2VJC
 
 | | Torpedo Californica Acetylcholinesterase In Complex With A Non Hydrolysable Substrate Analogue, 4-Oxo-N,N,N- Trimethylpentanaminium - Orthorhombic space group - Dataset A at 150K | | 分子名称: | (4R)-4-HYDROXY-N,N,N-TRIMETHYLPENTAN-1-AMINIUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... | | 著者 | Colletier, J.P, Bourgeois, D, Fournier, D, Silman, I, Sussman, J.L, Weik, M. | | 登録日 | 2007-12-09 | | 公開日 | 2008-07-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Shoot-and-Trap: Use of Specific X-Ray Damage to Study Structural Protein Dynamics by Temperature-Controlled Cryo-Crystallography.
Proc.Natl.Acad.Sci.USA, 105, 2008
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2VJA
 | | Torpedo Californica Acetylcholinesterase In Complex With A Non Hydrolysable Substrate Analogue, 4-Oxo-N,N,N- Trimethylpentanaminium - Orthorhombic space group - Dataset A at 100K | | 分子名称: | (4R)-4-HYDROXY-N,N,N-TRIMETHYLPENTAN-1-AMINIUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... | | 著者 | Colletier, J.P, Bourgeois, D, Fournier, D, Silman, I, Sussman, J.L, Weik, M. | | 登録日 | 2007-12-09 | | 公開日 | 2008-07-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Shoot-and-Trap: Use of Specific X-Ray Damage to Study Structural Protein Dynamics by Temperature-Controlled Cryo-Crystallography.
Proc.Natl.Acad.Sci.USA, 105, 2008
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8PSR
 | | ERK2 covalently bound to SynthRevD-12-opt artificial peptide | | 分子名称: | GLYCEROL, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Sok, P, Poti, A, Gogl, G, Remenyi, A. | | 登録日 | 2023-07-13 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold
To Be Published
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1PDW
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8PT0
 | | ERK2 covelently bound to RU75 cyclohexenone based inhibitor | | 分子名称: | GLYCEROL, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Sok, P, Poti, A, Remenyi, A, Gogl, G. | | 登録日 | 2023-07-13 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold
To Be Published
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1PAJ
 | | NMR SOLUTION STRUCTURE AND FLEXIBILITY OF A PEPTIDE ANTIGEN REPRESENTING THE RECEPTOR BINDING DOMAIN OF PSEUDOMONAS AERUGINOSA | | 分子名称: | FIMBRIAL PROTEIN PRECURSOR, HYDROXIDE ION | | 著者 | Mcinnes, C, Sonnichsen, F.D, Kay, C.M, Hodges, R.S, Sykes, B.D. | | 登録日 | 1993-08-25 | | 公開日 | 1994-01-31 | | 最終更新日 | 2017-11-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR solution structure and flexibility of a peptide antigen representing the receptor binding domain of Pseudomonas aeruginosa.
Biochemistry, 32, 1993
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8Q2B
 | | E. coli Adenylate Kinase variant D158A (AK D158A) showing significant changes to the stacking of catalytic arginine side chains | | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, ... | | 著者 | Sauer, U.H, Wolf-Watz, M, Nam, K. | | 登録日 | 2023-08-01 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Elucidating Dynamics of Adenylate Kinase from Enzyme Opening to Ligand Release.
J.Chem.Inf.Model., 64, 2024
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8CEP
 | | Kasugamycin bound to the 30S body | | 分子名称: | (1S,2R,3S,4R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL 2-AMINO-4-{[CARBOXY(IMINO)METHYL]AMINO}-2,3,4,6-TETRADEOXY-ALPHA-D-ARABINO-HEXOPYRANOSIDE, 16S rRNA, 23S rRNA, ... | | 著者 | Paternoga, H, Beckert, B, Wilson, D.N. | | 登録日 | 2023-02-02 | | 公開日 | 2023-07-19 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.04 Å) | | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CAI
 | | Streptomycin and Hygromycin B bound to the 30S body | | 分子名称: | 16S rRNA, 30S ribosomal protein S16, 30S ribosomal protein S2, ... | | 著者 | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | | 登録日 | 2023-01-24 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.08 Å) | | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CGU
 | | Gentamicin bound to the 30S body | | 分子名称: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 16S rRNA, 23S rRNA, ... | | 著者 | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | | 登録日 | 2023-02-06 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (1.89 Å) | | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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8CGJ
 | | Streptomycin bound to the 30S body | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S16, ... | | 著者 | Paternoga, H, Crowe-McAuliffe, C, Beckert, B, Wilson, D.N. | | 登録日 | 2023-02-05 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (1.79 Å) | | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes.
