5MDT
 
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7KKF
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1YVX
 | | Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor | | 分子名称: | 3-[ISOPROPYL(4-METHYLBENZOYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA dependent RNA polymerase, SULFATE ION | | 著者 | Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. | | 登録日 | 2005-02-16 | | 公開日 | 2005-03-22 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
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2XP1
 | | Structure of the tandem SH2 domains from Antonospora locustae transcription elongation factor Spt6 | | 分子名称: | CHLORIDE ION, SPT6, SULFATE ION | | 著者 | Diebold, M.-L, Koch, M, Cavarelli, J, Romier, C. | | 登録日 | 2010-08-24 | | 公開日 | 2010-09-29 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Noncanonical Tandem Sh2 Enables Interaction of Elongation Factor Spt6 with RNA Polymerase II.
J.Biol.Chem., 285, 2010
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6XKB
 | | Crystal structure of SR-related and CTD-associated factor 4(SCAF4-CID)with peptide S2,S5p-CTD | | 分子名称: | S2,S5p-CTD peptide, SR-related and CTD-associated factor 4, UNKNOWN ATOM OR ION | | 著者 | Zhou, M.Q, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2020-06-26 | | 公開日 | 2021-01-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural basis for the recognition of the S2, S5-phosphorylated RNA polymerase II CTD by the mRNA anti-terminator protein hSCAF4.
Febs Lett., 596, 2022
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8SZW
 | | Reconstituted E. coli RNA polymerase post-termination complex on negatively-supercoiled DNA: open duplex DNA (rPTCo) | | 分子名称: | DNA (25-MER), DNA (27-MER), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Brewer, J.J, Darst, S.A, Campbell, E.A. | | 登録日 | 2023-05-30 | | 公開日 | 2025-04-02 | | 最終更新日 | 2025-04-30 | | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | | 主引用文献 | RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation.
Nat.Struct.Mol.Biol., 32, 2025
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1YVZ
 | | Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor | | 分子名称: | 3-[(2,4-DICHLOROBENZOYL)(ISOPROPYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA dependent RNA polymerase, SULFATE ION | | 著者 | Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. | | 登録日 | 2005-02-16 | | 公開日 | 2005-03-22 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
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1NB6
 | | HC-J4 RNA polymerase complexed with UTP | | 分子名称: | MANGANESE (II) ION, URIDINE 5'-TRIPHOSPHATE, polyprotein | | 著者 | O'Farrell, D.J, Trowbridge, R, Rowlands, D.J, Jaeger, J. | | 登録日 | 2002-12-02 | | 公開日 | 2003-03-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation.
J.Mol.Biol., 326, 2003
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7MKJ
 | | Cryo-EM structure of Escherichia coli RNA polymerase bound to T7A1 promoter DNA | | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Saecker, R.M, Darst, S.A, Chen, J. | | 登録日 | 2021-04-23 | | 公開日 | 2021-09-29 | | 最終更新日 | 2025-05-14 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural origins of Escherichia coli RNA polymerase open promoter complex stability.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7MKE
 | | Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 2) | | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Saecker, R.M, Darst, S.A, Chen, J. | | 登録日 | 2021-04-23 | | 公開日 | 2021-09-29 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural origins of Escherichia coli RNA polymerase open promoter complex stability.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7MKI
 | | Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR (-5G to C) promoter DNA | | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Saecker, R.M, Darst, S.A, Chen, J. | | 登録日 | 2021-04-23 | | 公開日 | 2021-09-29 | | 最終更新日 | 2025-05-28 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural origins of Escherichia coli RNA polymerase open promoter complex stability.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7MKD
 | | Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 1) | | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Saecker, R.M, Darst, S.A, Chen, J. | | 登録日 | 2021-04-23 | | 公開日 | 2021-09-29 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural origins of Escherichia coli RNA polymerase open promoter complex stability.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7JV7
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6IRX
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6IRY
 | | Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to SAH | | 分子名称: | 1,2-ETHANEDIOL, PDX1 C-terminal-inhibiting factor 1, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Hirano, S, Nishimasu, H, Ishitani, R, Nureki, O. | | 登録日 | 2018-11-14 | | 公開日 | 2018-12-05 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II-associated methyltransferase.
