PDB: 1955 件ウェブページステータス検索Chemie searchBIRD

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1XR7	Crystal structure of RNA-dependent RNA Polymerase 3D from human rhinovirus serotype 16 分子名称: Genome polyprotein 著者 Love, R.A, Maegley, K.A, Yu, X, Ferre, R.A, Lingardo, L.K, Diehl, W, Parge, H.E, Dragovich, P.S, Fuhrman, S.A. 登録日 2004-10-13 公開日 2004-10-26 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Crystal Structure of the RNA-Dependent RNA Polymerase from Human Rhinovirus: A Dual-Function Target for Common Cold Antiviral Therapy Structure, 12, 2004
8FPJ	Co-structure of the Human Metapneunomovirus RNA-dependent RNA polymerase with MRK-1 分子名称: 4-(2-aminopropan-2-yl)-N'-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide, Phosphoprotein, RNA-directed RNA polymerase L 著者 Fischmann, T.O. 登録日 2023-01-04 公開日 2023-06-14 最終更新日 2023-07-05 実験手法 ELECTRON MICROSCOPY (2.74 Å) 主引用文献 Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases. Commun Biol, 6, 2023
8FPI	Co-structure of the Respiratory Syncytial Virus RNA-dependent RNA polymerase with MRK-1 分子名称: 4-(2-aminopropan-2-yl)-N'-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide, Phosphoprotein, RNA-directed RNA polymerase L 著者 Fischmann, T.O. 登録日 2023-01-04 公開日 2023-06-14 最終更新日 2023-07-05 実験手法 ELECTRON MICROSCOPY (2.39 Å) 主引用文献 Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases. Commun Biol, 6, 2023
4OOW	HCV NS5B polymerase with a fragment of quercetagetin 分子名称: CATECHOL, RNA-directed RNA polymerase 著者 Guichou, J.F, Ahmed-Belkacem, A, Rozenn, B, Nazim, N, Hernandez, E, Pallier, C, Pawlotsky, J.M. 登録日 2014-02-04 公開日 2014-12-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention. Nucleic Acids Res., 42, 2014
2JLF	STRUCTURAL EXPLANATION FOR THE ROLE OF MN IN THE ACTIVITY OF PHI6 RNA- DEPENDENT RNA POLYMERASE 分子名称: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Poranen, M.M, Salgado, P.S, Koivunen, M.R.L, Wright, S, Bamford, D.H, Stuart, D.I, Grimes, J.M. 登録日 2008-09-08 公開日 2008-11-04 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural Explanation for the Role of Mn2+ in the Activity of {Phi}6 RNA-Dependent RNA Polymerase. Nucleic Acids Res., 36, 2008
7BV2	The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP) 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E. 登録日 2020-04-09 公開日 2020-04-22 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science, 368, 2020
1QUV	CRYSTAL STRUCTURE OF THE RNA DIRECTED RNA POLYMERASE OF HEPATITIS C VIRUS 分子名称: PROTEIN (RNA-DIRECTED RNA POLYMERASE) 著者 Ago, H, Miyano, M, Adachi, T, Habuka, N. 登録日 1999-07-04 公開日 1999-11-05 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure Fold.Des., 7, 1999
7BV1	Cryo-EM structure of the apo nsp12-nsp7-nsp8 complex 分子名称: Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ... 著者 Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E. 登録日 2020-04-09 公開日 2020-04-22 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science, 368, 2020
3VQS	Crystal structure of HCV NS5B RNA polymerase with a novel piperazine inhibitor 分子名称: (2R)-4-(5-cyclopropyl[1,3]thiazolo[4,5-d]pyrimidin-2-yl)-N-[3-fluoro-4-(trifluoromethoxy)benzyl]-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine-2-carboxamide, CHLORIDE ION, RNA-directed RNA polymerase 著者 Adachi, T, Doi, S, Ando, I, Sugimoto, K, Orita, T, Nomura, A, Kamada, M. 登録日 2012-03-30 公開日 2012-08-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase. Antimicrob.Agents Chemother., 56, 2012
5HMX	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 10 分子名称: 2,2'-(5-(thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION 著者 Noble, C.G. 登録日 2016-01-17 公開日 2016-03-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59, 2016
5HMZ	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 23 分子名称: 5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-4-methoxy-2-methyl-N-(methylsulfonyl)benzamide, RNA-directed RNA polymerase NS5, ZINC ION 著者 Noble, C.G. 登録日 2016-01-17 公開日 2016-03-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59, 2016
