PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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2C5O	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design 分子名称: 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 著者 Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. 登録日 2005-10-30 公開日 2006-03-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006
2C5Y	DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN 分子名称: CELL DIVISION PROTEIN KINASE 2, HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM 著者 Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. 登録日 2005-11-03 公開日 2006-03-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006
2C6O	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 分子名称: CELL DIVISION PROTEIN KINASE 2, O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE 著者 Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. 登録日 2005-11-10 公開日 2005-12-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR. Bioorg. Med. Chem. Lett., 16, 2006
2C6L	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 分子名称: 4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 著者 Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. 登録日 2005-11-10 公開日 2005-12-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
6WGF	Atomic model of mutant Mcm2-7 hexamer with Mcm6 WHD truncation 分子名称: DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ... 著者 Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. 登録日 2020-04-05 公開日 2020-07-15 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (7.7 Å) 主引用文献 Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
2C6T	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 分子名称: 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 著者 Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. 登録日 2005-11-11 公開日 2005-12-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
6YW6	Cryo-EM structure of the ARP2/3 1B5CL isoform complex. 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ARPC1B, Actin-related protein 2, ... 著者 von Loeffelholz, O, Moores, C, Purkiss, A. 登録日 2020-04-29 公開日 2020-07-22 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms. Biol Open, 9, 2020
2C69	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 分子名称: (5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE, CELL DIVISION PROTEIN KINASE 2 著者 Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. 登録日 2005-11-08 公開日 2005-12-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR. Bioorg. Med. Chem. Lett., 16, 2006
2BEC	Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into the mechanism of pH regulation 分子名称: Calcineurin B homologous protein 2, Sodium/hydrogen exchanger 1, YTTRIUM (III) ION 著者 Ben Ammar, Y, Takeda, S, Hisamitsu, T, Mori, H, Wakabayashi, S. 登録日 2005-10-24 公開日 2006-06-27 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation Embo J., 25, 2006
6YW7	Cryo-EM structure of the ARP2/3 1A5C isoform complex. 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1A, ... 著者 von Loeffelholz, O, Moores, C, Purkiss, A. 登録日 2020-04-29 公開日 2020-07-22 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms. Biol Open, 9, 2020
2BPM	STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529 分子名称: (2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... 著者 Cameron, A, Fogliatto, G, Pevarello, P, Brasca, M.G, Orsini, P, Traquandi, G, Longo, A, Nesi, M, Orzi, F, Piutti, C, Sansonna, P, Varasi, M, Vulpetti, A, Roletto, F, Alzani, R, Ciomei, M, Albanese, C, Pastori, W, Marsiglio, A, Pesenti, E, Fiorentini, F, Bischoff, J.R, Mercurio, C. 登録日 2005-04-21 公開日 2005-12-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 3-Aminopyrazole Inhibitors of Cdk2-Cyclin a as Antitumor Agents. 2. Lead Optimization J.Med.Chem., 48, 2005
2DA1	Solution structure of the first homeobox domain of AT-binding transcription factor 1 (ATBF1) 分子名称: Alpha-fetoprotein enhancer binding protein 著者 Ohnishi, S, Kigawa, T, Tomizawa, T, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-13 公開日 2006-06-13 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the first homeobox domain of AT-binding transcription factor 1 (ATBF1) To be Published
2DA6	Solution structure of the homeobox domain of Hepatocyte nuclear factor 1-beta (HNF-1beta) 分子名称: Hepatocyte nuclear factor 1-beta 著者 Ohnishi, S, Kigawa, T, Sato, M, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-13 公開日 2006-12-26 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the homeobox domain of Hepatocyte nuclear factor 1-beta (HNF-1beta) To be Published
