5AWJ
 
 | | Crystal structure of VDR-LBD/partial agonist complex: 22S-hexyl analogue | | 分子名称: | (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3S)-3-(2-hydroxyethyl)nonan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidene-cyclohexane-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor,Vitamin D3 receptor | | 著者 | Anami, Y, Itoh, T, Inaba, Y, Nakabayashi, M, Ikura, T, Ito, N, Yamamoto, K. | | 登録日 | 2015-07-04 | | 公開日 | 2015-11-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity.
Bioorg.Med.Chem., 23, 2015
|
|
2C1P
 | | Fab-fragment of enantioselective antibody complexed with finrozole | | 分子名称: | 4-[(1S,2R)-3-(4-FLUOROPHENYL)-2-HYDROXY-1-(1H-1,2,4-TRIAZOL-1-YL)PROPYL]BENZONITRILE, IGH-4 PROTEIN, IGK-C PROTEIN | | 著者 | Parkkinen, T, Nevanen, T.K, Koivula, A, Rouvinen, J. | | 登録日 | 2005-09-19 | | 公開日 | 2006-01-25 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structures of an Enantioselective Fab-Fragment in Free and Complex Forms.
J.Mol.Biol., 357, 2006
|
|
1SG8
 | | Crystal structure of the procoagulant fast form of thrombin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, thrombin | | 著者 | Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E. | | 登録日 | 2004-02-23 | | 公開日 | 2004-06-08 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular dissection of na+ binding to thrombin.
J.Biol.Chem., 279, 2004
|
|
2BYT
 | | Thermus thermophilus Leucyl-tRNA synthetase complexed with a tRNAleu transcript in the post-editing conformation | | 分子名称: | LEUCINE, LEUCYL-TRNA SYNTHETASE, MERCURY (II) ION, ... | | 著者 | Cusack, S, Tukalo, M, Yaremchuk, A, Fukunaga, R, Yokoyama, S. | | 登録日 | 2005-08-04 | | 公開日 | 2005-09-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer-Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
|
|
2C1M
 | | Nup50:importin-alpha complex | | 分子名称: | IMPORTIN-ALPHA2 SUBUNIT, NUCLEOPORIN 50 KDA | | 著者 | Matsuura, Y, Stewart, M. | | 登録日 | 2005-09-16 | | 公開日 | 2005-11-23 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Nup50/Npap60 Function in Nuclear Protein Import Complex Disassembly and Importin Recycling.
Embo J., 24, 2005
|
|
2C1O
 | | ENAIIHis Fab fragment in the free form | | 分子名称: | IGH-4 PROTEIN, IGK-C PROTEIN | | 著者 | Parkkinen, T, Nevanen, T.K, Koivula, A, Rouvinen, J. | | 登録日 | 2005-09-19 | | 公開日 | 2006-01-25 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Crystal Structures of an Enantioselective Fab-Fragment in Free and Complex Forms.
J.Mol.Biol., 357, 2006
|
|
6G72
 | | Mouse mitochondrial complex I in the deactive state | | 分子名称: | ACETYL GROUP, ADENOSINE-5'-DIPHOSPHATE, Acyl carrier protein, ... | | 著者 | Agip, A.N.A, Blaza, J.N, Bridges, H.R, Viscomi, C, Rawson, S, Muench, S.P, Hirst, J. | | 登録日 | 2018-04-04 | | 公開日 | 2018-06-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states.
Nat. Struct. Mol. Biol., 25, 2018
|
|
1Z7S
 | | The crystal structure of coxsackievirus A21 | | 分子名称: | CALCIUM ION, GUANOSINE-5'-MONOPHOSPHATE, Human COXSACKIEVIRUS A21, ... | | 著者 | Xiao, C, Bator-Kelly, C.M, Rieder, E, Chipman, P.R, Craig, A, Kuhn, R.J, Wimmer, E, Rossmann, M.G. | | 登録日 | 2005-03-28 | | 公開日 | 2005-08-02 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | The crystal structure of coxsackievirus a21 and its interaction with icam-1.
Structure, 13, 2005
|
|
1ZL3
 | | Coupling of active site motions and RNA binding | | 分子名称: | 5'-R(*GP*GP*CP*AP*AP*CP*GP*GP*UP*(FLO) UP*CP*GP*AP*UP*CP*CP*CP*GP*UP*UP*GP*C)-3', SULFATE ION, tRNA pseudouridine synthase B | | 著者 | Hoang, C, Hamilton, C.S, Mueller, E.G, Ferre-D'Amare, A.R. | | 登録日 | 2005-05-05 | | 公開日 | 2005-08-09 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain
Protein Sci., 14, 2005
|
|
1ZCI
 | | HIV-1 DIS RNA subtype F- monoclinic form | | 分子名称: | 5'-R(*CP*(5BU)P*UP*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3', POTASSIUM ION | | 著者 | Ennifar, E, Dumas, P. | | 登録日 | 2005-04-12 | | 公開日 | 2006-01-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Polymorphism of Bulged-out Residues in HIV-1 RNA DIS Kissing Complex and Structure Comparison with Solution Studies.
