PDB: 13422 件ウェブページステータス検索Chemie searchBIRD

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4ACH	GSK3b in complex with inhibitor 分子名称: 3-AMINO-N-(3-METHOXYPROPYL)-6-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}PYRAZINE-2-CARBOXAMIDE, GLYCOGEN SYNTHASE KINASE-3 BETA 著者 Xue, Y, Ormo, M. 登録日 2011-12-15 公開日 2012-05-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery of novel potent and highly selective glycogen synthase kinase-3 beta (GSK3 beta ) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines. J. Med. Chem., 55, 2012
2JUP	FBP28WW2 domain in complex with the PPLIPPPP peptide 分子名称: Formin-1, Transcription elongation regulator 1 著者 Ramirez-Espain, X, Ruiz, L, Martin-Malpartida, P, Oschkinat, H, Macias, M.J. 登録日 2007-09-01 公開日 2007-11-06 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural Characterization of a New Binding Motif and a Novel Binding Mode in Group 2 WW Domains J.Mol.Biol., 373, 2007
8DSD	Human NAMPT in complex with substrate NAM and small molecule activator NP-A1-S 分子名称: (3S)-1-[2-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-N-{[4-(methylsulfanyl)phenyl]methyl}piperidine-3-carboxamide, CHLORIDE ION, GLYCEROL, ... 著者 Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. 登録日 2022-07-22 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.429 Å) 主引用文献 Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
8DSH	Human NAMPT in complex with quercitrin and AMPcP 分子名称: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, Nicotinamide phosphoribosyltransferase, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER 著者 Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. 登録日 2022-07-22 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
8DTJ	Human NAMPT in complex with small molecule activator ZN-43-S 分子名称: (3S)-N-[(1-benzothiophen-5-yl)methyl]-1-{2-[4-(trifluoromethyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine-3-carboxamide, CHLORIDE ION, GLYCEROL, ... 著者 Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. 登録日 2022-07-25 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.118 Å) 主引用文献 Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
8DSI	Human NAMPT in complex with substrate NAM 分子名称: CHLORIDE ION, GLYCEROL, NICOTINAMIDE, ... 著者 Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. 登録日 2022-07-22 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
8DSC	Human NAMPT in complex with substrate NAM and small molecule activator NP-A1-R 分子名称: (3R)-1-[2-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-N-{[4-(methylsulfanyl)phenyl]methyl}piperidine-3-carboxamide, CHLORIDE ION, GLYCEROL, ... 著者 Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. 登録日 2022-07-22 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.321 Å) 主引用文献 Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
8DSE	Human NAMPT in complex with substrate NAM and activator quercitrin 分子名称: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, CHLORIDE ION, NICOTINAMIDE, ... 著者 Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. 登録日 2022-07-22 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.428 Å) 主引用文献 Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
4ABN	Crystal structure of full length mouse Strap (TTC5) 分子名称: 1,2-ETHANEDIOL, TETRATRICOPEPTIDE REPEAT PROTEIN 5 著者 Pike, A.C.W, Bullock, A.N, Kleinekofort, W, Zimmermann, T, Burgess-Brown, N, Sharpe, T.D, Thangaratnarajah, C, Keates, T, Ugochukwu, E, Bunkoczi, G, Uppenberg, J, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, La Thangue, N.B, Knapp, S. 登録日 2011-12-09 公開日 2012-01-25 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 The P53 Cofactor Strap Exhibits an Unexpected Tpr Motif and Oligonucleotide-Binding (Ob)-Fold Structure. Proc.Natl.Acad.Sci.USA, 109, 2012
8DNH	Cryo-EM structure of nonmuscle beta-actin 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... 著者 Arora, A.S, Huang, H.L, Heissler, S.M, Chinthalapudi, K. 登録日 2022-07-11 公開日 2023-04-12 実験手法 ELECTRON MICROSCOPY (2.99 Å) 主引用文献 Structural insights into actin isoforms. Elife, 12, 2023
7E29	Crystal Structure of Saccharomyces cerevisiae Ioc4 PWWP domain fused with MBP 分子名称: Maltose/maltodextrin-binding periplasmic protein,ISWI one complex protein 4, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 Li, J, Smolle, M, Liang, H, Liu, Y. 登録日 2021-02-05 公開日 2022-02-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.303 Å) 主引用文献 H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeler function. Nucleic Acids Res., 50, 2022
1CKS	HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL 分子名称: CYCLIN-DEPENDENT KINASE SUBUNIT, TYPE 2, SULFATE ION 著者 Parge, H.E, Arvai, A.S, Tainer, J.A. 登録日 1993-09-16 公開日 1995-02-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control. Science, 262, 1993
8E4H	Human PU.1 ETS-Domain (165-270) Bound to d(AATAAGAGGAAGTGGG) 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*GP*AP*GP*GP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*TP*CP*TP*TP*AP*T)-3'), Transcription factor PU.1 著者 Terrell, J.R, Poon, G.M.K. 登録日 2022-08-18 公開日 2023-07-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 DNA selection by the master transcription factor PU.1. Cell Rep, 42, 2023