Nat.Struct.Mol.Biol., 30, 2023
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1O5R
 | | Crystal structure of adenosine deaminase complexed with a potent inhibitor | | 分子名称: | 1-[(1R)-3-(6-{[(BENZYLAMINO)CARBONYL]AMINO}-1H-INDOL-1-YL)-1-(HYDROXYMETHYL)PROPYL]-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION | | 著者 | Kinoshita, T. | | 登録日 | 2003-10-05 | | 公開日 | 2004-09-21 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
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8DT7
 | | X-ray structure of human acetylcholinesterase in complex with oxime MMB4 (hAChE-MMB4) | | 分子名称: | 1,1'-methylenebis{4-[(E)-(hydroxyimino)methyl]pyridin-1-ium}, Acetylcholinesterase, GLYCEROL, ... | | 著者 | Kovalevsky, A.Y, Gerlits, O, Radic, Z. | | 登録日 | 2022-07-25 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.207 Å) | | 主引用文献 | Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering.
Structure, 30, 2022
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8DT2
 | | X-ray structure of human acetylcholinesterase inhibited by paraoxon (POX-hAChE) | | 分子名称: | Acetylcholinesterase, DIETHYL PHOSPHONATE, DIMETHYL SULFOXIDE, ... | | 著者 | Kovalevsky, A.Y, Gerlits, O, Radic, Z. | | 登録日 | 2022-07-25 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.803 Å) | | 主引用文献 | Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering.
Structure, 30, 2022
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8DVS
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8DOG
 | | Dehaloperoxidase B in complex with Bisphenol E | | 分子名称: | 4-[1-(4-hydroxyphenyl)ethyl]phenol, Dehaloperoxidase B, GLYCEROL, ... | | 著者 | de Serrano, V.S, Yun, D, Ghiladi, R. | | 登録日 | 2022-07-13 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Oxidation of bisphenol A (BPA) and related compounds by the multifunctional catalytic globin dehaloperoxidase.
J.Inorg.Biochem., 238, 2023
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2W9Z
 | | Crystal Structure of CDK4 in complex with a D-type cyclin | | 分子名称: | CELL DIVISION PROTEIN KINASE 4, G1/S-SPECIFIC CYCLIN-D1 | | 著者 | Day, P.J, Cleasby, A, Tickle, I.J, Reilly, M.O, Coyle, J.E, Holding, F.P, McMenamin, R.L, Yon, J, Chopra, R, Lengauer, C, Jhoti, H. | | 登録日 | 2009-01-30 | | 公開日 | 2009-03-10 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
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1NMY
 | | Crystal structure of human thymidylate kinase with FLTMP and AppNHp | | 分子名称: | 3'-FLUORO-3'-DEOXYTHYMIDINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A. | | 登録日 | 2003-01-12 | | 公開日 | 2003-03-18 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structures of human thymidylate kinase in complex with prodrugs:
implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
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8QSJ
 | | Human mitoribosomal large subunit assembly intermediate 2 with GTPBP7 | | 分子名称: | 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... | | 著者 | Ritter, C, Nguyen, T.G, Kummer, E. | | 登録日 | 2023-10-10 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome.
Nat Commun, 14, 2023
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8DT5
 | | X-ray structure of human acetylcholinesterase ternary complex with paraoxon and oxime RS170B (POX-hAChE-RS170B) | | 分子名称: | 4-carbamoyl-1-(3-{2-[(E)-(hydroxyimino)methyl]-1H-imidazol-1-yl}propyl)pyridin-1-ium, Acetylcholinesterase, DIETHYL PHOSPHONATE, ... | | 著者 | Kovalevsky, A.Y, Gerlits, O, Radic, Z. | | 登録日 | 2022-07-25 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering.
Structure, 30, 2022
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8DVU
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2W9F
 | | Crystal Structure of CDK4 in complex with a D-type cyclin | | 分子名称: | CELL DIVISION PROTEIN KINASE 4, G1/S-SPECIFIC CYCLIN-D1 | | 著者 | Day, P.J, Cleasby, A, Tickle, I.J, Reilly, M.O, Coyle, J.E, Holding, F.P, McMenamin, R.L, Yon, J, Chopra, R, Lengauer, C, Jhoti, H. | | 登録日 | 2009-01-23 | | 公開日 | 2009-03-10 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
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8E2O
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2VZI
 | | Crystal structure of the C-terminal calponin homology domain of alpha- parvin in complex with paxillin LD4 motif | | 分子名称: | 1,2-ETHANEDIOL, Alpha-parvin, Paxillin,Paxillin, ... | | 著者 | Lorenz, S, Vakonakis, I, Lowe, E.D, Campbell, I.D, Noble, M.E.M, Hoellerer, M.K. | | 登録日 | 2008-08-01 | | 公開日 | 2008-10-28 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural analysis of the interactions between paxillin LD motifs and alpha-parvin.
Structure, 16, 2008
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1NMD
 | | Crystal Structure of D. Discoideum Actin-Gelsolin Segment 1 Complex Crystallized In Presence Of Lithium ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin, CALCIUM ION, ... | | 著者 | Vorobiev, S.M, Welti, S, Condeelis, J, Almo, S.C. | | 登録日 | 2003-01-09 | | 公開日 | 2003-02-04 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Structure Of The Non-Vertebrate Actin: Implications For The ATP Hydrolytic Mechanism
Proc.Natl.Acad.Sci.USA, 100, 2003
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