PDB: 97138 件ウェブページステータス検索Chemie searchBIRD

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5TJ5	Atomic model for the membrane-embedded motor of a eukaryotic V-ATPase 分子名称: V-type proton ATPase subunit a, V-type proton ATPase subunit c, V-type proton ATPase subunit c', ... 著者 Mazhab-Jafari, M.T, Rohou, A, Schmidt, C, Bueler, S.A, Benlekbir, S, Robinson, C.V, Rubinstein, J.L. 登録日 2016-10-03 公開日 2016-10-26 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase. Nature, 539, 2016
3IG8	Saccharomyces cerevisiae glutamate cysteine ligase in complex with Mg2+, L-glutamate and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLUTAMIC ACID, Glutamate-cysteine ligase, ... 著者 Biterova, E, Barycki, J.J. 登録日 2009-07-27 公開日 2009-09-01 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Mechanistic details of glutathione biosynthesis revealed by crystal structures of Saccharomyces cerevisiae glutamate cysteine ligase. J.Biol.Chem., 284, 2009
3IG5	Saccharomyces cerevisiae glutamate cysteine ligase in complex with Mg2+ and L-glutamate 分子名称: GLUTAMIC ACID, Glutamate-cysteine ligase, MAGNESIUM ION, ... 著者 Biterova, E, Barycki, J.J. 登録日 2009-07-27 公開日 2009-09-01 最終更新日 2012-12-26 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Mechanistic details of glutathione biosynthesis revealed by crystal structures of Saccharomyces cerevisiae glutamate cysteine ligase. J.Biol.Chem., 284, 2009
3RWU	RB69 DNA Polymerase (Y567A) Ternary Complex with dATP Opposite Difluorotoluene Nucleoside 分子名称: 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3', 5'-D(*TP*CP*GP*(DFT)P*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Xia, S, Konigsberg, W.H, Wang, J. 登録日 2011-05-09 公開日 2011-06-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Hydrogen-Bonding Capability of a Templating Difluorotoluene Nucleotide Residue in an RB69 DNA Polymerase Ternary Complex. J.Am.Chem.Soc., 133, 2011
2ENB	CRYSTAL STRUCTURES OF THE BINARY CA2+ AND PDTP COMPLEXES AND THE TERNARY COMPLEX OF THE ASP 21->GLU MUTANT OF STAPHYLOCOCCAL NUCLEASE. IMPLICATIONS FOR CATALYSIS AND LIGAND BINDING 分子名称: STAPHYLOCOCCAL NUCLEASE, THYMIDINE-3',5'-DIPHOSPHATE 著者 Libson, A, Gittis, A, Lattman, E.E. 登録日 1994-03-23 公開日 1994-05-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structures of the binary Ca2+ and pdTp complexes and the ternary complex of the Asp21-->Glu mutant of staphylococcal nuclease. Implications for catalysis and ligand binding. Biochemistry, 33, 1994
3SNN	RB69 DNA Polymerase (L561A/S565G/Y567A) Ternary Complex with dCTP Opposite dG in the presence of Mg2+ 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3', 5'-D(*TP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', ... 著者 Wang, M, Wang, J, Konigsberg, W.H. 登録日 2011-06-29 公開日 2011-10-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase. Biochemistry, 50, 2011
1HBZ	Catalase from Micrococcus lysodeikticu 分子名称: CATALASE, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION 著者 Murshudov, G.N, Grebenko, A.I, Barynin, V.V, Braningen, J, Wilson, K.S, Dauter, Z, Melik-Adamyan, W.R. 登録日 2001-04-24 公開日 2001-05-24 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Three-Dimensional Structure of Catalase from Micrococcus Lysodeikticus at 1.5A Resolution FEBS Lett., 312, 1992
7R4L	Crystal structure of human mitochondrial NAD kinase 分子名称: FE (III) ION, NAD kinase 2, mitochondrial, ... 著者 Labesse, G, Mary, C, Gelin, M, Lionne, C. 登録日 2022-02-08 公開日 2022-07-06 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation. Mol.Cell, 82, 2022
