4CT4
| CNOT1 MIF4G domain - DDX6 complex | 分子名称: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Ozgur, S, Basquin, J, Conti, E. | 登録日 | 2014-03-12 | 公開日 | 2014-05-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and Biochemical Insights to the Role of the Ccr4- not Complex and Ddx6 ATPase in Microrna Repression. Mol.Cell, 54, 2014
|
|
4CRU
| Complex of human CNOT9 and CNOT1 including one tryptophan | 分子名称: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CELL DIFFERENTIATION PROTEIN RCD1 HOMOLOG, GLYCEROL | 著者 | Chen, Y, Boland, A, Izaurralde, E, Weichenrieder, O. | 登録日 | 2014-03-01 | 公開日 | 2014-05-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | A Ddx6-Cnot1 Complex and W-Binding Pockets in Cnot9 Reveal Direct Links between Mirna Target Recognition and Silencing Mol.Cell, 54, 2014
|
|
4CRV
| Complex of human CNOT9 and CNOT1 including two tryptophans | 分子名称: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CELL DIFFERENTIATION PROTEIN RCD1 HOMOLOG, GLYCEROL, ... | 著者 | Boland, A, Chen, Y, Izaurralde, E, Weichenrieder, O. | 登録日 | 2014-03-01 | 公開日 | 2014-05-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | A Ddx6-Cnot1 Complex and W-Binding Pockets in Cnot9 Reveal Direct Links between Mirna Target Recognition and Silencing Mol.Cell, 54, 2014
|
|
4CRW
| Complex of human DDX6 (RECA-C) and CNOT1 (MIF4G) | 分子名称: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, GLYCEROL, PROBABLE ATP-DEPENDENT RNA HELICASE DDX6 | 著者 | Chen, Y, Boland, A, Izaurralde, E, Weichenrieder, O. | 登録日 | 2014-03-01 | 公開日 | 2014-05-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | A Ddx6-Cnot1 Complex and W-Binding Pockets in Cnot9 Reveal Direct Links between Mirna Target Recognition and Silencing Mol.Cell, 54, 2014
|
|
6R8R
| Structure of the Wnt deacylase Notum in complex with isoquinoline 45 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | 著者 | Vecchia, L, Zhao, Y, Ruza, R.R, Jones, E.Y. | 登録日 | 2019-04-02 | 公開日 | 2019-05-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen. Medchemcomm, 10, 2019
|
|
6R8Q
| STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A BENZOTRIAZOLE FRAGMENT | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Palmitoleoyl-protein carboxylesterase NOTUM, ... | 著者 | Ruza, R.R, Vecchia, L, Jones, E.Y. | 登録日 | 2019-04-02 | 公開日 | 2019-05-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen. Medchemcomm, 10, 2019
|
|
7B8J
| Notum-Fragment 163 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Palmitoleoyl-protein carboxylesterase NOTUM, SULFATE ION, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-12 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7B8Z
| Notum-Fragment 277 | 分子名称: | 2-[4-(3-chlorophenyl)piperazin-1-ium-1-yl]ethanenitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-13 | 公開日 | 2022-01-12 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7B8O
| Notum-Fragment 199 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Palmitoleoyl-protein carboxylesterase NOTUM, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-13 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7B8L
| Notum-Fragment 174 | 分子名称: | 1,2-ETHANEDIOL, 2,4-bis(fluoranyl)-6-(1~{H}-pyrazol-3-yl)phenol, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-13 | 公開日 | 2022-01-12 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7B8Y
| Notum-Fragment 276 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(3-ethoxyphenyl)-1,3,4-thiadiazol-2-amine, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-13 | 公開日 | 2022-01-12 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7B8K
| Notum-Fragment 173 | 分子名称: | 1,2-ETHANEDIOL, 1~{H}-benzimidazol-2-ylcyanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-12 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7B8G
| Notum-Fragment 159 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-phenylmethoxyaniline, Palmitoleoyl-protein carboxylesterase NOTUM, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-12 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7B8X
| Notum-Fragment 210 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-13 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7B8C
| Notum-Fragment 147 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methyl-~{N}-(2-methylpropyl)imidazo[1,2-a]pyridine-3-carboxamide, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-12 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7B8F
| Notum-Fragment 154 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(benzimidazol-1-ylmethyl)benzenecarbonitrile, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-12 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7B8D
| Notum-Fragment 151 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-amino-N-(pyridin-2-yl)benzenesulfonamide, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-12 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7B8U
| Notum-Fragment 201 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(piperidin-1-yl)-1,2,5-oxadiazol-3-amine, Palmitoleoyl-protein carboxylesterase NOTUM, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-13 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7B8N
| Notum-Fragment 197 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-azanyl-2-(pyridin-3-ylmethylamino)benzoic acid, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-13 | 公開日 | 2022-01-12 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7B8M
| Notum-Fragment 193 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-methoxy-2-(1~{H}-pyrazol-3-yl)phenol, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-13 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Structural Analysis and Development of Notum Fragment Screening Hits. Acs Chem Neurosci, 13, 2022
|
|
7BLI
| Notum-Bepridil complex | 分子名称: | 1-ISOBUTOXY-2-PYRROLIDINO-3[N-BENZYLANILINO] PROPANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2021-01-18 | 公開日 | 2022-03-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Notum Fragment Screen To Be Published
|
|
7BND
| |
7BLW
| Notum_Piperine complex | 分子名称: | (2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2021-01-19 | 公開日 | 2022-03-02 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Notum Inhibitor To Be Published
|
|
7BM1
| Notum_Valsartan complex | 分子名称: | (2~{S})-3-methyl-2-[pentanoyl-[[4-[2-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2021-01-19 | 公開日 | 2022-03-02 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Notum Inhibitor To Be Published
|
|
7B8A
| Notum-Fragment 110 | 分子名称: | 1,2-ETHANEDIOL, 1-cyclohexyl-3-(2-pyridin-4-ylethyl)urea, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhao, Y, Jonees, E.Y. | 登録日 | 2020-12-12 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | 主引用文献 | Notum Fragment Screen To Be Published
|
|