6FP3
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5K61
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![BU of 5k61 by Molmil](/molmil-images/mine/5k61) | Crystal structure of N-terminal amidase with Gln-Gly peptide | 分子名称: | GLUTAMINE, Nta1p | 著者 | Kim, M.K, Oh, S.-J, Lee, B.-G, Song, H.K. | 登録日 | 2016-05-24 | 公開日 | 2017-04-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Structural basis for dual specificity of yeast N-terminal amidase in the N-end rule pathway. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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6GBP
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![BU of 6gbp by Molmil](/molmil-images/mine/6gbp) | Crystal Structure of the oligomerization domain of VP35 from Ebola virus, mercury derivative | 分子名称: | MERCURY (II) ION, Polymerase cofactor VP35 | 著者 | Zinzula, L, Nagy, I, Orsini, M, Weyher-Stingl, E, Baumeister, W, Bracher, A. | 登録日 | 2018-04-16 | 公開日 | 2018-10-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | Structures of Ebola and Reston Virus VP35 Oligomerization Domains and Comparative Biophysical Characterization in All Ebolavirus Species. Structure, 27, 2019
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6DB5
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8V4S
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![BU of 8v4s by Molmil](/molmil-images/mine/8v4s) | Cryo-EM structure of the rat P2X7 receptor in the apo closed state purified in the absence of sodium | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, P2X purinoceptor 7, ... | 著者 | Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. | 登録日 | 2023-11-29 | 公開日 | 2024-08-14 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | 主引用文献 | High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15, 2024
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2NNU
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6H4Z
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![BU of 6h4z by Molmil](/molmil-images/mine/6h4z) | Crystal structure of human KDM5B in complex with compound 16a | 分子名称: | 1,2-ETHANEDIOL, 8-[4-[2-[4-(3-chlorophenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... | 著者 | Le Bihan, Y.V, Velupillai, S, van Montfort, R.L.M. | 登録日 | 2018-07-23 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur.J.Med.Chem., 177, 2019
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6H5S
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![BU of 6h5s by Molmil](/molmil-images/mine/6h5s) | Cryo-EM map of in vitro assembled Measles virus N into nucleocapsid-like particles (NCLPs) bound to viral genomic 5-prime RNA hexamers. | 分子名称: | Nucleocapsid, RNA (5'-R(*AP*CP*CP*AP*GP*A)-3') | 著者 | Desfosses, A, Milles, S, Ringkjobing Jensen, M, Guseva, S, Colletier, J.P, Maurin, D, Schoehn, G, Gutsche, I, Ruigrok, R, Blackledge, M. | 登録日 | 2018-07-25 | 公開日 | 2019-06-12 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Assembly and cryo-EM structures of RNA-specific measles virus nucleocapsids provide mechanistic insight into paramyxoviral replication. Proc.Natl.Acad.Sci.USA, 116, 2019
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6GIX
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![BU of 6gix by Molmil](/molmil-images/mine/6gix) | Water-soluble Chlorophyll Protein (WSCP) from Lepidium virginicum (Mutation L91P) with Chlorophyll-b | 分子名称: | CHLOROPHYLL B, Water-soluble chlorophyll protein | 著者 | Palm, D.M, Agostini, A, Averesch, V, Girr, P, Werwie, M, Takahashi, S, Satoh, H, Jaenicke, E, Paulsen, H. | 登録日 | 2018-05-15 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Chlorophyll a/b binding-specificity in water-soluble chlorophyll protein. Nat Plants, 4, 2018
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5K26
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6DQ8
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![BU of 6dq8 by Molmil](/molmil-images/mine/6dq8) | LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N49 i.e. 2-((2-chlorophenyl)(2-(1-methylpyrrolidin-2-yl)ethoxy)methyl)thieno[3,2-b]pyridine-7-carboxylic acid | 分子名称: | 1,2-ETHANEDIOL, 2-[(R)-(2-chlorophenyl){2-[(2S)-1-methylpyrrolidin-2-yl]ethoxy}methyl]thieno[3,2-b]pyridine-7-carboxylic acid, 2-[(S)-(2-chlorophenyl){2-[(2S)-1-methylpyrrolidin-2-yl]ethoxy}methyl]thieno[3,2-b]pyridine-7-carboxylic acid, ... | 著者 | Horton, J.R, Cheng, X. | 登録日 | 2018-06-10 | 公開日 | 2018-11-21 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A. J. Med. Chem., 61, 2018
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5K5V
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6GLC
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![BU of 6glc by Molmil](/molmil-images/mine/6glc) | Structure of phospho-Parkin bound to phospho-ubiquitin | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase parkin, GLYCEROL, ... | 著者 | Gladkova, C, Maslen, S.L, Skehel, J.M, Komander, D. | 登録日 | 2018-05-23 | 公開日 | 2018-06-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanism of parkin activation by PINK1. Nature, 559, 2018
