PDB: 4050 件ウェブページステータス検索Chemie searchBIRD

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1XUH	TRYPSIN-KETO-BABIM-CO+2, PH 8.2 分子名称: BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANONE, CALCIUM ION, COBALT (II) ION, ... 著者 Katz, B.A, Clark, J.M, Finer-Moore, J.S, Jenkins, T.E, Johnson, C.R, Rose, M.J, Luong, C, Moore, W.R, Stroud, R.M. 登録日 1997-10-10 公開日 1998-11-11 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998
1XUF	TRYPSIN-BABIM-ZN+2, PH 8.2 分子名称: BIS(5-AMIDINO-BENZIMIDAZOLYL)METHANE ZINC, CALCIUM ION, TRYPSIN 著者 Katz, B.A, Clark, J.M, Finer-Moore, J.S, Jenkins, T.E, Johnson, C.R, Rose, M.J, Luong, C, Moore, W.R, Stroud, R.M. 登録日 1997-10-10 公開日 1998-12-16 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998
1XUG	TRYPSIN-BABIM-ZN+2, PH 8.2 分子名称: BIS(5-AMIDINO-BENZIMIDAZOLYL)METHANE, CALCIUM ION, TRYPSIN, ... 著者 Katz, B.A, Clark, J.M, Finer-Moore, J.S, Jenkins, T.E, Johnson, C.R, Rose, M.J, Luong, C, Moore, W.R, Stroud, R.M. 登録日 1997-10-10 公開日 1998-12-16 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998
1XUK	TRYPSIN-BABIM-SULFATE, PH 5.9 分子名称: BIS(5-AMIDINO-BENZIMIDAZOLYL)METHANE, CALCIUM ION, SULFATE ION, ... 著者 Katz, B.A, Clark, J.M, Finer-Moore, J.S, Jenkins, T.E, Johnson, C.R, Rose, M.J, Luong, C, Moore, W.R, Stroud, R.M. 登録日 1997-10-10 公開日 1998-11-11 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998
1XUI	TRYPSIN-KETO-BABIM, ZN+2-FREE, PH 8.2 分子名称: BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANONE, CALCIUM ION, SODIUM ION, ... 著者 Katz, B.A, Clark, J.M, Finer-Moore, J.S, Jenkins, T.E, Johnson, C.R, Rose, M.J, Luong, C, Moore, W.R, Stroud, R.M. 登録日 1997-10-10 公開日 1998-11-11 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Design of potent selective zinc-mediated serine protease inhibitors. Nature, 391, 1998
2IT7	Solution structure of the squash trypsin inhibitor EETI-II 分子名称: Trypsin inhibitor 2 著者 Chiche, L, Heitz, A, Le-Nguyen, D. 登録日 2006-10-19 公開日 2007-10-02 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Knottin cyclization: Structure and stability of cyclic and linear squash inhibitors do not differ significantly To be Published
3I2X	Crystal structure of a chimeric trypsin inhibitor having reactive site loop of ETI on the scaffold of WCI 分子名称: Chymotrypsin inhibitor 3 著者 Sen, U, Khamrui, S, Dasgupta, J, Dattagupta, J.K, Majumder, S. 登録日 2009-06-30 公開日 2010-02-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Identification of a novel set of scaffolding residues that are instrumental for the inhibitory property of Kunitz (STI) inhibitors. Protein Sci., 19, 2010
3QYD	Crystal structure of a recombinant chimeric trypsin inhibitor 分子名称: Chymotrypsin inhibitor 3 著者 Sen, U, Majumder, S, Khamrui, S, Dasgupta, J. 登録日 2011-03-03 公開日 2011-05-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 Role of remote scaffolding residues in the inhibitory loop pre-organization, flexibility, rigidification and enzyme inhibition of serine protease inhibitors Biochim.Biophys.Acta, 1824, 2012
1EJM	CRYSTAL STRUCTURE OF THE BPTI ALA16LEU MUTANT IN COMPLEX WITH BOVINE TRYPSIN 分子名称: BETA-TRYPSIN, PANCREATIC TRYPSIN INHIBITOR, SULFATE ION 著者 Otlewski, J, Smalas, A, Helland, R, Grzesiak, A, Krowarsch, D. 登録日 2000-03-03 公開日 2001-03-03 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Substitutions at the P(1) position in BPTI strongly affect the association energy with serine proteinases. J.Mol.Biol., 301, 2000
1GHA	A SECOND ACTIVE SITE IN CHYMOTRYPSIN? THE X-RAY CRYSTAL STRUCTURE OF N-ACETYL-D-TRYPTOPHAN BOUND TO GAMMA-CHYMOTRYPSIN 分子名称: GAMMA-CHYMOTRYPSIN A, ISOPROPYL ALCOHOL, PRO GLY VAL TYR PEPTIDE, ... 著者 Yennawar, H.P, Yennawar, N.H, Farber, G.K. 登録日 1994-04-06 公開日 1994-06-22 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A STRUCTURAL EXPLANATION FOR ENZYME MEMORY IN NONAQUEOUS SOLVENTS. J.Am.Chem.Soc., 117, 1995
2BEA	Crystal structure of Asn14 to Gly mutant of WCI 分子名称: Chymotrypsin inhibitor 3 著者 Dattagupta, J.K, Sen, U, Dasgupta, J, Khamrui, S. 登録日 2005-10-24 公開日 2006-06-13 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Spacer Asn Determines the Fate of Kunitz (STI) Inhibitors, as Revealed by Structural and Biochemical Studies on WCI Mutants. Biochemistry, 45, 2006
2IT8	Solution structure of a linear analog of the cyclic squash trypsin inhibitor MCoTI-II 分子名称: Trypsin inhibitor 2 著者 Avrutina, O, Chiche, L, Diederichsen, U, Heitz, A, Kolmar, H. 登録日 2006-10-19 公開日 2007-10-02 最終更新日 2014-04-02 実験手法 SOLUTION NMR 主引用文献 Knottin cyclization: Structure and stability of cyclic and linear squash inhibitors do not differ significantly To be Published
