6MA8
 
 | | Human CYP3A4 bound to PMSF | | 分子名称: | 1,2-ETHANEDIOL, Cytochrome P450 3A4, DIMETHYL SULFOXIDE, ... | | 著者 | Sevrioukova, I.F. | | 登録日 | 2018-08-26 | | 公開日 | 2019-01-16 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Interaction of Human Drug-Metabolizing CYP3A4 with Small Inhibitory Molecules.
Biochemistry, 58, 2019
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9AT5
 | | Crystal structure of SARS-CoV-2 3CL protease in complex with a 1-methyl-4,4-difluorocyclohexyl 2-pyrrolidone inhibitor | | 分子名称: | (1R,2S)-2-({N-[({(2S)-1-[(4,4-difluorocyclohexyl)methyl]-5-oxopyrrolidin-2-yl}methoxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-2-({N-[({(2S)-1-[(4,4-difluorocyclohexyl)methyl]-5-oxopyrrolidin-2-yl}methoxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5, ... | | 著者 | Lovell, S, Cooper, A, Battaile, K.P, Dampalla, C.S, Groutas, W.C. | | 登録日 | 2024-02-26 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies.
J.Med.Chem., 2024
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2JX5
 | | Solution structure of the ubiquitin domain N-terminal to the S27a ribosomal subunit of Giardia lamblia | | 分子名称: | GlUb(S27a) | | 著者 | Catic, A, Sun, Z.J, Ratner, D.M, Misaghi, S, Spooner, E, Samuelson, J, Wagner, G, Ploegh, H.L. | | 登録日 | 2007-11-07 | | 公開日 | 2007-12-04 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Sequence and structure evolved separately in a ribosomal ubiquitin variant
EMBO J., 26, 2007
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6I6E
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9AT7
 | | Crystal structure of SARS-CoV-2 3CL protease in complex with a 2,2-difluoro-5-methylbenzo[1,3]dioxole 2-pyrrolidone inhibitor | | 分子名称: | (1R,2S)-2-({N-[({(2S)-1-[(2,2-difluoro-2H-1,3-benzodioxol-5-yl)methyl]-5-oxopyrrolidin-2-yl}methoxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-2-({N-[({(2S)-1-[(2,2-difluoro-2H-1,3-benzodioxol-5-yl)methyl]-5-oxopyrrolidin-2-yl}methoxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5, ... | | 著者 | Lovell, S, Cooper, A, Battaile, K.P, Dampalla, C.S, Groutas, W.C. | | 登録日 | 2024-02-26 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies.
J.Med.Chem., 2024
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8V98
 | | GII.24 Loreto 1972 norovirus protruding domain | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Capsid protein VP1 | | 著者 | Kher, G, Prewitt, A, Pancera, M, Hansman, G. | | 登録日 | 2023-12-07 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Development of a broad-spectrum therapeutic Fc-nanobody for human noroviruses.
J.Virol., 2024
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9AT1
 | | Crystal structure of SARS-CoV-2 3CL protease in complex with a methylcyclohexyl 2-pyrrolidone inhibitor (R-enantiomer) | | 分子名称: | (1S,2S)-2-{[N-({[(2R)-1-(cyclohexylmethyl)-5-oxopyrrolidin-2-yl]methoxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5, TETRAETHYLENE GLYCOL | | 著者 | Lovell, S, Cooper, A, Battaile, K.P, Dampalla, C.S, Groutas, W.C. | | 登録日 | 2024-02-26 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies.
J.Med.Chem., 2024
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9ATF
 | | Crystal structure of MERS 3CL protease in complex with a 1-methyl-4,4-difluorocyclohexyl 2-pyrrolidone inhibitor | | 分子名称: | (1R,2S)-2-({N-[({(2S)-1-[(4,4-difluorocyclohexyl)methyl]-5-oxopyrrolidin-2-yl}methoxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-2-({N-[({(2S)-1-[(4,4-difluorocyclohexyl)methyl]-5-oxopyrrolidin-2-yl}methoxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | | 著者 | Liu, L, Lovell, S, Battaile, K.P, Dampalla, C.S, Groutas, W.C. | | 登録日 | 2024-02-26 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies.
