PDB: 132 件ウェブページステータス検索Chemie searchBIRD

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6AOA	Monomeric crystal structure of the E497/C566D double mutant of the guanylyl cyclase domain of the RhoGC fusion protein from the aquatic fungus Blastocladiella emersonii 分子名称: Bacterio-rhodopsin/guanylyl cyclase 1 fusion protein 著者 Prem Kumar, R, Oprian, D.D. 登録日 2017-08-15 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC. J. Biol. Chem., 292, 2017
6AOB	Crystal structure of non-canonical dimeric guanylyl cyclase domain of RhoGC fusion protein from the aquatic fungus Blastocladiella emersonii 分子名称: Bacterio-rhodopsin/guanylyl cyclase 1 fusion protein, L(+)-TARTARIC ACID, MANGANESE (II) ION 著者 Prem Kumar, R, Oprian, D.D. 登録日 2017-08-15 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC. J. Biol. Chem., 292, 2017
4WPA	Crystal structure of Adenylyl cyclase Ma1120 from Mycobacterium Avium bound to Pyrophosphate and Calcium 分子名称: CALCIUM ION, Ma1120, PYROPHOSPHATE 著者 Bharambe, N.G, Barathy, D.V, Suguna, K. 登録日 2014-10-17 公開日 2015-09-02 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
5O5L	X-ray structure of a bacterial adenylyl cyclase soluble domain, solved at cryogenic temperature 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, MANGANESE (II) ION, ... 著者 Vercellino, I, Korkhov, V.M. 登録日 2017-06-02 公開日 2017-11-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7YZ9	Structure of catalytic domain of Rv1625c bound to nanobody NB4 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, GLYCEROL, ... 著者 Khanppnavar, B, Mehta, V.J, Iype, T, Korkhov, V.M. 登録日 2022-02-19 公開日 2022-08-31 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases. Elife, 11, 2022
5O5K	X-ray structure of a bacterial adenylyl cyclase soluble domain 分子名称: 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, MANGANESE (II) ION, ... 著者 Vercellino, I, Korkhov, V.M. 登録日 2017-06-02 公開日 2017-11-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6SIR	Crystal structure of the guanylate cyclase domain of RhGC from Catenaria anguillulae in complex with GTP 分子名称: CALCIUM ION, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Butryn, A, Orville, A.M. 登録日 2019-08-10 公開日 2019-12-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular basis for GTP recognition by light-activated guanylate cyclase RhGC. Febs J., 287, 2020
1WC4	Soluble adenylyl cyclase CyaC from S. platensis in complex with alpha, beta-methylene-ATP and Europium 分子名称: ADENYLATE CYCLASE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, EUROPIUM (III) ION 著者 Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H. 登録日 2004-11-08 公開日 2004-12-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment Nat.Struct.Mol.Biol., 12, 2005
1WC0	Soluble adenylyl cyclase CyaC from S. platensis in complex with alpha, beta-methylene-ATP 分子名称: ADENYLATE CYCLASE, CALCIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER 著者 Steegborn, C, Litvin, T.N, Levin, L.R, Buck, J, Wu, H. 登録日 2004-11-05 公開日 2004-12-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment Nat.Struct.Mol.Biol., 12, 2005
8B75	CRYSTAL STRUCTURE OF HUMAN SOLUBLE ADENYLYL CYCLASE IN COMPLEX WITH THE INHIBITOR TDI-011861 分子名称: Adenylate cyclase type 10, [(3~{R})-4-[2-[2-[[3-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-1-[bis(fluoranyl)methyl]pyrazol-4-yl]methyl]phenoxy]ethyl]morpholin-3-yl]methanol 著者 Steegborn, C, Kehr, M. 登録日 2022-09-28 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J.Med.Chem., 65, 2022
8CNH	Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-10512 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Adenylate cyclase type 10, ... 著者 Steegborn, C. 登録日 2023-02-23 公開日 2023-04-26 最終更新日 2023-05-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
8COT	Complex of human soluble adenylyl cyclase 10 catalytic core with inhibitor TDI-10962 分子名称: 1,2-ETHANEDIOL, 2-(dimethylamino)ethyl 5-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-2-methyl-4-(phenylmethyl)pyrazole-3-carboxylate, ACETATE ION, ... 著者 Steegborn, C, Fushimi, M. 登録日 2023-02-28 公開日 2023-04-26 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