8E80	Structure of LRRK2-CHK1 10-pt. mutant complex with heteroaryl-1H-indazole LRRK2 inhibitor 14 分子名称: 2-[(1r,4r)-2-{(6P)-6-[(6M)-6-(1H-pyrazol-5-yl)-1H-indazol-1-yl]pyrimidin-4-yl}-2-azabicyclo[2.1.1]hexan-4-yl]propan-2-ol, Serine/threonine-protein kinase Chk1 著者 Palte, R.L. 登録日 2022-08-25 公開日 2023-02-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease. J.Med.Chem., 65, 2022
8E81	Structure of LRRK2-CHK1 10-pt. mutant complex with heteroaryl-1H-indazole LRRK2 inhibitor 25 分子名称: (1S)-1-[(1P)-1-{6-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]pyrimidin-4-yl}-1H-indazol-6-yl]spiro[2.2]pentane-1-carbonitrile, Serine/threonine-protein kinase Chk1 著者 Palte, R.L. 登録日 2022-08-25 公開日 2023-02-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease. J.Med.Chem., 65, 2022
1TON	RAT SUBMAXILLARY GLAND SERINE PROTEASE, TONIN. STRUCTURE SOLUTION AND REFINEMENT AT 1.8 ANGSTROMS RESOLUTION 分子名称: TONIN, ZINC ION 著者 Fujinaga, M, James, M.N.G. 登録日 1987-06-03 公開日 1988-01-16 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution. J.Mol.Biol., 195, 1987
3OMW	Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II 分子名称: CG14216 著者 Zhang, Y, Zhang, M, Zhang, Y. 登録日 2010-08-27 公開日 2011-01-19 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8701 Å) 主引用文献 Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue. Biochem.J., 434, 2011
5G0T	InhA in complex with a DNA encoded library hit 分子名称: 1-benzyl-N-[cis-4-(2-{[(4-fluorophenyl)methyl][2-(methylamino)-2-oxoethyl]amino}-2-oxoethyl)cyclohexyl]-5-methyl-1H-1,2,3-triazole-4-carboxamide, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Read, J.A, Breed, J. 登録日 2016-03-22 公開日 2016-11-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Discovery of Cofactor-Specific, Bactericidal Mycobacterium Tuberculosis Inha Inhibitors Using DNA-Encoded Library Technology Proc.Natl.Acad.Sci.USA, 113, 2016
5G0U	InhA in complex with a DNA encoded library hit 分子名称: 5-[(4-fluoranyl-3-phenoxy-phenyl)methylamino]-~{N}-methyl-6-[(1-pyridin-2-ylpiperidin-4-yl)amino]pyridine-3-carboxamide, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Read, J.A, Breed, J. 登録日 2016-03-22 公開日 2016-11-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Discovery of Cofactor-Specific, Bactericidal Mycobacterium Tuberculosis Inha Inhibitors Using DNA-Encoded Library Technology Proc.Natl.Acad.Sci.USA, 113, 2016
2I1A	A Retroviral Protease-Like Domain in the Eukaryotic Protein Ddi1 分子名称: DNA damage-inducible protein DDI1 著者 Fass, D, Sirkis, R. 登録日 2006-08-14 公開日 2006-10-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Ddi1, a eukaryotic protein with the retroviral protease fold. J.Mol.Biol., 364, 2006
1EMD	CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF ESCHERICHIA COLI MALATE DEHYDROGENASE, CITRATE AND NAD AT 1.9 ANGSTROMS RESOLUTION 分子名称: CITRIC ACID, MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Hall, M.D, Banaszak, L.J. 登録日 1993-03-25 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of a ternary complex of Escherichia coli malate dehydrogenase citrate and NAD at 1.9 A resolution. J.Mol.Biol., 232, 1993
2HH5	Crystal Structure of Cathepsin S in complex with a Zinc mediated non-covalent arylaminoethyl amide 分子名称: CHLORIDE ION, Cathepsin S, N-[(1R)-1-[(BENZYLSULFONYL)METHYL]-2-{[(1S)-1-METHYL-2-{[4-(TRIFLUOROMETHOXY)PHENYL]AMINO}ETHYL]AMINO}-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE, ... 著者 Spraggon, G, Hornsby, M, Lesley, S.A, Tully, D.C, Harris, J.L, Karenewsky, D.S. 登録日 2006-06-27 公開日 2006-08-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers. Bioorg.Med.Chem.Lett., 16, 2006
