5HL7
 
 | | The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with lefamulin | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 23S ribosomal RNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Eyal, Z, Matzov, D, Krupkin, M, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A. | | 登録日 | 2016-01-14 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | | 主引用文献 | A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism.
Sci Rep, 6, 2016
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6S98
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8J02
 | | Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II | | 分子名称: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | | 著者 | Ma, D, Li, X, Guo, J. | | 登録日 | 2023-04-09 | | 公開日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Ligand activation mechanisms of human KCNQ2 channel.
Nat Commun, 14, 2023
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6S9W
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8J01
 | | Human KCNQ2-CaM in complex with CBD and PIP2 | | 分子名称: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | | 著者 | Ma, D, Li, X, Guo, J. | | 登録日 | 2023-04-09 | | 公開日 | 2023-12-13 | | 最終更新日 | 2025-09-24 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Ligand activation mechanisms of human KCNQ2 channel.
Nat Commun, 14, 2023
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6SA1
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6SAN
 | | SALSA / DMBT1 / GP340 SRCR domain 8 soaked in calcium and magnesium | | 分子名称: | CHLORIDE ION, Deleted in malignant brain tumors 1 protein, GLYCEROL, ... | | 著者 | Reichhardt, M.P, Johnson, S, Loimaranta, V, Lea, S.M. | | 登録日 | 2019-07-17 | | 公開日 | 2020-03-18 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold.
Life Sci Alliance, 3, 2020
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9EDN
 | | GII.23: Loreto1847 norovirus protruding domain | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, VP1 | | 著者 | Holroyd, D.L, Kumar, A, Bruning, J.B, Hansman, G.S. | | 登録日 | 2024-11-17 | | 公開日 | 2025-03-05 | | 最終更新日 | 2025-04-23 | | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | | 主引用文献 | Antigenic structural analysis of bat and human norovirus protruding (P) domains.
J.Virol., 99, 2025
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7ZY9
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7R5B
 | | Crystal structure of BRD4(1) in complex with the inhibitor MPM2 | | 分子名称: | (R,R)-2,3-BUTANEDIOL, 1-(3-aminophenyl)-3-methyl-5,6,7,8-tetrahydro-2~{H}-cyclohepta[c]pyrrol-4-one, Bromodomain-containing protein 4, ... | | 著者 | Huegle, M. | | 登録日 | 2022-02-10 | | 公開日 | 2023-02-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | A novel pan-selective bromodomain inhibitor for epigenetic drug design
Eur.J.Med.Chem., 249, 2023
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9B8E
 | | Structure of S-nitrosylated Legionella pneumophila Ceg10. | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | | 著者 | Tomchick, D.R, Heisler, D.B, Alto, N.M. | | 登録日 | 2024-03-29 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery.
Plos Pathog., 20, 2024
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6SGX
 | | Structure of protomer 1 of the ESX-3 core complex | | 分子名称: | ESX-3 secretion system EccB3, ESX-3 secretion system protein EccC3, ESX-3 secretion system protein EccD3, ... | | 著者 | Famelis, N, Rivera-Calzada, A, Llorca, O, Geibel, S. | | 登録日 | 2019-08-05 | | 公開日 | 2019-10-09 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Architecture of the mycobacterial type VII secretion system.
Nature, 576, 2019
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5N87
 | | TTK kinase domain in complex with NTRC 0066-0 | | 分子名称: | 2,5,8,11-TETRAOXATRIDECANE, Dual specificity protein kinase TTK, SODIUM ION, ... | | 著者 | Uitdehaag, J, Willemsen-Seegers, N, Sterrenburg, J.G, de Man, J, Buijsman, R.C, Zaman, G.J.R. | | 登録日 | 2017-02-23 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
J. Mol. Biol., 429, 2017
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8YJC
 | | Structure of Vibrio vulnificus MARTX cysteine protease domain C3727A | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, INOSITOL HEXAKISPHOSPHATE, Multifunctional autoprocessing repeat-in-toxin (MARTX), ... | | 著者 | Chen, L, Khan, H, Tan, L, Li, X, Zhang, G, Im, Y.J. | | 登録日 | 2024-03-01 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structural basis of the activation of MARTX cysteine protease domain from Vibrio vulnificus.