J.Mol.Biol., 356, 2006
|
|
5B5B
 | | Crystal structure of VDR-LBD complexed with 2-methylidene-26,27-diphenyl-19-nor-1,25-dihydroxyvitamin D3 | | 分子名称: | (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-oxidanyl-7-phenyl-6-(phenylmethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidene-cyclohexane-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | | 著者 | Kato, A, Itoh, T, Yamamoto, K. | | 登録日 | 2016-05-02 | | 公開日 | 2016-06-29 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Helix12-Stabilization Antagonist of Vitamin D Receptor
Bioconjug.Chem., 27, 2016
|
|
1WFC
 | | STRUCTURE OF APO, UNPHOSPHORYLATED, P38 MITOGEN ACTIVATED PROTEIN KINASE P38 (P38 MAP KINASE) THE MAMMALIAN HOMOLOGUE OF THE YEAST HOG1 PROTEIN | | 分子名称: | MITOGEN-ACTIVATED PROTEIN KINASE P38 | | 著者 | Wilson, K.P, Fitzgibbon, M.J, Caron, P.R, Griffith, J.P, Chen, W, Mccaffrey, P.G, Chambers, S.P, Su, M.S.-S. | | 登録日 | 1996-09-13 | | 公開日 | 1997-09-19 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of p38 mitogen-activated protein kinase.
J.Biol.Chem., 271, 1996
|
|
6G07
 | |
1ZDY
 | |
5APJ
 | | Ligand complex of RORg LBD | | 分子名称: | 2-CHLORO-6-FLUORO-N-[4-[3-(TRIFLUOROMETHYL)PHENYL]SULFONYL-3,5-DIHYDRO-2H-1,4-BENZOXAZEPIN-7-YL]BENZAMIDE, NUCLEAR RECEPTOR COACTIVATOR 2, NUCLEAR RECEPTOR ROR-GAMMA, ... | | 著者 | Xue, Y, Aagaard, A, Narjes, F. | | 登録日 | 2015-09-16 | | 公開日 | 2015-11-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor ROR gamma.
ChemMedChem, 11, 2016
|
|
1YYK
 | | Crystal structure of RNase III from Aquifex Aeolicus complexed with double-stranded RNA at 2.5-angstrom resolution | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*G)-3', Ribonuclease III | | 著者 | Gan, J, Tropea, J.E, Austin, B.P, Court, D.L, Waugh, D.S, Ji, X. | | 登録日 | 2005-02-25 | | 公開日 | 2005-11-22 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Intermediate states of ribonuclease III in complex with double-stranded RNA
Structure, 13, 2005
|
|
5DVC
 | |
5E1B
 | | Crystal structure of NRMT1 in complex with SPKRIA peptide | | 分子名称: | GLYCEROL, N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, ... | | 著者 | Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2015-09-29 | | 公開日 | 2015-10-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Genes Dev., 29, 2015
|
|
5APH
 | | Ligand complex of RORg LBD | | 分子名称: | DIMETHYL SULFOXIDE, N-(2-FLUOROPHENYL)-4-[(4-FLUOROPHENYL)SULFONYL]-2,3,4,5-TETRAHYDRO-1,4-BENZOXAZEPIN-6-AMINE, NUCLEAR RECEPTOR COACTIVATOR 2, ... | | 著者 | Xue, Y, Aagaard, A, Narjes, F. | | 登録日 | 2015-09-16 | | 公開日 | 2015-11-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor ROR gamma.
ChemMedChem, 11, 2016
|
|
1S3M
 | | Structural and Functional Characterization of a Novel Archaeal Phosphodiesterase | | 分子名称: | Hypothetical protein MJ0936, NICKEL (II) ION | | 著者 | Chen, S, Busso, D, Yakunin, A.F, Kuznetsova, E, Proudfoot, M, Jancrick, J, Kim, R, Kim, S.-H, Berkeley Structural Genomics Center (BSGC) | | 登録日 | 2004-01-13 | | 公開日 | 2004-08-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural and functional characterization of a novel phosphodiesterase from Methanococcus jannaschii
J.Biol.Chem., 279, 2004
|
|
2BC4
 | | Crystal structure of HLA-DM | | 分子名称: | CHLORIDE ION, HLA class II histocompatibility antigen, DM alpha chain, ... | | 著者 | Nicholson, M.J, Moradi, B, Seth, N.P, Xing, X, Cuny, G.D, Stein, R.L, Wucherpfennig, K.W. | | 登録日 | 2005-10-18 | | 公開日 | 2006-05-23 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Small molecules that enhance the catalytic efficiency of HLA-DM.
J.Immunol., 176, 2006
|
|
6E5A
 | | PPARg in complex with compound 4b | | 分子名称: | (5Z)-5-({4-[(prop-2-yn-1-yl)oxy]phenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one, Peroxisome proliferator-activated receptor gamma | | 著者 | Bruning, J.B, Chua, B.S.K. | | 登録日 | 2018-07-19 | | 公開日 | 2019-03-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.
Eur J Med Chem, 167, 2019
|
|
5C4O
 | |
5C4T
 | |
1PX0
 | | Crystal structure of the haloalcohol dehalogenase HheC complexed with the haloalcohol mimic (R)-1-para-nitro-phenyl-2-azido-ethanol | | 分子名称: | (R)-1-PARA-NITRO-PHENYL-2-AZIDO-ETHANOL, halohydrin dehalogenase | | 著者 | de Jong, R.M, Tiesinga, J.J.W, Rozeboom, H.J, Kalk, K.H, Tang, L, Janssen, D.B, Dijkstra, B.W. | | 登録日 | 2003-07-02 | | 公開日 | 2003-10-07 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure and Mechanism of a Bacterial Haloalcohol Dehalogenase: a new variation of the short-chain dehydrogenase/reductase fold without an NAD(P)H binding site
EMBO J., 22, 2003
|
|