5G0W	InhA in complex with a DNA encoded library hit 分子名称: (2S,4S)-N-methyl-4-[[(2S,3R)-3-[(2-methylpropan-2-yl)oxy]-2-[[4-(pyrazol-1-ylmethyl)phenyl]carbonylamino]butanoyl]amino]-1-(phenylcarbonyl)pyrrolidine-2-carboxamide, ENOYL-ACYL CARRIER PROTEIN REDUCTASE, MAGNESIUM ION, ... 著者 Read, J.A, Breed, J. 登録日 2016-03-22 公開日 2016-11-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery of Cofactor-Specific, Bactericidal Mycobacterium Tuberculosis Inha Inhibitors Using DNA-Encoded Library Technology Proc.Natl.Acad.Sci.USA, 113, 2016
5G0V	InhA in complex with a DNA encoded library hit 分子名称: ENOYL-ACYL CARRIER PROTEIN REDUCTASE, MAGNESIUM ION, N-[2-(methylamino)-2-oxidanylidene-ethyl]-2-(4-pyrazol-1-ylphenyl)-N-(1-pyridin-2-ylpiperidin-4-yl)ethanamide, ... 著者 Read, J.A, Breed, J. 登録日 2016-03-22 公開日 2016-11-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery of Cofactor-Specific, Bactericidal Mycobacterium Tuberculosis Inha Inhibitors Using DNA-Encoded Library Technology Proc.Natl.Acad.Sci.USA, 113, 2016
7PX9	Substrate-engaged mycobacterial Proteasome-associated ATPase - focused 3D refinement (state A) 分子名称: AAA ATPase forming ring-shaped complexes, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Jomaa, A, Kavalchuk, M, Weber-Ban, E. 登録日 2021-10-08 公開日 2022-01-19 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex. Nat Commun, 13, 2022
7PXC	Substrate-engaged mycobacterial Proteasome-associated ATPase in complex with open-gate 20S CP - composite map (state A) 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Jomaa, A, Kavalchuk, M, Weber-Ban, E. 登録日 2021-10-08 公開日 2022-01-19 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.84 Å) 主引用文献 Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex. Nat Commun, 13, 2022
7PXB	Substrate-engaged mycobacterial Proteasome-associated ATPase - focused 3D refinement (state B) 分子名称: AAA ATPase forming ring-shaped complexes, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Jomaa, A, Kavalchuk, M, Weber-Ban, E. 登録日 2021-10-08 公開日 2022-01-19 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex. Nat Commun, 13, 2022
7PXD	Substrate-engaged mycobacterial Proteasome-associated ATPase in complex with open-gate 20S CP - composite map (state B) 分子名称: AAA ATPase forming ring-shaped complexes, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Jomaa, A, Kavalchuk, M, Weber-Ban, E. 登録日 2021-10-08 公開日 2022-01-19 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex. Nat Commun, 13, 2022
5G0S	InhA in complex with a DNA encoded library hit 分子名称: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], N-[4-[2-[(2S)-4-[2-(methylamino)-2-oxidanylidene-ethyl]-3-oxidanylidene-2-(phenylmethyl)piperazin-1-yl]-2-oxidanylidene-ethyl]cyclohexyl]-2-(3-methyl-1-benzothiophen-2-yl)ethanamide, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Read, J.A, Breed, J. 登録日 2016-03-22 公開日 2016-11-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Discovery of Cofactor-Specific, Bactericidal Mycobacterium Tuberculosis Inha Inhibitors Using DNA-Encoded Library Technology Proc.Natl.Acad.Sci.USA, 113, 2016
6E1Y	Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design 分子名称: N-[(1S)-1-(3-chlorophenyl)ethyl]-3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}benzamide, WD repeat-containing protein 5 著者 Phan, J, Fesik, S.W. 登録日 2018-07-10 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.219 Å) 主引用文献 Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019

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