6HMW
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7INS
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![BU of 7ins by Molmil](/molmil-images/mine/7ins) | STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z | 分子名称: | GENERAL PROTAMINE CHAIN, INSULIN (CHAIN A), INSULIN (CHAIN B), ... | 著者 | Balschmidt, P, Hansen, F.B, Dodson, E, Dodson, G, Korber, F. | 登録日 | 1991-09-03 | 公開日 | 1994-01-31 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of porcine insulin cocrystallized with clupeine Z. Acta Crystallogr.,Sect.B, 47, 1991
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6BJL
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![BU of 6bjl by Molmil](/molmil-images/mine/6bjl) | Human ABO(H) blood group glycosyltransferase GTB D302L mutant | 分子名称: | ABO blood group (Transferase A, alpha 1-3-N-acetylgalactosaminyltransferase transferase B, alpha 1-3-galactosyltransferase), ... | 著者 | Gagnon, S.M.L, Legg, M.S.G, Evans, S.V. | 登録日 | 2017-11-06 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases. Glycobiology, 28, 2018
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6W7V
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![BU of 6w7v by Molmil](/molmil-images/mine/6w7v) | Structure of rabbit actin in complex with truncated analog of Mycalolide B | 分子名称: | (1E,3R,4R,5S,6R,9S,10S,12S)-12-[(4-aminobutanoyl)oxy]-1-[ethyl(formyl)amino]-4,10-dimethoxy-3,5,9,13-tetramethyltetradec-1-en-6-yl (2R)-oxolane-2-carboxylate, 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Allingham, J.S, Deng, X, Trofimova, D. | 登録日 | 2020-03-19 | 公開日 | 2020-10-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Truncated Actin-Targeting Macrolide Derivative Blocks Cancer Cell Motility and Invasion of Extracellular Matrix. J.Am.Chem.Soc., 143, 2021
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6MFP
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![BU of 6mfp by Molmil](/molmil-images/mine/6mfp) | Crystal Structure of the RV305 C1-C2 specific ADCC potent antibody DH677.3 Fab in complex with HIV-1 clade A/E gp120 and M48U1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Tolbert, W.D, Young, B, Pazgier, M. | 登録日 | 2018-09-11 | 公開日 | 2019-09-18 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency. J.Virol., 94, 2020
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6BJK
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![BU of 6bjk by Molmil](/molmil-images/mine/6bjk) | Human ABO(H) blood group glycosyltransferase GTB D302C mutant | 分子名称: | ABO blood group (Transferase A, alpha 1-3-N-acetylgalactosaminyltransferase transferase B, alpha 1-3-galactosyltransferase), ... | 著者 | Gagnon, S.M.L, Legg, M.S.G, Evans, S.V. | 登録日 | 2017-11-06 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases. Glycobiology, 28, 2018
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5D7R
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![BU of 5d7r by Molmil](/molmil-images/mine/5d7r) | Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a ligand | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-hydroxy-5-[5-(6-hydroxy-7-propyl-2H-indazol-3-yl)-1,3-thiazol-2-yl]pyridine-2-carboxylic acid, CHLORIDE ION, ... | 著者 | Zhang, J, Yang, Q, Cross, J.B, Romero, J.A.C, Ryan, M.D, Lippa, B, Dolle, R.E, Andersen, O.A, Barker, J, Cheng, R.K, Kahmann, J, Felicetti, B, Wood, M, Scheich, C. | 登録日 | 2015-08-14 | 公開日 | 2015-11-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors. Acs Med.Chem.Lett., 6, 2015
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6BJJ
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6GRQ
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6CN5
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6TNN
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![BU of 6tnn by Molmil](/molmil-images/mine/6tnn) | Mini-RNase III (Mini-III) bound to 50S ribosome with precursor 23S rRNA | 分子名称: | 50S ribosomal protein L10, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Oerum, S, Dendooven, T, Gilet, L, Catala, M, Degut, C, Trinquier, A, Barraud, P, Luisi, B, Condon, C, Tisne, C. | 登録日 | 2019-12-09 | 公開日 | 2020-09-30 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structures of B. subtilis Maturation RNases Captured on 50S Ribosome with Pre-rRNAs. Mol.Cell, 80, 2020
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8ETR
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![BU of 8etr by Molmil](/molmil-images/mine/8etr) | CryoEM Structure of NLRP3 NACHT domain in complex with G2394 | 分子名称: | (6S,8R)-N-[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl]-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Murray, J.M, Johnson, M.C. | 登録日 | 2022-10-17 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Overcoming Preclinical Safety Obstacles to Discover ( S )- N -((1,2,3,5,6,7-Hexahydro- s -indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H -pyrazolo[5,1- b ][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor. J.Med.Chem., 65, 2022
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6BJM
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![BU of 6bjm by Molmil](/molmil-images/mine/6bjm) | Human ABO(H) blood group glycosyltransferase GTB R188K mutant | 分子名称: | ABO blood group (Transferase A, alpha 1-3-N-acetylgalactosaminyltransferase transferase B, alpha 1-3-galactosyltransferase), ... | 著者 | Gagnon, S.M.L, Legg, M.S.G, Evans, S.V. | 登録日 | 2017-11-06 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases. Glycobiology, 28, 2018
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5KQY
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![BU of 5kqy by Molmil](/molmil-images/mine/5kqy) | Protease E35D-DRV | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease E35D-DRV | 著者 | Liu, Z, Poole, K.M, Mahon, B.P, McKenna, R, Fanucci, G.E. | 登録日 | 2016-07-06 | 公開日 | 2016-09-21 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution. J.Biol.Chem., 291, 2016
