PDB: 1957 件ウェブページステータス検索Chemie searchBIRD

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6LD5	Zika NS5 polymerase domain 分子名称: 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, RNA-directed RNA polymerase NS5, ZINC ION, ... 著者 El Sahili, A, Lescar, J. 登録日 2019-11-20 公開日 2020-08-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
6LD4	Zika NS5 polymerase domain 分子名称: 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, 3-methoxybenzenesulfonamide, RNA-directed RNA polymerase NS5, ... 著者 El Sahili, A, Lescar, J. 登録日 2019-11-20 公開日 2020-08-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
6LD3	Zika NS5 polymerase domain 分子名称: 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, RNA-directed RNA polymerase NS5, ZINC ION, ... 著者 El Sahili, A, Lescar, J. 登録日 2019-11-20 公開日 2020-08-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
1CSJ	CRYSTAL STRUCTURE OF THE RNA-DEPENDENT RNA POLYMERASE OF HEPATITIS C VIRUS 分子名称: HEPATITIS C VIRUS RNA POLYMERASE (NS5B) 著者 Bressanelli, S, Tomei, L, Roussel, A, Incitti, I, Vitale, R.L, Mathieu, M, De Francesco, R, Rey, F.A. 登録日 1999-08-18 公開日 1999-11-08 最終更新日 2013-02-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc.Natl.Acad.Sci.USA, 96, 1999
2JLF	STRUCTURAL EXPLANATION FOR THE ROLE OF MN IN THE ACTIVITY OF PHI6 RNA- DEPENDENT RNA POLYMERASE 分子名称: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Poranen, M.M, Salgado, P.S, Koivunen, M.R.L, Wright, S, Bamford, D.H, Stuart, D.I, Grimes, J.M. 登録日 2008-09-08 公開日 2008-11-04 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural Explanation for the Role of Mn2+ in the Activity of {Phi}6 RNA-Dependent RNA Polymerase. Nucleic Acids Res., 36, 2008
3VQS	Crystal structure of HCV NS5B RNA polymerase with a novel piperazine inhibitor 分子名称: (2R)-4-(5-cyclopropyl[1,3]thiazolo[4,5-d]pyrimidin-2-yl)-N-[3-fluoro-4-(trifluoromethoxy)benzyl]-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine-2-carboxamide, CHLORIDE ION, RNA-directed RNA polymerase 著者 Adachi, T, Doi, S, Ando, I, Sugimoto, K, Orita, T, Nomura, A, Kamada, M. 登録日 2012-03-30 公開日 2012-08-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase. Antimicrob.Agents Chemother., 56, 2012
1QUV	CRYSTAL STRUCTURE OF THE RNA DIRECTED RNA POLYMERASE OF HEPATITIS C VIRUS 分子名称: PROTEIN (RNA-DIRECTED RNA POLYMERASE) 著者 Ago, H, Miyano, M, Adachi, T, Habuka, N. 登録日 1999-07-04 公開日 1999-11-05 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure Fold.Des., 7, 1999
4IEG	Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12 (P1 crystal form) 分子名称: MAGNESIUM ION, RNA-dependent RNA polymerase P2 著者 Ren, Z, Franklin, M.C, Ghose, R. 登録日 2012-12-13 公開日 2013-07-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of the RNA-directed RNA Polymerase from the cystovirus 12. Proteins, 81, 2013
8GY6	Structure of SARS-CoV-2 RNA-dependent RNA polymerase with gossypol binding 分子名称: Gossypol, Non-structural protein 7, Non-structural protein 8, ... 著者 Wang, W, Ren, M, Li, F. 登録日 2022-09-21 公開日 2023-11-01 実験手法 ELECTRON MICROSCOPY 主引用文献 Structure of SARS-CoV-2 RNA-dependent RNA polymerase with gossypol binding To Be Published
4GZK	Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12 分子名称: FORMIC ACID, MAGNESIUM ION, RNA-dependent RNA polymerase P2 著者 Ren, Z, Franklin, M, Ghose, R. 登録日 2012-09-06 公開日 2013-07-24 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Structure of the RNA-directed RNA Polymerase from the cystovirus 12. Proteins, 81, 2013
4KHR	HCV NS5B GT1A C316Y with GSK5852 分子名称: NS5B RNA-dependent RNA polymerase, SULFATE ION, [4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid 著者 Williams, S.P, Kahler, K.M, Shotwell, J.B. 登録日 2013-05-01 公開日 2013-05-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase. J.Med.Chem., 57, 2014
7AAP	Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP 分子名称: MAGNESIUM ION, Non-structural protein 12, Non-structural protein 7, ... 著者 Naydenova, K, Muir, K.W, Wu, L.F, Zhang, Z, Coscia, F, Peet, M, Castro-Hartman, P, Qian, P, Sader, K, Dent, K, Kimanius, D, Sutherland, J.D, Lowe, J, Barford, D, Russo, C.J. 登録日 2020-09-04 公開日 2020-09-23 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP. Proc.Natl.Acad.Sci.USA, 118, 2021
