9BF2
 
 | | MID domain of Ago2 bound to UMP | | 分子名称: | Protein argonaute-2, URIDINE-5'-MONOPHOSPHATE | | 著者 | Harp, J.M, Egli, M. | | 登録日 | 2024-04-16 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
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5K52
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5JRG
 | | Crystal structure of the nucleosome containing the DNA with tetrahydrofuran (THF) | | 分子名称: | CHLORIDE ION, DNA (145-MER), Histone H2A type 1-B/E, ... | | 著者 | Osakabe, A, Arimura, Y, Horikoshi, N, Kurumizaka, H. | | 登録日 | 2016-05-06 | | 公開日 | 2017-03-08 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Polymorphism of apyrimidinic DNA structures in the nucleosome
Sci Rep, 7, 2017
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2IHO
 | | Crystal structure of MOA, a lectin from the mushroom Marasmius oreades in complex with the trisaccharide Gal(1,3)Gal(1,4)GlcNAc | | 分子名称: | Lectin, beta-D-galactopyranose-(1-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Grahn, E, Askarieh, G, Holmner, A, Tateno, H, Winter, H.C, Goldstein, I.J, Krengel, U. | | 登録日 | 2006-09-27 | | 公開日 | 2007-05-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Crystal structure of the marasmius oreades mushroom lectin in complex with a xenotransplantation epitope.
J.Mol.Biol., 369, 2007
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9BAZ
 | | CryoEM structure of DIM2-HP1 complex | | 分子名称: | DNA (cytosine-5-)-methyltransferase, Heterochromatin protein one, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Song, J, Shao, Z. | | 登録日 | 2024-04-05 | | 公開日 | 2024-07-24 | | 最終更新日 | 2025-02-05 | | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | | 主引用文献 | Multi-layered heterochromatin interaction as a switch for DIM2-mediated DNA methylation.
Nat Commun, 15, 2024
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5K6F
 | | Crystal structure of prefusion-stabilized RSV F single-chain 9-19 DS-Cav1 variant. | | 分子名称: | Fusion glycoprotein F0 | | 著者 | Joyce, M.G, Zhang, B, Lai, Y.T, Mascola, J.R, Kwong, P.D. | | 登録日 | 2016-05-24 | | 公開日 | 2016-08-10 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.
Nat.Struct.Mol.Biol., 23, 2016
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2II2
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9BIR
 | | Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cefadroxil | | 分子名称: | Cefadroxil, Solute carrier family 15 member 2, nanobody | | 著者 | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | 登録日 | 2024-04-24 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis for antibiotic transport and inhibition in PepT2.
Nat Commun, 15, 2024
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2II9
 | | Anabaena sensory rhodopsin transducer | | 分子名称: | Sensory rhodopsin transducer protein | | 著者 | Vogeley, L. | | 登録日 | 2006-09-27 | | 公開日 | 2007-03-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the anabaena sensory rhodopsin transducer.
J.Mol.Biol., 367, 2007
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9B67
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5K7G
 | | IRAK4 in complex with AZ3862 | | 分子名称: | (3~{a}~{S},7~{a}~{R})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one, Interleukin-1 receptor-associated kinase 4, SULFATE ION | | 著者 | Ferguson, A.D. | | 登録日 | 2016-05-26 | | 公開日 | 2017-12-06 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma.
J. Med. Chem., 60, 2017
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9BDN
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9B9O
 | | Crystal structure of FlcD from Pseudomonas aeruginosa bond to iron(II) and substrate | | 分子名称: | (2R)-2-{[(2Z)-2-(hydroxyimino)ethyl]sulfanyl}butanedioic acid, FE (II) ION, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C | | 著者 | Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R. | | 登録日 | 2024-04-02 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-09-18 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme.
Acs Cent.Sci., 10, 2024
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5JRZ
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9BRX
 | | SARS-CoV-2 Papain-like Protease (PLpro) with Fragment 10 | | 分子名称: | (4R)-N-(2,4-dimethylphenyl)-7-methyl[1,2,4]triazolo[4,3-a]pyrimidin-5-amine, Papain-like protease nsp3, SULFATE ION, ... | | 著者 | Amporndanai, K, Zhao, B, Fesik, S.W. | | 登録日 | 2024-05-11 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PL pro ).
Acs Med.Chem.Lett., 15, 2024
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1LU2
 | | DOLICHOS BIFLORUS SEED LECTIN IN COMPLEX WITH THE BLOOD GROUP A TRISACCHARIDE | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, CALCIUM ION, LECTIN, ... | | 著者 | Hamelryck, T.W, Loris, R, Bouckaert, J, Strecker, G, Imberty, A, Fernandez, E, Wyns, L, Etzler, M.E. | | 登録日 | 1998-07-30 | | 公開日 | 1998-12-09 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Carbohydrate binding, quaternary structure and a novel hydrophobic binding site in two legume lectin oligomers from Dolichos biflorus.
J.Mol.Biol., 286, 1999
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9BK3
 | | Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (R-enantiomer, orthorhombic P form) | | 分子名称: | (2R)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid, CHLORIDE ION, L-lactate dehydrogenase A chain, ... | | 著者 | Lovell, S, Cooper, A, Battaile, K.P, Sharma, H. | | 登録日 | 2024-04-26 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer.
Eur.J.Med.Chem., 275, 2024
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9BNR
 | | 4-(2-isothiocyanatoethyl)benzenesulfonamide complexed with Macrophage Migration Inhibitory Factor | | 分子名称: | Macrophage migration inhibitory factor, N-[2-(4-sulfamoylphenyl)ethyl]methanethioamide, SULFATE ION | | 著者 | Fellner, M, Rutledge, M.T, Putha, L, Kok, L.K, Gamble, A.B, Wilbanks, S.M, Vernall, A.J, Tyndall, J.D.A. | | 登録日 | 2024-05-02 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Covalent Isothiocyanate Inhibitors of Macrophage Migration Inhibitory Factor as Potential Colorectal Cancer Treatments.
Chemmedchem, 19, 2024
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9B60
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2IMB
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2IMT
 | | The X-ray Structure of a Bak Homodimer Reveals an Inhibitory Zinc Binding Site | | 分子名称: | Apoptosis regulator BAK, ZINC ION | | 著者 | Moldoveanu, T, Liu, Q, Tocilj, A, Watson, M, Shore, G.C, Gehring, K.B. | | 登録日 | 2006-10-04 | | 公開日 | 2007-01-23 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site.
Mol.Cell, 24, 2006
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9BCT
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5JSP
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7RTQ
 | | Sterol 14alpha demethylase (CYP51) from Naegleria fowleri in complex with an inhibitor R)-N-(1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide | | 分子名称: | N-[(1R)-2-(1H-imidazol-1-yl)-1-(3,4',5-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, PROTOPORPHYRIN IX CONTAINING FE, Protein CYP51 | | 著者 | Lepesheva, G.I, Hargrove, T.Y, Wawrzak, Z. | | 登録日 | 2021-08-13 | | 公開日 | 2021-11-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Relaxed Substrate Requirements of Sterol 14 alpha-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition.
J.Med.Chem., 64, 2021
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9B6A
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