PDB: 72150 件ウェブページステータス検索Chemie searchBIRD

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4AGQ	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5196 分子名称: 2-{[4-(diethylamino)piperidin-1-yl]methyl}-6-iodo-4-[3-(phenylamino)prop-1-yn-1-yl]phenol, CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R. 登録日 2012-01-30 公開日 2012-03-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012
4AGP	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5176 分子名称: 2-{[4-(diethylamino)piperidin-1-yl]methyl}-6-iodo-4-(3-phenoxyprop-1-yn-1-yl)phenol, CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C, Wilcken, R, Fersht, A.R, Boeckler, F.M. 登録日 2012-01-30 公開日 2012-03-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012
4AGL	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan784 分子名称: 2,4-BIS(IODANYL)-6-[[METHYL-(1-METHYLPIPERIDIN-4-YL)AMINO]METHYL]PHENOL, CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R. 登録日 2012-01-30 公開日 2012-03-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012
4AGM	Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5086 分子名称: 2-{[4-(DIETHYLAMINO)PIPERIDIN-1-YL]METHYL}-4,6-DIIODOPHENOL, CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C, Wilcken, R, Boeckler, F.M, Fersht, A.R. 登録日 2012-01-30 公開日 2012-03-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant P53. J.Am.Chem.Soc., 134, 2012
3QO1	Monoclinic form of IgG1 Fab fragment (apo form) sharing same Fv as IgA 分子名称: Fab fragment of IMMUNOGLOBULIN G1 HEAVY CHAIN, Fab fragment of IMMUNOGLOBULIN G1 LIGHT CHAIN, GLYCEROL 著者 Trajtenberg, F, Correa, A, Buschiazzo, A. 登録日 2011-02-09 公開日 2012-02-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of a human IgA1 Fab fragment at 1.55 angstrom resolution: potential effect of the constant domains on antigen-affinity modulation Acta Crystallogr.,Sect.D, 69, 2013
3QYM	Structure of p63 DNA Binding Domain in Complex with a 10 Base Pair A/T Rich Response Element Half Site 分子名称: 5'-D(*AP*AP*AP*CP*AP*TP*GP*TP*TP*T)-3', Tumor protein 63, ZINC ION 著者 Herzberg, O, Chen, C. 登録日 2011-03-03 公開日 2011-04-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements. Proc.Natl.Acad.Sci.USA, 108, 2011
4GI3	Crystal structure of Greglin in complex with subtilisin 分子名称: Greglin, KerA 著者 Kellenberger, C, Roussel, A. 登録日 2012-08-08 公開日 2012-11-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal structure of greglin, a novel non-classical Kazal inhibitor, in complex with subtilisin Febs J., 279, 2012
4L7P	Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0395 分子名称: (2E)-N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-3-(4-oxo-1,4-dihydroquinazolin-2-yl)prop-2-enamide, Poly [ADP-ribose] polymerase 3 著者 Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H. 登録日 2013-06-14 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3. J.Med.Chem., 56, 2013
4GV2	Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0354 分子名称: 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1R)-1-(pyridin-2-yl)ethyl]propanamide, DIMETHYL SULFOXIDE, Poly [ADP-ribose] polymerase 3 著者 Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H. 登録日 2012-08-30 公開日 2013-06-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3 Acs Chem.Biol., 8, 2013
4GV4	Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0328 分子名称: 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-phenylethyl]propanamide, DIMETHYL SULFOXIDE, Poly [ADP-ribose] polymerase 3 著者 Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H. 登録日 2012-08-30 公開日 2013-06-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3 Acs Chem.Biol., 8, 2013
3QRP	Structure of Thermus Thermophilus Cse3 bound to an RNA representing a product mimic complex 分子名称: Putative uncharacterized protein TTHB192, RNA (5'-R(*GP*UP*CP*CP*CP*CP*AP*CP*(PGP))-3'), RNA (5'-R(P*(U5P)P*GP*UP*GP*GP*GP*G)-3'), ... 著者 Schellenberg, M.J, Gesner, E.M, Garside, E.L, MacMillan, A.M. 登録日 2011-02-18 公開日 2011-05-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.352 Å) 主引用文献 Recognition and maturation of effector RNAs in a CRISPR interference pathway. Nat.Struct.Mol.Biol., 18, 2011
3QRQ	Structure of Thermus Thermophilus Cse3 bound to an RNA representing a pre-cleavage complex 分子名称: Putative uncharacterized protein TTHB192, RNA (5'-R(*GP*UP*CP*CP*CP*CP*AP*CP*GP*CP*GP*UP*GP*UP*GP*GP*GP*GP*A)-3') 著者 Schellenberg, M.J, Gesner, E.G, Garside, E.L, MacMillan, A.M. 登録日 2011-02-18 公開日 2011-05-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.194 Å) 主引用文献 Recognition and maturation of effector RNAs in a CRISPR interference pathway. Nat.Struct.Mol.Biol., 18, 2011