5HMY	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 15 分子名称: 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION 著者 Noble, C.G. 登録日 2016-01-17 公開日 2016-03-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design. J.Med.Chem., 59, 2016
5HMW	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 5 分子名称: 2,2'-biphenyl-3,5-diyldiacetic acid, RNA-directed RNA polymerase NS5, ZINC ION 著者 Noble, C.G. 登録日 2016-01-17 公開日 2016-03-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59, 2016
5HN0	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 4 分子名称: (6-hydroxybiphenyl-3-yl)acetic acid, RNA-directed RNA polymerase NS5, ZINC ION 著者 Noble, C.G. 登録日 2016-01-17 公開日 2016-03-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design. J.Med.Chem., 59, 2016
1TQL	POLIOVIRUS POLYMERASE G1A MUTANT 分子名称: ACETIC ACID, RNA-directed RNA polymerase 著者 Thompson, A.A, Peersen, O.B. 登録日 2004-06-17 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase Embo J., 23, 2004
1YV2	Hepatitis C virus NS5B RNA-dependent RNA Polymerase genotype 2a 分子名称: GLYCEROL, RNA dependent RNA polymerase, SULFATE ION 著者 Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. 登録日 2005-02-14 公開日 2005-03-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors J.Biol.Chem., 280, 2005
8GY6	Structure of SARS-CoV-2 RNA-dependent RNA polymerase with gossypol binding 分子名称: Gossypol, Non-structural protein 7, Non-structural protein 8, ... 著者 Wang, W, Ren, M, Li, F. 登録日 2022-09-21 公開日 2023-11-01 実験手法 ELECTRON MICROSCOPY 主引用文献 Structure of SARS-CoV-2 RNA-dependent RNA polymerase with gossypol binding To Be Published
8IIB	Crystal structure of Israeli acute paralysis virus RNA-dependent RNA polymerase delta85 mutant (residues 86-546) 分子名称: CADMIUM ION, CHLORIDE ION, MAGNESIUM ION, ... 著者 Fang, X, Lu, G, Hou, C, Gong, P. 登録日 2023-02-24 公開日 2023-06-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virol Sin, 38, 2023
8IIC	Crystal structure of Israeli acute paralysis virus RNA-dependent RNA polymerase delta40 mutant (residues 41-546) 分子名称: Polymerase polyprotein 著者 Fang, X, Lu, G, Hou, C, Gong, P. 登録日 2023-02-24 公開日 2023-06-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virol Sin, 38, 2023
6KWR	Crystal structure of enterovirus 71 polymerase elongation complex (ddCTP form) 分子名称: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (31-MER), ... 著者 Shi, W, Gong, P. 登録日 2019-09-08 公開日 2019-12-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability. Nucleic Acids Res., 48, 2020
6KWQ	Crystal structure of enterovirus 71 polymerase elongation complex (native form) 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, MAGNESIUM ION, ... 著者 Shi, W, Gong, P. 登録日 2019-09-08 公開日 2019-12-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability. Nucleic Acids Res., 48, 2020
8WIL	Crystal structure of Jingmen tick virus RNA-dependent RNA polymerase (D55 construct) 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Jingmen tick virus NSP1, ... 著者 Wang, X, Jing, X, Deng, F, Gong, P. 登録日 2023-09-24 公開日 2024-01-17 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase. Nucleic Acids Res., 52, 2024
8WIM	Crystal structure of Jingmen tick virus RNA-dependent RNA polymerase (D307 construct) 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Jingmen tick virus NSP1, ... 著者 Wang, X, Jing, X, Deng, F, Gong, P. 登録日 2023-09-24 公開日 2024-01-17 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 A jingmenvirus RNA-dependent RNA polymerase structurally resembles the flavivirus counterpart but with different features at the initiation phase. Nucleic Acids Res., 52, 2024
4KHR	HCV NS5B GT1A C316Y with GSK5852 分子名称: NS5B RNA-dependent RNA polymerase, SULFATE ION, [4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid 著者 Williams, S.P, Kahler, K.M, Shotwell, J.B. 登録日 2013-05-01 公開日 2013-05-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase. J.Med.Chem., 57, 2014
4HHJ	Dengue serotype 3 RNA-dependent RNA polymerase 分子名称: DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Non-structural protein 5, ... 著者 Noble, C.G, Lescar, J. 登録日 2012-10-10 公開日 2013-02-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor J.Virol., 87, 2013

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