PDB: 1980 件ウェブページステータス検索Chemie searchBIRD

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7YEZ	In situ structure of polymerase complex of mammalian reovirus in the reloaded state 分子名称: Lambda-2 protein, Mu-2 protein, RNA helicase, ... 著者 Bao, K.Y, Zhang, X.L, Li, D.Y, Zhu, P. 登録日 2022-07-06 公開日 2023-03-29 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation. Proc.Natl.Acad.Sci.USA, 119, 2022
7DTE	SARS-CoV-2 RdRP catalytic complex with T33-1 RNA 分子名称: Non-structural protein 7, Non-structural protein 8, RNA (33-MER), ... 著者 Wang, Q, Gong, P. 登録日 2021-01-04 公開日 2021-10-20 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex. Cell Rep, 37, 2021
2WHO	CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE FROM 1B GENOTYPE IN COMPLEX WITH A NON-NUCLEOSIDE INHIBITOR 分子名称: 2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Di Marco, S. 登録日 2009-05-05 公開日 2009-08-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors. J. Med. Chem., 52, 2009
8R6W	Structure of the SFTSV L protein in a transcription-priming state with bound capped RNA [TRANSCRIPTION-PRIMING] 分子名称: RNA (5'-R(*(M7G)*AP*AP*A)-3'), RNA (5'-R(*AP*CP*AP*C)-3'), RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*G)-3'), ... 著者 Williams, H.M, Thorkelsson, S.R, Vogel, D, Busch, C, Milewski, M, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. 登録日 2023-11-23 公開日 2024-04-24 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Structural snapshots of phenuivirus cap-snatching and transcription. Nucleic Acids Res., 52, 2024
8R6U	Structure of the SFTSV L protein in a transcription-priming state without capped RNA [TRANSCRIPTION-PRIMING (in vitro)] 分子名称: MAGNESIUM ION, RNA (5'-R(P*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3'), RNA primer, ... 著者 Williams, H.M, Thorkelsson, S.R, Vogel, D, Busch, C, Milewski, M, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. 登録日 2023-11-23 公開日 2024-04-24 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 Structural snapshots of phenuivirus cap-snatching and transcription. Nucleic Acids Res., 52, 2024
4E76	Apo crystal structure of HCV NS5B genotype 2A JFH-1 isolate with beta hairpin loop deletion 分子名称: 1,2-ETHANEDIOL, RNA-directed RNA polymerase, SULFATE ION 著者 Edwards, T.E, Mosley, R.T. 登録日 2012-03-16 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of hepatitis C virus polymerase in complex with primer-template RNA. J.Virol., 86, 2012
5TRH	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 2-[(benzenecarbonyl)amino]-3-[(4-chlorophenyl)methoxy]benzoic acid 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 2-[(benzenecarbonyl)amino]-3-[(4-chlorophenyl)methoxy]benzoic acid, NS5B RNA-DEPENDENT RNA POLYMERASE, ... 著者 Sheriff, S. 登録日 2016-10-26 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase. Bioorg. Med. Chem. Lett., 27, 2017
5TRI	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 3-[(4-chlorophenyl)methoxy]-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 3-[(4-chlorophenyl)methoxy]-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid, NS5B RNA-DEPENDENT RNA POLYMERASE, ... 著者 Sheriff, S. 登録日 2016-10-26 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase. Bioorg. Med. Chem. Lett., 27, 2017
3CM8	A RNA polymerase subunit structure from virus 分子名称: Polymerase acidic protein, peptide from RNA-directed RNA polymerase catalytic subunit 著者 He, X, Zhou, J, Zeng, Z, Ma, J, Zhang, R, Rao, Z, Liu, Y. 登録日 2008-03-21 公開日 2008-07-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.899 Å) 主引用文献 Crystal structure of the polymerase PAC-PB1N complex from an avian influenza H5N1 virus Nature, 454, 2008
3QGH	Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase genotype 1a complex with N-cyclopropyl-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide 分子名称: N-cyclopropyl-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide, PHOSPHATE ION, RNA-directed RNA polymerase 著者 Sheriff, S. 登録日 2011-01-24 公開日 2011-04-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase. Bioorg.Med.Chem.Lett., 21, 2011
3QGI	Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase genotype 1a complex with N-[(2S)-butan-2-yl]-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide 分子名称: GLYCEROL, N-[(2S)-butan-2-yl]-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide, RNA-directed RNA polymerase 著者 Sheriff, S. 登録日 2011-01-24 公開日 2011-04-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase. Bioorg.Med.Chem.Lett., 21, 2011
