1AU9
 
 | | SUBTILISIN BPN' MUTANT 8324 IN CITRATE | | 分子名称: | CALCIUM ION, ISOPROPYL ALCOHOL, SUBTILISIN BPN', ... | | 著者 | Whitlow, M, Howard, A.J, Wood, J.F. | | 登録日 | 1997-09-12 | | 公開日 | 1997-12-31 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding.
Biochemistry, 28, 1989
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1G1O
 | | CRYSTAL STRUCTURE OF THE HIGHLY AMYLOIDOGENIC TRANSTHYRETIN MUTANT TTR G53S/E54D/L55S | | 分子名称: | TRANSTHYRETIN | | 著者 | Eneqvist, T, Andersson, K, Olofsson, A, Lundgren, E, Sauer-Eriksson, A.E. | | 登録日 | 2000-10-13 | | 公開日 | 2001-10-17 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The beta-slip: a novel concept in transthyretin amyloidosis.
Mol.Cell, 6, 2000
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1S01
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4QZS
 | | Crystal structure of the first bromodomain of human 3-fluoro tyrosine-labeled brd4 in complex with jq1 | | 分子名称: | (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ... | | 著者 | Ember, S.W, Schonbrunn, E. | | 登録日 | 2014-07-28 | | 公開日 | 2014-10-29 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Fluorinated aromatic amino acids are sensitive (19)f NMR probes for bromodomain-ligand interactions.
Acs Chem.Biol., 9, 2014
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2UUF
 | | Thrombin-hirugen binary complex at 1.26A resolution | | 分子名称: | CALCIUM ION, HIRUDIN I, HUMAN ALPHA THROMBIN, ... | | 著者 | Ahmed, H.U, Blakeley, M.P, Cianci, M, Cruickshank, D.W.J, Hubbard, J.A, Helliwell, J.R. | | 登録日 | 2007-03-02 | | 公開日 | 2007-09-04 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | | 主引用文献 | The Determination of Protonation States in Proteins.
Acta Crystallogr.,Sect.D, 63, 2007
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1Y0T
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1XXT
 | | The T-to-T High Transitions in Human Hemoglobin: wild-type deoxy Hb A (low salt, one test set) | | 分子名称: | Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Kavanaugh, J.S, Rogers, P.H, Arnone, A. | | 登録日 | 2004-11-08 | | 公開日 | 2004-12-07 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions.
Biochemistry, 44, 2005
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1YE1
 | | T-To-T(High) quaternary transitions in human hemoglobin: betaY35A oxy (2MM IHP, 20% PEG) (1 test set) | | 分子名称: | Hemoglobin alpha chain, Hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Kavanaugh, J.S, Rogers, P.H, Arnone, A. | | 登録日 | 2004-12-27 | | 公開日 | 2005-01-04 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (4.5 Å) | | 主引用文献 | Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions.
Biochemistry, 44, 2005
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1Y31
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1Y35
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1Y22
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1Y2Z
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4WUY
 | | Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor | | 分子名称: | 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl]biphenyl-3-carboxamide, GLYCEROL, N-lysine methyltransferase SMYD2, ... | | 著者 | Nguyen, H, Allali-Hassani, A, Antonysamy, S, Chang, S, Chen, L.H, Curtis, C, Emtage, S, Fan, L, Gheyi, T, Li, F, Liu, S, Martin, J.R, Mendel, D, Olsen, J.B, Pelletier, L, Shatseva, T, Wu, S, Zhang, F.F, Arrowsmith, C.H, Brown, P.J, Campbell, R.M, Garcia, B.A, Barsyte-Lovejoy, D, Mader, M, Vedadi, M. | | 登録日 | 2014-11-04 | | 公開日 | 2015-04-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.
J.Biol.Chem., 290, 2015
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6MP4
 | | Human liver FABP1 bound to tetrahydrocannabinol | | 分子名称: | (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, Fatty acid-binding protein, liver, ... | | 著者 | McGoldrick, L.L, Giuliano, C.J, Elmes, M.W, Deutsch, D.G, Kaczocha, M, Glynn, S.E. | | 登録日 | 2018-10-05 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.502 Å) | | 主引用文献 | FABP1 controls hepatic transport and biotransformation of Delta 9 -THC.
