PDB: 971 件ウェブページステータス検索Chemie searchBIRD

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4S2Z	ERK2 Intrinsically active mutant R65S 分子名称: Mitogen-activated protein kinase 1 著者 Livnah, O, Karamansha, Y. 登録日 2015-01-25 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Multiple mechanisms render Erk proteins MEK-independent To be Published
4S34	ERK2 (I84A) in complex with AMP-PNP 分子名称: MAGNESIUM ION, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Livnah, O, Karamansha, Y, Tzarum, N. 登録日 2015-01-26 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Multiple mechanisms render Erk proteins MEK-independent To be Published
4S32	Crystal structure of ERK2 AMP-PNP complex 分子名称: MAGNESIUM ION, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Livnah, O, Karamansha, Y, Tzarum, N. 登録日 2015-01-26 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Crystal structure of ERK2 AMP-PNP complex To be Published
4S30	ERK2 intrinsically active mutant (I84A) 分子名称: Mitogen-activated protein kinase 1 著者 Livnah, O, Karamansha, Y. 登録日 2015-01-26 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Multiple mechanisms render Erk proteins MEK-independent To be Published
4S31	Crystal structure of mitogen-activated protein kinase 1 wtERK2 at 1.45A 分子名称: Mitogen-activated protein kinase 1 著者 Livnah, O, Karamansha, Y. 登録日 2015-01-26 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Multiple mechanisms render Erk proteins MEK-independent To be Published
4S33	ERK2 R65S mutant complexed with AMP-PNP 分子名称: MAGNESIUM ION, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Livnah, O, Karamansha, Y, Tzarum, N. 登録日 2015-01-26 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Multiple mechanisms render Erk proteins MEK-independent To be Published
4U0F	Hexameric HIV-1 CA in Complex with BI-2 分子名称: (4S)-4-(4-hydroxyphenyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one, 1,2-ETHANEDIOL, Capsid protein p24 著者 Price, A.J, Jacques, D.A, James, L.C. 登録日 2014-07-11 公開日 2014-11-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. Plos Pathog., 10, 2014
4U0B	Hexamer HIV-1 CA in complex with CPSF6 peptide, P212121 crystal form 分子名称: Capsid protein p24, Cleavage and polyadenylation specificity factor subunit 6 著者 Price, A.J, Jacques, D.A, James, L.C. 登録日 2014-07-11 公開日 2014-11-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. Plos Pathog., 10, 2014
4U0D	Hexameric HIV-1 CA in complex with Nup153 peptide, P212121 crystal form 分子名称: CHLORIDE ION, Gag polyprotein, Nuclear pore complex protein Nup153 著者 Price, A.J, Jacques, D.A, James, L.C. 登録日 2014-07-11 公開日 2014-11-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. Plos Pathog., 10, 2014
4U81	MEK1 Kinase bound to small molecule inhibitor G659 分子名称: 8-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-7-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Robarge, K.D, Ultsch, M.H, Weismann, C. 登録日 2014-07-31 公開日 2014-09-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.701 Å) 主引用文献 Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. Bioorg.Med.Chem.Lett., 24, 2014
4U0A	Hexameric HIV-1 CA in complex with CPSF6 peptide, P6 crystal form 分子名称: CHLORIDE ION, Capsid protein p24, Cleavage and polyadenylation specificity factor subunit 6 著者 Price, A.J, Jacques, D.A, James, L.C. 登録日 2014-07-11 公開日 2014-11-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. Plos Pathog., 10, 2014
4U0E	Hexameric HIV-1 CA in complex with PF3450074 分子名称: CHLORIDE ION, Capsid protein p24, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE 著者 Price, A.J, Jacques, D.A, James, L.C. 登録日 2014-07-11 公開日 2014-11-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.043 Å) 主引用文献 Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. Plos Pathog., 10, 2014
4U7Z	Mitogen-Activated Protein Kinase Kinase (MEK1) bound to G805 分子名称: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Robarge, K.D, Ultsch, M.H, Wiesmann, C. 登録日 2014-07-31 公開日 2014-09-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.805 Å) 主引用文献 Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. Bioorg.Med.Chem.Lett., 24, 2014
4U0C	Hexameric HIV-1 CA in complex with Nup153 peptide, P6 crystal form 分子名称: Capsid protein p24, Nuclear pore complex protein Nup153 著者 Price, A.J, Jacques, D.A, James, L.C. 登録日 2014-07-11 公開日 2014-11-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. Plos Pathog., 10, 2014
4U80	MEK 1 kinase bound to G799 分子名称: 3-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)furo[3,2-c]pyridine-2-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Ultsch, M.H, Robarge, K.D, Weismann, C. 登録日 2014-07-31 公開日 2014-09-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. Bioorg.Med.Chem.Lett., 24, 2014
4UED	Complex of human eIF4E with the 4E binding protein 4E-BP1 分子名称: EUKARYOTIC TRANSLATION FACTOR 4E-BINDING PROTEIN 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E 著者 Peter, D, Weichenrieder, O. 登録日 2014-12-16 公開日 2015-02-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Molecular Architecture of 4E-BP Translational Inhibitors Bound to Eif4E. Mol.Cell, 57, 2015
6DMG	A multiconformer ligand model of EK6 bound to ERK2 分子名称: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Hudson, B.M, van Zundert, G.C.P, Keedy, D.A, Fonseca, R, Heliou, A, Suresh, P, Borrelli, K, Day, T, Fraser, J.S, van den Bedem, H. 登録日 2018-06-05 公開日 2018-12-19 最終更新日 2019-04-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps. J. Med. Chem., 61, 2018
6ES8	HIV capsid hexamer with IP6 ligand 分子名称: Gag protein, INOSITOL HEXAKISPHOSPHATE 著者 James, L.C. 登録日 2017-10-19 公開日 2018-08-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis. Elife, 7, 2018
6ECN	HIV-1 CA 1/2-hexamer-EE 分子名称: HIV-1 CA 著者 Summers, B.J, Xiong, Y. 登録日 2018-08-08 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms. Cell Host Microbe, 26, 2019
6EC2	Structure of HIV-1 CA 1/3-hexamer 分子名称: ACETATE ION, Capsid protein p24 著者 Summers, B.J, Xiong, Y. 登録日 2018-08-07 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms. Cell Host Microbe, 26, 2019
6ECO	Hexamer-2-Foldon HIV-1 capsid platform 分子名称: HIV-1 capsid platform protein 著者 Summers, B.J, Xiong, Y. 登録日 2018-08-08 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.2 Å) 主引用文献 Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms. Cell Host Microbe, 26, 2019
6FJB	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: 5'-O-prop-2-yn-1-yladenosine, Mitogen-activated protein kinase 1, SULFATE ION 著者 Gelin, M, Labesse, G. 登録日 2018-01-22 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structure of ERK2 in complex with an adenosine derivative To be published
6FJ0	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: 5'-deoxy-5'-(prop-2-yn-1-ylamino)adenosine, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 Gelin, M, Labesse, G. 登録日 2018-01-19 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.659 Å) 主引用文献 Crystal structure of ERK2 in complex with an adenosine derivative To be published
6FI3	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-(azanyloxymethyl)oxolane-3,4-diol, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 Gelin, M, Labesse, G. 登録日 2018-01-16 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Crystal structure of ERK2 in complex with an adenosine derivative To be published
6FRP	Crystal structure of ERK2 in complex with an adenosine derivative 分子名称: 5'-azido-5'-deoxyadenosine, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 Gelin, M, Labesse, G. 登録日 2018-02-16 公開日 2019-03-13 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 None To be published

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