8E3K	Human PU.1 ETS-Domain (165-270) Bound to d(AATAAGCGGAAGTGGG) 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*GP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), SODIUM ION, ... 著者 Terrell, J.R, Poon, G.M.K. 登録日 2022-08-17 公開日 2023-07-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 DNA selection by the master transcription factor PU.1. Cell Rep, 42, 2023
8E5Y	Human PU.1 ETS-Domain Bound to d(AATAAGCGGAAGTGGG) Acetate Free at pH 5.4 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*GP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), SODIUM ION, ... 著者 Terrell, J.R, Poon, G.M.K. 登録日 2022-08-22 公開日 2023-07-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 DNA selection by the master transcription factor PU.1. Cell Rep, 42, 2023
8EBH	Human PU.1 ETS-Domain (165-270) Bound to d(AATAAGCGGAATGGGG) 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*GP*AP*AP*TP*GP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*CP*AP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), Transcription factor PU.1 著者 Terrell, J.R, Poon, G.M.K. 登録日 2022-08-31 公開日 2023-07-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 DNA selection by the master transcription factor PU.1. Cell Rep, 42, 2023
1CJT	COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MN, AND MG 分子名称: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... 著者 Tesmer, J.J.G, Sprang, S.R. 登録日 1999-04-16 公開日 1999-08-31 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Two-metal-Ion catalysis in adenylyl cyclase. Science, 285, 1999
4ACG	GSK3b in complex with inhibitor 分子名称: 2-AMINO-5-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-N-[4-(PYRROLIDIN-1-YLMETHYL)PYRIDIN-3-YL]PYRIDINE-3-CARBOXAMIDE, GLYCOGEN SYNTHASE KINASE-3 BETA 著者 Xue, Y, Ormo, M. 登録日 2011-12-15 公開日 2012-05-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery of novel potent and highly selective glycogen synthase kinase-3 beta (GSK3 beta ) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines. J. Med. Chem., 55, 2012
8DSM	Human NAMPT in complex with inhibitor ZN-4-3 分子名称: (3S)-N-[(1-benzothiophen-5-yl)methyl]-1-[6-(4-{2-[(2E)-3-(pyridin-3-yl)prop-2-enamido]ethyl}phenyl)thieno[2,3-d]pyrimidin-4-yl]piperidine-3-carboxamide, CHLORIDE ION, GLYCEROL, ... 著者 Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. 登録日 2022-07-22 公開日 2023-08-02 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 A structural mechanism for positive allosteric modulation of nicotinamide phosphoribosyltransferase to elevate cellular NAD+ To Be Published
8EDG	Cryo-EM structure of the Hermes transposase bound to two left-ends of its DNA transposon 分子名称: DNA (46-MER), DNA (5'-D(*GP*CP*GP*TP*GP*AP*A)-3'), DNA (55-MER), ... 著者 Lannes, L, Dyda, F. 登録日 2022-09-04 公開日 2023-08-02 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (4.64 Å) 主引用文献 Zinc-finger BED domains drive the formation of the active Hermes transpososome by asymmetric DNA binding. Nat Commun, 14, 2023
8E67	ETV6 H396Y variant bound to DNA containing the sequence GGAT 分子名称: Complementary 15 bp strand, GGAT-containing 15 bp DNA, Transcription factor ETV6 著者 Scheu, K, Chan, A.C, Murphy, M.E, McIntosh, L.P. 登録日 2022-08-22 公開日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The functional role of histidine within the ETV6 ETS domain to be published
1C20	SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN FROM THE DEAD RINGER PROTEIN 分子名称: DEAD RINGER PROTEIN 著者 Iwahara, J, Clubb, R.T. 登録日 1999-07-22 公開日 1999-11-10 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structure of the DNA binding domain from Dead ringer, a sequence-specific AT-rich interaction domain (ARID). EMBO J., 18, 1999
8E66	ETV6 H396Y variant bound to DNA containing the sequence GGAA 分子名称: CACODYLATE ION, Complementary 15 bp strand, GGAA-containing 15 bp DNA, ... 著者 Scheu, K, Chan, A.C, Murphy, M.E, McIntosh, L.P. 登録日 2022-08-22 公開日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 The functional role of histidine within the ETV6 ETS domain to be published
4ACC	GSK3b in complex with inhibitor 分子名称: 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE, DIMETHYL SULFOXIDE, GLYCOGEN SYNTHASE KINASE-3 BETA 著者 Xue, Y, Ormo, M. 登録日 2011-12-14 公開日 2012-05-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Discovery of novel potent and highly selective glycogen synthase kinase-3 beta (GSK3 beta ) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines. J. Med. Chem., 55, 2012
8DPU	The crystal structure of the IL-11 signalling complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ... 著者 Metcalfe, R.D, Aizel, K, Griffin, M.D.W. 登録日 2022-07-17 公開日 2023-11-29 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.78 Å) 主引用文献 Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant. Nat Commun, 14, 2023

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