4W92
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![BU of 4w92 by Molmil](/molmil-images/mine/4w92) | Crystal structure of Bacillus subtilis cyclic-di-AMP riboswitch ydaO | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, 1,2-ETHANEDIOL, C-di-AMP ribsoswitch, ... | 著者 | Jones, C.P, Ferre-D'Amare, A.R. | 登録日 | 2014-08-26 | 公開日 | 2014-10-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.209 Å) | 主引用文献 | Crystal structure of a c-di-AMP riboswitch reveals an internally pseudo-dimeric RNA. Embo J., 33, 2014
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6X88
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![BU of 6x88 by Molmil](/molmil-images/mine/6x88) | PDE6 chicken GAF domain | 分子名称: | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | 著者 | Ke, H. | 登録日 | 2020-06-01 | 公開日 | 2020-11-04 | 実験手法 | X-RAY DIFFRACTION (3.1997447 Å) | 主引用文献 | Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway. J.Mol.Biol., 432, 2020
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6XNU
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![BU of 6xnu by Molmil](/molmil-images/mine/6xnu) | |
8IK3
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4QK9
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![BU of 4qk9 by Molmil](/molmil-images/mine/4qk9) | Thermovirga lienii c-di-AMP riboswitch | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, C-di-AMP riboswitch, MAGNESIUM ION | 著者 | Gao, A, Serganov, A. | 登録日 | 2014-06-05 | 公開日 | 2014-08-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Structural insights into recognition of c-di-AMP by the ydaO riboswitch. Nat.Chem.Biol., 10, 2014
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4QK8
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![BU of 4qk8 by Molmil](/molmil-images/mine/4qk8) | Thermoanaerobacter pseudethanolicus c-di-AMP riboswitch | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, C-di-AMP riboswitch, MAGNESIUM ION, ... | 著者 | Gao, A, Serganov, A. | 登録日 | 2014-06-05 | 公開日 | 2014-08-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Structural insights into recognition of c-di-AMP by the ydaO riboswitch. Nat.Chem.Biol., 10, 2014
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1ROR
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![BU of 1ror by Molmil](/molmil-images/mine/1ror) | CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, ZINC ION, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 著者 | Xu, R.X, Rocque, W.J, Lambert, M.H, Vanderwall, D.E, Nolte, R.T. | 登録日 | 2003-12-02 | 公開日 | 2004-12-07 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J.Mol.Biol., 337, 2004
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4QKA
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![BU of 4qka by Molmil](/molmil-images/mine/4qka) | c-di-AMP riboswitch from Thermoanaerobacter pseudethanolicus, iridium hexamine soak | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, C-di-AMP riboswitch, IRIDIUM HEXAMMINE ION, ... | 著者 | Gao, A, Serganov, A. | 登録日 | 2014-06-05 | 公開日 | 2014-08-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural insights into recognition of c-di-AMP by the ydaO riboswitch. Nat.Chem.Biol., 10, 2014
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1RO9
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![BU of 1ro9 by Molmil](/molmil-images/mine/1ro9) | CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-Br-AMP | 分子名称: | 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE, ZINC ION, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 著者 | Xu, R.X, Rocque, W.J, Lambert, M.H, Vanderwall, D.E, Nolte, R.T. | 登録日 | 2003-12-01 | 公開日 | 2004-12-07 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J.Mol.Biol., 337, 2004
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1RO6
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![BU of 1ro6 by Molmil](/molmil-images/mine/1ro6) | Crystal structure of PDE4B2B complexed with Rolipram (R & S) | 分子名称: | ARSENIC, MANGANESE (II) ION, ROLIPRAM, ... | 著者 | Xu, R.X, Rocque, W.J, Lambert, M.H, Vanderwall, D.E, Nolte, R.T. | 登録日 | 2003-12-01 | 公開日 | 2004-12-07 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J.Mol.Biol., 337, 2004
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4N9I
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![BU of 4n9i by Molmil](/molmil-images/mine/4n9i) | Crystal Structure of Transcription regulation protein CRP complexed with cGMP | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Catabolite gene activator | 著者 | Lee, B.-J, Seok, S.-H, Im, H, Yoon, H.-J. | 登録日 | 2013-10-21 | 公開日 | 2014-07-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Structures of inactive CRP species reveal the atomic details of the allosteric transition that discriminates cyclic nucleotide second messengers. Acta Crystallogr.,Sect.D, 70, 2014
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6EO1
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![BU of 6eo1 by Molmil](/molmil-images/mine/6eo1) | The electron crystallography structure of the cAMP-bound potassium channel MloK1 (PCO-refined) | 分子名称: | Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION | 著者 | Kowal, J, Biyani, N, Chami, M, Scherer, S, Rzepiela, A, Baumgartner, P, Upadhyay, V, Nimigean, C, Stahlberg, H. | 登録日 | 2017-10-08 | 公開日 | 2017-12-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (4.5 Å) | 主引用文献 | High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer. Structure, 26, 2018
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4YXM
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![BU of 4yxm by Molmil](/molmil-images/mine/4yxm) | Structure of Thermotoga maritima DisA D75N mutant with reaction product c-di-AMP | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, (4S)-2-METHYL-2,4-PENTANEDIOL, DNA integrity scanning protein DisA | 著者 | Mueller, M, Deimling, T, Hopfner, K.-P, Witte, G. | 登録日 | 2015-03-23 | 公開日 | 2015-06-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP. Biochem.J., 469, 2015
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1UDU
