9CBS
 
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9EO6
 | | SARS-CoV2 major protease in complex with a covalent inhibitor SLL11. | | 分子名称: | 3C-like proteinase nsp5, Inhibitor SLL11, POTASSIUM ION | | 著者 | Moche, M, Lennerstrand, J, Nyman, T, Strandback, E, Akaberi, D. | | 登録日 | 2024-03-14 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries.
Antimicrob.Agents Chemother., 2024
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9F1C
 | | Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | 著者 | Yudin, D, Scaiola, A, Ban, N. | | 登録日 | 2024-04-18 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | | 主引用文献 | NAC guides a ribosomal multienzyme complex for nascent protein processing.
Nature, 2024
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9C7V
 | | Structure of the human BOS:human EMC complex in GDN | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BOS complex subunit NOMO2, ... | | 著者 | Nguyen, V.N, Tomaleri, G.P, Voorhees, R.M. | | 登録日 | 2024-06-11 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins.
Mol.Cell, 84, 2024
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9BDD
 | | Cryo-EM Structure of Non-Cognate Substrate Bound in the Entry Site (ES) of Human Mitochondrial Transcription Elongation Complex | | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase, mitochondrial, ... | | 著者 | Herbine, K.H, Nayak, A.R, Temiakov, D. | | 登録日 | 2024-04-11 | | 公開日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
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9EOX
 | | SARS-CoV2 major protease in covalent complex with a soluble inhibitor. | | 分子名称: | 3C-like proteinase nsp5, POTASSIUM ION, Soluble inhibitor | | 著者 | Moche, M, Lennerstrand, J, Nyman, T, Strandback, E, Akaberi, D. | | 登録日 | 2024-03-15 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries.
Antimicrob.Agents Chemother., 2024
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9BDC
 | | Cryo-EM Structure of the TEFM bound Human Mitochondrial Transcription Elongation Complex in a Closed Fingers Domain Conformation | | 分子名称: | DNA-directed RNA polymerase, mitochondrial, Non-Template Strand DNA (NT27mt_+1T), ... | | 著者 | Herbine, K.H, Nayak, A.R, Temiakov, D. | | 登録日 | 2024-04-11 | | 公開日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
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7PQD
 | | Cryo-EM structure of the dimeric Rhodobacter sphaeroides RC-LH1 core complex at 2.9 A: the structural basis for dimerisation | | 分子名称: | (2R,5R,11R,14R)-5,8,11-trihydroxy-5,11-dioxido-17-oxo-2,14-bis(tetradecanoyloxy)-4,6,10,12,16-pentaoxa-5,11-diphosphatriacont-1-yl tetradecanoate, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | | 著者 | Qian, P, Hunter, C.N. | | 登録日 | 2021-09-17 | | 公開日 | 2021-11-24 | | 最終更新日 | 2022-12-07 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM structure of the dimeric Rhodobacter sphaeroides RC-LH1 core complex at 2.9 angstrom : the structural basis for dimerisation.
Biochem.J., 478, 2021
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9EMU
 | | RosC-8-demethyl-8-amino-FMN - Phosphate complex | | 分子名称: | 1-deoxy-1-[8-(dimethylamino)-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl]-D-ribitol, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Ermler, U, Mack, M, Demmer, U. | | 登録日 | 2024-03-11 | | 公開日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The Phosphatase RosC from Streptomyces davaonensis is Used for Roseoflavin Biosynthesis and has Evolved to Largely Prevent Dephosphorylation of the Important Cofactor Riboflavin-5'-phosphate.
