1NL7
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7PXQ
| GH115 alpha-1,2-glucuronidase D303A | 分子名称: | CALCIUM ION, xylan alpha-1,2-glucuronidase | 著者 | Wilkens, C, Morth, J.P, Polikarpov, I. | 登録日 | 2021-10-08 | 公開日 | 2022-01-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A GH115 alpha-glucuronidase structure reveals dimerization-mediated substrate binding and a proton wire potentially important for catalysis. Acta Crystallogr D Struct Biol, 78, 2022
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5L6L
| Structure of Caulobacter crescentus VapBC1 bound to operator DNA | 分子名称: | DNA (27-MER), Ribonuclease VapC, VapB family protein | 著者 | Bendtsen, K.L, Xu, K, Luckmann, M, Brodersen, D.E. | 登録日 | 2016-05-30 | 公開日 | 2016-12-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Toxin inhibition in C. crescentus VapBC1 is mediated by a flexible pseudo-palindromic protein motif and modulated by DNA binding. Nucleic Acids Res., 45, 2017
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2RG6
| Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11J | 分子名称: | 4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methyl-N-[(1S)-1-phenylethyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Sack, J.S. | 登録日 | 2007-10-02 | 公開日 | 2008-01-15 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha Mitogen-Activated Protein Kinase Inhibitors J.Med.Chem., 51, 2008
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7PTZ
| High resolution X-ray structure of E. coli expressed Lentinus similis LPMO. | 分子名称: | Auxiliary activity 9, CHLORIDE ION, COPPER (II) ION | 著者 | Banerjee, S, Muderspach, S.J, Tandrup, T, Ipsen, J.O, Hernandez-Rollan, C, Norholm, H.H.M, Johansen, K.S, Lo Leggio, L. | 登録日 | 2021-09-27 | 公開日 | 2022-03-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.093 Å) | 主引用文献 | Protonation State of an Important Histidine from High Resolution Structures of Lytic Polysaccharide Monooxygenases. Biomolecules, 12, 2022
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7PU1
| High resolution X-ray structure of Thermoascus aurantiacus LPMO | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COPPER (II) ION, ... | 著者 | Banerjee, S, Frandsen, K.E.H, Singh, R.K, Bjerrum, M.J, Lo Leggio, L. | 登録日 | 2021-09-28 | 公開日 | 2022-03-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | 主引用文献 | Protonation State of an Important Histidine from High Resolution Structures of Lytic Polysaccharide Monooxygenases. Biomolecules, 12, 2022
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5LDO
| Crystal structure of E.coli LigT complexed with 3'-AMP | 分子名称: | RNA 2',3'-cyclic phosphodiesterase, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate | 著者 | Myllykoski, M, Kursula, P. | 登録日 | 2016-06-27 | 公開日 | 2017-01-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.752 Å) | 主引用文献 | Structural aspects of nucleotide ligand binding by a bacterial 2H phosphoesterase. PLoS ONE, 12, 2017
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7Q1Y
| X-ray structure of human A2ML1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1, ... | 著者 | Andersen, G.R, Zarantonello, A, Enghild, J.J, Nielsen, N.S. | 登録日 | 2021-10-22 | 公開日 | 2022-04-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. Nat Commun, 13, 2022
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5LHP
| The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7 | 分子名称: | 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment, P-AMINO BENZAMIDINE, ... | 著者 | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A. | 登録日 | 2016-07-12 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep, 7, 2017
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1OOW
| The crystal structure of the spinach plastocyanin double mutant G8D/L12E gives insight into its low reactivity towards photosystem 1 and cytochrome f | 分子名称: | COPPER (II) ION, Plastocyanin, chloroplast | 著者 | Jansson, H, Okvist, M, Jacobson, F, Ejdeback, M, Hansson, O, Sjolin, L. | 登録日 | 2003-03-04 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The crystal structure of the spinach plastocyanin double mutant G8D/L12E gives insight into its low reactivity towards photosystem 1 and cytochrome f. Biochim.Biophys.Acta, 1607, 2003
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7PFL
| The SARS-CoV2 major protease (Mpro) apo structure to 1.8 A resolution | 分子名称: | Replicase polyprotein 1ab, SODIUM ION | 著者 | Moche, M, Moodie, L, Strandback, E, Nyman, T, Akaberi, D, Lennerstrand, J. | 登録日 | 2021-08-11 | 公開日 | 2022-08-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The SARS-CoV2 major protease (Mpro) in complex with a non-covalent inhibitory ligand at 2 A resolution To Be Published
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7PHF
| Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and 10-decarboxylase TamK | 分子名称: | Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate | 著者 | Dinis, P, MetsaKetela, M. | 登録日 | 2021-08-17 | 公開日 | 2022-09-07 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Evolution-inspired engineering of anthracycline methyltransferases. Pnas Nexus, 2, 2023
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5LHN
| The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7 | 分子名称: | 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, SULFATE ION, ... | 著者 | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P, Andreasen, P.A. | 登録日 | 2016-07-12 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep, 7, 2017
