PDB: 82203 件ウェブページステータス検索Chemie searchBIRD

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4YFH	HU38-20bp 分子名称: DNA-binding protein HU-alpha, synthetic DNA strand 著者 Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. 登録日 2015-02-25 公開日 2016-06-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.49 Å) 主引用文献 HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
7F0A	Crystal structure of capreomycin phosphotransferase 分子名称: Capreomycin phosphotransferase 著者 Chang, C.Y, Pan, Y.C, Wang, Y.L, Toh, S.I. 登録日 2021-06-03 公開日 2022-05-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin. Acs Chem.Biol., 17, 2022
7F0B	Crystal structure of capreomycin phosphotransferase in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Capreomycin phosphotransferase 著者 Chang, C.Y, Pan, Y.C, Wang, Y.L, Toh, S.I. 登録日 2021-06-03 公開日 2022-05-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin. Acs Chem.Biol., 17, 2022
4YF0	HU38-19bp 分子名称: DNA-binding protein HU-alpha, synthetic DNA strand 著者 Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. 登録日 2015-02-24 公開日 2016-06-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
1FZZ	THE CRYSTAL STRUCTURE OF THE COMPLEX OF NON-PEPTIDIC INHIBITOR ONO-6818 AND PORCINE PANCREATIC ELASTASE. 分子名称: 2-(5-AMINO-6-OXO-2-PHENYL-6H-PYRIMIDIN-1-YL)-N-[2-(5-TERT-BUTYL-1,3,4-OXADIAZOL-2-YL)-1-(METHYLETHYL)-2-HYDROXYETHYL]ACETAMIDE, ELASTASE 1 著者 Odagaki, Y, Ohmoto, K, Matsuoka, S, Hamanaka, N, Nakai, H, Toda, M, Katsuya, Y. 登録日 2000-10-04 公開日 2001-10-04 最終更新日 2017-10-04 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase. Bioorg.Med.Chem., 9, 2001
8FUM	AibH1H2 metalated with Fe in the presence of Tris 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Amidohydrolase, DI(HYDROXYETHYL)ETHER, ... 著者 Powell, M.M, Rittle, J. 登録日 2023-01-17 公開日 2023-04-05 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Enzymatic Hydroxylation of Aliphatic C-H Bonds by a Mn/Fe Cofactor. J.Am.Chem.Soc., 145, 2023
1PIS	SOLUTION STRUCTURE OF PORCINE PANCREATIC PHOSPHOLIPASE A2 分子名称: CALCIUM ION, PHOSPHOLIPASE A2 著者 Van Den Berg, B.D, Tessari, M, De Haas, G.H, Verheij, H.M, Boelens, R, Kaptein, R. 登録日 1994-12-22 公開日 1995-06-03 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Solution structure of porcine pancreatic phospholipase A2. EMBO J., 14, 1995
1PIR	SOLUTION STRUCTURE OF PORCINE PANCREATIC PHOSPHOLIPASE A2 分子名称: CALCIUM ION, PHOSPHOLIPASE A2 著者 Van Den Berg, B.D, Tessari, M, De Haas, G.H, Verheij, H.M, Boelens, R, Kaptein, R. 登録日 1994-12-22 公開日 1995-06-03 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Solution structure of porcine pancreatic phospholipase A2. EMBO J., 14, 1995
4YEX	HUaa-19bp 分子名称: DNA-binding protein HU-alpha, synthetic DNA strand 著者 Hammel, M, Reyes, F.E, Parpana, R, Tainer, J.A, Adhya, S, Amlanjyoti, D. 登録日 2015-02-24 公開日 2016-06-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 HU multimerization shift controls nucleoid compaction. Sci Adv, 2, 2016
5DOV	Crystal structure of JamJ enoyl reductase (apo form) 分子名称: GLYCEROL, JamJ 著者 Khare, D, Smith, J.L. 登録日 2015-09-11 公開日 2015-11-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase. Structure, 23, 2015
1Q9E	RNase T1 variant with adenine specificity 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Guanyl-specific ribonuclease T1 precursor 著者 Czaja, R, Struhalla, M, Hoeschler, K, Saenger, W, Straeter, N, Hahn, U. 登録日 2003-08-25 公開日 2004-03-23 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 RNase T1 Variant RV Cleaves Single-Stranded RNA after Purines Due to Specific Recognition by the Asn46 Side Chain Amide. Biochemistry, 43, 2004
5DP1	Crystal structure of CurK enoyl reductase 分子名称: CurK, GLYCEROL, PHOSPHATE ION 著者 Khare, D, Smith, J.L. 登録日 2015-09-12 公開日 2015-11-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase. Structure, 23, 2015
