PDB: 1223 件ウェブページステータス検索Chemie searchBIRD

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5NB6	Complement factor D in complex with the inhibitor (2S,4S)-4-Amino-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide] 分子名称: (2~{S},4~{S})-~{N}1-(1-aminocarbonylindol-3-yl)-4-azanyl-~{N}2-[3-(trifluoromethyloxy)phenyl]pyrrolidine-1,2-dicarboxamide, Complement factor D 著者 Mac Sweeney, A, Ostermann, N. 登録日 2017-03-01 公開日 2017-06-28 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem., 60, 2017
5NAR	Complement factor D in complex with the inhibitor (S)-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide] 分子名称: (2~{S})-~{N}1-(1-aminocarbonylindol-3-yl)-~{N}2-[3-(trifluoromethyloxy)phenyl]pyrrolidine-1,2-dicarboxamide, Complement factor D, SULFATE ION 著者 Mac Sweeney, A, Ostermann, N. 登録日 2017-02-28 公開日 2017-06-28 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem., 60, 2017
5NAW	Complement factor D in complex with the inhibitor (1R,3S,5R)-2-Aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol-3-yl)-amide] 3-[(3-trifluoromethoxy-phenyl)-amide] 分子名称: (1~{R},3~{S},5~{R})-~{N}2-(1-aminocarbonylindol-3-yl)-~{N}3-[3-(trifluoromethyloxy)phenyl]-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamide, Complement factor D 著者 Mac Sweeney, A, Ostermann, N. 登録日 2017-02-28 公開日 2017-06-28 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem., 60, 2017
5NBA	Complement factor D in complex with the inhibitor (2S,4R)-4-Fluoro-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide] 分子名称: (2~{S},4~{R})-~{N}1-(1-aminocarbonylindol-3-yl)-4-fluoranyl-~{N}2-[3-(trifluoromethyloxy)phenyl]pyrrolidine-1,2-dicarboxamide, Complement factor D 著者 Mac Sweeney, A, Ostermann, N. 登録日 2017-03-01 公開日 2017-06-28 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem., 60, 2017
5NB7	Complement factor D 分子名称: 1-[2-[(1~{R},3~{S},5~{R})-3-[(6-bromanylpyridin-2-yl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxidanylidene-ethyl]indazole-3-carboxamide, Complement factor D, DIMETHYL SULFOXIDE 著者 Mac Sweeney, A, Ostermann, N. 登録日 2017-03-01 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem., 60, 2017
3F9Q	Re-refinement of uncomplexed plasmepsin II from Plasmodium falciparum. 分子名称: Plasmepsin-2 著者 Robbins, A.H, Mckenna, R. 登録日 2008-11-14 公開日 2009-03-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank. Acta Crystallogr.,Sect.D, 65, 2009
2R9B	Structural Analysis of Plasmepsin 2 from Plasmodium falciparum complexed with a peptide-based inhibitor 分子名称: Plasmepsin-2, peptide-based inhibitor 著者 Liu, P, Marzahn, M.R, Robbins, A.H, McKenna, R, Dunn, B.M. 登録日 2007-09-12 公開日 2007-11-27 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Recombinant plasmepsin 1 from the human malaria parasite plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis. Biochemistry, 48, 2009
1HDO	Human biliverdin IX beta reductase: NADP complex 分子名称: BILIVERDIN IX BETA REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Pereira, P.J.B, Macedo-Ribeiro, S, Parraga, A, Perez-Luque, R, Cunningham, O, Darcy, K, Mantle, T.J, Coll, M. 登録日 2000-11-16 公開日 2001-02-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Structure of Human Biliverdin Ix Beta Reductase, an Early Fetal Bilirubin Ix Producing Enzyme Nat.Struct.Biol., 8, 2001
1IB0	CRYSTAL STRUCTURE OF RAT B5R IN COMPLEX WITH FAD AND NAD 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, NADH-CYTOCHROME B5 REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Bewley, M.C, Marohnic, C.C, Barber, M.J. 登録日 2001-03-26 公開日 2001-12-12 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The structure and biochemistry of NADH-dependent cytochrome b5 reductase are now consistent. Biochemistry, 40, 2001
1HJT	SPERM WHALE MYOGLOBIN (FERROUS, NITRIC OXIDE BOUND) 分子名称: MYOGLOBIN, NITRIC OXIDE, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Brucker, E.A, Phillips Jr, G.N. 登録日 1997-06-24 公開日 1997-11-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Nitric oxide myoglobin: crystal structure and analysis of ligand geometry. Proteins, 30, 1998
3BPM	Crystal Structure of Falcipain-3 with Its inhibitor, Leupeptin 分子名称: Cysteine protease falcipain-3, Leupeptin, SULFATE ION 著者 kerr, I.D, Lee, J.H, Brinen, L.S. 登録日 2007-12-18 公開日 2008-12-30 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. J.Med.Chem., 52, 2009
