PDB: 8631 件ウェブページステータス検索Chemie searchBIRD

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6P1O	Post-catalytic nicked complex of human DNA Polymerase Mu with 1-nt gapped substrate containing template 8OG and newly incorporated dAMP 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. 登録日 2019-05-20 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res., 47, 2019
7ENJ	Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B) 分子名称: Isoform 2 of Mediator of RNA polymerase II transcription subunit 8, Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, ... 著者 Yin, X, Li, J, Wu, Z, Liu, W, Xu, Y. 登録日 2021-04-17 公開日 2021-05-19 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Structures of the human Mediator and Mediator-bound preinitiation complex. Science, 372, 2021
7EMF	Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation 分子名称: Isoform 2 of Mediator of RNA polymerase II transcription subunit 16, Isoform 2 of Mediator of RNA polymerase II transcription subunit 8, Mediator of RNA polymerase II transcription subunit 1, ... 著者 Yin, X, Li, J, Wu, Z, Liu, W, Xu, Y. 登録日 2021-04-13 公開日 2021-05-05 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structures of the human Mediator and Mediator-bound preinitiation complex. Science, 372, 2021
7UBK	Transcription antitermination factor Qlambda, type-II crystal 分子名称: 1,2-ETHANEDIOL, Antitermination protein Q, CHLORIDE ION, ... 著者 Yin, Z, Ebright, R.H. 登録日 2022-03-15 公開日 2022-09-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 In transcription antitermination by Q lambda , NusA induces refolding of Q lambda to form a nozzle that extends the RNA polymerase RNA-exit channel. Proc.Natl.Acad.Sci.USA, 119, 2022
3RJ1	Architecture of the Mediator Head module 分子名称: Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 17, Mediator of RNA polymerase II transcription subunit 18, ... 著者 Imasaki, T, Calero, G, Cai, G, Tsai, K.L, Yamada, K, Cardelli, F, Erdjument-Bromage, H, Tempst, P, Berger, I, Kornberg, G.L, Asturias, F.J, Kornberg, R.D, Takagi, Y. 登録日 2011-04-14 公開日 2011-07-27 最終更新日 2017-08-02 実験手法 X-RAY DIFFRACTION (4.3 Å) 主引用文献 Architecture of the Mediator head module. Nature, 475, 2011
4RQF	human Seryl-tRNA synthetase dimer complexed with one molecule of tRNAsec 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SERINE, Serine--tRNA ligase, ... 著者 Xie, W, Wang, C, Guo, Y, Tian, Q, Jia, Q. 登録日 2014-11-03 公開日 2015-11-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.503 Å) 主引用文献 SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. Nucleic Acids Res., 43, 2015
4RQE	human Seryl-tRNA synthetase dimer complexed with two molecules of tRNAsec 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SERINE, Serine--tRNA ligase, ... 著者 Xie, W, Wang, C, Guo, Y, Tian, Q, Jia, Q. 登録日 2014-11-03 公開日 2015-11-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. Nucleic Acids Res., 43, 2015
2HZM	Structure of the Mediator head subcomplex Med18/20 分子名称: PHOSPHATE ION, RNA polymerase II mediator complex subunit 18, RNA polymerase II mediator complex subunit 20 著者 Lariviere, L, Geiger, S, Hoeppner, S, Rother, S, Straesser, K, Cramer, P. 登録日 2006-08-09 公開日 2006-09-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20. Nat.Struct.Mol.Biol., 13, 2006
2O1P	Structure of yeast Poly(A) Polymerase in a somewhat closed state 分子名称: Poly(A) polymerase 著者 Bohm, A, Balbo, P, Toth, J. 登録日 2006-11-29 公開日 2007-01-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 X-ray crystallographic and steady state fluorescence characterization of the protein dynamics of yeast polyadenylate polymerase. J.Mol.Biol., 366, 2007
2LTO	TDRD3 complex 分子名称: DNA-directed RNA polymerase II subunit RPB1, Tudor domain-containing protein 3 著者 Sikorsky, T. 登録日 2012-05-30 公開日 2013-01-16 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Recognition of asymmetrically dimethylated arginine by TDRD3. Nucleic Acids Res., 40, 2012
5N2G	Structure of the E9 DNA polymerase from vaccinia virus in complex with manganese 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Tarbouriech, N, Burmeister, W.P, Iseni, F. 登録日 2017-02-07 公開日 2017-11-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 The vaccinia virus DNA polymerase structure provides insights into the mode of processivity factor binding. Nat Commun, 8, 2017
3AGQ	Structure of viral polymerase form II 分子名称: Elongation factor Ts, Elongation factor Tu 1, LINKER, ... 著者 Takeshita, D, Tomita, K. 登録日 2010-04-06 公開日 2010-09-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts Proc.Natl.Acad.Sci.USA, 107, 2010
8G1U	Structure of the methylosome-Lsm10/11 complex 分子名称: ADENOSINE, Methylosome protein 50, Methylosome subunit pICln, ... 著者 Lin, M, Paige, A, Tong, L. 登録日 2023-02-03 公開日 2023-08-23 最終更新日 2023-10-25 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome. Rna, 29, 2023
