PDB: 683 件ウェブページステータス検索Chemie searchBIRD

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3VVO	Crystal structure of MATE in the bent conformation 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Putative uncharacterized protein 著者 Tanaka, Y, Ishitani, R, Nureki, O. 登録日 2012-07-27 公開日 2013-04-03 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.504 Å) 主引用文献 Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature, 496, 2013
3VVN	Crystal structure of MATE in the straight conformation 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Putative uncharacterized protein 著者 Tanaka, Y, Ishitani, R, Nureki, O. 登録日 2012-07-27 公開日 2013-04-03 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.398 Å) 主引用文献 Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature, 496, 2013
3W4T	Crystal structure of MATE P26A mutant 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Putative uncharacterized protein 著者 Tanaka, Y, Ishitani, R, Nureki, O. 登録日 2013-01-16 公開日 2013-04-03 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.096 Å) 主引用文献 Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature, 496, 2013
3WBN	Crystal structure of MATE in complex with MaL6 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, MaL6, Putative uncharacterized protein 著者 Tanaka, Y, Ishitani, R, Nureki, O. 登録日 2013-05-20 公開日 2013-06-12 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Nature, 496, 2013
6IDR	Crystal structure of Vibrio cholerae MATE transporter VcmN in the bent form 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, MATE family efflux transporter 著者 Kusakizako, T, Claxton, D.P, Tanaka, Y, Maturana, A.D, Kuroda, T, Ishitani, R, Mchaourab, H.S, Nureki, O. 登録日 2018-09-11 公開日 2019-01-16 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter. Structure, 27, 2019
6IDP	Crystal structure of Vibrio cholerae MATE transporter VcmN in the straight form 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, MATE family efflux transporter 著者 Kusakizako, T, Claxton, D.P, Tanaka, Y, Maturana, A.D, Kuroda, T, Ishitani, R, Mchaourab, H.S, Nureki, O. 登録日 2018-09-11 公開日 2019-01-16 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.205 Å) 主引用文献 Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter. Structure, 27, 2019
6IDS	Crystal structure of Vibrio cholerae MATE transporter VcmN D35N mutant 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, MATE family efflux transporter 著者 Kusakizako, T, Claxton, D.P, Tanaka, Y, Maturana, A.D, Kuroda, T, Ishitani, R, Mchaourab, H.S, Nureki, O. 登録日 2018-09-11 公開日 2019-01-16 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter. Structure, 27, 2019
7SFQ	EmrE S64V Mutant Bound to tetra(4-fluorophenyl)phosphonium at pH 8.0 分子名称: Multidrug transporter EmrE, tetrakis(4-fluorophenyl)phosphanium 著者 Shcherbakov, A.A, Spreacker, P.J, Dregni, A.J, Henzler-Wildman, K.A, Hong, M. 登録日 2021-10-04 公開日 2022-03-02 最終更新日 2024-05-15 実験手法 SOLID-STATE NMR 主引用文献 High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport. Nat Commun, 13, 2022
8WM5	multidrug transporter EfpA from Mycobacterium tuberculosis bound with lipids 分子名称: CARDIOLIPIN, Efflux pump A, PHOSPHATIDYLETHANOLAMINE 著者 Wang, S, Liao, M. 登録日 2023-10-03 公開日 2024-09-11 最終更新日 2024-09-18 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Structures of the Mycobacterium tuberculosis efflux pump EfpA reveal the mechanisms of transport and inhibition. Nat Commun, 15, 2024
6ETI	Structure of inhibitor-bound ABCG2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... 著者 Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P. 登録日 2017-10-26 公開日 2018-04-11 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25, 2018
7SVX	Structure of EmrE-D3 mutant in complex with monobody L10 and harmane 分子名称: 1-methyl-9H-pyrido[3,4-b]indole, L10 monobody, Multidrug transporter EmrE 著者 Kermani, A.A, Stockbridge, R.B. 登録日 2021-11-19 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. Elife, 11, 2022
7SV9	Structure of EmrE-D3 mutant in complex with monobody L10 and TPP 分子名称: L10 monobody, Multidrug transporter EmrE, TETRAPHENYLPHOSPHONIUM 著者 Kermani, A.A, Stockbridge, R.B. 登録日 2021-11-18 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.36 Å) 主引用文献 Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. Elife, 11, 2022
