PDB: 731 件ウェブページステータス検索Chemie searchBIRD

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4W92	Crystal structure of Bacillus subtilis cyclic-di-AMP riboswitch ydaO 分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, 1,2-ETHANEDIOL, C-di-AMP ribsoswitch, ... 著者 Jones, C.P, Ferre-D'Amare, A.R. 登録日 2014-08-26 公開日 2014-10-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.209 Å) 主引用文献 Crystal structure of a c-di-AMP riboswitch reveals an internally pseudo-dimeric RNA. Embo J., 33, 2014
6X88	PDE6 chicken GAF domain 分子名称: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 著者 Ke, H. 登録日 2020-06-01 公開日 2020-11-04 実験手法 X-RAY DIFFRACTION (3.1997447 Å) 主引用文献 Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway. J.Mol.Biol., 432, 2020
6XNU	CRYSTAL STRUCTURE OF CBPB PROTEIN (LMO1009) FROM LISTERIA MONOCYTOGENES 分子名称: CBS domain-containing protein, CHLORIDE ION 著者 Luo, S, Tong, L. 登録日 2020-07-04 公開日 2020-09-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 (p)ppGpp and c-di-AMP Homeostasis Is Controlled by CbpB in Listeria monocytogenes. Mbio, 11, 2020
8IK3	Structure of Stimulator of interferon genes/ligand complex 分子名称: Stimulator of interferon genes protein,Immune protein Tsi3, cGAMP 著者 Lu, D.F, Shang, G.J. 登録日 2023-02-28 公開日 2023-05-17 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The mechanism of STING autoinhibition and activation. Mol.Cell, 83, 2023
4QK9	Thermovirga lienii c-di-AMP riboswitch 分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, C-di-AMP riboswitch, MAGNESIUM ION 著者 Gao, A, Serganov, A. 登録日 2014-06-05 公開日 2014-08-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Structural insights into recognition of c-di-AMP by the ydaO riboswitch. Nat.Chem.Biol., 10, 2014
4QK8	Thermoanaerobacter pseudethanolicus c-di-AMP riboswitch 分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, C-di-AMP riboswitch, MAGNESIUM ION, ... 著者 Gao, A, Serganov, A. 登録日 2014-06-05 公開日 2014-08-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Structural insights into recognition of c-di-AMP by the ydaO riboswitch. Nat.Chem.Biol., 10, 2014
1ROR	CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH AMP 分子名称: ADENOSINE MONOPHOSPHATE, ZINC ION, cAMP-specific 3',5'-cyclic phosphodiesterase 4B 著者 Xu, R.X, Rocque, W.J, Lambert, M.H, Vanderwall, D.E, Nolte, R.T. 登録日 2003-12-02 公開日 2004-12-07 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J.Mol.Biol., 337, 2004
4QKA	c-di-AMP riboswitch from Thermoanaerobacter pseudethanolicus, iridium hexamine soak 分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, C-di-AMP riboswitch, IRIDIUM HEXAMMINE ION, ... 著者 Gao, A, Serganov, A. 登録日 2014-06-05 公開日 2014-08-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural insights into recognition of c-di-AMP by the ydaO riboswitch. Nat.Chem.Biol., 10, 2014
1RO9	CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-Br-AMP 分子名称: 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE, ZINC ION, cAMP-specific 3',5'-cyclic phosphodiesterase 4B 著者 Xu, R.X, Rocque, W.J, Lambert, M.H, Vanderwall, D.E, Nolte, R.T. 登録日 2003-12-01 公開日 2004-12-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J.Mol.Biol., 337, 2004
1RO6	Crystal structure of PDE4B2B complexed with Rolipram (R & S) 分子名称: ARSENIC, MANGANESE (II) ION, ROLIPRAM, ... 著者 Xu, R.X, Rocque, W.J, Lambert, M.H, Vanderwall, D.E, Nolte, R.T. 登録日 2003-12-01 公開日 2004-12-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J.Mol.Biol., 337, 2004
4N9I	Crystal Structure of Transcription regulation protein CRP complexed with cGMP 分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, Catabolite gene activator 著者 Lee, B.-J, Seok, S.-H, Im, H, Yoon, H.-J. 登録日 2013-10-21 公開日 2014-07-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Structures of inactive CRP species reveal the atomic details of the allosteric transition that discriminates cyclic nucleotide second messengers. Acta Crystallogr.,Sect.D, 70, 2014
6EO1	The electron crystallography structure of the cAMP-bound potassium channel MloK1 (PCO-refined) 分子名称: Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION 著者 Kowal, J, Biyani, N, Chami, M, Scherer, S, Rzepiela, A, Baumgartner, P, Upadhyay, V, Nimigean, C, Stahlberg, H. 登録日 2017-10-08 公開日 2017-12-27 最終更新日 2024-05-15 実験手法 ELECTRON CRYSTALLOGRAPHY (4.5 Å) 主引用文献 High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer. Structure, 26, 2018
4YXM	Structure of Thermotoga maritima DisA D75N mutant with reaction product c-di-AMP 分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, (4S)-2-METHYL-2,4-PENTANEDIOL, DNA integrity scanning protein DisA 著者 Mueller, M, Deimling, T, Hopfner, K.-P, Witte, G. 登録日 2015-03-23 公開日 2015-06-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP. Biochem.J., 469, 2015