3G86	Hepatitis C virus polymerase NS5B (BK 1-570) with thiazine inhibitor 分子名称: N-{3-[6-fluoro-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide, NICKEL (II) ION, RNA-directed RNA polymerase 著者 Harris, S.F, Ghate, M. 登録日 2009-02-11 公開日 2009-09-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones Bioorg.Med.Chem.Lett., 19, 2009
3U4R	Novel HCV NS5B polymerase Inhibitors: Discovery of Indole C2 Acyl sulfonamides 分子名称: 1-[(2-aminopyridin-4-yl)methyl]-5-chloro-N-({3-[(methylsulfonyl)amino]phenyl}sulfonyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide, RNA-directed RNA polymerase 著者 Anilkumar, G.N, Selyutin, O, Rosenblum, S.B, Zeng, Q, Jiang, Y, Chan, T.-Y, Pu, H, Wang, L, Bennett, F, Chen, K.X, Lesburg, C.A, Duca, J.S, Gavalas, S, Huang, Y, Pinto, P, Sannagrahi, M, Velazquez, F, Venkataraman, S, Vilbubhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Huang, H.-C, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. 登録日 2011-10-10 公開日 2011-12-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides. Bioorg.Med.Chem.Lett., 22, 2012
3U4O	Novel HCV NS5B polymerase Inhibitors: Discovery of Indole C2 Acyl sulfonamides 分子名称: 1-[(2-aminopyridin-4-yl)methyl]-5-chloro-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase 著者 Anilkumar, G.N, Selyutin, O, Rosenblum, S.B, Zeng, Q, Jiang, Y, Chan, T.-Y, Pu, H, Wang, L, Bennett, F, Chen, K.X, Lesburg, C.A, Duca, J.S, Gavalas, S, Huang, Y, Pinto, P, Sannigrahi, M, Velazquez, F, Venkataraman, S, Vilbubhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Huang, H.-C, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. 登録日 2011-10-10 公開日 2011-12-07 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides. Bioorg.Med.Chem.Lett., 22, 2012
5TYW	DNA Polymerase Mu Reactant Complex, Mn2+ (10 min) 分子名称: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Jamsen, J.A, Wilson, S.H. 登録日 2016-11-21 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
5TYV	DNA Polymerase Mu Reactant Complex, Mn2+ (7.5 min) 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ... 著者 Jamsen, J.A, Wilson, S.H. 登録日 2016-11-21 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
5TYY	DNA Polymerase Mu Product Complex, Mn2+ (60 min) 分子名称: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Jamsen, J.A, Wilson, S.H. 登録日 2016-11-21 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.931 Å) 主引用文献 Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
5TYX	DNA Polymerase Mu Product Complex, Mn2+ (15 min) 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ... 著者 Jamsen, J.A, Wilson, S.H. 登録日 2016-11-21 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.948 Å) 主引用文献 Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
5TYZ	DNA Polymerase Mu Product Complex, Mn2+ (960 min) 分子名称: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Jamsen, J.A, Wilson, S.H. 登録日 2016-11-21 公開日 2017-08-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.977 Å) 主引用文献 Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
5TYU	DNA Polymerase Mu Reactant Complex, Mn2+ (4 min) 分子名称: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Jamsen, J.A, Wilson, S.H. 登録日 2016-11-21 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.048 Å) 主引用文献 Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
4M0A	Human DNA Polymerase Mu post-catalytic complex 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA-directed DNA/RNA polymerase mu, ... 著者 Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. 登録日 2013-08-01 公開日 2014-02-05 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Sustained active site rigidity during synthesis by human DNA polymerase mu. Nat.Struct.Mol.Biol., 21, 2014
8PPV	Intermediate conformer of Pyrococcus abyssi DNA polymerase D (PolD) bound to a primer/template substrate containing three consecutive mismatches 分子名称: DNA (5'-D(*P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*(GS)P*(G7P)P*(PST)P*(PST)P*(PST))-3'), DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA polymerase II small subunit, ... 著者 Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. 登録日 2023-07-10 公開日 2023-12-20 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.02 Å) 主引用文献 Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023
8PPT	Pyrococcus abyssi DNA polymerase D (PolD) in its editing mode bound to a primer/template substrate containing a mismatch 分子名称: DNA (5'-D(P*AP*GP*CP*AP*CP*GP*GP*CP*TP*CP*GP*GP*CP*CP*CP*GP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*GP*CP*CP*GP*AP*GP*CP*CP*GP*TP*GP*CP*TP*TP*T)-3'), DNA polymerase II small subunit, ... 著者 Betancurt-Anzola, L, Martinez-Carranza, M, Zatopek, K.M, Gardner, A.F, Sauguet, L. 登録日 2023-07-10 公開日 2023-12-20 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases. Nat Commun, 14, 2023

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