2BKR	NEDD8 NEDP1 complex 分子名称: NEDDYLIN, SENTRIN-SPECIFIC PROTEASE 8 著者 Shen, L.N, Liu, H, Dong, C, Xirodimas, D, Naismith, J.H, Hay, R.T. 登録日 2005-02-18 公開日 2005-09-15 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Basis of Nedd8 Ubiquitin Discrimination by the Deneddylating Enzyme Nedp1 Embo J., 24, 2005
2C6K	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor 分子名称: 4-{[5-(CYCLOHEXYLAMINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 著者 Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. 登録日 2005-11-10 公開日 2005-12-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
2BTR	STRUCTURE OF CDK2 COMPLEXED WITH PNU-198873 分子名称: CELL DIVISION PROTEIN KINASE 2, N-(5-ISOPROPYL-THIAZOL-2-YL)-2-PYRIDIN-3-YL-ACETAMIDE 著者 Vulpetti, A, Casale, E, Roletto, F, Amici, R, Villa, M, Pevarello, P. 登録日 2005-06-06 公開日 2005-11-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure-Based Drug Design to the Discovery of New 2-Aminothiazole Cdk2 Inhibitors. J.Mol.Graph.Model., 24, 2006
2C5V	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design 分子名称: 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE, ALA-ALA-ABA-ARG-SER-LEU-ILE-PFF-NH2, CELL DIVISION PROTEIN KINASE 2, ... 著者 Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. 登録日 2005-11-02 公開日 2006-03-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006
2C5N	Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE 著者 Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. 登録日 2005-10-30 公開日 2006-03-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006
2D9Q	Crystal Structure of the Human GCSF-Receptor Signaling Complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CSF3, Granulocyte colony-stimulating factor receptor 著者 Tamada, T, Kuroki, R. 登録日 2005-12-12 公開日 2006-02-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex Proc.Natl.Acad.Sci.Usa, 103, 2006
2DA3	Solution structure of the third homeobox domain of AT-binding transcription factor 1 (ATBF1) 分子名称: Alpha-fetoprotein enhancer binding protein 著者 Ohnishi, S, Kigawa, T, Tomizawa, T, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-13 公開日 2006-06-13 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the third homeobox domain of AT-binding transcription factor 1 (ATBF1) To be Published
1RHW	The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila 分子名称: Dynein light chain 1, cytoplasmic 著者 Makokha, M, Huang, Y.J, Montelione, G, Edison, A.S, Barbar, E. 登録日 2003-11-14 公開日 2004-04-27 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The solution structure of the pH-induced monomer of dynein light-chain LC8 from Drosophila. Protein Sci., 13, 2004
6XTB	Subunit BBS 5 of the human core BBSome complex 分子名称: Bardet-Biedl syndrome 5 protein 著者 Klink, B.U, Raunser, S, Gatsogiannis, C. 登録日 2020-01-15 公開日 2020-02-19 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structure of the human BBSome core complex. Elife, 9, 2020
6XWD	14-3-3 sigma bound to canonical mono-phosphorylated aminopeptidase N (APN, CD13) binding motif 分子名称: 14-3-3 protein sigma, Amino peptidase N 38-46, CALCIUM ION, ... 著者 Kiehstaller, S, Hennig, S. 登録日 2020-01-23 公開日 2020-11-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.60000193 Å) 主引用文献 MMP activation-associated aminopeptidase N reveals a bivalent 14-3-3 binding motif. J.Biol.Chem., 295, 2020
2BHE	HUMAN CYCLIN DEPENDENT PROTEIN KINASE 2 IN COMPLEX WITH THE INHIBITOR 5-BROMO-INDIRUBINE 分子名称: (2Z)-5'-BROMO-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE AMMONIATE, CELL DIVISION PROTEIN KINASE 2 著者 Schaefer, M, Jautelat, R, Brumby, T, Briem, H, Eisenbrand, G, Schwahn, S, Krueger, M, Luecking, U, Prien, O, Siemeister, G. 登録日 2005-01-10 公開日 2005-03-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 From the Insoluble Dye Indirubin Towards Highly Active, Soluble Cdk2-Inhibitors Chembiochem, 6, 2005
1IB1	CRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX 分子名称: 14-3-3 ZETA ISOFORM, COA-S-ACETYL TRYPTAMINE, SEROTONIN N-ACETYLTRANSFERASE 著者 Obsil, T, Ghirlando, R, Klein, D.C, Ganguly, S, Dyda, F. 登録日 2001-03-26 公開日 2001-05-02 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. Cell(Cambridge,Mass.), 105, 2001

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