PDB: 88 件ウェブページステータス検索Chemie searchBIRD

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5ETV	S. aureus 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.72 angstrom resolution 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-azanyl-8-[2-(4-bromophenyl)-2-oxidanylidene-ethyl]sulfanyl-1,9-dihydropurin-6-one, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... 著者 Dennis, M.L, Peat, T.S, Swarbrick, J.D. 登録日 2015-11-18 公開日 2016-05-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli. J.Med.Chem., 59, 2016
5ETS	S. aureus 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.95 angstrom resolution 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-azanyl-8-[(4-chlorophenyl)methylsulfanyl]-1,9-dihydropurin-6-one, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... 著者 Dennis, M.L, Peat, T.S, Swarbrick, J.D. 登録日 2015-11-18 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli. J.Med.Chem., 59, 2016
5ETT	S. aureus 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.55 angstrom resolution 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 4-[(2-azanyl-6-oxidanylidene-1,9-dihydropurin-8-yl)sulfanylmethyl]-3-fluoranyl-benzenecarbonitrile, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... 著者 Dennis, M.L, Peat, T.S, Swarbrick, J.D. 登録日 2015-11-18 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli. J.Med.Chem., 59, 2016
5ETQ	S. aureus 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.96 angstrom resolution 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 4-{[(2-amino-6-oxo-6,9-dihydro-1H-purin-8-yl)sulfanyl]methyl}benzonitrile, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... 著者 Dennis, M.L, Peat, T.S, Swarbrick, J.D. 登録日 2015-11-18 公開日 2016-05-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli. J.Med.Chem., 59, 2016
5ETP	E. coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.05 angstrom resolution 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-azanyl-8-[2-(4-bromophenyl)-2-oxidanylidene-ethyl]sulfanyl-1,9-dihydropurin-6-one, CALCIUM ION, ... 著者 Dennis, M.L, Peat, T.S, Swarbrick, J.D. 登録日 2015-11-17 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli. J.Med.Chem., 59, 2016
5ETR	S. aureus 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.32 angstrom resolution 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-azanyl-8-[(4-fluorophenyl)methylsulfanyl]-1,7-dihydropurin-6-one, CHLORIDE ION, ... 著者 Dennis, M.L, Peat, T.S, Swarbrick, J.D. 登録日 2015-11-18 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli. J.Med.Chem., 59, 2016
3ILL	Crystal structure of E. coli HPPK(D97A) 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, CHLORIDE ION 著者 Blaszczyk, J, Li, Y, Yan, H, Ji, X. 登録日 2009-08-07 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Structural and functional roles of residues D95 and D97 in E. coli HPPK To be Published
3ILI	Crystal structure of E. coli HPPK(D95A) 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ACETATE ION, ... 著者 Blaszczyk, J, Li, Y, Yan, H, Ji, X. 登録日 2009-08-07 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural and functional roles of residues D95 and D97 in E. coli HPPK To be Published
3IP0	Crystal structure of E. coli HPPK in complex with MgAMPCPP and 6-hydroxymethylpterin/6-carboxypterin 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 6-CARBOXYPTERIN, 6-HYDROXYMETHYLPTERIN, ... 著者 Blaszczyk, J, Ji, X. 登録日 2009-08-15 公開日 2009-08-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (0.89 Å) 主引用文献 Dynamic roles of arginine residues 82 and 92 of Escherichia coli 6-hydroxymethyl-7,8-dihydroptein pyrophosphokinase: Crystallographic studies Biochemistry, 42, 2003
3ILO	Crystal structure of E. coli HPPK(D97A) in complex with MgAMPCPP and 6-hydroxymethyl-7,8-dihydropterin 分子名称: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ACETATE ION, ... 著者 Blaszczyk, J, Li, Y, Yan, H, Ji, X. 登録日 2009-08-07 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Structural and functional roles of residues D95 and D97 in E. coli HPPK To be Published
3KUE	Crystal structure of E. coli HPPK(E77A) 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ACETATE ION, CHLORIDE ION 著者 Blaszczyk, J, Li, Y, Yan, H, Ji, X. 登録日 2009-11-27 公開日 2010-11-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.538 Å) 主引用文献 Roles of residues E77 and H115 in E. coli HPPK To be Published
3KUG	Crystal structure of E. coli HPPK(H115A) 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase 著者 Blaszczyk, J, Li, Y, Yan, H, Ji, X. 登録日 2009-11-27 公開日 2010-11-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.996 Å) 主引用文献 Roles of residues E77 and H115 in E. coli HPPK To be Published