8COJ	Crystal structure of human soluble adenylyl cyclase catalytic domain in complex with the inhibitor TDI-10228 分子名称: 1,2-ETHANEDIOL, 4-chloranyl-6-[4-[(3-fluorophenyl)methyl]-1-methyl-pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... 著者 Steegborn, C, Fushimi, M. 登録日 2023-02-28 公開日 2023-04-26 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation. J.Chem.Inf.Model., 63, 2023
4NI2	Crystal structure of the heterodimeric catalytic domain of wild-type human soluble guanylate cyclase 分子名称: 1,2-ETHANEDIOL, Guanylate cyclase soluble subunit alpha-3, Guanylate cyclase soluble subunit beta-1 著者 Seeger, F, Williams, G.J, Tainer, J.A, Garcin, E.D. 登録日 2013-11-05 公開日 2014-04-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity. Biochemistry, 53, 2014
4OYI	Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone 分子名称: (4-azanyl-1,2,5-oxadiazol-3-yl)-phenyl-methanone, Adenylate cyclase type 10, GLYCEROL 著者 Vinkovic, M. 登録日 2014-02-12 公開日 2014-04-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
4OYW	Crystal Structure of Human Soluble Adenylate Cyclase 分子名称: Adenylate cyclase type 10, CHLORIDE ION, GLYCEROL 著者 Vinkovic, M. 登録日 2014-02-13 公開日 2014-04-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
4OYM	Human solAC Complexed with (4-Amino-furazan-3-yl)-(3-methoxy-phenyl)-methanone 分子名称: (4-azanyl-1,2,5-oxadiazol-3-yl)-(3-methoxyphenyl)methanone, Adenylate cyclase type 10, GLYCEROL 著者 Vinkovic, M. 登録日 2014-02-12 公開日 2014-04-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
4OYX	Human solAC Complexed with AMPCPP 分子名称: Adenylate cyclase type 10, CALCIUM ION, CHLORIDE ION, ... 著者 Vinkovic, M. 登録日 2014-02-13 公開日 2014-04-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
4OYA	Human solAC Complexed with (4-Aminofurazan-3-yl)-[3-(1H-benzoimidazol-2-ylmethoxy)phenyl]methanone 分子名称: (4-azanyl-1,2,5-oxadiazol-3-yl)-[3-(1H-benzimidazol-2-ylmethoxy)phenyl]methanone, Adenylate cyclase type 10, GLYCEROL 著者 Vinkovic, M. 登録日 2014-02-11 公開日 2014-04-02 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
4OYZ	Human solAC Complexed with Bicarbonate 分子名称: Adenylate cyclase type 10, BICARBONATE ION, GLYCEROL 著者 Vinkovic, M. 登録日 2014-02-13 公開日 2014-04-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
4OYB	Crystal Structure Analysis of the solAC 分子名称: Adenylate cyclase type 10, GLYCEROL, ethyl 2-[3-[(4-azanyl-1,2,5-oxadiazol-3-yl)carbonyl]phenoxy]ethanoate 著者 Vinkovic, M. 登録日 2014-02-11 公開日 2014-04-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
4OYO	Human solAC Complexed with 4-(2-Chlorophenyl)-3-methyl-1H-pyrazole 分子名称: 4-(2-chlorophenyl)-5-methyl-1H-pyrazole, Adenylate cyclase type 10, GLYCEROL 著者 Vinkovic, M. 登録日 2014-02-12 公開日 2014-04-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
4OZ3	Human solAC Complexed with 4-phenyl-3-(trifluoromethyl)-1H-pyrazole 分子名称: 4-phenyl-3-(trifluoromethyl)-1H-pyrazole, Adenylate cyclase type 10, GLYCEROL 著者 Vinkovic, M. 登録日 2014-02-13 公開日 2014-04-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
7OVD	Human soluble adenylyl cyclase in complex with the inhibitor TDI10229 分子名称: 1,2-ETHANEDIOL, 4-chloranyl-6-[1,5-dimethyl-4-(phenylmethyl)pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ... 著者 Steegborn, C, Quast, J. 登録日 2021-06-14 公開日 2021-10-06 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). Acs Med.Chem.Lett., 12, 2021
4P2F	Monomeric form of a single mutant (F363R) of Mycobacterial Adenylyl cyclase Rv1625c 分子名称: 1,2-ETHANEDIOL, Adenylate cyclase, DI(HYDROXYETHYL)ETHER, ... 著者 Barathy, D.V, Mattoo, R, Visweswariah, S.S, Suguna, K. 登録日 2014-03-04 公開日 2014-09-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 New structural forms of a mycobacterial adenylyl cyclase Rv1625c. Iucrj, 1, 2014

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