J.Med.Chem., 2024
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8V95
 | | GII.8 Amsterdam norovirus protruding domain | | 分子名称: | 1,2-ETHANEDIOL, Capsid protein (Fragment) | | 著者 | Kher, G, Prewitt, A, Pancera, M, Hansman, G. | | 登録日 | 2023-12-07 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Development of a broad-spectrum therapeutic Fc-nanobody for human noroviruses.
J.Virol., 2024
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1ETL
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1EY4
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2YU1
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1EYA
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8TI2
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1EWH
 | | STRUCTURE OF CYTOCHROME F FROM CHLAMYDOMONAS REINHARDTII | | 分子名称: | ACETATE ION, CYTOCHROME F, HEME C | | 著者 | Sainz, G, Carrell, C.J, Ponamarev, M.V, Soriano, G.M, Cramer, W.A, Smith, J.L. | | 登録日 | 2000-04-25 | | 公開日 | 2000-08-09 | | 最終更新日 | 2021-03-03 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Interruption of the internal water chain of cytochrome f impairs photosynthetic function.
Biochemistry, 39, 2000
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6MAS
 | | X-ray Structure of Branchiostoma floridae fluorescent protein lanFP10G | | 分子名称: | GLYCEROL, Uncharacterized protein | | 著者 | Muslinkina, L, Pletneva, N, Pletnev, V, Pletnev, S. | | 登録日 | 2018-08-28 | | 公開日 | 2019-03-13 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structural Factors Enabling Successful GFP-Like Proteins with Alanine as the Third Chromophore-Forming Residue.
J. Mol. Biol., 431, 2019
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8V99
 | | GII.26 Leon 4509 norovirus protruding domain | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Capsid protein VP1, ... | | 著者 | Kher, G, Reese, T, Pancera, M, Hansman, G. | | 登録日 | 2023-12-07 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | Development of a broad-spectrum therapeutic Fc-nanobody for human noroviruses.
J.Virol., 2024
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1ETM
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8XJ3
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4QC3
 | | Crystal structure of human BAZ2B bromodomain in complex with a diacetylated histone 4 peptide (H4K8acK12ac) | | 分子名称: | 1,2-ETHANEDIOL, Bromodomain adjacent to zinc finger domain protein 2B, diacetylated histone 4 peptide (H4K8acK12ac) | | 著者 | Tallant, C, Jose, B, Picaud, S, Chaikuad, A, Filippakopoulos, P, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2014-05-09 | | 公開日 | 2014-05-21 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.
Structure, 23, 2015
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8CK2
 | | MUC2 CysD1 G1352S | | 分子名称: | ACETATE ION, CALCIUM ION, Mucin-2, ... | | 著者 | Khmelnitsky, L, Fass, D. | | 登録日 | 2023-02-14 | | 公開日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Pulmonary Fibrosis Mutation Undermines Mucin 5B Supramolecular Assembly
To Be Published
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6IE9
 | | RamR in complex with chenodeoxycholic acid | | 分子名称: | CHENODEOXYCHOLIC ACID, Regulatory protein, SULFATE ION | | 著者 | Nakashima, R, Sakurai, K, Yamasaki, S, Nishino, K. | | 登録日 | 2018-09-13 | | 公開日 | 2019-02-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Crystal structure of the multidrug resistance regulator RamR complexed with bile acids.
Sci Rep, 9, 2019
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1EY5
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1EY9
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8X15
 | | Structure of nucleosome-bound SRCAP-C in the apo state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | 著者 | Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. | | 登録日 | 2023-11-06 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into histone exchange by human SRCAP complex.
Cell Discov, 10, 2024
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