PDB: 83630 件ウェブページステータス検索Chemie searchBIRD

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3W1M	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-bromoorotate 分子名称: 5-bromo-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A. 登録日 2012-11-16 公開日 2013-11-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-bromoorotate To be Published
3W2M	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-183 分子名称: 2,6-dioxo-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-30 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-183. To be Published
405D	STRUCTURE OF A 16-MER RNA DUPLEX R(GCAGACUUAAAUCUGC)2 WITH WOBBLE LIKE A.C MISMATCHES 分子名称: RNA (5'-R(*GP*CP*AP*GP*AP*CP*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3') 著者 Pan, B, Sundaralingam, M, Mitra, S.N. 登録日 1998-06-17 公開日 1999-01-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of a 16-mer RNA duplex r(GCAGACUUAAAUCUGC)2 with wobble C.A+ mismatches. J.Mol.Biol., 283, 1998
5G57	Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-001 分子名称: (4~{a}~{S},8~{a}~{R})-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(1~{H}-1,2,3,4-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-one, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ... 著者 Singh, A.K, Brown, D.G. 登録日 2016-05-22 公開日 2017-11-29 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity. J. Med. Chem., 61, 2018
5G2B	Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-008 分子名称: CLASS 1 PHOSPHODIESTERASE PDEB1, FORMIC ACID, GLYCEROL, ... 著者 Singh, A.K, Anthonyrajah, E.S, Brown, D.G. 登録日 2016-04-07 公開日 2017-11-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity. J. Med. Chem., 61, 2018
4E2B	High resolution crystal structure of the old yellow enzyme from Trypanosoma cruzi 分子名称: DI(HYDROXYETHYL)ETHER, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Murakami, M.T, Rodrigues, N.C, Gava, L.M, Canduri, F, Oliva, G, Barbosa, L.R.S, Borgers, J.C. 登録日 2012-03-08 公開日 2013-03-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.269 Å) 主引用文献 High resolution crystal structure and in solution studies of the old yellow enzyme from Trypanosoma cruzi: Insights into oligomerization, enzyme dynamics and specificity To be Published
3W1L	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-chloroorotate 分子名称: 5-chloro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-16 公開日 2013-11-20 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-chloroorotate TO BE PUBLISHED
3W1A	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-halogenated orotate derivatives 分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-13 公開日 2013-11-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-halogenated orotate derivatives To be Published
3W23	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-131 分子名称: 5-[2-(3-chlorophenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-26 公開日 2013-11-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-131 To be Published
3W1T	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-095 分子名称: 2,6-dioxo-5-{2-[3-(trifluoromethyl)phenyl]ethyl}-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-21 公開日 2013-11-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-095 To be Published
3W22	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-125 分子名称: 5-[2-(4-tert-butylphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-26 公開日 2013-11-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-125 To be Published
3W1U	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-111 分子名称: 5-[2-(4-methylphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-21 公開日 2013-11-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-111 To be Published
3W6Y	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-2-199 分子名称: 5-[2-(5-carboxynaphthalen-2-yl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2013-02-27 公開日 2014-03-05 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-2-199 To be Published
3W72	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-107 分子名称: 5-[2-(naphthalen-1-yl)ethyl]-2,6-dioxo-1,2,3,6- tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2013-02-27 公開日 2014-03-05 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-107 To be Published
3W7D	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-170 分子名称: 5-[2-(8-methoxynaphthalen-2-yl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2013-02-28 公開日 2014-03-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-170 To be Published
3W7P	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-4-031 分子名称: 5-[2-(4-carboxyphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2013-03-02 公開日 2014-03-05 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-4-031 To be Published
3W88	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with SH-1-200 分子名称: 1,2-ETHANEDIOL, 5-[4-(6-carboxynaphthalen-2-yl)butyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, CACODYLATE ION, ... 著者 Inaoka, D.K, Hashimoto, S, Rocha, J.R, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Kuranaga, T, Shiba, T, Balogun, E.O, Sakamoto, K, Suzuki, S, Montanari, C.A, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2013-03-12 公開日 2014-03-12 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with SH-1-200 To be Published
3W7L	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-075 分子名称: 5-[2-(6-methoxynaphthalen-1-yl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2013-03-02 公開日 2014-03-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-075 To be Published
3W3O	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-053 分子名称: 5-[2-(6-methoxynaphthalen-2-yl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Rocha, J.R, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-12-27 公開日 2014-01-01 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-053 To be Published
3W7K	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-6-066 分子名称: 5-[2-(3,6-dimethoxynaphthalen-2-yl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2013-02-28 公開日 2014-03-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-6-066 To be Published
3W84	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-6-101 分子名称: 5-{2-[3-(methoxymethoxy)naphthalen-2-yl]ethyl}-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Hashimoto, S, Matsuoka, S, Kuranaga, T, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2013-03-12 公開日 2014-03-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-6-101 To be Published
4EFD	Crystal Structure of an M17 aminopeptidase from Trypanosoma Brucei, Tb427tmp.02.4440 分子名称: Aminopeptidase, GLYCEROL, MANGANESE (II) ION, ... 著者 Wernimont, A.K, Osman, K.T, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Lin, Y.H, Structural Genomics Consortium (SGC) 登録日 2012-03-29 公開日 2012-05-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal Structure of an M17 aminopeptidase from Trypanosoma Brucei, Tb427tmp.02.4440 To be Published
3W2K	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-165 分子名称: 5-[2-(4-fluoro-3-methylphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-29 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-165 To be Published
3W2N	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-185 分子名称: 2,6-dioxo-5-{2-[2-(trifluoromethyl)phenyl]ethyl}-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-12-03 公開日 2013-12-04 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-185 To be Published
3W2L	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-169 分子名称: 5-[2-(4-methoxyphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... 著者 Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. 登録日 2012-11-29 公開日 2013-12-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-169 To be Published

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