1UDU	Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis) 分子名称: 6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1',2':1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE, MAGNESIUM ION, ZINC ION, ... 著者 Sung, B.-J, Lee, J.I, Heo, Y.-S, Kim, J.H, Moon, J, Yoon, J.M, Hyun, Y.-L, Kim, E, Eum, S.J, Lee, T.G, Cho, J.M, Park, S.-Y, Lee, J.-O, Jeon, Y.H, Hwang, K.Y, Ro, S. 登録日 2003-05-06 公開日 2004-05-11 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules Nature, 425, 2003
1UHO	Crystal structure of Human Phosphodiesterase 5 complexed with Vardenafil(Levitra) 分子名称: 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, MAGNESIUM ION, ZINC ION, ... 著者 Sung, B.-J, Lee, J.I, Heo, Y.-S, Kim, J.H, Moon, J, Yoon, J.M, Hyun, Y.-L, Kim, E, Eum, S.J, Lee, T.G, Cho, J.M, Park, S.-Y, Lee, J.-O, Jeon, Y.H, Hwang, K.Y, Ro, S. 登録日 2003-07-09 公開日 2004-07-09 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules Nature, 425, 2003
4N9H	Crystal structure of Transcription regulation Protein CRP 分子名称: Catabolite gene activator 著者 Lee, B.J, Seok, S.H, Im, H, Yoon, H.J. 登録日 2013-10-21 公開日 2014-07-09 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structures of inactive CRP species reveal the atomic details of the allosteric transition that discriminates cyclic nucleotide second messengers. Acta Crystallogr.,Sect.D, 70, 2014
4Y87	Crystal structure of phosphodiesterase 9 in complex with (R)-C33 (6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) 分子名称: 6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... 著者 Huang, M. 登録日 2015-02-16 公開日 2015-09-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol.Pharmacol., 88, 2015
6XNV	CRYSTAL STRUCTURE OF LISTERIA MONOCYTOGENES CBPB PROTEIN (LMO1009) IN COMPLEX WITH C-DI-AMP 分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, CBS domain-containing protein 著者 Luo, S, Tong, L. 登録日 2020-07-04 公開日 2020-09-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 (p)ppGpp and c-di-AMP Homeostasis Is Controlled by CbpB in Listeria monocytogenes. Mbio, 11, 2020
4Y8C	Crystal structure of phosphodiesterase 9 in complex with (S)-C33 分子名称: 6-{[(1S)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... 著者 Huang, M. 登録日 2015-02-16 公開日 2015-09-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol.Pharmacol., 88, 2015
4Y86	Crystal structure of PDE9 in complex with racemic inhibitor C33 分子名称: 6-{[(1R)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, 6-{[(1S)-1-(4-chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ... 著者 Huang, M. 登録日 2015-02-16 公開日 2015-09-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol.Pharmacol., 88, 2015
2YQ9	Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, with mutation V321A, crystallized with 2'-AMP 分子名称: 2', 3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE, ADENOSINE-2'-MONOPHOSPHATE 著者 Myllykoski, M, Raasakka, A, Lehtimaki, M, Han, H, Kursula, P. 登録日 2012-11-07 公開日 2013-07-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family J.Mol.Biol., 425, 2013
2YOZ	Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, crystallized with 2'-AMPS 分子名称: 2'-O-(sulfidophosphinato)adenosine, 2,3-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE, ACETATE ION, ... 著者 Myllykoski, M, Raasakka, A, Lehtimaki, M, Han, H, Kursula, P. 登録日 2012-10-29 公開日 2013-07-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystallographic Analysis of the Reaction Cycle of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family J.Mol.Biol., 425, 2013
2Y3X	Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with sulfate 分子名称: 2', 3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE, GLYCEROL, ... 著者 Myllykoski, M, Kursula, P. 登録日 2011-01-04 公開日 2012-01-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Myelin 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase: Active-Site Ligand Binding and Molecular Conformation. Plos One, 7, 2012
2XMI	Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with citrate 分子名称: 2', 3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE, CITRATE ANION, ... 著者 Myllykoski, M, Kursula, P. 登録日 2010-07-28 公開日 2011-08-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Myelin 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase: Active-Site Ligand Binding and Molecular Conformation. Plos One, 7, 2012
2Y1P	Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with citrate 分子名称: 2', 3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE, CITRIC ACID, ... 著者 Myllykoski, M, Kursula, P. 登録日 2010-12-09 公開日 2011-12-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Myelin 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase: Active-Site Ligand Binding and Molecular Conformation. Plos One, 7, 2012

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