4QTQ
 
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4RUV
 
 | Crystal structure of thioredoxin 2 from Staphylococcus aureus NCTC8325 | 分子名称: | Thioredoxin | 著者 | Bose, M, Biswas, R, Roychowdhury, A, Bhattacharyya, S, Ghosh, A.K, Das, A.K. | 登録日 | 2014-11-22 | 公開日 | 2015-12-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Elucidation of the mechanism of disulfide exchange between staphylococcal thioredoxin2 and thioredoxin reductase2: A structural insight. Biochimie, 160, 2019
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4RVL
 
 | CHK1 kinase domain with diazacarbazole compound 7: 3-(2-hydroxyphenyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile | 分子名称: | 3-(2-hydroxyphenyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, Serine/threonine-protein kinase Chk1 | 著者 | Wiesmann, C, Wu, P. | 登録日 | 2014-11-26 | 公開日 | 2015-06-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1. J.Med.Chem., 58, 2015
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4RV2
 
 | Crystal Structure of (3R)-hydroxyacyl-ACP dehydratase HadAB hetero-dimer from Mycobacterium smegmatis | 分子名称: | MaoC family protein, SULFATE ION, UPF0336 protein MSMEG_1340/MSMEI_1302 | 著者 | Biswas, R, Hazra, D, Dutta, D, Das, A.K. | 登録日 | 2014-11-24 | 公開日 | 2015-02-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of dehydratase component HadAB complex of mycobacterial FAS-II pathway. Biochem.Biophys.Res.Commun., 458, 2015
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4RVK
 
 | CHK1 kinase domain with diazacarbazole compound 8: N-[3-(6-cyano-9H-pyrrolo[2,3-b:5,4-c']dipyridin-3-yl)phenyl]acetamide | 分子名称: | N-[3-(6-cyano-9H-pyrrolo[2,3-b:5,4-c']dipyridin-3-yl)phenyl]acetamide, Serine/threonine-protein kinase Chk1 | 著者 | Wiesmann, C, Wu, P. | 登録日 | 2014-11-26 | 公開日 | 2015-06-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1. J.Med.Chem., 58, 2015
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4RL4
 
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2FBN
 
 | Plasmodium falciparum putative FK506-binding protein PFL2275c, C-terminal TPR-containing domain | 分子名称: | 70 kDa peptidylprolyl isomerase, putative | 著者 | Dong, A, Lew, J, Koeieradzki, I, Sundararajan, E, Melone, M, Wasney, G, Zhao, Y, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Hills, T, Structural Genomics Consortium (SGC) | 登録日 | 2005-12-09 | 公開日 | 2006-01-24 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide. Protein Sci., 18, 2009
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7NRL
 
 | 14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1032 | 分子名称: | 14-3-3 protein sigma, 2-(hydroxymethyl)-5-(2-phenylimidazol-1-yl)phenol, DI(HYDROXYETHYL)ETHER, ... | 著者 | Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. | 登録日 | 2021-03-04 | 公開日 | 2021-06-16 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
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7NJ8
 
 | 14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1007 | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, MAGNESIUM ION, ... | 著者 | Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. | 登録日 | 2021-02-16 | 公開日 | 2021-06-16 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
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7NIG
 
 | 14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1008 | 分子名称: | 14-3-3 protein sigma, 2-bromanyl-4-imidazol-1-yl-benzaldehyde, CALCIUM ION, ... | 著者 | Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. | 登録日 | 2021-02-12 | 公開日 | 2021-06-16 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
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3H4C
 
 | Structure of the C-terminal Domain of Transcription Factor IIB from Trypanosoma brucei | 分子名称: | 1,2-ETHANEDIOL, Transcription factor TFIIB-like | 著者 | Syed Ibrahim, B, Kanneganti, N, Rieckhof, G.E, Das, A, Laurents, D.V, Palenchar, J.B, Bellofatto, V, Wah, D.A. | 登録日 | 2009-04-18 | 公開日 | 2009-08-11 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of the C-terminal domain of transcription factor IIB from Trypanosoma brucei. Proc.Natl.Acad.Sci.USA, 106, 2009
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7NJA
 
 | 14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1006 | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | 著者 | Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. | 登録日 | 2021-02-16 | 公開日 | 2021-06-16 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
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7NH7
 
