8F0P
| Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-1305 | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Kschonsak, M, Jao, C.C, Arthur, C.P, Rohou, A.L, Bergeron, P, Ortwine, D, McKerall, S.J, Hackos, D.H, Deng, L, Chen, J, Sutherlin, D, Dragovich, P.S, Volgraf, M, Wright, M.R, Payandeh, J, Ciferri, C, Tellis, J.C. | 登録日 | 2022-11-03 | 公開日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors. Elife, 12, 2023
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8F0R
| Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the arylsulfonamide inhibitor GNE-3565 | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-4-({(1S,2S,4S)-2-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]cyclohexyl}amino)-2-fluoro-N-(pyrimidin-4-yl)benzene-1-sulfonamide, ... | 著者 | Kschonsak, M, Jao, C.C, Arthur, C.P, Rohou, A.L, Bergeron, P, Ortwine, D, McKerall, S.J, Hackos, D.H, Deng, L, Chen, J, Sutherlin, D, Dragovich, P.S, Volgraf, M, Wright, M.R, Payandeh, J, Ciferri, C, Tellis, J.C. | 登録日 | 2022-11-03 | 公開日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors. Elife, 12, 2023
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6S1U
| Crystal structure of dimeric M-PMV protease C7A/D26N/C106A mutant in complex with inhibitor | 分子名称: | Gag-Pro-Pol polyprotein, PRO-0A1-VAL-PSA-ALA-MET-THR | 著者 | Wosicki, S, Gilski, M, Jaskolski, M, Zabranska, H, Pichova, I. | 登録日 | 2019-06-19 | 公開日 | 2019-10-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Comparison of a retroviral protease in monomeric and dimeric states. Acta Crystallogr D Struct Biol, 75, 2019
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6S1W
| Crystal structure of dimeric M-PMV protease D26N mutant | 分子名称: | Gag-Pro-Pol polyprotein | 著者 | Wosicki, S, Gilski, M, Jaskolski, M, Zabranska, H, Pichova, I. | 登録日 | 2019-06-19 | 公開日 | 2019-10-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Comparison of a retroviral protease in monomeric and dimeric states. Acta Crystallogr D Struct Biol, 75, 2019
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4U14
| Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L) | 分子名称: | (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, Muscarinic acetylcholine receptor M3,Endolysin,Muscarinic acetylcholine receptor M3 | 著者 | Thorsen, T.S, Matt, R.A, Weis, W.I, Kobilka, B.K. | 登録日 | 2014-07-15 | 公開日 | 2014-11-26 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.57 Å) | 主引用文献 | Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis. Structure, 22, 2014
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6S1V
| Crystal structure of dimeric M-PMV protease D26N mutant in complex with inhibitor | 分子名称: | Gag-Pro-Pol polyprotein, PRO-0A1-VAL-PSA-ALA-MET-THR | 著者 | Wosicki, S, Gilski, M, Jaskolski, M, Zabranska, H, Pichova, I. | 登録日 | 2019-06-19 | 公開日 | 2019-10-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Comparison of a retroviral protease in monomeric and dimeric states. Acta Crystallogr D Struct Biol, 75, 2019
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4TSS
| TOXIC SHOCK SYNDROME TOXIN-1: TETRAGONAL P4(1)2(1)2 CRYSTAL FORM | 分子名称: | TOXIC SHOCK SYNDROME TOXIN-1, ZINC ION | 著者 | Prasad, G.S, Radhakrishnan, R, Mitchell, D.T, Earhart, C.A, Dinges, M.M, Cook, W.J, Schlivert, P.M, Ohlendorf, D.H. | 登録日 | 1996-12-11 | 公開日 | 1997-12-24 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity. Protein Sci., 6, 1997
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8FLL
| Crystal structure of BTK kinase domain in complex with pirtobrutinib | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, SULFATE ION, ... | 著者 | Cedervall, E.P, Morales, T.H, Allerston, C.K. | 登録日 | 2022-12-21 | 公開日 | 2023-03-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.498 Å) | 主引用文献 | Preclinical characterization of pirtobrutinib, a highly selective, noncovalent (reversible) BTK inhibitor. Blood, 142, 2023
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8FYN
| MicroED structure of A2A from plasma milled lamellae | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ... | 著者 | Martynowycz, M.W, Shiriaeva, A, Clabbers, M.T.B, Nicolas, W.J, Weaver, S.J, Hattne, J, Gonen, T. | 登録日 | 2023-01-26 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-22 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2 Å) | 主引用文献 | A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals. Nat Commun, 14, 2023
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4U3X
| Structure of a human VH antibody domain binding to the cleft of hen egg lysozyme | 分子名称: | 1,2-ETHANEDIOL, Human VH domain antibody, Lysozyme C | 著者 | Rouet, R, Langley, D.B, Christ, D. | 登録日 | 2014-07-23 | 公開日 | 2015-03-11 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies J.Biol.Chem., 290, 2015
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4TW1
| Crystal structure of the octameric pore complex of the Staphylococcus aureus Bi-component Toxin LukGH | 分子名称: | Possible leukocidin subunit | 著者 | Logan, D.T, Hakansson, M, Saline, M, Kimbung, R, Badarau, A, Rouha, H, Nagy, E. | 登録日 | 2014-06-29 | 公開日 | 2014-11-12 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure-Function Analysis of Heterodimer Formation, Oligomerization, and Receptor Binding of the Staphylococcus aureus Bi-component Toxin LukGH. J.Biol.Chem., 290, 2015