Plos One, 19, 2024
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9ITI
 | | Nav1.7 with mutations that eliminate beta1 binding | | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Yan, N, Li, Z, Wu, T. | | 登録日 | 2024-07-20 | | 公開日 | 2025-08-20 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Critical role of extracellular loops in differential modulations of TTX-sensitive and TTX-resistant Na v channels.
Proc.Natl.Acad.Sci.USA, 122, 2025
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7R2A
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8ID0
 | | Crystal structure of PflD bound to 1,5-anhydromannitol-6-phosphate in Streptococcus dysgalactiae subsp. equisimilis | | 分子名称: | [(2R,3S,4R,5R)-3,4,5-tris(oxidanyl)oxan-2-yl]methyl dihydrogen phosphate, formate C-acetyltransferase | | 著者 | Ma, K.L, Zhang, Y. | | 登録日 | 2023-02-11 | | 公開日 | 2024-10-02 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | A Widespread Radical-Mediated Glycolysis Pathway.
J.Am.Chem.Soc., 146, 2024
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8A56
 | | Coenzyme A-persulfide reductase (CoAPR) from Enterococcus faecalis | | 分子名称: | 1,2-ETHANEDIOL, 3'-PHOSPHATE-ADENOSINE-5'-DIPHOSPHATE, Coenzyme A-persulfide reductase, ... | | 著者 | Costa, S.S, Walsh, B.J, Giedroc, D.P, Brito, J.A. | | 登録日 | 2022-06-14 | | 公開日 | 2022-09-14 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Metabolic and Structural Insights into Hydrogen Sulfide Mis-Regulation in Enterococcus faecalis.
Antioxidants, 11, 2022
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5N0P
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5N0X
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7R4B
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5K2B
 | | 2.5 angstrom A2a adenosine receptor structure with MR phasing using XFEL data | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ... | | 著者 | Batyuk, A, Galli, L, Ishchenko, A, Han, G.W, Gati, C, Popov, P, Lee, M.-Y, Stauch, B, White, T.A, Barty, A, Aquila, A, Hunter, M.S, Liang, M, Boutet, S, Pu, M, Liu, Z.-J, Nelson, G, James, D, Li, C, Zhao, Y, Spence, J.C.H, Liu, W, Fromme, P, Katritch, V, Weierstall, U, Stevens, R.C, Cherezov, V, GPCR Network (GPCR) | | 登録日 | 2016-05-18 | | 公開日 | 2016-09-21 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Native phasing of x-ray free-electron laser data for a G protein-coupled receptor.
Sci Adv, 2, 2016
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8RUA
 | | Crystal structure of Rhizobium etli L-asparaginase ReAV C135A mutant | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | | 著者 | Pokrywka, K, Grzechowiak, M, Sliwiak, J, Worsztynowicz, P, Loch, J.I, Ruszkowski, M, Gilski, M, Jaskolski, M. | | 登録日 | 2024-01-30 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Probing the active site of Class 3 L-asparaginase by mutagenesis. I. Tinkering with the zinc coordination site of ReAV.
Front Chem, 12, 2024
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8DGC
 | | Avs3 bound to phage PhiV-1 terminase | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SeAvs3, ... | | 著者 | Wilkinson, M.E, Gao, L, Strecker, J, Makarova, K.S, Macrae, R.K, Koonin, E.V, Zhang, F. | | 登録日 | 2022-06-23 | | 公開日 | 2022-08-03 | | 最終更新日 | 2025-05-14 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Prokaryotic innate immunity through pattern recognition of conserved viral proteins.
Science, 377, 2022
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8IVP
 | | Crystal structure of MV in complex with LLP and FRU from Mycobacterium vanbaalenii | | 分子名称: | Branched chain amino acid: 2-keto-4-methylthiobutyrate aminotransferase, D-fructose | | 著者 | Li, Q, Zhu, Y.M, Gao, J, Wei, H.L, Han, X, Liu, W.D, Sun, Y.X. | | 登録日 | 2023-03-28 | | 公開日 | 2024-01-24 | | 最終更新日 | 2025-08-06 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Protein engineering of transaminase facilitating enzyme cascade reaction for the biosynthesis of azasugars.
Iscience, 27, 2024
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