4FQQ
 
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3TX4
 | | Crystal Structure of Mutant (C354A) M. tuberculosis LD-transpeptidase type 2 | | 分子名称: | Mycobacterium Tuberculosis LD-transpeptidase type 2 | | 著者 | Erdemli, S, Bianchet, M.A, Gupta, R, Lamichhane, G, Amzel, L.M. | | 登録日 | 2011-09-22 | | 公開日 | 2012-12-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2.
Structure, 20, 2012
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3H5L
 | | Crystal structure of a putative branched-chain amino acid ABC transporter from Silicibacter pomeroyi | | 分子名称: | putative Branched-chain amino acid ABC transporter | | 著者 | Bonanno, J.B, Freeman, J, Bain, K.T, Iizuka, M, Sampathkumar, P, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2009-04-22 | | 公開日 | 2009-05-05 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of a putative branched-chain amino acid ABC transporter from Silicibacter pomeroyi
To be Published
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4NWL
 | | Crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide | | 分子名称: | HCV NS3 1a Protease, N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-L-prolinamide, ZINC ION | | 著者 | Muckelbauer, J.K, Klei, H.E. | | 登録日 | 2013-12-06 | | 公開日 | 2014-03-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
J.Med.Chem., 57, 2014
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3H65
 | | The Crystal Structure of C176A Mutated [Fe]-Hydrogenase (Hmd) Holoenzyme in Complex with Methylenetetrahydromethanopterin | | 分子名称: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 5'-O-[(S)-hydroxy{[2-hydroxy-3,5-dimethyl-6-(2-oxoethyl)pyridin-4-yl]oxy}phosphoryl]guanosine, 5,10-DIMETHYLENE TETRAHYDROMETHANOPTERIN, ... | | 著者 | Hiromoto, T, Warkentin, E, Shima, S, Ermler, U. | | 登録日 | 2009-04-23 | | 公開日 | 2009-09-01 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | The crystal structure of an [Fe]-hydrogenase-substrate complex reveals the framework for H2 activation.
Angew.Chem.Int.Ed.Engl., 48, 2009
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3H0J
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3UDN
 | | Crystal Structure of BACE with Compound 9 | | 分子名称: | 1,2-ETHANEDIOL, 4-cyanobenzyl (3S,5'R)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylate, Beta-secretase 1, ... | | 著者 | Efremov, I.V, Vajdos, F.F, Borzilleri, K, Capetta, S, Dorff, P, Dutra, J, Mansour, M, Oborski, C, O'Connell, T, O'Sullivan, T.J, Pandit, J, Wang, H, Withka, J. | | 登録日 | 2011-10-28 | | 公開日 | 2012-04-18 | | 最終更新日 | 2018-04-04 | | 実験手法 | X-RAY DIFFRACTION (2.193 Å) | | 主引用文献 | Discovery and optimization of a novel spiropyrrolidine inhibitor of {beta}-secretase (BACE1) through fragment-based drug design.
J.Med.Chem., 55, 2012
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4NWV
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2G7O
 | | Protonation-mediated structural flexibility in the F conjugation regulatory protein, TraM | | 分子名称: | Protein traM | | 著者 | Lu, J, Edwards, R.A, Wong, J.J, Manchak, J, Scott, P.G, Frost, L.S, Glover, J.N. | | 登録日 | 2006-02-28 | | 公開日 | 2006-06-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Protonation-mediated structural flexibility in the F conjugation regulatory protein, TraM.
Embo J., 25, 2006
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2FSK
 | | Crystal structure of Ta0583, an archaeal actin homolog, SeMet data | | 分子名称: | hypothetical protein Ta0583 | | 著者 | Roeben, A, Kofler, C, Nagy, I, Nickell, S, Ulrich Hartl, F, Bracher, A. | | 登録日 | 2006-01-23 | | 公開日 | 2006-04-18 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of an archaeal actin homolog
J.Mol.Biol., 358, 2006
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3H1O
 | | The Structure of Fluorescent Protein FP480 | | 分子名称: | Fluorescent protein FP480, GLYCEROL | | 著者 | Pletnev, S, Morozova, K.S, Verkhusha, V.V, Dauter, Z. | | 登録日 | 2009-04-13 | | 公開日 | 2009-09-08 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Rotational order-disorder structure of fluorescent protein FP480
Acta Crystallogr.,Sect.D, 65, 2009
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2G8J
 | | Calpain 1 proteolytic core in complex with SNJ-1945, a alpha-ketoamide-type inhibitor. | | 分子名称: | ((1S)-1-((((1S)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2,3-DIOXOPROPYL)AMINO)CARBONYL)-3-METHYLBUTYL)CARBAMIC ACID 5-METHOXY-3-OXAPENTYL ESTER, CALCIUM ION, Calpain-1 catalytic subunit | | 著者 | Cuerrier, D, Moldoveanu, T, Davies, P.L, Campbell, R.L. | | 登録日 | 2006-03-02 | | 公開日 | 2006-06-06 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Calpain Inhibition by alpha-Ketoamide and Cyclic Hemiacetal Inhibitors Revealed by X-ray Crystallography
Biochemistry, 45, 2006
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3UG0
 | | Crystal structure of a Trp-less green fluorescent protein translated by the simplified genetic code | | 分子名称: | Green fluorescent protein | | 著者 | Kawahara-Kobayashi, A, Araiso, Y, Matsuda, T, Yokoyama, S, Kigawa, T, Nureki, O, Kiga, D. | | 登録日 | 2011-11-02 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.093 Å) | | 主引用文献 | Simplification of the genetic code: restricted diversity of genetically encoded amino acids.