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1NLI
| Complex of [E160A-E189A] trichosanthin and adenine | 分子名称: | ADENINE, Ribosome-inactivating protein alpha-trichosanthin | 著者 | Shaw, P.C, Wong, K.B, Chan, D.S.B, Williams, R.L. | 登録日 | 2003-01-07 | 公開日 | 2003-01-21 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structural basis for the interaction of [E160A-E189A]-trichosanthin with adenine. Toxicon, 41, 2003
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1N92
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1NDM
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8I09
| Crystal structure of serine acetyltransferase from Salmonella typhimurium complexed with butyl gallate | 分子名称: | CYSTEINE, PHOSPHATE ION, Serine acetyltransferase, ... | 著者 | Toyomoto, T, Ono, K, Shiba, T, Momitani, K, Zhang, T, Tsutsuki, H, Ishikawa, T, Hoso, K, Hamada, K, Rahman, A, Zhong, H, Akaike, T, Yamamoto, K, Matsuoka, M, Hanaoka, K, Niidome, T, Sawa, T. | 登録日 | 2023-01-10 | 公開日 | 2023-11-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Alkyl gallates inhibit serine O -acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics. Front Microbiol, 14, 2023
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8I06
| Crystal structure of serine acetyltransferase from Salmonella typhimurium complexed with CoA | 分子名称: | COENZYME A, CYSTEINE, Serine acetyltransferase | 著者 | Toyomoto, T, Ono, K, Shiba, T, Momitani, K, Zhang, T, Tsutsuki, H, Ishikawa, T, Hoso, K, Hamada, K, Rahman, A, Zhong, H, Akaike, T, Yamamoto, K, Matsuoka, M, Hanaoka, K, Niidome, T, Sawa, T. | 登録日 | 2023-01-10 | 公開日 | 2023-11-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Alkyl gallates inhibit serine O -acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics. Front Microbiol, 14, 2023
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8I04
| Crystal structure of serine acetyltransferase from Salmonella typhimurium complexed with serine | 分子名称: | PHOSPHATE ION, SERINE, Serine acetyltransferase | 著者 | Toyomoto, T, Ono, K, Shiba, T, Momitani, K, Zhang, T, Tsutsuki, H, Ishikawa, T, Hoso, K, Hamada, K, Rahman, A, Zhong, H, Akaike, T, Yamamoto, K, Matsuoka, M, Hanaoka, K, Niidome, T, Sawa, T. | 登録日 | 2023-01-10 | 公開日 | 2023-11-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Alkyl gallates inhibit serine O -acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics. Front Microbiol, 14, 2023
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8I6U
| The cryo-EM structure of OsCyc1 dimer state | 分子名称: | Syn-copalyl diphosphate synthase, chloroplastic | 著者 | Ma, X.L, Xu, H.F, Tong, Y.R, Luo, Y.F, Dong, Q.H, Jiang, T. | 登録日 | 2023-01-29 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (7.9 Å) | 主引用文献 | Structural and functional investigations of syn-copalyl diphosphate synthase from Oryza sativa. Commun Chem, 6, 2023
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8I6T
| The cryo-EM structure of OsCyc1 hexamer state | 分子名称: | Syn-copalyl diphosphate synthase, chloroplastic | 著者 | Ma, X.L, Xu, H.F, Tong, Y.R, Luo, Y.F, Dong, Q.H, Jiang, T. | 登録日 | 2023-01-29 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural and functional investigations of syn-copalyl diphosphate synthase from Oryza sativa. Commun Chem, 6, 2023
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8I6P
| The cryo-EM structure of OsCyc1 tetramer state | 分子名称: | Syn-copalyl diphosphate synthase, chloroplastic | 著者 | Ma, X.L, Xu, H.F, Tong, Y.R, Luo, Y.F, Dong, Q.H, Jiang, T. | 登録日 | 2023-01-29 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural and functional investigations of syn-copalyl diphosphate synthase from Oryza sativa. Commun Chem, 6, 2023
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8IH5
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1NU1
| Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO) | 分子名称: | 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE, Cytochrome b, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Gao, X, Wen, X, Esser, L, Quinn, B, Yu, L, Yu, C.-A, Xia, D. | 登録日 | 2003-01-30 | 公開日 | 2003-10-07 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for the quinone reduction in the bc(1) complex: a comparative analysis of crystal structures of mitochondrial cytochrome bc(1) with bound substrate and inhibitors at the Q(i) site Biochemistry, 42, 2003
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8IDU
| Crystal structure of substrate bound-form dehydroquinate dehydratase from Corynebacterium glutamicum | 分子名称: | 1,3,4-TRIHYDROXY-5-OXO-CYCLOHEXANECARBOXYLIC ACID, 3-dehydroquinate dehydratase, GLYCEROL, ... | 著者 | Lee, C.H, Kim, S, Kim, K.-J. | 登録日 | 2023-02-14 | 公開日 | 2023-12-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and Biochemical Analysis of 3-Dehydroquinate Dehydratase from Corynebacterium glutamicum . J Microbiol Biotechnol., 33, 2023
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8IDR
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8Q6T
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