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6WPW
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![BU of 6wpw by Molmil](/molmil-images/mine/6wpw) | GCGR-Gs signaling complex bound to a designed glucagon derivative | 分子名称: | Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hilger, D, Krishna Kumar, K, Hu, H, Mathiesen, J.M, Skiniotis, G, Kobilka, B.K. | 登録日 | 2020-04-28 | 公開日 | 2020-08-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into differences in G protein activation by family A and family B GPCRs. Science, 369, 2020
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5KR1
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![BU of 5kr1 by Molmil](/molmil-images/mine/5kr1) | Protease PR5-DRV | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease PR5-DRV | 著者 | Liu, Z, Poole, K.M, Mahon, B.P, McKenna, R, Fanucci, G.E. | 登録日 | 2016-07-06 | 公開日 | 2016-09-21 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution. J.Biol.Chem., 291, 2016
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7ER6
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![BU of 7er6 by Molmil](/molmil-images/mine/7er6) | Crystal structure of human Biliverdin IX-beta reductase B | 分子名称: | Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION | 著者 | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | 登録日 | 2021-05-06 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target. J.Med.Chem., 65, 2022
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7ER7
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![BU of 7er7 by Molmil](/molmil-images/mine/7er7) | Crystal structure of hyman Biliverdin IX-beta reductase B with Tamibarotene (A80) | 分子名称: | 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | 登録日 | 2021-05-06 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target. J.Med.Chem., 65, 2022
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7ERD
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![BU of 7erd by Molmil](/molmil-images/mine/7erd) | Crystal structure of human Biliverdin IX-beta reductase B with Flunixin Meglumin (FMG) | 分子名称: | 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | 登録日 | 2021-05-06 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target. J.Med.Chem., 65, 2022
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7ER8
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![BU of 7er8 by Molmil](/molmil-images/mine/7er8) | Crystal structure of human Biliverdin IX-beta reductase B with Sulfasalazine (SAS) | 分子名称: | 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | 登録日 | 2021-05-06 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target. J.Med.Chem., 65, 2022
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7ERA
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![BU of 7era by Molmil](/molmil-images/mine/7era) | Crystal structure of human Biliverdin IX-beta reductase B with Olsalazine Sodium (OSS) | 分子名称: | 5-[(E)-(3-carboxy-4-oxidanyl-phenyl)diazenyl]-2-oxidanyl-benzoic acid, Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Griesinger, C, Lee, D, Ryu, K.S, Kim, M, Ha, J.H. | 登録日 | 2021-05-06 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target. J.Med.Chem., 65, 2022
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7XX3
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![BU of 7xx3 by Molmil](/molmil-images/mine/7xx3) | Crystal structure of human Superoxide Dismutase (SOD1) in complex with a fungal metabolite molecule, Phialomustin B (PB) | 分子名称: | (2~{E},4~{E},6~{S})-4,6-dimethyldeca-2,4-dienoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Padmanabhan, B, Unni, S. | 登録日 | 2022-05-28 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Phialomustin-B a fungal metabolite isolated from Phialophora mustea modulates Superoxide Dismutase 1 (SOD1) aggregation: Therapeutic potential in Amyotrophic lateral sclerosis (ALS) To Be Published
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6ENK
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![BU of 6enk by Molmil](/molmil-images/mine/6enk) | The X-ray crystal structure of DesE bound to desferrioxamine B | 分子名称: | DesE, SODIUM ION, desferrioxamine B | 著者 | Naismith, J.H, McMahon, S.A, Challis, G.L, Kadi, N, Oke, M, Liu, H, Carter, L.G, Johnson, K.A. | 登録日 | 2017-10-05 | 公開日 | 2018-05-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC. Philos. Trans. R. Soc. Lond., B, Biol. Sci., 373, 2018
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5U3L
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![BU of 5u3l by Molmil](/molmil-images/mine/5u3l) | Crystal Structure of DH511.2 Fab in Complex with HIV-1 gp41 MPER 670-683 Peptide | 分子名称: | DH511.2 Fab Heavy Chain, DH511.2 Fab Light Chain, gp41 MPER peptide | 著者 | Ofek, G, Wu, L, Lougheed, C.S, Williams, L.D, Nicely, N.I, Haynes, B.F. | 登録日 | 2016-12-02 | 公開日 | 2017-02-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.165 Å) | 主引用文献 | Potent and broad HIV-neutralizing antibodies in memory B cells and plasma. Sci Immunol, 2, 2017
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5U4R
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![BU of 5u4r by Molmil](/molmil-images/mine/5u4r) | Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 53-1A09 Fab. | 分子名称: | VRC 315 53-1A09 Fab Heavy chain, VRC 315 53-1A09 Fab Light chain | 著者 | Joyce, M.G, Andrews, S.F, Mascola, J.R, McDermott, A.B, Kwong, P.D. | 登録日 | 2016-12-05 | 公開日 | 2017-11-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.762 Å) | 主引用文献 | Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans. Sci Immunol, 2, 2017
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