1OPH	NON-COVALENT COMPLEX BETWEEN ALPHA-1-PI-PITTSBURGH AND S195A TRYPSIN 分子名称: Alpha-1-antitrypsin precursor, Trypsinogen, cationic precursor 著者 Dementiev, A, Simonovic, M, Volz, K, Gettins, P.G. 登録日 2003-03-05 公開日 2003-08-05 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases J.Biol.Chem., 278, 2003
1BTX	Episelection: Novel Ki ~Nanomolar Inhibitors of Serine Proteases Selected by Binding or Chemistry on an Enzyme Surface 分子名称: BETA-TRYPSIN, CALCIUM ION, N-(tert-butoxycarbonyl)-L-alanyl-N-[(1S)-5-amino-1-(diethoxyboranyl)pentyl]-L-valinamide 著者 Stroud, R.M, Katz, B.A, Finer-Moore, J. 登録日 1995-05-17 公開日 1995-10-15 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface. Biochemistry, 34, 1995
1BTZ	Episelection: novel KI ~nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface 分子名称: BETA-TRYPSIN, CALCIUM ION, N-(tert-butoxycarbonyl)-L-alanyl-N-{(1R)-5-ammonio-1-[hydroxy(methoxy)boranyl]pentyl}-L-valinamide 著者 Stroud, R.M, Katz, B.A, Finer-Moore, J. 登録日 1995-05-17 公開日 1995-10-15 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface. Biochemistry, 34, 1995
1BTW	Episelection: novel KI ~nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface 分子名称: BETA-TRYPSIN, CALCIUM ION, N-(tert-butoxycarbonyl)-L-alanyl-N-{(1S)-5-ammonio-1-[hydroxy(3-hydroxypropoxy)boranyl]pentyl}-L-valinamide 著者 Stroud, R.M, Katz, B.A, Finer-Moore, J. 登録日 1995-05-17 公開日 1995-10-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface. Biochemistry, 34, 1995
5OM7	Crystal structure of Alpha1-antichymotrypsin variant DBS-II: a drug-binding serpin for doxorubicin 分子名称: Alpha-1-antichymotrypsin, DOXORUBICIN 著者 Schmidt, K, Kern, A, Muller, Y.A. 登録日 2017-07-28 公開日 2018-05-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.727 Å) 主引用文献 Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HGH	Crystal structure of Alpha1-antichymotrypsin variant NewBG-III: a new binding globulin without any bound ligand 分子名称: Alpha-1-antichymotrypsin, MALONIC ACID, alpha1-Antichymotrypsin 著者 Schmidt, K, Muller, Y.A. 登録日 2018-08-23 公開日 2019-05-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy. J.Struct.Biol., 207, 2019
6HGE	Crystal structure of Alpha1-antichymotrypsin variant NewBG-I in the uncleaved S-conformation 分子名称: Alpha-1-antichymotrypsin 著者 Gardill, B.R, Schmidt, K, Muller, Y.A. 登録日 2018-08-23 公開日 2019-05-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy. J.Struct.Biol., 207, 2019
6HGL	Crystal structure of Alpha1-antichymotrypsin variant NewBG-III: a new binding globulin in complex with testosterone 分子名称: Alpha-1-antichymotrypsin, TESTOSTERONE 著者 Schmidt, K, Muller, Y.A. 登録日 2018-08-23 公開日 2019-05-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy. J.Struct.Biol., 207, 2019
6HGI	Crystal structure of Alpha1-antichymotrypsin variant NewBG-III: a new binding globulin in complex with corticosterone 分子名称: Alpha-1-antichymotrypsin, CORTICOSTERONE 著者 Schmidt, K, Muller, Y.A. 登録日 2018-08-23 公開日 2019-05-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.517 Å) 主引用文献 NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy. J.Struct.Biol., 207, 2019
6HGD	Crystal structure of Alpha1-antichymotrypsin variant NewBG-0: a new binding globulin variant that is devoid of any cortisol-binding capabilities 分子名称: Alpha-1-antichymotrypsin 著者 Gardill, B.R, Schmidt, K, Muller, Y.A. 登録日 2018-08-23 公開日 2019-05-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy. J.Struct.Biol., 207, 2019
3NDD	Cleaved antitrypsin with P10 Pro, and P9-P6 Asp 分子名称: Alpha-1-antitrypsin 著者 Yamasaki, M, Sendall, T.J, Huntington, J.A. 登録日 2010-06-07 公開日 2010-07-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations J. Biol. Chem., 285, 2010
3NDF	Cleaved antitrypsin with P8-P6 Asp 分子名称: Alpha-1-antitrypsin 著者 Huntington, J.A, Sendall, T.J, Yamasaki, M. 登録日 2010-06-07 公開日 2010-07-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations J. Biol. Chem., 285, 2010
1QMB	Cleaved alpha-1-antitrypsin polymer 分子名称: ALPHA-1-ANTITRYPSIN 著者 Huntington, J.A, Pannu, N.S, Hazes, B, Read, R.J, Lomas, D.A, Carrell, R.W. 登録日 1999-09-24 公開日 2000-02-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A 2.6A Structure of a Serpin Polymer and Implications for Conformational Disease J.Mol.Biol., 293, 1999

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