7T00	Structure of EmrE-D3 mutant in complex with monobody L10 and benzyltrimethylammonium 分子名称: L10 monobody, Multidrug transporter EmrE, benzyltrimethylammonium 著者 Kermani, A.A, Stockbridge, R.B. 登録日 2021-11-29 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.91 Å) 主引用文献 Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. Elife, 11, 2022
7SSU	Structure of EmrE-D3 mutant in complex with monobody L10 and methyltriphenylphosphonium 分子名称: L10 monobody, Multidrug transporter EmrE, methyltriphenylphosphonium 著者 Kermani, A.A, Stockbridge, R.B. 登録日 2021-11-11 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. Elife, 11, 2022
6EUQ	MdfA(Q131R/L339E) 分子名称: (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, ACETATE ION, HEXANE, ... 著者 Tam, H.K, Zomot, E, Bibi, E, Pos, K.M. 登録日 2017-10-31 公開日 2018-08-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A New Critical Conformational Determinant of Multidrug Efflux by an MFS Transporter. J. Mol. Biol., 430, 2018
7BG4	Multidrug resistance transporter BmrA mutant E504A bound with ATP, Mg, and Rhodamine 6G solved by Cryo-EM 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding/permease protein BmrA, ... 著者 Wiseman, B, Chaptal, V, Zampieri, V, Magnard, S, Hogbom, M, Falson, P. 登録日 2021-01-05 公開日 2022-01-12 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter. Sci Adv, 8, 2022
8IZ8	cryo EM structure of apo hMRP4 分子名称: ATP-binding cassette sub-family C member 4 著者 Liu, Z.M, Huang, Y. 登録日 2023-04-06 公開日 2024-04-10 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4. Commun Biol, 6, 2023
8IZ7	cryo-EM structure of sulindac-bound hMRP4 分子名称: ATP-binding cassette sub-family C member 4, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid 著者 Liu, Z.M, Huang, Y. 登録日 2023-04-06 公開日 2024-04-10 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4. Commun Biol, 6, 2023
8IZ9	cryo-EM structure of PGE1-bound hMRP4 分子名称: 7-[(1R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]heptanoic acid, ATP-binding cassette sub-family C member 4 著者 Liu, Z.M, Huang, Y. 登録日 2023-04-06 公開日 2024-04-10 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4. Commun Biol, 6, 2023
8IZA	cryo-EM structure of ATP-bound hMRP4 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 4, MAGNESIUM ION 著者 Liu, Z.M, Huang, Y. 登録日 2023-04-06 公開日 2024-04-10 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.48 Å) 主引用文献 Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4. Commun Biol, 6, 2023
8JW4	Cryo-EM structure of Plasmodium falciparum multidrug resistance protein 1 in the apo state without H1 helix 分子名称: Multidrug resistance protein 1 著者 Li, M, Si, K. 登録日 2023-06-28 公開日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain. Proc.Natl.Acad.Sci.USA, 120, 2023
8JVH	Cryo-EM structure of Plasmodium falciparum multidrug resistance protein 1 in the apo state with H1 helix 分子名称: Multidrug resistance protein 1 著者 Li, M, Si, K. 登録日 2023-06-28 公開日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.19 Å) 主引用文献 The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain. Proc.Natl.Acad.Sci.USA, 120, 2023
6FEQ	Structure of inhibitor-bound ABCG2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... 著者 Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P. 登録日 2018-01-03 公開日 2018-04-11 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25, 2018
7MH6	Structure of EmrE-D3 mutant in complex with monobody L10 in low pH (protonated state) 分子名称: Monobody L10, Multidrug transporter EmrE 著者 Kermani, A.A, Stockbridge, R.B. 登録日 2021-04-14 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. Elife, 11, 2022
7MGX	Structure of EmrE-D3 mutant in complex with monobody L10 and methyl viologen 分子名称: 1,1'-dimethyl-4,4'-bipyridin-1-ium, L10 Monobody, Multidrug transporter EmrE 著者 Kermani, A.A, Stockbridge, R.B. 登録日 2021-04-13 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.13 Å) 主引用文献 Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates. Elife, 11, 2022

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