Nucleic Acids Res., 40, 2012
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3H20
 | | Crystal structure of primase RepB' | | 分子名称: | DIPHOSPHATE, Replication protein B, SULFATE ION | | 著者 | Geibel, S, Banchenko, S, Engel, M, Lanka, E, Saenger, W. | | 登録日 | 2009-04-14 | | 公開日 | 2009-04-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structure and function of primase RepB' encoded by broad-host-range plasmid RSF1010 that replicates exclusively in leading-strand mode
Proc.Natl.Acad.Sci.USA, 106, 2009
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4NZS
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3H9G
 | | Crystal structure of E. coli MccB + MccA-N7isoASN | | 分子名称: | MccB protein, Microcin C7 analog, SULFATE ION, ... | | 著者 | Regni, C.A, Roush, R.F, Miller, D, Nourse, A, Walsh, C.T, Schulman, B.A. | | 登録日 | 2009-04-30 | | 公開日 | 2009-06-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic.
Embo J., 28, 2009
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2FWV
 | | Crystal Structure of Rv0813 | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, GLYCEROL, hypothetical protein MtubF_01000852 | | 著者 | Shepard, W, Haouz, A, Grana, M, Buschiazzo, A, Betton, J.M, Cole, S.T, Alzari, P.M, Structural Proteomics in Europe (SPINE) | | 登録日 | 2006-02-03 | | 公開日 | 2006-08-03 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The Crystal Structure of Rv0813c from Mycobacterium tuberculosis Reveals a New Family of Fatty Acid-Binding Protein-Like Proteins in Bacteria
J.Bacteriol., 189, 2007
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3UDK
 | | Crystal Structure of BACE with Compound 6 | | 分子名称: | 1,2-ETHANEDIOL, Beta-secretase 1, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Efremov, I.V, Vajdos, F.F, Borzilleri, K, Capetta, S, Dorff, P, Dutra, J, Mansour, M, Oborski, C, O'Connell, T, O'Sullivan, T.J, Pandit, J, Wang, H, Withka, J. | | 登録日 | 2011-10-28 | | 公開日 | 2012-04-18 | | 最終更新日 | 2018-04-04 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Discovery and optimization of a novel spiropyrrolidine inhibitor of {beta}-secretase (BACE1) through fragment-based drug design.
J.Med.Chem., 55, 2012
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2FYF
 | | Structure of a putative phosphoserine aminotransferase from Mycobacterium Tuberculosis | | 分子名称: | GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION, ... | | 著者 | Coulibaly, F, Lassalle, E, Baker, E.N, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | | 登録日 | 2006-02-07 | | 公開日 | 2007-01-16 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis.
Acta Crystallogr.,Sect.D, 68, 2012
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3UCD
 | | Asymmetric complex of human neuron specific enolase-2-PGA/PEP | | 分子名称: | 2-PHOSPHOGLYCERIC ACID, Gamma-enolase, MAGNESIUM ION, ... | | 著者 | Qin, J, Chai, G, Brewer, J, Lovelace, L, Lebioda, L. | | 登録日 | 2011-10-26 | | 公開日 | 2012-08-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | Structures of asymmetric complexes of human neuron specific enolase with resolved substrate and product and an analogous complex with two inhibitors indicate subunit interaction and inhibitor cooperativity.
J.Inorg.Biochem., 111, 2012
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4O3W
 | | Crystal structure of the vaccine antigen Transferrin Binding Protein B (TbpB) mutant Tyr-63-Ala from Actinobacillus suis H57 | | 分子名称: | GLYCEROL, SULFATE ION, Transferrin binding protein B | | 著者 | Calmettes, C, Yu, R.H, Schryvers, A.B, Moraes, T.F. | | 登録日 | 2013-12-18 | | 公開日 | 2015-01-14 | | 最終更新日 | 2015-03-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities.
Infect.Immun., 83, 2015
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4NYA
 | | Crystal structure of the E. coli thiM riboswitch in complex with 5-(azidomethyl)-2-methylpyrimidin-4-amine | | 分子名称: | 5-(azidomethyl)-2-methylpyrimidin-4-amine, MAGNESIUM ION, thiM TPP riboswitch | | 著者 | Warner, K.D, Homan, P, Weeks, K.M, Smith, A.G, Abell, C, Ferre-D'Amare, A.R. | | 登録日 | 2013-12-10 | | 公開日 | 2014-06-04 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically.
Chem.Biol., 21, 2014
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3GMG
 | | Crystal structure of an uncharacterized conserved protein from Mycobacterium tuberculosis | | 分子名称: | Uncharacterized protein Rv1825/MT1873 | | 著者 | Bonanno, J.B, Rutter, M, Bain, K.T, Chang, S, Ozyurt, S, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2009-03-13 | | 公開日 | 2009-03-24 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structure of an uncharacterized conserved protein from Mycobacterium tuberculosis
To be Published
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3GMS
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4NZB
 | | NS9283 bound to Ls-AChBP | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl]benzonitrile, ACETATE ION, ... | | 著者 | Olsen, J.A, Kastrup, J.S, Gajhede, M. | | 登録日 | 2013-12-11 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at alpha 4 beta 2 nicotinic acetylcholine receptors.
J.Biol.Chem., 289, 2014
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