1YV2	Hepatitis C virus NS5B RNA-dependent RNA Polymerase genotype 2a 分子名称: GLYCEROL, RNA dependent RNA polymerase, SULFATE ION 著者 Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. 登録日 2005-02-14 公開日 2005-03-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors J.Biol.Chem., 280, 2005
7BV1	Cryo-EM structure of the apo nsp12-nsp7-nsp8 complex 分子名称: Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ... 著者 Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E. 登録日 2020-04-09 公開日 2020-04-22 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science, 368, 2020
7BV2	The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP) 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E. 登録日 2020-04-09 公開日 2020-04-22 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science, 368, 2020
1XR6	Crystal Structure of RNA-dependent RNA Polymerase 3D from human rhinovirus serotype 1B 分子名称: Genome polyprotein, POTASSIUM ION 著者 Love, R.A, Maegley, K.A, Yu, X, Ferre, R.A, Lingardo, L.K, Diehl, W, Parge, H.E, Dragovich, P.S, Fuhrman, S.A. 登録日 2004-10-13 公開日 2004-10-26 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Crystal Structure of the RNA-Dependent RNA Polymerase from Human Rhinovirus: A Dual-Function Target for Common Cold Antiviral Therapy Structure, 12, 2004
1XR7	Crystal structure of RNA-dependent RNA Polymerase 3D from human rhinovirus serotype 16 分子名称: Genome polyprotein 著者 Love, R.A, Maegley, K.A, Yu, X, Ferre, R.A, Lingardo, L.K, Diehl, W, Parge, H.E, Dragovich, P.S, Fuhrman, S.A. 登録日 2004-10-13 公開日 2004-10-26 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Crystal Structure of the RNA-Dependent RNA Polymerase from Human Rhinovirus: A Dual-Function Target for Common Cold Antiviral Therapy Structure, 12, 2004
1XR5	Crystal Structure of the RNA-dependent RNA Polymerase 3D from human rhinovirus serotype 14 分子名称: Genome polyprotein, SAMARIUM (III) ION 著者 Love, R.A, Maegley, K.A, Yu, X, Ferre, R.A, Lingardo, L.K, Diehl, W, Parge, H.E, Dragovich, P.S, Fuhrman, S.A. 登録日 2004-10-13 公開日 2004-10-26 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The Crystal Structure of the RNA-Dependent RNA Polymerase from Human Rhinovirus: A Dual-Function Target for Common Cold Antiviral Therapy Structure, 12, 2004
6KWQ	Crystal structure of enterovirus 71 polymerase elongation complex (native form) 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, MAGNESIUM ION, ... 著者 Shi, W, Gong, P. 登録日 2019-09-08 公開日 2019-12-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability. Nucleic Acids Res., 48, 2020
2E9R	Foot-and-mouth disease virus RNA-dependent RNA polymerase in complex with a template-primer RNA and with ribavirin 分子名称: 5'-R(*CP*AP*UP*GP*GP*GP*CP*CP*C)-3', 5'-R(*CP*CP*C*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... 著者 Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. 登録日 2007-01-26 公開日 2007-06-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
1TQL	POLIOVIRUS POLYMERASE G1A MUTANT 分子名称: ACETIC ACID, RNA-directed RNA polymerase 著者 Thompson, A.A, Peersen, O.B. 登録日 2004-06-17 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase Embo J., 23, 2004
5U04	Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase 分子名称: PHOSPHATE ION, ZINC ION, Zika Virus NS5 RdRp 著者 Godoy, A.S, Lima, G.M.A, Oliveira, K.I.Z, Torres, N.U, Maluf, F.V, Guido, R.V.C, Oliva, G. 登録日 2016-11-22 公開日 2017-02-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase. Nat Commun, 8, 2017
2F8E	Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with uridylylated VPg protein 分子名称: MAGNESIUM ION, MANGANESE (II) ION, RNA-dependent RNA polymerase, ... 著者 Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. 登録日 2005-12-02 公開日 2006-03-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The structure of a protein primer-polymerase complex in the initiation of genome replication Embo J., 25, 2006
6IZZ	The RNA-dependent RNA polymerase domain of dengue 3 NS5, bound with RK-0404678 分子名称: 2-oxo-2H-1,3-benzoxathiol-5-yl acetate, Genome polyprotein, ZINC ION 著者 Shimizu, H, Sekine, S. 登録日 2018-12-20 公開日 2019-12-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. Plos Negl Trop Dis, 13, 2019
6J00	The RNA-dependent RNA polymerase domain of dengue 3 NS5 分子名称: Genome polyprotein, ZINC ION 著者 Shimizu, H, Sekine, S. 登録日 2018-12-20 公開日 2019-12-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. Plos Negl Trop Dis, 13, 2019

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