PDB: 1957 件ウェブページステータス検索Chemie searchBIRD

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8FJL	Golden Shiner Reovirus Core Tropical Vertex 分子名称: Clamp protein VP6, Major inner capsid protein VP3, Microtubule-associated protein VP5, ... 著者 Stevens, A.S, Zhou, Z.H. 登録日 2022-12-19 公開日 2023-03-08 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation. Protein Cell, 14, 2023
6KUJ	Structure of influenza D virus polymerase bound to cRNA promoter in class 1 分子名称: 3'-cRNA promoter, 5'-cRNA promoter, Polymerase 3, ... 著者 Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. 登録日 2019-09-02 公開日 2019-10-02 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of influenza D virus polymerase bound to cRNA promoter in Mode A conformation NAT NANOTECHNOL, 2019
7ORJ	La Crosse virus polymerase at transcription capped RNA cleavage stage 分子名称: 5' capped RNA, ADENOSINE-5'-TRIPHOSPHATE, RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*CP*AP*AP*G)-3'), ... 著者 Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. 登録日 2021-06-06 公開日 2022-02-16 最終更新日 2022-03-02 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription. Nat Commun, 13, 2022
7ORL	La Crosse virus polymerase at transcription initiation stage 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, MAGNESIUM ION, PYROPHOSPHATE 2-, ... 著者 Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. 登録日 2021-06-06 公開日 2022-02-16 最終更新日 2022-03-02 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription. Nat Commun, 13, 2022
7ORK	La Crosse virus polymerase in transcription mode with cleaved capped RNA entering the polymerase active site 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (5'-D(*(GTG))-R(P*A)-3'), ... 著者 Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. 登録日 2021-06-06 公開日 2022-02-16 最終更新日 2022-03-02 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription. Nat Commun, 13, 2022
6L42	Structure of severe fever with thrombocytopenia syndrome virus L protein 分子名称: MAGNESIUM ION, RNA polymerase 著者 Wang, P, Lou, Z. 登録日 2019-10-15 公開日 2020-05-13 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation. Nat Microbiol, 5, 2020
8FU3	Structure Of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor 分子名称: 8-methoxy-3-methyl-N-{(2S)-3,3,3-trifluoro-2-[5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-hydroxypropyl}cinnoline-6-carboxamide, Phosphoprotein, RNA-directed RNA polymerase L 著者 Yu, X, Abeywickrema, P, Bonneux, B, Behera, I, Jacoby, E, Fung, A, Adhikary, S, Bhaumik, A, Carbajo, R.J, Bruyn, S.D, Miller, R, Patrick, A, Pham, Q, Piassek, M, Verheyen, N, Shareef, A, Sutto-Ortiz, P, Ysebaert, N, Vlijmen, H.V, Jonckers, T.H.M, Herschke, F, McLellan, J.S, Decroly, E, Fearns, R, Grosse, S, Roymans, D, Sharma, S, Rigaux, P, Jin, Z. 登録日 2023-01-16 公開日 2023-11-01 実験手法 ELECTRON MICROSCOPY (2.88 Å) 主引用文献 Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor. Commun Biol, 6, 2023
6TW1	Bat Influenza A polymerase termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence 分子名称: 5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid, MAGNESIUM ION, PYROPHOSPHATE 2-, ... 著者 Wandzik, J.M, Kouba, T, Cusack, S. 登録日 2020-01-11 公開日 2020-04-15 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 2020
5FMZ	Crystal structure of Influenza B polymerase with bound 5' vRNA 分子名称: 5'-R(*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP)-3', POLYMERASE ACIDIC PROTEIN, POLYMERASE BASIC PROTEIN 2, ... 著者 Guilligay, D, Cusack, S. 登録日 2015-11-10 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016
5CZB	HCV NS5B IN COMPLEX WITH LIGAND IDX17119-5 分子名称: 1-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-3-{[(R)-(2,4-dimethylphenyl)(methoxy)phosphoryl]amino}-1H-pyrazole-4-carboxylic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... 著者 Pierra, C, Dousson, C, Augustin, M. 登録日 2015-07-31 公開日 2016-06-15 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase. Bioorg.Med.Chem.Lett., 26, 2016
5EPI	CRYSTAL STRUCTURE OF INFLUENZA B POLYMERASE WITH BOUND 5' CRNA EXHIBITS A NOVEL DOMAIN ARRANGEMENT 分子名称: CRNA 5' END, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Guilligay, D, Cusack, S. 登録日 2015-11-11 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (4.1 Å) 主引用文献 Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains. Mol.Cell, 61, 2016
3TYV	SAR development and discovery of potent indole-based inhibitors of the hepatitis C virus NS5B polymerase 分子名称: N-(cyclopropylsulfonyl)-1-(2,5-difluorobenzyl)-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide, PHOSPHATE ION, RNA-directed RNA polymerase 著者 Lesburg, C.A, Chen, K.X. 登録日 2011-09-26 公開日 2012-02-01 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structure-Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase. J.Med.Chem., 55, 2012
