PDB: 75 件ウェブページステータス検索Chemie searchBIRD

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3K8T	Structure of eukaryotic rnr large subunit R1 complexed with designed adp analog compound 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2'-deoxy-2'-(2-hydroxyethyl)adenosine 5'-(trihydrogen diphosphate), GLYCEROL, ... 著者 Sun, D, Xu, H, Dealwis, C, Lee, R.E. 登録日 2009-10-14 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors Chemmedchem, 4, 2009
3HNE	Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
3HND	Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP and substrate GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
3HNF	Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and dATP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.16 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
3HNC	Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP 分子名称: MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, SULFATE ION, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
2ZLF	The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase 分子名称: FTLDADF, Ribonucleoside-diphosphate reductase large chain 1 著者 Xu, H, Fairman, J.W, Wijerathna, S.R, LaMacchia, J, Kreischer, N.R, Helmbrecht, E, Cooperman, B.S, Dealwis, C. 登録日 2008-04-09 公開日 2008-08-19 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore J.Med.Chem., 51, 2008
2ZLG	The Structual Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase 分子名称: (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL, Ribonucleoside-diphosphate reductase large chain 1 著者 Xu, H, Fairman, J.W, Wijerathna, S.R, LaMacchia, J, Kreischer, N.R, Helmbrecht, E, Cooperman, B.S, Dealwis, C. 登録日 2008-04-09 公開日 2008-08-19 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore J.Med.Chem., 51, 2008
2EUD	Structures of Yeast Ribonucleotide Reductase I complexed with Ligands and Subunit Peptides 分子名称: GEMCITABINE DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Dealwis, C, Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J. 登録日 2005-10-28 公開日 2006-03-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly. Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVX	Structures of Yeast Ribonucleotide Reductase I 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. 登録日 2005-06-14 公開日 2006-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVT	Structures of Yeast Ribonucleotide Reductase I 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribonucleoside-diphosphate reductase large chain 1 著者 Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. 登録日 2005-06-14 公開日 2006-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVV	Structures of Yeast Ribonucleotide Reductase I 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribonucleoside-diphosphate reductase large chain 1, ... 著者 Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. 登録日 2005-06-14 公開日 2006-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVU	Structures of Yeast Ribonucleotide Reductase I 分子名称: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. 登録日 2005-06-14 公開日 2006-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVS	Structures of Yeast Ribonucleotide Reductase I 分子名称: Ribonucleoside-diphosphate reductase large chain 1 著者 Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. 登録日 2005-06-14 公開日 2006-03-07 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVY	Structures of Yeast Ribonucleotide Reductase I 分子名称: 9-per peptide from Ribonucleoside-diphosphate reductase small chain 1, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1, ... 著者 Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. 登録日 2005-06-14 公開日 2006-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
2CVW	Structures of Yeast Ribonucleotide Reductase I 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1, ... 著者 Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. 登録日 2005-06-14 公開日 2006-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
1ZYZ	Structures of Yeast Ribonucloetide Reductase I 分子名称: GLYCINE, Ribonucleoside-diphosphate reductase large chain 1 著者 Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. 登録日 2005-06-13 公開日 2006-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
1ZZD	Structures of Yeast Ribonucleotide Reductase I 分子名称: Ribonucleoside-diphosphate reductase large chain 1, Ribonucleoside-diphosphate reductase small chain 2 著者 Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. 登録日 2005-06-13 公開日 2006-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
6R1R	RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN 著者 Eriksson, M, Eklund, H. 登録日 1997-09-17 公開日 1998-03-18 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J.Biol.Chem., 272, 1997
7R1R	RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN 著者 Eriksson, M, Eklund, H. 登録日 1997-09-17 公開日 1998-03-18 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J.Biol.Chem., 272, 1997
5R1R	RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN 著者 Eriksson, M, Eklund, H. 登録日 1997-09-17 公開日 1998-03-18 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase. J.Biol.Chem., 272, 1997
4R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI 分子名称: GUANOSINE-5'-DIPHOSPHATE, RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, ... 著者 Eriksson, M, Eklund, H. 登録日 1997-07-22 公開日 1998-01-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
2R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH DTTP OCCUPYING THE SPECIFICITY SITE FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, THYMIDINE-5'-TRIPHOSPHATE 著者 Eriksson, M, Eklund, H. 登録日 1997-07-21 公開日 1998-01-28 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
3R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH AMPPNP OCCUPYING THE ACTIVITY SITE FROM ESCHERICHIA COLI 分子名称: ADENOSINE-5'-TRIPHOSPHATE, RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN 著者 Eriksson, M, Eklund, H. 登録日 1997-07-21 公開日 1998-01-28 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
1R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN 著者 Eriksson, M, Eklund, H. 登録日 1997-07-15 公開日 1998-01-28 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
1RLR	STRUCTURE OF RIBONUCLEOTIDE REDUCTASE PROTEIN R1 分子名称: RIBONUCLEOTIDE REDUCTASE PROTEIN R1 著者 Uhlin, U, Eklund, H. 登録日 1994-08-12 公開日 1996-12-23 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of ribonucleotide reductase protein R1. Nature, 370, 1994

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