PDB: 8627 件ウェブページステータス検索Chemie searchBIRD

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6KQM	Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 5 nt 分子名称: DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Zhang, Y, Li, L, Ebright, R.H. 登録日 2019-08-18 公開日 2020-03-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.197 Å) 主引用文献 RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KQD	Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 3 nt 分子名称: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), ... 著者 Zhang, Y, Li, L, Ebright, R.H. 登録日 2019-08-17 公開日 2020-03-11 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6KQL	Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 4 nt 分子名称: DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Zhang, Y, Li, L, Ebright, R.H. 登録日 2019-08-18 公開日 2020-03-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6TYF	Crystal structure of MTB sigma L transcription initiation complex with 6 nt long RNA primer 分子名称: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*AP*TP*CP*GP*AP*GP*GP*GP*T)-3'), DNA (5'-D(P*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Molodtsov, V, Ebright, R.H. 登録日 2019-08-08 公開日 2020-03-11 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6QCX	Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer 分子名称: MAGNESIUM ION, PHOSPHATE ION, PYROPHOSPHATE 2-, ... 著者 Cusack, S, Drncova, P. 登録日 2018-12-31 公開日 2019-06-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
6QCW	Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer 分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Cusack, S, Drncova, P. 登録日 2018-12-31 公開日 2019-06-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
6TYE	Crystal structure of MTB sigma L transcription initiation complex with 5 nt long RNA primer 分子名称: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*AP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(P*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Molodtsov, V, Ebright, R.H. 登録日 2019-08-08 公開日 2020-03-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.79 Å) 主引用文献 RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6QCV	Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP 分子名称: CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Cusack, S, Drncova, P. 登録日 2018-12-31 公開日 2019-06-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
4Y2C	M300V 3D polymerase mutant of EMCV 分子名称: GLYCEROL, Genome polyprotein 著者 Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L. 登録日 2015-02-09 公開日 2015-04-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015
8OKI	Cryo-EM structure of Pyrococcus furiosus transcription elongation complex bound to Spt4/5 分子名称: DNA Non-Template Strand, DNA Template Strand, DNA-directed RNA polymerase subunit Rpo10, ... 著者 Tarau, D.M, Reichelt, R, Heiss, F.B, Pilsl, M, Hausner, W, Engel, C, Grohmann, D. 登録日 2023-03-28 公開日 2024-04-24 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment. Nucleic Acids Res., 52, 2024
6L74	Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 2 nt 分子名称: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Zhang, Y, Li, L, Ebright, R.H. 登録日 2019-10-31 公開日 2020-03-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
5O7X	CRYSTAL STRUCTURE OF S. CEREVISIAE CORE FACTOR AT 3.2A RESOLUTION 分子名称: MAGNESIUM ION, RNA polymerase I-specific transcription initiation factor RRN11, RNA polymerase I-specific transcription initiation factor RRN6, ... 著者 Engel, C, Gubbey, T, Neyer, S, Sainsbury, S, Oberthuer, C, Baejen, C, Bernecky, C, Cramer, P. 登録日 2017-06-09 公開日 2017-08-02 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural Basis of RNA Polymerase I Transcription Initiation. Cell, 169, 2017
5X21	Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM) 分子名称: (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zhang, Y, Ebright, R. 登録日 2017-01-29 公開日 2017-07-05 最終更新日 2022-10-12 実験手法 X-RAY DIFFRACTION (3.323 Å) 主引用文献 Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
5X22	Crystal structure of Thermus thermophilus transcription initiation complex with GpA and CMPcPP 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zhang, Y, Ebright, R. 登録日 2017-01-29 公開日 2017-07-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
4ROE	Human TFIIB-related factor 2 (Brf2) and TBP bound to RPPH1 promoter 分子名称: MAGNESIUM ION, Non-template strand, TATA-box-binding protein, ... 著者 Vannini, A, Gouge, J, Satia, K, Guthertz, N. 登録日 2014-10-28 公開日 2015-12-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2. Cell(Cambridge,Mass.), 163, 2015
4ROC	Human TFIIB-related factor 2 (Brf2) and TBP bound to U6#2 promoter 分子名称: MAGNESIUM ION, Non-template strand, TATA-box-binding protein, ... 著者 Vannini, A, Gouge, J, Satia, K, Guthertz, N. 登録日 2014-10-28 公開日 2015-12-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2. Cell(Cambridge,Mass.), 163, 2015
7RKP	The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with cyclic compound SJ001034733 分子名称: (5R)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2,6(28),11(27),12,14,22,24-octaene-4,7-dione, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2021-07-22 公開日 2022-07-27 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
3H5Y	Norovirus polymerase+primer/template+CTP complex at 6 mM MnCl2 分子名称: 5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3', 5'-R(P*UP*GP*CP*CP*CP*GP*GP*GP*C)-3', CYTIDINE-5'-TRIPHOSPHATE, ... 著者 Zamyatkin, D.F, Parra, F, Machin, A, Grochulski, P, Ng, K.K.S. 登録日 2009-04-22 公開日 2009-05-19 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site. J.Mol.Biol., 390, 2009
7K87	The crystal structure of the 2009 H1N1 PA endonuclease in complex with SJ000986436 分子名称: 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, P.J, Jayaraman, S, Rankovic, Z, White, S.W. 登録日 2020-09-25 公開日 2021-09-29 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
3BSO	Norwalk Virus polymerase bound to cytidine 5'-triphosphate and primer-template RNA 分子名称: CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ... 著者 Zamyatkin, D.F, Ng, K.K.S. 登録日 2007-12-26 公開日 2008-01-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase. J.Biol.Chem., 283, 2008
3BSN	Norwalk Virus polymerase bound to 5-nitrocytidine triphosphate and primer-template RNA 分子名称: 5-nitrocytidine 5'-(tetrahydrogen triphosphate), GLYCEROL, MANGANESE (II) ION, ... 著者 Zamyatkin, D.F, Ng, K.K.S. 登録日 2007-12-26 公開日 2008-01-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase. J.Biol.Chem., 283, 2008
7UUH	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001034732-2 (cis-form) 分子名称: (1P,18Z)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2(28),5,11(27),12,14,18,22,24-nonaene-4,7-dione, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2022-04-28 公開日 2022-11-02 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
5ZVT	Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly 分子名称: C-terminus of outer capsid protein VP5, Core protein VP6, MYRISTIC ACID, ... 著者 Liu, H, Fang, Q, Cheng, L. 登録日 2018-05-12 公開日 2018-07-04 最終更新日 2018-07-25 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7N68	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988288 分子名称: Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, Polymerase acidic protein,Polymerase acidic protein, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2021-06-07 公開日 2022-06-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
3RTX	Crystal structure of mammalian capping enzyme (Mce1) and Pol II CTD complex 分子名称: GUANINE, RNA Polymerase II C-terminal domain, mRNA-capping enzyme 著者 Ghosh, A, Lima, C.D. 登録日 2011-05-04 公開日 2011-06-29 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Structural insights to how mammalian capping enzyme reads the CTD code. Mol.Cell, 43, 2011

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