3MF5	Hepatitis C virus polymerase NS5B (BK) with amide bioisostere thumb site inhibitor 分子名称: 3-[2-(trans-4-methylcyclohexyl)phenyl]-5-phenylthiophene-2-carboxylic acid, GLYCEROL, RNA-directed RNA polymerase 著者 Harris, S.F, Tavares, G, Ghate, M. 登録日 2010-04-01 公開日 2010-07-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
2WCX	Crystal Structure of Hepatitis C Virus NS5B Polymerase in Complex with Thienopyrrole-Based Finger-Loop Inhibitors 分子名称: 6-CYCLOHEXYL-4-METHYL-5-PHENYL-4H-THIENO[3,2-B]PYRROLE-2-CARBOXYLIC ACID, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Di Marco, S. 登録日 2009-03-17 公開日 2009-08-18 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Optimization of Thienopyrrole-Based Finger-Loop Inhibitors of the Hepatitis C Virus Ns5B Polymerase. Chemmedchem, 4, 2009
8H69	Cryo-EM structure of influenza RNA polymerase 分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-R(*UP*AP*AP*AP*CP*UP*CP*CP*UP*GP*CP*UP*UP*UP*UP*GP*CP*U)-3'), ... 著者 Li, H, Wu, Y, Liang, H, Liu, Y. 登録日 2022-10-16 公開日 2023-06-28 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles. Nat.Struct.Mol.Biol., 30, 2023
7ORM	La Crosse virus polymerase at transcription early-elongation stage 分子名称: MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3'), RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*C)-3'), ... 著者 Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. 登録日 2021-06-06 公開日 2022-02-16 最終更新日 2022-03-02 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription. Nat Commun, 13, 2022
2IM1	Crystal structure of poliovirus polymerase complexed with CTP and Mn2+ 分子名称: ACETIC ACID, CYTIDINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Thompson, A.A, Peersen, O.B. 登録日 2006-10-03 公開日 2006-12-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions. J.Mol.Biol., 366, 2007
2IM3	Crystal structure of poliovirus polymerase complexed with UTP and Mn2+ 分子名称: ACETIC ACID, MANGANESE (II) ION, SODIUM ION, ... 著者 Thompson, A.A, Peersen, O.B. 登録日 2006-10-03 公開日 2006-12-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions. J.Mol.Biol., 366, 2007
2ILZ	Crystal structure of poliovirus polymerase complexed with GTP and Mn2+ 分子名称: ACETIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Thompson, A.A, Peersen, O.B. 登録日 2006-10-03 公開日 2006-12-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions. J.Mol.Biol., 366, 2007
2IM0	Crystal structure of poliovirus polymerase complexed with CTP and Mg2+ 分子名称: ACETIC ACID, CYTIDINE-5'-TRIPHOSPHATE, SODIUM ION, ... 著者 Thompson, A.A, Peersen, O.B. 登録日 2006-10-03 公開日 2006-12-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions. J.Mol.Biol., 366, 2007
2IM2	Crystal structure of poliovirus polymerase complexed with UTP and Mg2+ 分子名称: ACETIC ACID, SODIUM ION, URIDINE 5'-TRIPHOSPHATE, ... 著者 Thompson, A.A, Peersen, O.B. 登録日 2006-10-03 公開日 2006-12-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions. J.Mol.Biol., 366, 2007
2ILY	Crystal structure of poliovirus polymerase complexed with ATP and Mg2+ 分子名称: ACETIC ACID, ADENOSINE-5'-TRIPHOSPHATE, Poliovirus polymerase, ... 著者 Thompson, A.A, Peersen, O.B. 登録日 2006-10-03 公開日 2006-12-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions. J.Mol.Biol., 366, 2007
8POH	Influenza A/H7N9 polymerase symmetric dimer bound to the promoter (PA K289A/C489R) 分子名称: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ... 著者 Arragain, B, Cusack, S. 登録日 2023-07-04 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
6QW5	Structure and function of the toscana virus cap snatching endonuclease 分子名称: 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MANGANESE (II) ION, RNA-dependent RNA polymerase, ... 著者 Reguera, J, Jones, R, Bragagniolo, G, Lessoued, S, Mate, M. 登録日 2019-03-05 公開日 2019-09-25 最終更新日 2019-11-20 実験手法 X-RAY DIFFRACTION (1.988 Å) 主引用文献 Structure and function of the Toscana virus cap-snatching endonuclease. Nucleic Acids Res., 47, 2019
6QVV	Structure and function of phenuiviridae cap snatching endonucleases 分子名称: GLYCEROL, MANGANESE (III) ION, RNA-dependent RNA polymerase, ... 著者 Reguera, J, Jones, R, Bragagniolo, G, Lessoued, S, Mate, M. 登録日 2019-03-05 公開日 2019-09-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure and function of the Toscana virus cap-snatching endonuclease. Nucleic Acids Res., 47, 2019

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