PDB: 1553 件ウェブページステータス検索Chemie searchBIRD

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4E3F	Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors 分子名称: 2,6-DIHYDROXYBENZOIC ACID, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ... 著者 Cohen, S.M, Martin, D.P. 登録日 2012-03-09 公開日 2012-06-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors Chem.Commun.(Camb.), 48, 2012
4E4A	Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors 分子名称: 2-sulfanylbenzoic acid, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ... 著者 Cohen, S.M, Martin, D.P. 登録日 2012-03-12 公開日 2012-06-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors Chem.Commun.(Camb.), 48, 2012
2A8D	Haemophilus influenzae beta-carbonic anhydrase complexed with bicarbonate 分子名称: BICARBONATE ION, Carbonic anhydrase 2, SULFATE ION, ... 著者 Cronk, J.D, Rowlett, R.S, Zhang, K.Y.J, Tu, C, Endrizzi, J.A, Lee, J, Gareiss, P.C, Preiss, J.R. 登録日 2005-07-07 公開日 2006-04-18 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Identification of a Novel Noncatalytic Bicarbonate Binding Site in Eubacterial beta-Carbonic Anhydrase Biochemistry, 45, 2006
1RAZ	THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE 分子名称: BROMIDE ION, CARBONIC ANHYDRASE II, ZINC ION 著者 Jonsson, B.M, Hakansson, K, Liljas, A. 登録日 1993-04-02 公開日 1993-10-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The structure of human carbonic anhydrase II in complex with bromide and azide. FEBS Lett., 322, 1993
1RAY	THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE 分子名称: AZIDE ION, CARBONIC ANHYDRASE II, ZINC ION 著者 Jonsson, B.M, Hakansson, K, Liljas, A. 登録日 1993-04-02 公開日 1993-10-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The structure of human carbonic anhydrase II in complex with bromide and azide. FEBS Lett., 322, 1993
2ESF	Identification of a Novel Non-Catalytic Bicarbonate Binding Site in Eubacterial beta-Carbonic Anhydrase 分子名称: BICARBONATE ION, Carbonic anhydrase 2, ZINC ION 著者 Cronk, J.D, Rowlett, R.S, Zhang, K.Y.J, Tu, C, Endrizzi, J.A, Gareiss, P.C. 登録日 2005-10-26 公開日 2006-04-18 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Identification of a Novel Noncatalytic Bicarbonate Binding Site in Eubacterial beta-Carbonic Anhydrase. Biochemistry, 45, 2006
3E2W	H. influenzae beta-carbonic anhydrase, variant Y181F with 1M bicarbonate 分子名称: BICARBONATE ION, Carbonic anhydrase 2, SULFATE ION, ... 著者 Rowlett, R.S, Lee, J. 登録日 2008-08-06 公開日 2009-08-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.296 Å) 主引用文献 Allosteric site variants of Haemophilus influenzae beta-carbonic anhydrase. Biochemistry, 48, 2009
3E2A	H. influenzae beta-carbonic anhydrase, variant Y181F with 100 mM bicarbonate 分子名称: BICARBONATE ION, Carbonic anhydrase 2, SULFATE ION, ... 著者 Rowlett, R.S, Lee, J. 登録日 2008-08-05 公開日 2009-06-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Allosteric site variants of Haemophilus influenzae beta-carbonic anhydrase. Biochemistry, 48, 2009
4YGF	Crystal structure of the complex of Helicobacter pylori alpha-Carbonic Anhydrase with acetazolamide 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Alpha-carbonic anhydrase, CHLORIDE ION, ... 著者 Roujeinikova, A, Modak, J.K. 登録日 2015-02-26 公開日 2015-07-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis for the Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase by Sulfonamides. Plos One, 10, 2015
3UCJ	Coccomyxa beta-carbonic anhydrase in complex with acetazolamide 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CHLORIDE ION, Carbonic anhydrase, ... 著者 Huang, S, Hainzl, T, Sauer-Eriksson, A.E. 登録日 2011-10-27 公開日 2011-11-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural studies of [beta]-carbonic anhydrase from the green alga Coccomyxa: inhibitor complexes with anions and acetazolamide. Plos One, 6, 2011
3UCK	Coccomyxa beta-carbonic anhydrase in complex with phosphate 分子名称: CHLORIDE ION, Carbonic anhydrase, PHOSPHATE ION, ... 著者 Huang, S, Hainzl, T, Sauer-Eriksson, A.E. 登録日 2011-10-27 公開日 2011-11-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural studies of [beta]-carbonic anhydrase from the green alga Coccomyxa: inhibitor complexes with anions and acetazolamide. Plos One, 6, 2011
3UCN	Coccomyxa beta-carbonic anhydrase in complex with azide 分子名称: AZIDE ION, CHLORIDE ION, Carbonic anhydrase, ... 著者 Huang, S, Hainzl, T, Sauer-Eriksson, A.E. 登録日 2011-10-27 公開日 2011-11-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural studies of [beta]-carbonic anhydrase from the green alga Coccomyxa: inhibitor complexes with anions and acetazolamide. Plos One, 6, 2011