3KUH	Crystal structure of E. coli HPPK(H115A) in complex with AMPCPP and HP 分子名称: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ACETATE ION, ... 著者 Blaszczyk, J, Li, Y, Yan, H, Ji, X. 登録日 2009-11-27 公開日 2010-11-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Roles of residues E77 and H115 in E. coli HPPK To be Published
3HSZ	Crystal structure of E. coli HPPK(F123A) 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CHLORIDE ION, ... 著者 Blaszczyk, J, Li, Y, Yan, H, Ji, X. 登録日 2009-06-11 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK To be Published
3HSG	Crystal structure of E. coli HPPK(Y53A) in complex with MgAMPCPP 分子名称: ACETATE ION, CHLORIDE ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... 著者 Blaszczyk, J, Li, Y, Yan, H, Ji, X. 登録日 2009-06-10 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.14 Å) 主引用文献 Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK To be Published
3HSJ	Crystal structure of E. coli HPPK(N55A) 分子名称: ACETATE ION, GLYCEROL, HPPK 著者 Blaszczyk, J, Li, Y, Yan, H, Ji, X. 登録日 2009-06-10 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK To be Published
3HSD	Crystal structure of E. coli HPPK(Y53A) 分子名称: CHLORIDE ION, GLYCEROL, HPPK, ... 著者 Blaszczyk, J, Li, Y, Yan, H, Ji, X. 登録日 2009-06-10 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.652 Å) 主引用文献 Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK. To be Published
3ILJ	Crystal structure of E. coli HPPK(D95A) in complex with MgAMPCPP 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ACETATE ION, CHLORIDE ION, ... 著者 Blaszczyk, J, Li, Y, Yan, H, Ji, X. 登録日 2009-08-07 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural and functional roles of residues D95 and D97 in E. coli HPPK To be Published
3HT0	Crystal structure of E. coli HPPK(F123A) in complex with MgAMPCPP 分子名称: CHLORIDE ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, HPPK, ... 著者 Blaszczyk, J, Li, Y, Yan, H, Ji, X. 登録日 2009-06-11 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK To be Published
2CG8	The bifunctional dihydroneopterin aldolase 6-hydroxymethyl-7,8- dihydropterin synthase from Streptococcus pneumoniae 分子名称: DIHYDRONEOPTERIN ALDOLASE 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN SYNTHASE 著者 Garcon, A, Levy, C, Derrick, J.P. 登録日 2006-02-28 公開日 2006-06-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal Structure of the Bifunctional Dihydroneopterin Aldolase/6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase from Streptococcus Pneumoniae. J.Mol.Biol., 360, 2006
6KCM	Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613S with pterin and p-hydrobenzoate 分子名称: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase, ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Chitnumsub, P, Jaruwat, A, Yuthavong, Y. 登録日 2019-06-28 公開日 2020-02-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance. Febs J., 287, 2020
7MPY	Crystal structure of cytosolic HPPK-DHPS from A.thaliana 分子名称: Folate synthesis bifunctional protein 著者 Vadlamani, G, Bond, C.S. 登録日 2021-05-05 公開日 2021-12-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of Arabidopsis thaliana HPPK/DHPS, a bifunctional enzyme and target of the herbicide asulam. Plant Commun., 3, 2022
4PZV	Crystal structure of Francisella tularensis HPPK-DHPS in complex with bisubstrate analog HPPK inhibitor J1D 分子名称: 1,2-ETHANEDIOL, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase, 5'-{[2-({N-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)carbonyl]glycyl}amino)ethyl]sulfonyl}-5'-deoxyadenosine 著者 Shaw, G.X, Shi, G, Ji, X. 登録日 2014-03-31 公開日 2014-07-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.704 Å) 主引用文献 Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis. Febs J., 281, 2014
5Z79	Crystal Structure Analysis of the HPPK-DHPS in complex with substrates 分子名称: 4-AMINOBENZOIC ACID, 5'-DEOXYADENOSINE, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, ... 著者 Manickam, Y, Karl, H, Sharma, A. 登録日 2018-01-27 公開日 2018-08-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance J. Biol. Chem., 293, 2018
8SL9	Crystal structure of Francisella tularensis HPPK-DHPS in complex with HPPK inhibitor HP-73 分子名称: 1,2-ETHANEDIOL, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]-5'-thioadenosine, ... 著者 Shaw, G.X, Shi, G, Cherry, S, Needle, D, Tropea, J.E, Waugh, D.S, Ji, X. 登録日 2023-04-21 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal structure of Francisella tularensis HPPK-DHPS in complex with HPPK inhibitor HP-73 To be published

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