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1WA4
 
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1W45
 
 | The 2.5 Angstroem structure of the K16A mutant of annexin A8, which has an intact N-terminus. | 分子名称: | ANNEXIN A8 | 著者 | Rety, S, Sopkova-de Oliveira Santos, J, Raguenes-Nicol, C, Dreyfuss, L, Blondeau, K, Hofbauerova, K, Renouard, M, Russo-Marie, F, Lewit-Bentley, A. | 登録日 | 2004-07-22 | 公開日 | 2005-01-18 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | The Crystal Structure of Annexin A8 is Similar to that of Annexin A3 J.Mol.Biol., 345, 2005
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7NW2
 
 | Crystal Structure of SARS-CoV-2 main protease in complex with LON-WEI-adc59df6-47 | 分子名称: | 3C-like proteinase, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Fearon, D, Douangamath, A, Aimon, A, Brandao-Neto, J, Dias, A, Dunnett, L, Gehrtz, P, Gorrie-Stone, T.J, Lukacik, P, Powell, A.J, Skyner, R, Strain-Damerell, C.M, Zaidman, D, London, N, Walsh, M.A, von Delft, F, Covid Moonshot Consortium | 登録日 | 2021-03-16 | 公開日 | 2021-07-07 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 M pro inhibitor. Cell Chem Biol, 28, 2021
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1W1H
 
 | Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain | 分子名称: | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION | 著者 | Komander, D, Deak, M, Alessi, D.R, Van Aalten, D.M.F. | 登録日 | 2004-06-21 | 公開日 | 2004-11-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates Embo J., 23, 2004
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1W37
 
 | 2-keto-3-deoxygluconate(KDG) aldolase of Sulfolobus solfataricus | 分子名称: | 2-KETO-3-DEOXY GLUCONATE ALDOLASE, GLYCEROL, SODIUM ION | 著者 | Theodossis, A, Walden, H, Westwick, E.J, Connaris, H, Lamble, H.J, Hough, D.W, Danson, M.J, Taylor, G.L. | 登録日 | 2004-07-13 | 公開日 | 2004-09-02 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus. J. Biol. Chem., 279, 2004
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7NXM
 
 | Structure of human cathepsin K in complex with the selective activity-based probe Gu3416 | 分子名称: | Cathepsin K, N-(4-(dibenzylamino)-4-oxobutyl)-2-(5-(dimethylamino)pentanamido)-4-methylpentanamide, SULFATE ION | 著者 | Busa, M, Benysek, J, Lemke, C, Gutschow, M, Mares, M. | 登録日 | 2021-03-18 | 公開日 | 2021-09-08 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity. J.Med.Chem., 64, 2021
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7NXL
 
 | Structure of human cathepsin K in complex with the acrylamide inhibitor Gu3110 | 分子名称: | Cathepsin K, SULFATE ION, tert-butyl (1-((4-(dibenzylamino)-4-oxobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate | 著者 | Busa, M, Benysek, J, Lemke, C, Gutschow, M, Mares, M. | 登録日 | 2021-03-18 | 公開日 | 2021-09-08 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity. J.Med.Chem., 64, 2021
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3GRY
 
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8TY3
 
 | MI-31 ligand bound to SARS-CoV-2 Mpro | 分子名称: | (1S,3aR,6aS)-2-[(3,4-dichlorophenoxy)acetyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}octahydrocyclopenta[c]pyrrole-1-carboxamide, 3C-like proteinase nsp5 | 著者 | Blankenship, L.R, Liu, W.R. | 登録日 | 2023-08-24 | 公開日 | 2024-08-28 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | MI-31 bound to SARS-CoV-2 Mpro To Be Published
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8TY5
 
 | MI-14 bound to Mpro of SARS-CoV-2 | 分子名称: | (1R,2S,5S)-3-[(2,4-dichlorophenoxy)acetyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Blankenship, L.R, Liu, W.R. | 登録日 | 2023-08-24 | 公開日 | 2024-08-28 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | MI-14 bound to SARS-CoV-2 Mpro To Be Published
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8TY4
 
 | MI-30 bound to Mpro of SARS-CoV-2 | 分子名称: | (1S,3aR,6aS)-2-[(2,4-dichlorophenoxy)acetyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}octahydrocyclopenta[c]pyrrole-1-carboxamide, 3C-like proteinase nsp5 | 著者 | Blankenship, L.R, Liu, W.R. | 登録日 | 2023-08-24 | 公開日 | 2024-08-28 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | MI-30 bound to SARS-CoV-2 Mpro To Be Published
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8U0R
 
 | The crystal structure of protein A21, a component of the conserved poxvirus entry-fusion complex | 分子名称: | 1,2-ETHANEDIOL, 1,3-PROPANDIOL, 2-(2-METHOXYETHOXY)ETHANOL, ... | 著者 | Diesterbeck, U, Gittis, A.G, Garboczi, D.N, Moss, B. | 登録日 | 2023-08-29 | 公開日 | 2024-09-04 | 最終更新日 | 2025-04-09 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The 2.3 angstrom Structure of A21, a Protein Component of the Conserved Poxvirus Entry-Fusion Complex. J.Mol.Biol., 437, 2025
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