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6LRC
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BU of 6lrc by Molmil
Human cGAS catalytic domain bound with the inhibitor PF-06928215
分子名称: (1R,2S)-2-[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acid, Cyclic GMP-AMP synthase, ZINC ION
著者Zhao, W.F, Xu, Y.C.
登録日2020-01-15
公開日2020-06-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.831 Å)
主引用文献In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing.
J.Chem.Inf.Model., 60, 2020
6LRL
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BU of 6lrl by Molmil
Human cGAS catalytic domain bound with compound s2
分子名称: 3-[[5-(1,2,4-triazol-4-yl)-4H-1,2,4-triazol-3-yl]carbonylamino]benzoic acid, Cyclic GMP-AMP synthase, ZINC ION
著者Zhao, W.F, Xiong, M.Y, Yuan, X.J, Sun, H.B, Xu, Y.C.
登録日2020-01-16
公開日2020-06-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.655 Å)
主引用文献In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing.
J.Chem.Inf.Model., 60, 2020
6LRJ
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BU of 6lrj by Molmil
Human cGAS catalytic domain bound with compound 23
分子名称: 4-[2-(2-methyl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)hydrazinyl]-4-oxidanylidene-butanoic acid, Cyclic GMP-AMP synthase, ZINC ION
著者Zhao, W.F, Xiong, M.Y, Yuan, X.J, Sun, H.B, Xu, Y.C.
登録日2020-01-16
公開日2020-06-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing.
J.Chem.Inf.Model., 60, 2020
5FT3
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BU of 5ft3 by Molmil
Aedes aegypti GSTe2
分子名称: GLUTATHIONE, GLUTATHIONE S-TRANSFERASE EPSILON 2
著者Yunta, C.
登録日2016-01-11
公開日2017-02-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.431 Å)
主引用文献A Simple Test for the Determination of Ddt on Sprayed Surfaces
To be Published
5ABW
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BU of 5abw by Molmil
Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases
分子名称: 1-(3-CHLOROPHENYL)-5-(3,5-DIMETHYLISOXAZOL-4-YL)-6-METHYL-N-[4-(METHYLSULFONYL)BENZYL]-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者von Nussbaum, F, Li, V.M, Schaefer, M.
登録日2015-08-10
公開日2015-08-19
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores.
Bioorg. Med. Chem. Lett., 25, 2015
6LRI
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BU of 6lri by Molmil
Human cGAS catalytic domain bound with compound 17
分子名称: 3-[5-(2-hydroxy-2-oxoethyl)-3-oxidanylidene-[1,2,4]triazino[2,3-a]benzimidazol-2-yl]propanoic acid, Cyclic GMP-AMP synthase, ZINC ION
著者Zhao, W.F, Xiong, M.Y, Yuan, X.J, Sun, H.B, Xu, Y.C.
登録日2020-01-16
公開日2020-06-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing.
J.Chem.Inf.Model., 60, 2020
6LRE
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BU of 6lre by Molmil
Human cGAS catalytic domain bound with compound 3
分子名称: 1,3-bis(oxidanylidene)benzo[de]isoquinoline-6,7-dicarboxylic acid, Cyclic GMP-AMP synthase, ZINC ION
著者Zhao, W.F, Xiong, M.Y, Yuan, X.J, Sun, H.B, Xu, Y.C.
登録日2020-01-16
公開日2020-06-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing.
J.Chem.Inf.Model., 60, 2020
6LRK
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BU of 6lrk by Molmil
Human cGAS catalytic domain bound with compound 40
分子名称: (3R)-1-pyrrolo[1,2-a]quinoxalin-4-ylpiperidine-3-carboxylic acid, Cyclic GMP-AMP synthase, ZINC ION
著者Zhao, W.F, Xiong, M.Y, Yuan, X.J, Sun, H.B, Xu, Y.C.
登録日2020-01-16
公開日2020-06-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing.
J.Chem.Inf.Model., 60, 2020
7TXE
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BU of 7txe by Molmil
Plasmodium falciparum Cyt c2 DSD
分子名称: Cytochrome c2, HEME C
著者Hill, C.P, Wienkers, H.J, Whitby, F.G.
登録日2022-02-08
公開日2023-05-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Direct tests of cytochrome c and c1 functions in the electron transport chain of malaria parasites
Proc Natl Acad Sci U S A, 120, 2023
7U2V
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BU of 7u2v by Molmil
Plasmodium falciparum Cyt c2 DSD
分子名称: Cytochrome c2, HEME C
著者Hill, C.P, Wienkers, H.J, Whitby, F.G.
登録日2022-02-24
公開日2023-05-10
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Direct tests of cytochrome c and c1 functions in the electron transport chain of malaria parasites
Proc Natl Acad Sci U S A, 120, 2023
5UOI
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BU of 5uoi by Molmil
Solution structure of the de novo mini protein HHH_rd1_0142
分子名称: HHH_rd1_0142
著者Houliston, S, Rocklin, G.J, Lemak, A, Carter, L, Chidyausiku, T.M, Baker, D, Arrowsmith, C.H.
登録日2017-01-31
公開日2017-07-26
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Global analysis of protein folding using massively parallel design, synthesis, and testing.
Science, 357, 2017
5UYO
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BU of 5uyo by Molmil
Solution NMR structure of the de novo mini protein HEEH_rd4_0097
分子名称: HEEH_rd4_0097
著者Lemak, A, Rocklin, G.J, Houliston, S, Carter, L, Chidyausiku, T.M, Baker, D, Arrowsmith, C.H.
登録日2017-02-24
公開日2017-07-26
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Global analysis of protein folding using massively parallel design, synthesis, and testing.