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![BU of 1udu by Molmil](/molmil-images/mine/1udu) | Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis) | 分子名称: | 6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1',2':1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE, MAGNESIUM ION, ZINC ION, ... | 著者 | Sung, B.-J, Lee, J.I, Heo, Y.-S, Kim, J.H, Moon, J, Yoon, J.M, Hyun, Y.-L, Kim, E, Eum, S.J, Lee, T.G, Cho, J.M, Park, S.-Y, Lee, J.-O, Jeon, Y.H, Hwang, K.Y, Ro, S. | 登録日 | 2003-05-06 | 公開日 | 2004-05-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules Nature, 425, 2003
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1UHO
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![BU of 1uho by Molmil](/molmil-images/mine/1uho) | Crystal structure of Human Phosphodiesterase 5 complexed with Vardenafil(Levitra) | 分子名称: | 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, MAGNESIUM ION, ZINC ION, ... | 著者 | Sung, B.-J, Lee, J.I, Heo, Y.-S, Kim, J.H, Moon, J, Yoon, J.M, Hyun, Y.-L, Kim, E, Eum, S.J, Lee, T.G, Cho, J.M, Park, S.-Y, Lee, J.-O, Jeon, Y.H, Hwang, K.Y, Ro, S. | 登録日 | 2003-07-09 | 公開日 | 2004-07-09 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules Nature, 425, 2003
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4N9H
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![BU of 4n9h by Molmil](/molmil-images/mine/4n9h) | Crystal structure of Transcription regulation Protein CRP | 分子名称: | Catabolite gene activator | 著者 | Lee, B.J, Seok, S.H, Im, H, Yoon, H.J. | 登録日 | 2013-10-21 | 公開日 | 2014-07-09 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of inactive CRP species reveal the atomic details of the allosteric transition that discriminates cyclic nucleotide second messengers. Acta Crystallogr.,Sect.D, 70, 2014
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4Y87
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![BU of 4y87 by Molmil](/molmil-images/mine/4y87) | Crystal structure of phosphodiesterase 9 in complex with (R)-C33 (6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) | 分子名称: | 6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | 著者 | Huang, M. | 登録日 | 2015-02-16 | 公開日 | 2015-09-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol.Pharmacol., 88, 2015
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6XNV
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![BU of 6xnv by Molmil](/molmil-images/mine/6xnv) | CRYSTAL STRUCTURE OF LISTERIA MONOCYTOGENES CBPB PROTEIN (LMO1009) IN COMPLEX WITH C-DI-AMP | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, CBS domain-containing protein | 著者 | Luo, S, Tong, L. | 登録日 | 2020-07-04 | 公開日 | 2020-09-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | (p)ppGpp and c-di-AMP Homeostasis Is Controlled by CbpB in Listeria monocytogenes. Mbio, 11, 2020
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4Y8C
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![BU of 4y8c by Molmil](/molmil-images/mine/4y8c) | Crystal structure of phosphodiesterase 9 in complex with (S)-C33 | 分子名称: | 6-{[(1S)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | 著者 | Huang, M. | 登録日 | 2015-02-16 | 公開日 | 2015-09-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol.Pharmacol., 88, 2015
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4Y86
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![BU of 4y86 by Molmil](/molmil-images/mine/4y86) | Crystal structure of PDE9 in complex with racemic inhibitor C33 | 分子名称: | 6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, 6-{[(1S)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ... | 著者 | Huang, M. | 登録日 | 2015-02-16 | 公開日 | 2015-09-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol.Pharmacol., 88, 2015
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2YQ9
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![BU of 2yq9 by Molmil](/molmil-images/mine/2yq9) | Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, with mutation V321A, crystallized with 2'-AMP | 分子名称: | 2', 3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE, ADENOSINE-2'-MONOPHOSPHATE | 著者 | Myllykoski, M, Raasakka, A, Lehtimaki, M, Han, H, Kursula, P. | 登録日 | 2012-11-07 | 公開日 | 2013-07-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family J.Mol.Biol., 425, 2013
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2YOZ
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![BU of 2yoz by Molmil](/molmil-images/mine/2yoz) | Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, crystallized with 2'-AMPS | 分子名称: | 2'-O-(sulfidophosphinato)adenosine, 2,3-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE, ACETATE ION, ... | 著者 | Myllykoski, M, Raasakka, A, Lehtimaki, M, Han, H, Kursula, P. | 登録日 | 2012-10-29 | 公開日 | 2013-07-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family J.Mol.Biol., 425, 2013
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2Y3X
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![BU of 2y3x by Molmil](/molmil-images/mine/2y3x) | Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with sulfate | 分子名称: | 2', 3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE, GLYCEROL, ... | 著者 | Myllykoski, M, Kursula, P. | 登録日 | 2011-01-04 | 公開日 | 2012-01-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Myelin 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase: Active-Site Ligand Binding and Molecular Conformation. Plos One, 7, 2012
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2XMI
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![BU of 2xmi by Molmil](/molmil-images/mine/2xmi) | Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with citrate | 分子名称: | 2', 3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE, CITRATE ANION, ... | 著者 | Myllykoski, M, Kursula, P. | 登録日 | 2010-07-28 | 公開日 | 2011-08-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Myelin 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase: Active-Site Ligand Binding and Molecular Conformation. Plos One, 7, 2012
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2Y1P
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![BU of 2y1p by Molmil](/molmil-images/mine/2y1p) | Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with citrate | 分子名称: | 2', 3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE, CITRIC ACID, ... | 著者 | Myllykoski, M, Kursula, P. | 登録日 | 2010-12-09 | 公開日 | 2011-12-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Myelin 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase: Active-Site Ligand Binding and Molecular Conformation. Plos One, 7, 2012
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