4GV0	Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0355 分子名称: 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-(pyridin-2-yl)ethyl]propanamide, DIMETHYL SULFOXIDE, Poly [ADP-ribose] polymerase 3 著者 Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H. 登録日 2012-08-30 公開日 2013-06-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3 Acs Chem.Biol., 8, 2013
3ZY0	Crystal structure of a truncated variant of the human p63 tetramerization domain lacking the C-terminal helix 分子名称: TUMOR PROTEIN P63 著者 Joerger, A.C. 登録日 2011-08-16 公開日 2011-11-30 最終更新日 2019-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure and Kinetic Stability of the P63 Tetramerization Domain. J.Mol.Biol., 415, 2012
4L6Z	Human artd3 (parp3) - catalytic domain in complex with inhibitor STO1168 分子名称: 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-(pyridin-4-yl)ethyl]propanamide, DIMETHYL SULFOXIDE, Poly [ADP-ribose] polymerase 3 著者 Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H. 登録日 2013-06-13 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3. J.Med.Chem., 56, 2013
4L7O	Human artd3 (parp3) - catalytic domain in complex with inhibitor STO1542 分子名称: DIMETHYL SULFOXIDE, N-{(1S)-1-[4-(1H-imidazol-1-yl)phenyl]ethyl}-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide, Poly [ADP-ribose] polymerase 3 著者 Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H. 登録日 2013-06-14 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3. J.Med.Chem., 56, 2013
4L7L	Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0368 分子名称: DIMETHYL SULFOXIDE, N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide, Poly [ADP-ribose] polymerase 3 著者 Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H. 登録日 2013-06-14 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3. J.Med.Chem., 56, 2013
4L7U	Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0398 分子名称: Poly [ADP-ribose] polymerase 3, methyl N-[3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanoyl]-L-phenylalaninate 著者 Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H. 登録日 2013-06-14 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3. J.Med.Chem., 56, 2013
3ZUG	E268D mutant of FAD synthetase from Corynebacterium ammoniagenes 分子名称: RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBF, SULFATE ION 著者 Herguedas, B, Martinez-Julvez, M, Serrano, A, Medina, M. 登録日 2011-07-19 公開日 2012-08-01 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Key Residues at the Riboflavin Kinase Catalytic Site of the Bifunctional Riboflavin Kinase/Fmn Adenylyltransferase from Corynebacterium Ammoniagenes. Cell Biochem.Biophys., 65, 2013
4IBQ	Human p53 core domain with hot spot mutation R273C 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Cellular tumor antigen p53, ... 著者 Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z. 登録日 2012-12-09 公開日 2013-08-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
4M7B	Human tankyrase 2 - catalytic Parp domain in complex with an inhibitor UPF1854 分子名称: 4-{2-[(6-methyl[1,2,4]triazolo[4,3-b]pyridazin-8-yl)amino]ethyl}phenol, SULFATE ION, Tankyrase-2, ... 著者 Karlberg, T, Camaioni, E, Schuler, H. 登録日 2013-08-12 公開日 2014-03-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3-b]pyridazin-8-amine Derivatives as Tankyrase Inhibitors. J.Med.Chem., 57, 2014
4M8B	Fungal Protein 分子名称: 1,2-ETHANEDIOL, Chain A of dsDNA containing the cis-regulatory element, Chain B of dsDNA containing the cis-regulatory element, ... 著者 Rosenberg, O.S, Lohse, M.L, Stroud, R.M, Johnson, A.D. 登録日 2013-08-13 公開日 2014-06-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi. Proc.Natl.Acad.Sci.USA, 111, 2014
4IBS	Human p53 core domain with hot spot mutation R273H (form I) 分子名称: 1,2-ETHANEDIOL, Cellular tumor antigen p53, ZINC ION 著者 Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z. 登録日 2012-12-09 公開日 2013-08-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
4IJT	Human p53 core domain with hot spot mutation R273H (form II) 分子名称: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Cellular tumor antigen p53, ... 著者 Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z. 登録日 2012-12-23 公開日 2013-08-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
4L70	Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0352 分子名称: 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-phenylpropyl]propanamide, DIMETHYL SULFOXIDE, Poly [ADP-ribose] polymerase 3 著者 Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Ekblad, T, Spjut, S, Andersson, C.D, Weigelt, J, Linusson, A, Elofsson, M, Schuler, H. 登録日 2013-06-13 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3. J.Med.Chem., 56, 2013

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