2AZD	X-Ray studies on Maltodextrin Phosphorylase (MalP) Complexes: recognition of substrates and CATALYTIC mechanism of phosphorylase family 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Maltodextrin phosphorylase, PYRIDOXAL-5'-PHOSPHATE, ... 著者 Geremia, S, Campagnolo, M. 登録日 2005-09-10 公開日 2005-09-20 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 X-ray studies on ternary complexes of maltodextrin phosphorylase. Arch.Biochem.Biophys., 471, 2008
1TZ4	[hPP19-23]-pNPY bound to DPC Micelles 分子名称: neuropeptide Y,Pancreatic prohormone,neuropeptide Y 著者 Lerch, M, Kamimori, H, Folkers, G, Aguilar, M.I, Beck-Sickinger, A.G, Zerbe, O. 登録日 2004-07-09 公開日 2005-07-05 最終更新日 2020-01-01 実験手法 SOLUTION NMR 主引用文献 Strongly Altered Receptor Binding Properties in PP and NPY Chimeras Are Accompanied by Changes in Structure and Membrane Binding Biochemistry, 44, 2005
5CBS	Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution 分子名称: (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2015-07-01 公開日 2015-12-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. J.Med.Chem., 59, 2016
6UNC	The crystal structure of Phosphopantetheinyl Hydrolase (PptH) from Mycobacterium tuberculosis 分子名称: FE (III) ION, MANGANESE (II) ION, Metallophos domain-containing protein 著者 Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2019-10-11 公開日 2020-04-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis. Protein Sci., 29, 2020
7E35	Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant bound to compound S43 分子名称: N-[(3-acetamidophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, Non-structural protein 3, ZINC ION 著者 Liu, J, Wang, Y, Xu, X, Pan, L. 登録日 2021-02-08 公開日 2021-03-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem Biol, 28, 2021
1HMC	THREE-DIMENSIONAL STRUCTURE OF DIMERIC HUMAN RECOMBINANT MACROPHAGE COLONY STIMULATING FACTOR 分子名称: HUMAN MACROPHAGE COLONY STIMULATING FACTOR 著者 Bohm, A, Pandit, J, Jancarik, J, Halenbeck, R, Koths, K, Kim, S.-H. 登録日 1993-12-22 公開日 1994-04-30 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor. Science, 258, 1992
8UIA	Crystal structure of SARS CoV-2 3CL protease in complex with GSK4365097A 分子名称: 3C-like proteinase nsp5, CHLORIDE ION, GLYCEROL, ... 著者 Concha, N.O, Williams, S.P. 登録日 2023-10-10 公開日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement. Bioorg.Med.Chem., 100, 2024
5OQ4	PQR309 - a Potent, Brain-Penetrant, Orally Bioavailable, pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology 分子名称: 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION 著者 Williams, R.L, Zhang, X. 登録日 2017-08-10 公開日 2017-09-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. J. Med. Chem., 60, 2017
2DE9	Crystal structure of porcine pancreatic elastase complexed with Tris after soaking a tris-free solution 分子名称: Elastase-1, SULFATE ION 著者 Kinoshita, T, Tada, T. 登録日 2006-02-09 公開日 2006-07-11 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Tris(hydroxymethyl)aminomethane induces conformational change and crystal-packing contraction of porcine pancreatic elastase. Acta Crystallogr.,Sect.F, 62, 2006
5AKY	ligand complex structure of soluble epoxide hydrolase 分子名称: 3-(2-phenylethyl)-1H-indazole, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, ... 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-05 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5AK5	ligand complex structure of soluble epoxide hydrolase 分子名称: 3-PROPYL-5-(3-PYRIDYL)-1H-PYRAZIN-2-ONE, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-02 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5AKH	ligand complex structure of soluble epoxide hydrolase 分子名称: 4-[5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]pyridine, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, ... 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-03 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
6UVM	Cocrystal of BRD4(D1) with a methyl carbamate thiazepane inhibitor 分子名称: 1,2-ETHANEDIOL, 1-[(7S)-7-(thiophen-2-yl)-6,7-dihydro-1,4-thiazepin-4(5H)-yl]ethan-1-one, Bromodomain-containing protein 4 著者 Johnson, J.A, Pomerantz, W.C.K. 登録日 2019-11-03 公開日 2020-01-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains. Acs Med.Chem.Lett., 10, 2019

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