3E3I	H. influenzae beta-carbonic anhydrase, variant G41A with 100 mM bicarbonate 分子名称: BICARBONATE ION, Carbonic anhydrase 2, SULFATE ION, ... 著者 Rowlett, R.S, Failing, H. 登録日 2008-08-07 公開日 2009-08-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Evidence for a bicarbonate "escort" site in Haemophilus influenzae beta-carbonic anhydrase . Biochemistry, 49, 2010
8OGD	Structure of zinc(II) double mutant human carbonic anhydrase II bound to thiocyanate 分子名称: 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase 2, THIOCYANATE ION, ... 著者 Silva, J.M, Cerofolini, L, Carvalho, A.L, Ravera, E, Fragai, M, Parigi, G, Macedo, A.L, Geraldes, C.F.G.C, Luchinat, C. 登録日 2023-03-20 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Elucidating the concentration-dependent effects of thiocyanate binding to carbonic anhydrase. J.Inorg.Biochem., 244, 2023
8OGE	Structure of cobalt(II) substituted double mutant human carbonic anhydrase II bound to thiocyanate 分子名称: 4-(HYDROXYMERCURY)BENZOIC ACID, COBALT (II) ION, Carbonic anhydrase 2, ... 著者 Silva, J.M, Cerofolini, L, Carvalho, A.L, Ravera, E, Fragai, M, Parigi, G, Macedo, A.L, Geraldes, C.F.G.C, Luchinat, C. 登録日 2023-03-20 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Elucidating the concentration-dependent effects of thiocyanate binding to carbonic anhydrase. J.Inorg.Biochem., 244, 2023
6D2O	Beta Carbonic anhydrase in complex with 4-methylimidazole 分子名称: 4-METHYLIMIDAZOLE, Carbonic anhydrase, ZINC ION 著者 Murray, A, Aggarwal, M, Pinard, M, McKenna, R. 登録日 2018-04-13 公開日 2018-09-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Mapping of Anion Inhibitors to beta-Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa. ChemMedChem, 13, 2018
6G6T	Crystal structure of human carbonic anhydrase isozyme II with N-butyl-2,4-dichloro-5-sulfamoyl-benzamide 分子名称: BICINE, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2018-04-03 公開日 2019-03-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases. Eur J Med Chem, 156, 2018
6KLZ	Human Carbonic Anhydrase II V143I variant 00 atm CO2 分子名称: BICARBONATE ION, Carbonic anhydrase 2, GLYCEROL, ... 著者 Kim, C.U, Kim, J.K. 登録日 2019-07-30 公開日 2020-08-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (0.9 Å) 主引用文献 Structural insights into the effect of active-site mutation on the catalytic mechanism of carbonic anhydrase. Iucrj, 7, 2020
6G5U	Crystal structure of human carbonic anhydrase isozyme XIII with N-butyl-2,4-dichloro-5-sulfamoyl-benzamide 分子名称: 1,2-ETHANEDIOL, CITRIC ACID, Carbonic anhydrase 13, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2018-03-30 公開日 2019-03-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases. Eur J Med Chem, 156, 2018
2FOU	Human Carbonic Anhydrase II complexed with two-prong inhibitors 分子名称: COPPER (II) ION, Carbonic Anhydrase II, GLYCEROL, ... 著者 Jude, K.M, Christianson, D.W. 登録日 2006-01-14 公開日 2006-04-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (0.99 Å) 主引用文献 Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity. J.Am.Chem.Soc., 128, 2006
5JE7	Human carbonic anhydrase II (F131Y) complexed with benzo[d]thiazole-2-sulfonamide 分子名称: 1,3-benzothiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Fox, J.M, Kang, K, Sastry, M, Sherman, W, Sankaran, B, Zwart, P.H, Whitesides, G.M. 登録日 2016-04-17 公開日 2017-01-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase. Angew. Chem. Int. Ed. Engl., 56, 2017
5JGT	Human carbonic anhydrase II (F131Y/L198A) complexed with 1,3-thiazole-2-sulfonamide 分子名称: 1,3-thiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Fox, J.M, Kang, K, Sastry, M, Sherman, W, Sankaran, B, Zwart, P.H, Whitesides, G.M. 登録日 2016-04-20 公開日 2017-01-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase. Angew. Chem. Int. Ed. Engl., 56, 2017
2FOV	Human Carbonic Anhydrase II complexed with two-prong inhibitors 分子名称: ACETONITRILE, COPPER (II) ION, Carbonic Anhydrase II, ... 著者 Jude, K.M, Christianson, D.W. 登録日 2006-01-14 公開日 2006-04-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity. J.Am.Chem.Soc., 128, 2006
2FOS	Human Carbonic Anhydrase II complexed with two-prong inhibitors 分子名称: COPPER (II) ION, Carbonic Anhydrase II, ZINC ION, ... 著者 Jude, K.M, Christianson, D.W. 登録日 2006-01-13 公開日 2006-04-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity. J.Am.Chem.Soc., 128, 2006
5JDV	Human carbonic anhydrase II (F131W) complexed with benzo[d]thiazole-2-sulfonamide 分子名称: 1,3-benzothiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Fox, J.M, Kang, K, Sastry, M, Sherman, W, Sankaran, B, Zwart, P.H, Whitesides, G.M. 登録日 2016-04-17 公開日 2017-01-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase. Angew. Chem. Int. Ed. Engl., 56, 2017

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