3BPF	Crystal Structure of Falcipain-2 with Its inhibitor, E64 分子名称: Cysteine protease falcipain-2, GLYCEROL, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE 著者 kerr, I.D, Lee, J.H, Brinen, L.S. 登録日 2007-12-18 公開日 2008-12-30 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. J.Med.Chem., 52, 2009
1PWO	Crystal Structure of Phospholipase A2 (MIPLA2) from Micropechis Ikaheka 分子名称: Phospholipase A2 著者 Lok, S.M, Swaminathan, K. 登録日 2003-07-02 公開日 2005-03-01 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure and function comparison of Micropechis ikaheka snake venom phospholipase A2 isoenzymes. Febs J., 272, 2005
3QKG	Crystal structure of alpha-1-microglobulin at 2.3 A resolution 分子名称: GLYCEROL, NICKEL (II) ION, Protein AMBP 著者 Meining, W, Skerra, A. 登録日 2011-02-01 公開日 2012-02-08 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The crystal structure of human alpha(1)-microglobulin reveals a potential haem-binding site. Biochem.J., 445, 2012
1OZY	Crystal Structure of Phospholipase A2 (MIPLA3) From Micropechis Ikaheka 分子名称: PHOSPHOLIPASE A2, SULFATE ION 著者 Lok, S.M, Swaminathan, K. 登録日 2003-04-10 公開日 2004-09-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure and function comparison of Micropechis ikaheka snake venom phospholipase A2 isoenzymes FEBS J., 272, 2005
1P7O	Crystal structure of phospholipase A2 (MIPLA4) from Micropechis ikaheka 分子名称: PHOSPHOLIPASE A2 著者 Lok, S.M, Swaminathan, K. 登録日 2003-05-05 公開日 2004-09-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure and function comparison of Micropechis ikaheka snake venom phospholipase A2 isoenzymes FEBS J., 272, 2005
1ME6	CRYSTAL STRUCTURE OF PLASMEPSIN II, AN ASPARTYL PROTEASE FROM PLASMODIUM FALCIPARUM, IN COMPLEX WITH A STATINE-BASED INHIBITOR 分子名称: 3-HYDROXY-6-METHYL-4-(3-METHYL-2-(3-METHYL-2-(3-METHYL-BUTYRYLAMINO)-BUTYRYLAMINO)-BUTYRYLAMINO)-HEPTANOIC ACID ETHYL ESTER, Plasmepsin II 著者 Freire, E, Nezami, A.G, Amzel, L.M. 登録日 2002-08-08 公開日 2004-01-20 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 CRYSTAL STRUCTURE OF PLASMEPSIN II, AN ASPARTYL PROTEASE FROM PLASMODIUM FALCIPARUM, IN COMPLEX WITH A STATINE-BASED INHIBITOR TO BE PUBLISHED
2IGX	Achiral, Cheap and Potent Inhibitors of Plasmepsins II 分子名称: 5-PENTYL-N-{[4'-(PIPERIDIN-1-YLCARBONYL)BIPHENYL-4-YL]METHYL}-N-[1-(PYRIDIN-2-YLMETHYL)PIPERIDIN-4-YL]PYRIDINE-2-CARBOXAMIDE, Plasmepsin-2 著者 Prade, L. 登録日 2006-09-25 公開日 2006-11-28 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Achiral, Cheap, and Potent Inhibitors of Plasmepsins I, II, and IV. Chemmedchem, 1, 2006
1HYN	CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF HUMAN ERYTHROCYTE BAND-3 PROTEIN 分子名称: BAND 3 ANION TRANSPORT PROTEIN 著者 Zhang, D, Kiyatkin, A, Bolin, J.T, Low, P.S. 登録日 2001-01-20 公開日 2001-05-16 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystallographic structure and functional interpretation of the cytoplasmic domain of erythrocyte membrane band 3. Blood, 96, 2000
1XE6	Structure of plasmepsin II in complex of an pepstatin analogue 分子名称: 5,5,5-TRIFLUORO-3-HYDROXY-4-[2-(5,5,5-TRIFLUORO-3-HYDROXY-4-{3-METHYL-2-[3-METHYL-2-(3-METHYL-BUTYRYLAMINO)-BUTYRYLAMINO]-BUTYRYLAMINO}-PENTANOYLAMINO)-PROPIONYLAMINO]-PENTANOIC ACID, Plasmepsin 2 著者 Prade, L. 登録日 2004-09-09 公開日 2005-08-23 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of plasmepsin II in complex of an pepstatin analogue To be published
1XDH	Structure of plasmepsin II in complex with pepstatin A 分子名称: Pepstatin, Plasmepsin 2 著者 Prade, L. 登録日 2004-09-06 公開日 2005-08-23 最終更新日 2013-02-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of plasmepsin II in complex with pepstatin A To be published
1XI1	Phi29 DNA polymerase ssDNA complex, monoclinic crystal form 分子名称: 5'-D(P*TP*TP*TP*TP*T)-3', DNA polymerase, MAGNESIUM ION 著者 Kamtekar, S, Berman, A.J, Wang, J, Lazaro, J.M, de Vega, M, Blanco, L, Salas, M, Steitz, T.A. 登録日 2004-09-21 公開日 2004-12-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Correction of X-ray intensities from single crystals containing lattice-translocation defects Acta Crystallogr.,Sect.D, 61, 2005
1XE5	Structure of plasmepsin II in complex of an pepstatin analogue 分子名称: 5,5,5-TRIFLUORO-3-HYDROXY-4-[2-(5,5,5-TRIFLUORO-3-HYDROXY-4-{3-METHYL-2-[3-METHYL-2-(3-METHYL-BUTYRYLAMINO)-BUTYRYLAMINO]-BUTYRYLAMINO}-PENTANOYLAMINO)-PROPIONYLAMINO]-PENTANOIC ACID METHYL ESTER, Plasmepsin 2 著者 Prade, L. 登録日 2004-09-09 公開日 2005-08-23 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of plasmepsin II in complex of an pepstatin analogue To be published

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