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7PFM
| A SARS-CoV2 major protease non-covalent ligand structure determined to 2.0 A resolution | 分子名称: | N-[(1R)-2-(tert-butylamino)-2-oxidanylidene-1-pyridin-3-yl-ethyl]-N-(4-tert-butylphenyl)-1H-imidazole-5-carboxamide, Replicase polyprotein 1ab | 著者 | Moche, M, Moodie, L, Strandback, E, Nyman, T, Sandstrom, A, Akaberi, D, Lennerstrand, J. | 登録日 | 2021-08-11 | 公開日 | 2022-08-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The SARS-CoV2 major protease (Mpro) in complex with a non-covalent inhibitory ligand at 2 A resolution To Be Published
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5LHQ
| The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7 | 分子名称: | 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ... | 著者 | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A. | 登録日 | 2016-07-12 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep, 7, 2017
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7PHE
| Chimeric carminomycin-4-O-methyltransferase (DnrK) with regions from 10-hydroxylase RdmB and 10-decarboxylase TamK | 分子名称: | Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB, methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate | 著者 | Dinis, P, MetsaKetela, M. | 登録日 | 2021-08-17 | 公開日 | 2022-09-07 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Evolution-inspired engineering of anthracycline methyltransferases. Pnas Nexus, 2, 2023
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7PZ1
| Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH8535 | 分子名称: | 1,2-ETHANEDIOL, 4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(3-methoxy-4-methyl-phenyl)piperidine-1-carboxamide, GLYCEROL, ... | 著者 | Scaletti, E.R, Helleday, T, Stenmark, P. | 登録日 | 2021-10-11 | 公開日 | 2022-11-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1. Chemmedchem, 18, 2023
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1OLR
| The Humicola grisea Cel12A Enzyme Structure at 1.2 A Resolution | 分子名称: | ENDO-BETA-1,4-GLUCANASE | 著者 | Sandgren, M, Gualfetti, P.J, Shaw, A, Gross, L.S, Saldajeno, M, Berglund, G.I, Jones, T.A, Mitchinson, C. | 登録日 | 2003-08-11 | 公開日 | 2003-11-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | The Humicola Grisea Cel12A Enzyme Structure at 1.2 A Resolution and the Impact of its Free Cysteine Residues on Thermal Stability Protein Sci., 12, 2003
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7Q3J
| Computationally designed thioredoxin subjected to stability optimizing mutations. | 分子名称: | GLYCEROL, MM9 | 著者 | Norrild, R.K, Johansson, K.E, O'Shea, C, Lindorff-Larsen, K, Winther, J.R, Morth, J.P. | 登録日 | 2021-10-27 | 公開日 | 2022-11-16 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Increasing protein stability by inferring substitution effects from high-throughput experiments. Cell Rep Methods, 2, 2022
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7PX1
| Conotoxin from Conus mucronatus | 分子名称: | CADMIUM ION, Conus mucronatus, IODIDE ION | 著者 | Mueller, E, Hackney, C.M, Ellgaard, L, Morth, J.P. | 登録日 | 2021-10-07 | 公開日 | 2022-11-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3. Plos Biol., 21, 2023
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7PX2
| Conotoxin Mu8.1 from Conus mucronatus | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Conotoxin Mu8.1 | 著者 | Mueller, E, Hackney, C, Ellgaard, L, Morth, J.P. | 登録日 | 2021-10-07 | 公開日 | 2022-11-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3. Plos Biol., 21, 2023
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2RG5
| Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11B | 分子名称: | Mitogen-activated protein kinase 14, N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide | 著者 | Sack, J.S. | 登録日 | 2007-10-02 | 公開日 | 2008-01-15 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha Mitogen-Activated Protein Kinase Inhibitors J.Med.Chem., 51, 2008
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1OVD
| THE K136E MUTANT OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE A IN COMPLEX WITH OROTATE | 分子名称: | DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | 著者 | Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. | 登録日 | 2003-03-26 | 公開日 | 2003-08-19 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function. J.Biol.Chem., 278, 2003
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7Q3K
| Computationally designed thioredoxin subjected to stability optimizing mutations. | 分子名称: | SULFATE ION, eMM9 | 著者 | Norrild, R.K, Johansson, K.E, O'Shea, C, Lindorff-Larsen, K, Winther, J.R, Morth, J.P. | 登録日 | 2021-10-27 | 公開日 | 2022-11-16 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Increasing protein stability by inferring substitution effects from high-throughput experiments. Cell Rep Methods, 2, 2022
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5MFW
| Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-121 at 2.10 A resolution | 分子名称: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, ... | 著者 | Larsen, A.P, Frydenvang, K, Kastrup, J.S. | 登録日 | 2016-11-18 | 公開日 | 2017-04-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol. Pharmacol., 91, 2017
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