J.Mol.Biol., 436, 2024
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9CF0
 | | Parasitella parasitica Fanzor (PpFz) State 1 | | 分子名称: | DNA (5'-D(P*AP*CP*CP*CP*GP*GP*GP*AP*TP*AP*A)-3'), DNA (5'-D(P*TP*GP*TP*TP*TP*AP*TP*CP*CP*CP*GP*GP*GP*T)-3'), DNA/RNA (54-MER), ... | | 著者 | Xu, P, Saito, M, Zhang, F. | | 登録日 | 2024-06-27 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | | 主引用文献 | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9C9Q
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9CET
 | | Guillardia theta Fanzor (GtFz) State 3 | | 分子名称: | DNA (28-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*TP*AP*AP*AP*GP*GP*CP*CP*CP*CP*GP*GP*G)-3'), Maltose/maltodextrin-binding periplasmic protein, ... | | 著者 | Xu, P, Saito, M, Zhang, F. | | 登録日 | 2024-06-27 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CER
 | | Guillardia theta Fanzor (GtFz) State 1 | | 分子名称: | Maltose/maltodextrin-binding periplasmic protein, Guillardia theta Fanzor1 chimera, RNA (142-MER) | | 著者 | Xu, P, Saito, M, Zhang, F. | | 登録日 | 2024-06-27 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CEZ
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9EM5
 | | OPR3 variant Y364P in its monomeric form | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 12-oxophytodienoate reductase 3, CHLORIDE ION, ... | | 著者 | Bijelic, A, Macheroux, P, Kerschbaumer, B. | | 登録日 | 2024-03-07 | | 公開日 | 2024-08-14 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Analysis of homodimer formation in 12-oxophytodienoate reductase 3 in solutio and crystallo challenges the physiological role of the dimer.
Sci Rep, 14, 2024
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9C6W
 | | Crystal Structure of a single chain trimer composed of HLA-B*39:06 Y84C variant, beta-2microglobulin, and NRVMLPKAA peptide from NLRP2 (2 molecules/asymmetric unit) | | 分子名称: | 1,2-ETHANEDIOL, 3,6,9,12,15-PENTAOXAHEPTADECANE, CHLORIDE ION, ... | | 著者 | Sharma, R, Amdare, N.P, Celikgil, A, Garforth, S.J, DiLorenzo, T.P, Almo, S.C, Ghosh, A. | | 登録日 | 2024-06-09 | | 公開日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes.
J.Biol.Chem., 2024
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9C6X
 | | Crystal Structure of a single chain trimer composed of HLA-B*39:01 Y84C variant, beta-2microglobulin, and NRVMLPKAA peptide from NLRP2 | | 分子名称: | 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, NACHT, ... | | 著者 | Sharma, R, Amdare, N.P, Celikgil, A, Garforth, S.J, DiLorenzo, T.P, Almo, S.C, Ghosh, A. | | 登録日 | 2024-06-09 | | 公開日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes.
J.Biol.Chem., 2024
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9EOR
 | | SARS-CoV2 major protease in complex with a covalent inhibitor SLL12. | | 分子名称: | 3C-like proteinase nsp5, Inhibitor SLL12, POTASSIUM ION | | 著者 | Moche, M, Lennerstrand, J, Nyman, T, Strandback, E, Akaberi, D. | | 登録日 | 2024-03-15 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries.
Antimicrob.Agents Chemother., 2024
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9CEX
 | | Spizellomyces punctatus Fanzor (SpuFz) State 4 | | 分子名称: | DNA (29-MER), DNA (5'-D(*(MG)*(MG)P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*CP*GP*GP*TP*AP*CP*CP*CP*GP*GP*GP*CP*AP*TP*A)-3'), ... | | 著者 | Xu, P, Saito, M, Zhang, F. | | 登録日 | 2024-06-27 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Structural insights into the diversity and DNA cleavage mechanism of Fanzor.
Cell, 2024
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9CEY
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9CF3
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9C4G
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6CQ8
 | | K2P2.1(TREK-1):ML335 complex | | 分子名称: | CADMIUM ION, HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, ... | | 著者 | Lolicato, M, Minor, D.L. | | 登録日 | 2018-03-14 | | 公開日 | 2018-03-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Nature, 547, 2017
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9F1B
 | | Mammalian ternary complex of a translating 80S ribosome, NAC and NatA/E | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | 著者 | Yudin, D, Scaiola, A, Ban, N. | | 登録日 | 2024-04-18 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | NAC guides a ribosomal multienzyme complex for nascent protein processing.
Nature, 2024
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9CEV
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