Sci Rep, 9, 2019
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4QR5
 | | Brd4 Bromodomain 1 complex with its novel inhibitors | | 分子名称: | Bromodomain-containing protein 4, N-[3-(cyclopentylsulfamoyl)-5-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)phenyl]cyclopropanecarboxamide | | 著者 | Xiong, B, Cao, D.Y, Chen, T.T, Xu, Y.C. | | 登録日 | 2014-06-30 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization
J.Med.Chem., 58, 2015
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4QR3
 | | Brd4 Bromodomain 1 complex with its novel inhibitors | | 分子名称: | Bromodomain-containing protein 4, N-cyclopentyl-3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)benzenesulfonamide | | 著者 | Xiong, B, Cao, D.Y, Chen, T.T, Xu, Y.C. | | 登録日 | 2014-06-30 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.374 Å) | | 主引用文献 | Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization
J.Med.Chem., 58, 2015
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4QR4
 | | Brd4 Bromodomain 1 complex with its novel inhibitors | | 分子名称: | 2-chloro-N-cyclopentyl-5-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)benzenesulfonamide, Bromodomain-containing protein 4 | | 著者 | Xiong, B, Cao, D.Y, Chen, T.T, Xu, Y.C. | | 登録日 | 2014-06-30 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization
J.Med.Chem., 58, 2015
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1REJ
 | | Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 1 | | 分子名称: | 3-[(4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-HYDROXYBENZOATE, cAMP-dependent protein kinase, alpha-catalytic subunit | | 著者 | Akamine, P, Madhusudan, Brunton, L.L, Ou, H.D, Canaves, J.M, Xuong, N.H, Taylor, S.S. | | 登録日 | 2003-11-06 | | 公開日 | 2004-02-24 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit
Biochemistry, 43, 2004
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1TB3
 | | Crystal Structure Analysis of Recombinant Rat Kidney Long-chain Hydroxy Acid Oxidase | | 分子名称: | ACETIC ACID, FLAVIN MONONUCLEOTIDE, Hydroxyacid oxidase 3 | | 著者 | Cunane, L.M, Barton, J.D, Chen, Z.W, Le, K.H.D, Amar, D, Lederer, F, Mathews, F.S. | | 登録日 | 2004-05-19 | | 公開日 | 2005-02-01 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structure Analysis of Recombinant Rat Kidney Long Chain Hydroxy Acid Oxidase.
Biochemistry, 44, 2005
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1HCC
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1FMG
 | | CRYSTAL STRUCTURE OF PORCINE BETA TRYPSIN WITH 0.04% POLYDOCANOL | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, SULFATE ION, ... | | 著者 | Deepthi, S, Johnson, A, Pattabhi, V. | | 登録日 | 2000-08-17 | | 公開日 | 2000-09-13 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structures of porcine beta-trypsin-detergent complexes: the stabilization of proteins through hydrophilic binding of polydocanol.
Acta Crystallogr.,Sect.D, 57, 2001
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1FNI
 | | CRYSTAL STRUCTURE OF PORCINE BETA TRYPSIN WITH 0.01% POLYDOCANOL | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, SULFATE ION, ... | | 著者 | Deepthi, S, Johnson, A, Pattabhi, V. | | 登録日 | 2000-08-22 | | 公開日 | 2000-09-13 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structures of porcine beta-trypsin-detergent complexes: the stabilization of proteins through hydrophilic binding of polydocanol.
Acta Crystallogr.,Sect.D, 57, 2001
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1FN6
 | | CRYSTAL STRUCTURE OF PORCINE BETA TRYPSIN WITH 0.1% POLYDOCANOL | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, METHANOL, ... | | 著者 | Deepthi, S, Johnson, A, Pattabhi, V. | | 登録日 | 2000-08-21 | | 公開日 | 2000-09-13 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structures of porcine beta-trypsin-detergent complexes: the stabilization of proteins through hydrophilic binding of polydocanol.
Acta Crystallogr.,Sect.D, 57, 2001
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1REK
 | | Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 8 | | 分子名称: | 3-[(3-SEC-BUTYL-4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-(2-HYDROXY-5-METHOXYBENZOYL)BENZOATE, PENTANAL, cAMP-dependent protein kinase, ... | | 著者 | Akamine, P, Madhusudan, Brunton, L.L, Ou, H.D, Canaves, J.M, Xuong, N.H, Taylor, S.S. | | 登録日 | 2003-11-06 | | 公開日 | 2004-02-24 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit
Biochemistry, 43, 2004
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1RE8
 | | Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2 | | 分子名称: | 3-[(4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-(2-HYDROXYBENZOYL)BENZOATE, N-OCTANE, cAMP-dependent protein kinase, ... | | 著者 | Akamine, P, Madhusudan, Brunton, L.L, Ou, H.D, Canaves, J.M, Xuong, N.H, Taylor, S.S. | | 登録日 | 2003-11-06 | | 公開日 | 2004-02-24 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit
Biochemistry, 43, 2004
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