PDB: 1556 件ウェブページステータス検索Chemie searchBIRD

---

6S03	Carbonic Anhydrase CAIX mimic in complex with inhibitor I39LT379 分子名称: 4-[[4-[5,5-dimethyl-2-(6-methylpyridin-2-yl)-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-yl]amino]benzenesulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Kugler, M, Brynda, J, Rezacova, P. 登録日 2019-06-13 公開日 2020-06-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA). SLAS Discov, 25, 2020
6RZX	Carbonic Anhydrase CAIX mimic in complex with inhibitor FBSA 分子名称: 1,1,2,2,3,3,4,4,4-nonakis(fluoranyl)butane-1-sulfonamide, Carbonic anhydrase 2, ZINC ION 著者 Kugler, M, Brynda, J, Rezacova, P. 登録日 2019-06-13 公開日 2020-06-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA). SLAS Discov, 25, 2020
1HVA	ENGINEERING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF THE HIS-94-> CYS APOENZYME IN A NEW CRYSTALLINE FORM 分子名称: CARBONIC ANHYDRASE II 著者 Alexander, R.S, Christianson, D.W. 登録日 1992-10-27 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form. Biochemistry, 32, 1993
6QN2	Three dimensional structure of human carbonic anhydrase IX in complex with benzenesulfonamide 分子名称: Carbonic anhydrase 9, ZINC ION, methyl 4-[(4-chloranyl-2-cyclohexylsulfanyl-5-sulfamoyl-phenyl)carbonylamino]butanoate 著者 Leitans, J, Tars, K. 登録日 2019-02-08 公開日 2020-02-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185, 2020
6QN0	Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide 分子名称: Carbonic anhydrase 12, ZINC ION, ~{N}-butyl-4-chloranyl-2-(2-phenylethylsulfanyl)-5-sulfamoyl-benzamide 著者 Dvinskis, E, Leitans, J, Tars, K. 登録日 2019-02-08 公開日 2020-02-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185, 2020
1BNU	CARBONIC ANHYDRASE II INHIBITOR 分子名称: 3,4-DIHYDRO-4-HYDROXY-2-(2-THIENYMETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-30 公開日 1999-06-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNM	CARBONIC ANHYDRASE II INHIBITOR 分子名称: (R)-3,4-DIHYDRO-2-(3-METHOXYPHENYL)-4-METHYLAMINO-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-30 公開日 1999-05-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
6QNL	Three dimensional structure of human carbonic anhydrase XII in complex with benzenesulfonamide 分子名称: Carbonic anhydrase 12, ZINC ION, methyl 4-[(4-chloranyl-2-cyclohexylsulfanyl-5-sulfamoyl-phenyl)carbonylamino]butanoate 著者 Dvinskis, E, Leitans, J, Tars, K. 登録日 2019-02-11 公開日 2020-03-04 最終更新日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185, 2020
6QN6	Three dimensional structure of human carbonic anhydrase IX in complex with benzenesulfonamide 分子名称: Carbonic anhydrase 9, ZINC ION, ~{N}-butyl-4-chloranyl-2-(2-phenylethylsulfanyl)-5-sulfamoyl-benzamide 著者 Leitans, J, Tars, K. 登録日 2019-02-09 公開日 2020-02-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur.J.Med.Chem., 185, 2020
1BNT	CARBONIC ANHYDRASE II INHIBITOR 分子名称: 3,4-DIHYDRO-4-HYDROXY-2-(4-METHOXYPHENYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-30 公開日 1999-06-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BN3	CARBONIC ANHYDRASE II INHIBITOR 分子名称: 2-(3-METHOXYPHENYL)-2H-THIENO-[3,2-E]-1,2-THIAZINE-6-SULFINAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-31 公開日 1999-05-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNN	CARBONIC ANHYDRASE II INHIBITOR 分子名称: 3,,4-DIHYDRO-2-(3-METHOXYPHENYL)-2H-THIENO-[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-30 公開日 1999-05-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNQ	CARBONIC ANHYDRASE II INHIBITOR 分子名称: (R)-4-ETHYLAMINO-3,4-DIHYDRO-2-(2-METHOYLETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-30 公開日 1999-06-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNV	CARBONIC ANHYDRASE II INHIBITOR 分子名称: (S)-3,4-DIHYDRO-2-(3-METHOXYPHENYL)-4-METHYLAMINO-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE, MERCURY (II) ION, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-30 公開日 1999-02-16 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1CNY	SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS 分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDE, ... 著者 Boriack, P.A, Christianson, D.W. 登録日 1995-07-21 公開日 1995-11-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants. J.Med.Chem., 38, 1995
1ZSB	CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CARBONIC ANHYDRASE II, ZINC ION 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
1CAL	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. 登録日 1992-09-17 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993
1DCA	STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Ippolito, J.A, Christianson, D.W. 登録日 1992-12-18 公開日 1993-07-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of an engineered His3Cys zinc binding site in human carbonic anhydrase II. Biochemistry, 32, 1993
1DCB	STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Ippolito, J.A, Christianson, D.W. 登録日 1993-03-10 公開日 1993-07-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of an engineered His3Cys zinc binding site in human carbonic anhydrase II. Biochemistry, 32, 1993
1CVB	STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION 著者 Ippolito, J.A, Christianson, D.W. 登録日 1993-02-04 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II. J.Biol.Chem., 268, 1993
3UK8	The crystal structure of the cd-bound domain 3 of the cadmium carbonic anhydrase from marine diatom Thalassiosira weissflogii 分子名称: ACETATE ION, CADMIUM ION, Cadmium-specific carbonic anhydrase 著者 Alterio, V, De Simone, G. 登録日 2011-11-09 公開日 2012-07-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and inhibition insights into carbonic anhydrase CDCA1 from the marine diatom Thalassiosira weissflogii. Biochimie, 94, 2012
1H9Q	H119Q CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Lesburg, C.A, Christianson, D.W. 登録日 1997-05-29 公開日 1997-09-17 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry, 36, 1997
1H9N	H119N CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Lesburg, C.A, Christianson, D.W. 登録日 1997-05-29 公開日 1997-09-17 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry, 36, 1997
1CAI	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION 著者 Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. 登録日 1992-09-17 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993
1CAK	STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION 著者 Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S. 登録日 1992-09-17 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins, 17, 1993

<13141516171819202122232425262728>