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5K6D
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![BU of 5k6d by Molmil](/molmil-images/mine/5k6d) | Structure of FS50 an antagonist of NaV1.5 | 分子名称: | Putative secreted salivary protein | 著者 | Andersen, J.F, Xu, X. | 登録日 | 2016-05-24 | 公開日 | 2016-11-23 | 実験手法 | X-RAY DIFFRACTION (1.139 Å) | 主引用文献 | Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5. Sci Rep, 6, 2016
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8B9N
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8BFW
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![BU of 8bfw by Molmil](/molmil-images/mine/8bfw) | The structures of Ace2 in complex with bicyclic peptide inhibitor | 分子名称: | 1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one, ALA-CYS-VAL-ARG-SER-HIS-CYS-SER-SER-LEU-LEU-PRO-ARG-ILE-HIS-CYS-ALA-NH2, Processed angiotensin-converting enzyme 2 | 著者 | Brear, P, Lulla, A, Harman, M, Dods, R, Chen, L, Bezerra, G, Demydchuk, Y, Stanway, S, Hyvonen, M. | 登録日 | 2022-10-27 | 公開日 | 2023-10-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Structure-Guided Chemical Optimization of Bicyclic Peptide ( Bicycle ) Inhibitors of Angiotensin-Converting Enzyme 2. J.Med.Chem., 66, 2023
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6DJD
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![BU of 6djd by Molmil](/molmil-images/mine/6djd) | Crystal structure of Tdp1 catalytic domain in complex with Zenobia fragment ZT1982 (single soak) | 分子名称: | 1,2-ETHANEDIOL, 4-hydroxyquinoline-3-carboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. | 登録日 | 2018-05-25 | 公開日 | 2019-05-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.777 Å) | 主引用文献 | Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Res., 2019
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8B8O
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5JDT
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![BU of 5jdt by Molmil](/molmil-images/mine/5jdt) | Structure of Spin-labelled T4 lysozyme mutant L118C-R1 at 100K | 分子名称: | AZIDE ION, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | 著者 | Loll, B, Consentius, P, Gohlke, U, Mueller, R, Kaupp, M, Heinemann, U, Wahl, M.C, Risse, T. | 登録日 | 2016-04-17 | 公開日 | 2016-09-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Tracking Transient Conformational States of T4 Lysozyme at Room Temperature Combining X-ray Crystallography and Site-Directed Spin Labeling. J.Am.Chem.Soc., 138, 2016
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6O8R
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![BU of 6o8r by Molmil](/molmil-images/mine/6o8r) | Syn-safencin 24 | 分子名称: | Circular bacteriocin, circularin A/uberolysin family | 著者 | Fields, F.R, Lee, S.W. | 登録日 | 2019-03-11 | 公開日 | 2020-05-13 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. Acs Pharmacol Transl Sci, 3, 2020
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2NLJ
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![BU of 2nlj by Molmil](/molmil-images/mine/2nlj) | Potassium Channel KcsA(M96V)-Fab complex in KCl | 分子名称: | DIACYL GLYCEROL, POTASSIUM ION, Voltage-gated potassium channel, ... | 著者 | Lockless, S.W, Zhou, M, MacKinnon, R. | 登録日 | 2006-10-20 | 公開日 | 2007-05-15 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Structural and Thermodynamic Properties of Selective Ion Binding in a K(+) Channel. Plos Biol., 5, 2007
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6OSW
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![BU of 6osw by Molmil](/molmil-images/mine/6osw) | An order-to-disorder structural switch activates the FoxM1 transcription factor | 分子名称: | Forkhead box M1 | 著者 | Marceau, A.H, Rubin, S.M, Nerli, S, McShane, A.C, Sgourakis, N.G. | 登録日 | 2019-05-02 | 公開日 | 2019-05-29 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | An order-to-disorder structural switch activates the FoxM1 transcription factor. Elife, 8, 2019
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5J1F
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6O8J
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![BU of 6o8j by Molmil](/molmil-images/mine/6o8j) | Syn-safencin | 分子名称: | Circular bacteriocin, circularin A/uberolysin family | 著者 | Fields, F.R, Lee, S.W. | 登録日 | 2019-03-11 | 公開日 | 2020-04-15 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. Acs Pharmacol Transl Sci, 3, 2020
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6O8P
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![BU of 6o8p by Molmil](/molmil-images/mine/6o8p) | Syn-safencin 8 | 分子名称: | Circular bacteriocin, circularin A/uberolysin family | 著者 | Fields, F.R, Lee, S.W. | 登録日 | 2019-03-11 | 公開日 | 2020-05-13 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. Acs Pharmacol Transl Sci, 3, 2020
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