5HP0
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![BU of 5hp0 by Molmil](/molmil-images/mine/5hp0) | Solution Structure of TAZ2-p53AD2 | 分子名称: | CREB-binding protein,Cellular tumor antigen p53 fusion protein, ZINC ION | 著者 | Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | 登録日 | 2016-01-19 | 公開日 | 2016-03-16 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc.Natl.Acad.Sci.USA, 113, 2016
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5HOU
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![BU of 5hou by Molmil](/molmil-images/mine/5hou) | Solution Structure of p53TAD-TAZ1 | 分子名称: | Cellular tumor antigen p53,CREB-binding protein fusion protein, ZINC ION | 著者 | Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | 登録日 | 2016-01-19 | 公開日 | 2016-03-16 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc.Natl.Acad.Sci.USA, 113, 2016
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3IM4
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![BU of 3im4 by Molmil](/molmil-images/mine/3im4) | Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2 | 分子名称: | Dual specificity A kinase-anchoring protein 2, ZINC ION, cAMP-dependent protein kinase type I-alpha regulatory subunit | 著者 | Sarma, G.N, Kinderman, F.S, Kim, C, von Daake, S, Taylor, S.S. | 登録日 | 2009-08-09 | 公開日 | 2010-02-02 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (2.285 Å) | 主引用文献 | Structure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and Selectivity Structure, 18, 2010
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3X2W
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![BU of 3x2w by Molmil](/molmil-images/mine/3x2w) | Michaelis complex of cAMP-dependent Protein Kinase Catalytic Subunit | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CARBONATE ION, MAGNESIUM ION, ... | 著者 | Das, A, Langan, P, Gerlits, O, Kovalevsky, A.Y, Heller, W.T. | 登録日 | 2015-01-02 | 公開日 | 2015-12-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Protein Kinase A Catalytic Subunit Primed for Action: Time-Lapse Crystallography of Michaelis Complex Formation. Structure, 23, 2015
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3X2V
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![BU of 3x2v by Molmil](/molmil-images/mine/3x2v) | Michaelis-like complex of cAMP-dependent Protein Kinase Catalytic Subunit | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CARBONATE ION, MAGNESIUM ION, ... | 著者 | Das, A, Langan, P, Gerlits, O, Kovalevsky, A.Y, Heller, W.T. | 登録日 | 2015-01-02 | 公開日 | 2015-12-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Protein Kinase A Catalytic Subunit Primed for Action: Time-Lapse Crystallography of Michaelis Complex Formation. Structure, 23, 2015
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2M1C
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![BU of 2m1c by Molmil](/molmil-images/mine/2m1c) | HADDOCK structure of GtYybT PAS Homodimer | 分子名称: | DHH subfamily 1 protein | 著者 | Liang, Z.X, Pervushin, K, Tan, E, Rao, F, Pasunooti, S, Soehano, I, Lescar, J. | 登録日 | 2012-11-25 | 公開日 | 2013-03-27 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of the PAS Domain of a Thermophilic YybT Protein Homolog Reveals a Potential Ligand-binding Site. J.Biol.Chem., 288, 2013
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3SE5
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![BU of 3se5 by Molmil](/molmil-images/mine/3se5) | Fic protein from NEISSERIA MENINGITIDIS mutant delta8 in complex with AMPPNP | 分子名称: | Cell filamentation protein Fic-related protein, HEXAETHYLENE GLYCOL, MAGNESIUM ION, ... | 著者 | Goepfert, A, Stanger, F, Schirmer, T. | 登録日 | 2011-06-10 | 公開日 | 2012-01-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. Nature, 482, 2012
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3IM3
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![BU of 3im3 by Molmil](/molmil-images/mine/3im3) | Crystal structure of PKA RI alpha dimerization/docking domain | 分子名称: | FORMIC ACID, cAMP-dependent protein kinase type I-alpha regulatory subunit | 著者 | Sarma, G.N, Kinderman, F.S, Kim, C, von Daake, S, Taylor, S.S. | 登録日 | 2009-08-09 | 公開日 | 2010-02-02 | 最終更新日 | 2021-04-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and Selectivity Structure, 18, 2010
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8W6P
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![BU of 8w6p by Molmil](/molmil-images/mine/8w6p) | Crystal structure of dimeric murine SMPDL3A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, ... | 著者 | Zhang, C, Liu, P, Fan, S, Hou, Y. | 登録日 | 2023-08-29 | 公開日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity, 56, 2023
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8W6R
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![BU of 8w6r by Molmil](/molmil-images/mine/8w6r) | murine SMPDL3A bound to sulfate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, ... | 著者 | Zhang, C, Liu, P, Fan, S. | 登録日 | 2023-08-29 | 公開日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity, 56, 2023
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7SSB
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![BU of 7ssb by Molmil](/molmil-images/mine/7ssb) | Co-structure of PKG1 regulatory domain with compound 33 | 分子名称: | 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-nitrobenzoic acid, cGMP-dependent protein kinase 1 | 著者 | Fischmann, T.O. | 登録日 | 2021-11-10 | 公開日 | 2022-08-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1 alpha. J.Med.Chem., 65, 2022
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5GS5
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![BU of 5gs5 by Molmil](/molmil-images/mine/5gs5) | Crystal structure of apo rat STING | 分子名称: | SULFATE ION, Stimulator of interferon genes protein | 著者 | Zhang, H, Han, M.J, Tao, J.L, Ye, Z.Y, Du, X.X, Deng, M.J, Zhang, X.Y, Li, L.F, Jiang, Z.F, Su, X.D. | 登録日 | 2016-08-13 | 公開日 | 2017-10-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Crystal structure of apo ratSTING To Be Published