Science, 357, 2017
5UP5
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BU of 5up5 by Molmil
Solution structure of the de novo mini protein EHEE_rd1_0284
分子名称: EHEE_rd1_0284
著者Houliston, S, Rocklin, G.J, Lemak, A, Carter, L, Chidyausiku, T.M, Baker, D, Arrowsmith, C.H.
登録日2017-02-01
公開日2017-07-26
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Global analysis of protein folding using massively parallel design, synthesis, and testing.
Science, 357, 2017
5UP1
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BU of 5up1 by Molmil
Solution structure of the de novo mini protein EEHEE_rd3_1049
分子名称: EEHEE_rd3_1049
著者Houliston, S, Rocklin, G.J, Lemak, A, Carter, L, Chidyausiku, T.M, Baker, D, Arrowsmith, C.H.
登録日2017-02-01
公開日2017-07-26
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Global analysis of protein folding using massively parallel design, synthesis, and testing.
Science, 357, 2017
9C81
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BU of 9c81 by Molmil
X-ray crystal structure of AmpC beta-lactamase with inhibitor
分子名称: (2R)-2-phenoxy-3-{[(1S,2S,4S)-spiro[bicyclo[2.2.1]heptane-7,1'-cyclopropane]-2-carbonyl]amino}propanoic acid, AmpC Beta-lactamase
著者Liu, F, Shoichet, B.K, Bassim, V.
登録日2024-06-11
公開日2024-06-19
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Improved correlations with score, hit-rate, and affinity as docking library and testing scale increase
To Be Published
9C8J
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BU of 9c8j by Molmil
X-ray crystal structure of AmpC beta-lactamase with inhibitor
分子名称: AmpC Beta-lactamase, N-(1-acetyl-2,3-dihydro-1H-indol-4-yl)-3-chloro-2-hydroxybenzene-1-sulfonamide
著者Liu, F, Shoichet, B.K.
登録日2024-06-12
公開日2024-06-19
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Improved correlations with score, hit-rate, and affinity as docking library and testing scale increase
To Be Published
9C84
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BU of 9c84 by Molmil
X-ray crystal structure of AmpC beta-lactamase with inhibitor
分子名称: 3,5-dichloro-N-(8-fluoroisoquinolin-5-yl)-2-hydroxybenzene-1-sulfonamide, AmpC Beta-lactamase
著者Liu, F, Shoichet, B.K.
登録日2024-06-12
公開日2024-06-19
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Improved correlations with score, hit-rate, and affinity as docking library and testing scale increase
To Be Published
9C6P
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BU of 9c6p by Molmil
X-ray crystal structure of AmpC beta-lactamase with inhibitor
分子名称: 3-chloro-N-(5-chloro-2-methyl-1,3-benzothiazol-6-yl)-2-hydroxybenzene-1-sulfonamide, AmpC Beta-lactamase
著者Liu, F, Shoichet, B.K.
登録日2024-06-08
公開日2024-06-19
実験手法X-RAY DIFFRACTION (1.663 Å)
主引用文献Improved correlations with score, hit-rate, and affinity as docking library and testing scale increase
To Be Published
9C83
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BU of 9c83 by Molmil
X-ray crystal structure of AmpC beta-lactamase with inhibitor
分子名称: AmpC Beta-lactamase, N-[(3M)-3-(5-chloro-1,2,3-thiadiazol-4-yl)phenyl]-5-methyl-3-oxo-2,3-dihydro-1,2-oxazole-4-sulfonamide
著者Liu, F, Shoichet, B.K.
登録日2024-06-11
公開日2024-06-19
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Improved correlations with score, hit-rate, and affinity as docking library and testing scale increase
To Be Published
8FVZ
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BU of 8fvz by Molmil
PiPT Y150A
分子名称: CITRATE ANION, PHOSPHATE ION, Phosphate transporter
著者Gupta, M, Finer-Moore, J, Stroud, R.M.
登録日2023-01-20
公開日2024-01-03
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Roles of PiPT residues in phosphate binding and transport tested by mutagenesis
To be published
6YFW
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BU of 6yfw by Molmil
TGT H333F mutant crystallised at pH 8.5
分子名称: CHLORIDE ION, GLYCEROL, Queuine tRNA-ribosyltransferase, ...
著者Nguyen, A, Heine, A, Klebe, G.
登録日2020-03-26
公開日2020-04-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献Mutation study on tRNA-guanine transglycosylase for catalysis Testing
To Be Published
6YFX
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BU of 6yfx by Molmil
TGT Y330F mutant crystallised at pH 5.5
分子名称: GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION
著者Nguyen, A, Heine, A, Klebe, G.
登録日2020-03-26
公開日2020-04-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Mutation study on tRNA-guanine transglycosylase for catalysis Testing
To Be Published
6YRY
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BU of 6yry by Molmil
tRNA-Guanine Transglycosylase (TGT) H333A mutant crystallised at pH 5.5
分子名称: GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION
著者Nguyen, A, Heine, A, Klebe, G.
登録日2020-04-20
公開日2020-04-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Mutation study on tRNA-guanine transglycosylase for catalysis testing
To Be Published
6YGK
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BU of 6ygk by Molmil
TGT Y330F mutant crystallised at pH 8.5
分子名称: GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION
著者Nguyen, A, Heine, A, Klebe, G.
登録日2020-03-27
公開日2020-04-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Mutation study on tRNA-guanine transglycosylase for catalysis Testing
To Be Published
6Z0D
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BU of 6z0d by Molmil
tRNA-Guanine Transglycosylase (TGT) H333F mutant crystallised at pH 5.5
分子名称: GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION
著者Nguyen, A, Heine, A, Klebe, G.
登録日2020-05-08
公開日2020-05-20
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Mutation study on tRNA-guanine transglycosylase for catalysis testing
To Be Published

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件を2024-07-17に公開中

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