7UO4	SARS-CoV-2 replication-transcription complex bound to Remdesivir triphosphate, in a pre-catalytic state 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (3.38 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UOB	SARS-CoV-2 replication-transcription complex bound to GTP, in a pre-catalytic state 分子名称: 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.68 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UO9	SARS-CoV-2 replication-transcription complex bound to UTP, in a pre-catalytic state 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UO7	SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Non-structural protein 7, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UOE	SARS-CoV-2 replication-transcription complex bound to CTP, in a pre-catalytic state 分子名称: 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.67 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7YOT	Cryo-EM structure of RNA polymerase in complex with P protein tetramer of Newcastle disease virus 分子名称: NDV P protein, RNA-directed RNA polymerase L 著者 Chen, Y, Jingyuan, C. 登録日 2022-08-02 公開日 2023-02-15 最終更新日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure of the Newcastle Disease Virus L protein in complex with tetrameric phosphoprotein. Nat Commun, 14, 2023
7YOU	Cryo-EM structure of RNA polymerase in complex with P protein tetramer of Newcastle disease virus 分子名称: NDV P protein, RNA-directed RNA polymerase L 著者 Chen, Y, Jingyuan, C, Xiaoying, F. 登録日 2022-08-02 公開日 2023-02-15 最終更新日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.41 Å) 主引用文献 Structure of the Newcastle Disease Virus L protein in complex with tetrameric phosphoprotein. Nat Commun, 14, 2023
7YOV	Cryo-EM structure of RNA polymerase in complex with P protein tetramer of Newcastle disease virus 分子名称: NDV P protein, RNA-directed RNA polymerase L 著者 Chen, Y, Jingyuan, C, Xiaoying, F. 登録日 2022-08-02 公開日 2023-02-15 最終更新日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.25 Å) 主引用文献 Structure of the Newcastle Disease Virus L protein in complex with tetrameric phosphoprotein. Nat Commun, 14, 2023
3E51	Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor 分子名称: N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-pyrrolidin-1-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase 著者 Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. 登録日 2008-08-12 公開日 2009-08-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents. Bioorg.Med.Chem.Lett., 18, 2008
7X6S	lymphocytic choriomeningitis virus RNA-dependent RNA polymerase (LCMV-L protein) 分子名称: MANGANESE (II) ION, RNA-directed RNA polymerase L 著者 Liu, L, Lou, Z. 登録日 2022-03-08 公開日 2023-09-13 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein. Protein Cell, 14, 2023
2GIR	Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-1 inhibitor 分子名称: 3-{ISOPROPYL[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]AMINO}-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA-directed RNA polymerase 著者 Harris, S.F. 登録日 2006-03-29 公開日 2007-04-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus. J.Virol., 80, 2006
7VGQ	Cryo-EM structure of Machupo virus polymerase L in complex with matrix protein Z 分子名称: Maltose/maltodextrin-binding periplasmic protein,RING finger protein Z, RNA-directed RNA polymerase L, ZINC ION 著者 Zhang, X, Ma, J, Zhang, S. 登録日 2021-09-18 公開日 2021-09-29 最終更新日 2022-03-02 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structure of Machupo virus polymerase in complex with matrix protein Z. Nat Commun, 12, 2021
7VH1	Cryo-EM structure of Machupo virus dimeric L-Z complex 分子名称: Maltose/maltodextrin-binding periplasmic protein,RING finger protein Z, RNA-directed RNA polymerase L, ZINC ION 著者 Zhang, X, Ma, J, Zhang, S. 登録日 2021-09-20 公開日 2021-09-29 最終更新日 2022-03-02 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structure of Machupo virus polymerase in complex with matrix protein Z. Nat Commun, 12, 2021
3GYN	Crystal structure of HCV NS5B polymerase with a novel monocyclic dihydropyridinone inhibitor 分子名称: N-{3-[(5R)-1-cyclopentyl-4-hydroxy-5-methyl-5-(3-methylbutyl)-2-oxo-1,2,5,6-tetrahydropyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase 著者 Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. 登録日 2009-04-04 公開日 2009-12-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 19, 2009

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