Science, 363, 2019
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6IRW
 | | Crystal structure of the human cap-specific adenosine methyltransferase bound to SAH | | 分子名称: | Phosphorylated CTD-interacting factor 1, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Hirano, S, Nishimasu, H, Ishitani, R, Nureki, O. | | 登録日 | 2018-11-14 | | 公開日 | 2018-12-05 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II-associated methyltransferase.
Science, 363, 2019
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6IRV
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2O5I
 | | Crystal structure of the T. thermophilus RNA polymerase elongation complex | | 分子名称: | 5'-D(*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*AP*GP*GP*G)-3', 5'-D(P*CP*CP*CP*TP*GP*TP*CP*TP*GP*GP*CP*GP*TP*TP*CP*GP*CP*GP*CP*GP*CP*CP*G)-3', 5'-R(P*GP*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP*G)-3', ... | | 著者 | Vassylyev, D.G, Tahirov, T.H, Vassylyeva, M.N. | | 登録日 | 2006-12-06 | | 公開日 | 2007-07-03 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis for transcription elongation by bacterial RNA polymerase.
Nature, 448, 2007
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3FDF
 | | Crystal structure of the serine phosphatase of RNA polymerase II CTD (SSU72 superfamily) from Drosophila melanogaster. Orthorhombic crystal form. Northeast Structural Genomics Consortium target FR253. | | 分子名称: | FR253 | | 著者 | Kuzin, A.P, Chen, Y, Seetharaman, J, Forouhar, F, Chinag, Y, Fang, Y, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2008-11-25 | | 公開日 | 2009-01-06 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Orthorombic crystal structure of serine phosphatase of rna polymerase ii ctd from fly drosofila melanogaster. northeast structural genomics consortium target fr253.
To be Published
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1S0V
 | | Structural basis for substrate selection by T7 RNA polymerase | | 分子名称: | 5'-D(*G*GP*GP*AP*AP*TP*CP*GP*AP*TP*AP*TP*CP*GP*CP*CP*GP*C)-3', 5'-D(*GP*TP*CP*GP*AP*TP*TP*CP*CP*C)-3', 5'-R(*AP*AP*CP*U*GP*CP*GP*GP*CP*GP*AP*U)-3', ... | | 著者 | Temiakov, D, Patlan, V, Anikin, M, McAllister, W.T, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2004-01-05 | | 公開日 | 2004-02-24 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for substrate selection by t7 RNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
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2PA8
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5UAH
 | | Escherichia coli RNA polymerase and Rifampin complex, RpoB D516V mutant | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S. | | 登録日 | 2016-12-19 | | 公開日 | 2017-01-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | | 主引用文献 | Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
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5UAL
 | | Escherichia coli RNA polymerase and Rifampin complex, RpoB S531L mutant | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S. | | 登録日 | 2016-12-19 | | 公開日 | 2017-01-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3.887 Å) | | 主引用文献 | Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
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5UAC
 | | Escherichia coli RNA polymerase and Rifampin complex, wild-type | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S. | | 登録日 | 2016-12-19 | | 公開日 | 2017-01-18 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
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6FO1
 | | Human R2TP subcomplex containing 1 RUVBL1-RUVBL2 hexamer bound to 1 RBD domain from RPAP3. | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RNA polymerase II-associated protein 3, RuvB-like 1, ... | | 著者 | Martino, F, Munoz-Hernandez, H, Rodriguez, C.F, Pearl, L.H, Llorca, O. | | 登録日 | 2018-02-05 | | 公開日 | 2018-04-04 | | 最終更新日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | | 主引用文献 | RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.
Nat Commun, 9, 2018
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