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8YJY
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![BU of 8yjy by Molmil](/molmil-images/mine/8yjy) | |
6O8C
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![BU of 6o8c by Molmil](/molmil-images/mine/6o8c) | Crystal structure of STING CTT in complex with TBK1 | 分子名称: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | 著者 | Li, P, Zhao, B, Du, F. | 登録日 | 2019-03-09 | 公開日 | 2019-05-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.17 Å) | 主引用文献 | A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature, 569, 2019
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6O8B
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![BU of 6o8b by Molmil](/molmil-images/mine/6o8b) | Crystal structure of STING CTD in complex with TBK1 | 分子名称: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | 著者 | Li, P, Zhao, B, Du, F. | 登録日 | 2019-03-09 | 公開日 | 2019-05-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature, 569, 2019
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7UQ2
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![BU of 7uq2 by Molmil](/molmil-images/mine/7uq2) | Vs.4 from T4 phage in complex with cGAMP | 分子名称: | 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, CALCIUM ION, Vs.4 | 著者 | Jenson, J.M, Chen, Z.J. | 登録日 | 2022-04-18 | 公開日 | 2023-02-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence. Nature, 616, 2023
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4RWP
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![BU of 4rwp by Molmil](/molmil-images/mine/4rwp) | Crystal structure of porcine OAS1 in complex with dsRNA | 分子名称: | 2'-5'-oligoadenylate synthase 1, RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3'), RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3') | 著者 | Lohoefener, J, Steinke, N, Kay-Fedorov, P, Baruch, P, Nikulin, A, Tishchenko, S, Manstein, D.J, Fedorov, R. | 登録日 | 2014-12-05 | 公開日 | 2015-05-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity. Structure, 23, 2015
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4RWQ
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![BU of 4rwq by Molmil](/molmil-images/mine/4rwq) | Crystal structure of the apo-state of porcine OAS1 | 分子名称: | 2'-5'-oligoadenylate synthase 1 | 著者 | Lohoefener, J, Steinke, N, Kay-Fedorov, P, Baruch, P, Nikulin, A, Tishchenko, S, Manstein, D.J, Fedorov, R. | 登録日 | 2014-12-05 | 公開日 | 2015-05-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity. Structure, 23, 2015
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4RWN
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![BU of 4rwn by Molmil](/molmil-images/mine/4rwn) | Crystal structure of the pre-reactive state of porcine OAS1 | 分子名称: | 2'-5'-oligoadenylate synthase 1, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MAGNESIUM ION, ... | 著者 | Lohoefener, J, Steinke, N, Kay-Fedorov, P, Baruch, P, Nikulin, A, Tishchenko, S, Manstein, D.J, Fedorov, R. | 登録日 | 2014-12-05 | 公開日 | 2015-05-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity. Structure, 23, 2015
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5HPD
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![BU of 5hpd by Molmil](/molmil-images/mine/5hpd) | Solution Structure of TAZ2-p53TAD | 分子名称: | CREB-binding protein,Cellular tumor antigen p53 fusion protein, ZINC ION | 著者 | Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | 登録日 | 2016-01-20 | 公開日 | 2016-03-16 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc.Natl.Acad.Sci.USA, 113, 2016
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7SHP
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![BU of 7shp by Molmil](/molmil-images/mine/7shp) | Crystal structure of hSTING in complex with c[2',3'-(ribo-2'-G, xylo-3'-A)-MP](RJ244) | 分子名称: | (2S,5R,7R,8R,10S,12aR,14R,15R,15aR,16R)-7-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein | 著者 | Xie, W, Lama, L, Yang, X.J, Kuryavyi, V, Nudelman, I, Glickman, J.F, Jones, R.A, Tuschl, T, Patel, D.J. | 登録日 | 2021-10-11 | 公開日 | 2022-10-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists. Cell Chem Biol, 2023
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7SHO
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![BU of 7sho by Molmil](/molmil-images/mine/7sho) | Crystal structure of hSTING in complex with c[2',3'-(ara-2'-G, ribo-3'-A)-MP] (RJ242) | 分子名称: | (2R,5R,7R,8S,10R,12aR,14R,15R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein | 著者 | Xie, W, Lama, L, Yang, X.J, Kuryavyi, V, Nudelman, I, Glickman, J.F, Jones, R.A, Tuschl, T, Patel, D.J. | 登録日 | 2021-10-10 | 公開日 | 2022-10-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists. Cell Chem Biol, 2023
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7R4H
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![BU of 7r4h by Molmil](/molmil-images/mine/7r4h) | |
6WT5
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![BU of 6wt5 by Molmil](/molmil-images/mine/6wt5) | Structure of a bacterial STING receptor from Capnocytophaga granulosa | 分子名称: | Bacterial STING | 著者 | Morehouse, B.R, Govande, A.A, Millman, A, Keszei, A.F.A, Lowey, B, Ofir, G, Shao, S, Sorek, R, Kranzusch, P.J. | 登録日 | 2020-05-01 | 公開日 | 2020-09-09 | 最終更新日 | 2020-10-28 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | STING cyclic dinucleotide sensing originated in bacteria. Nature, 586, 2020
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6WT8
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![BU of 6wt8 by Molmil](/molmil-images/mine/6wt8) | Structure of a STING-associated CdnE c-di-GMP synthase from Flavobacteriaceae sp. | 分子名称: | STING-associated CdnE c-di-GMP synthase | 著者 | Morehouse, B.R, Govande, A.A, Millman, A, Keszei, A.F.A, Lowey, B, Ofir, G, Shao, S, Sorek, R, Kranzusch, P.J. | 登録日 | 2020-05-01 | 公開日 | 2020-09-09 | 最終更新日 | 2020-10-28 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | STING cyclic dinucleotide sensing originated in bacteria. Nature, 586, 2020
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