日 1997-02-12 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Carboxypeptidase A: native, zinc-removed and mercury-replaced forms. Acta Crystallogr.,Sect.D, 54, 1998

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